49,968 results match your criteria: "MIchigan State University[Affiliation]"

Carbapenem-Resistant Adherence to Magnetic Nanoparticles.

Nanomaterials (Basel)

December 2024

Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI 48824, USA.

Carbapenem-resistant (CRE) is an emerging global concern. Specifically, carbapenemase-producing (CP) strains in CRE have recently been found in clinical, environmental, and food samples worldwide, causing many hospitalizations and deaths. Their rapid identification and characterization are paramount in control, management options, and treatment choices.

View Article and Find Full Text PDF

Background/objectives: Common Variable Immunodeficiency Disease (CVID) and other immunodeficiencies can present in subtle and variable ways. Whether or not a genetic lesion can be identified, there are not well understood biomarkers that quantitatively describe how severe a deficiency is. Here we discuss two possible ranking systems, CD4/CD8 T cell ratios and Immune Health Grades, and how such data maybe applicable to some immunodeficiencies.

View Article and Find Full Text PDF

Tef [ (Zucc.) Trotter] is the major staple crop for millions of people in Ethiopia and Eritrea and is believed to have been domesticated several thousand years ago. Tef has the smallest grains of all the cereals, which directly impacts its productivity and presents numerous challenges to its cultivation.

View Article and Find Full Text PDF

Anthropogenic nitrogen (N) deposition is unequally distributed across space and time, with inputs to terrestrial ecosystems impacted by industry regulations and variations in human activity. Soil carbon (C) content normally controls the fraction of mineralized N that is nitrified (ƒ), affecting N bioavailability for plants and microbes. However, it is unknown whether N deposition has modified the relationships among soil C, net N mineralization, and net nitrification.

View Article and Find Full Text PDF

Given the ubiquitous nature of love, numerous theories have been proposed to explain its existence. One such theory refers to love as a commitment device, suggesting that romantic love evolved to foster commitment between partners and enhance their reproductive success. In the present study, we investigated this hypothesis using a large-scale sample of 86,310 individual responses collected across 90 countries.

View Article and Find Full Text PDF

Pythiosis in Dogs.

Vet Clin North Am Small Anim Pract

December 2024

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, East Lansing, MI, USA. Electronic address:

Pythiosis is caused by the oomycete Pythium insidiosum. Within the United States, Pythiosis is most seen in the Southeast and Gulf Coast states, but it has an expanding distribution. Pythiosis is characterized by gastrointestinal or cutaneous lesions, and rarely these lesions are seen together.

View Article and Find Full Text PDF

Hydrolysis of the acetyl-CoA allosteric activator by Staphylococcus aureus pyruvate carboxylase.

Arch Biochem Biophys

December 2024

Department of Biological Sciences, Marquette University, Milwaukee, WI 53201-1881, USA. Electronic address:

Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to oxaloacetate which serves as an important anaplerotic reaction to replenish citric acid cycle intermediates. In most organisms, the PC-catalyzed reaction is allosterically activated by acetyl-coenzyme A. It has previously been reported that vertebrate PC can catalyze the hydrolysis of acetyl-CoA, offering a potential means for the enzyme to attenuate its allosteric activation.

View Article and Find Full Text PDF

The goal of this study was to compare the bioaccumulation of the PCB mixture Aroclor 1254 in zebrafish to cardiac and neurologic outcomes. The establishment of effect concentrations (ECs) for cardiac and neurotoxic effects of PCBs in early life stage fish is challenging due to a lack of measured PCB concentrations in test media (e.g.

View Article and Find Full Text PDF

Introduction: Accumulating research suggests both eating disorders (EDs) and internalizing disorders (e.g., anxiety, depression) are associated with gastrointestinal disease (e.

View Article and Find Full Text PDF

Background: The design of smart, photoactivated nanomaterials for targeted drug delivery systems (DDS) has garnered significant research interest due in part to the ability of light to precisely control drug release in specific cells or tissues with high spatial and temporal resolution. The development of effective light-triggered DDS involves mechanisms including photocleavage, photoisomerization, photopolymerization, photosensitization, photothermal phenomena, and photorearrangement, which permit response to ultraviolet (UV), visible (Vis), and/or Near Infrared (NIR) light. This review explores recent advancements in light-responsive small molecules, polymers, and nanocarriers, detailing their underlying mechanisms and utility for drug delivery and/or imaging.

View Article and Find Full Text PDF

Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer.

Dev Cell

December 2024

Department of Surgery, Henry Ford Health, Detroit, MI, USA; Department of Pharmacology and Toxicology, Michigan State University, Lansing, MI, USA. Electronic address:

Pancreatic ductal adenocarcinoma (PDA) is partly initiated through the transdifferentiation of acinar cells to metaplasia, which progresses to neoplasia and cancer. Tuft cells (TCs) are chemosensory cells not found in the normal pancreas but arise in cancer precursor lesions and diminish during progression to carcinoma. These metaplastic TCs (mTCs) suppress tumor progression through communication with the tumor microenvironment, but their fate during progression is unknown.

View Article and Find Full Text PDF

Unraveling the degradation mechanism of multiple pyrethroid insecticides by Pseudomonas aeruginosa and its environmental bioremediation potential.

Environ Int

December 2024

State Key Laboratory of Green Pesticide, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; College of Plant Protection, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Extensive use of pyrethroid insecticides poses significant risks to both ecological ecosystems and human beings. Herein, Pseudomonas aeruginosa PAO1 exhibited exceptional degradation capabilities towards a range of pyrethroid family insecticides including etofenprox, bifenthrin, tetramethrin, D-cypermethrin, allethrin, and permethrin, with a degradation efficiency reaching over 84 % within 36 h (50 mg·L). Strain PAO1 demonstrated effective soil bioremediation by removing etofenprox across different concentrations (25-100 mg·kg), with a degradation efficiency over 77 % within 15 days.

View Article and Find Full Text PDF

Preparation of a As source sample for application in an offline ion source.

Appl Radiat Isot

December 2024

Facility for Rare Isotope Beams, Michigan State University, 640 South Shaw Lane, East Lansing, 48824, MI, USA; Department of Chemistry, Michigan State University, 640 South Shaw Lane, East Lansing, 48824, MI, USA. Electronic address:

For the generation of beams with the offline ion source at the Facility for Rare Isotope Beams (FRIB), suitable source samples are required. Arsenic-73 is a frequently requested user beam due to its significance in nuclear structure studies and astrophysics. In this work, we outline the process of preparing a As source sample, containing (5.

View Article and Find Full Text PDF

Objectives: Urothelial carcinoma in situ (CIS) with early papillary formation is terminology sometimes used to suggest incipient high-grade papillary urothelial carcinoma (PUC) but may lead to confusion between true CIS and lateral flat spread of PUC.

Methods: It remains unclear how pathologists and urologists interpret this scenario, so a survey was circulated to 68 pathologists (group 1 = 28 academic genitourinary pathologists; group 2 = 17 pathologists with a self-reported genitourinary focus; group 3 = 23 pathologists self-reported as not genitourinary specialists) and 32 urologists.

Results: Regarding atypical urothelial lesions that appear mainly flat but contain possible papillae, group 3 was more likely to label this as CIS compared with groups 1 and 2 (35% for group 3 vs 13% for groups 1 and 2), while groups 1 and 2 more often adopted another descriptive diagnosis, such as "CIS with early papillary features" (38% for groups 1 and 2 vs 13% for group 3).

View Article and Find Full Text PDF

Background: Latinas suffer disproportionately from breast cancer, partially due to lower uptake of guideline-concordant breast cancer screening. We describe the design of a study to compare two approaches addressing this important public health problem.

Design/methods: We are conducting a 5-year randomized controlled trial.

View Article and Find Full Text PDF

Autophagy is an essential cellular recycling process that maintains protein and organelle homeostasis. ATG9A vesicle recruitment is a critical early step in autophagy to initiate autophagosome biogenesis. The mechanisms of ATG9A vesicle recruitment are best understood in the context of starvation-induced non-selective autophagy, whereas less is known about the signals driving ATG9A vesicle recruitment to autophagy initiation sites in the absence of nutrient stress.

View Article and Find Full Text PDF

Adaptive radiations are rich laboratories for exploring, testing, and understanding key theories in evolution and ecology because they offer spectacular displays of speciation and ecological adaptation. Particular challenges to the study of adaptive radiation include high levels of species richness, rapid speciation, and gene flow between species. Over the last decade, high-throughput sequencing technologies and access to population genomic data have lessened these challenges by enabling the analysis of samples from many individual organisms at whole-genome scales.

View Article and Find Full Text PDF

Phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of a p110 catalytic subunit and a p85 regulatory subunit. The gene, which encodes the p110α, is the most frequently mutated oncogene in cancer. Oncogenic mutations activate the PI3K pathway, promote tumor initiation and development, and mediate resistance to anti-tumor treatments, making the mutant p110α an excellent target for cancer therapy.

View Article and Find Full Text PDF

PFAS in agroecosystems: Sources, impacts, and opportunities for mitigating risks to human and ecosystem health.

J Environ Qual

December 2024

Energy and Environmental Sustainability Laboratories, Institute for Energy and the Environment, The Pennsylvania State University, University Park, Pennsylvania, USA.

Concerns regarding per- and polyfluoroalkyl substances (PFAS) and their precursors have driven increased research into their sources, impacts, and mitigation strategies, aiming to reduce their prevalence in the environment. While much of this research has centered on known large sources of PFAS (e.g.

View Article and Find Full Text PDF

The morphologic diagnosis of colorectal carcinoma (CRC) is typically straight forward. However, there are certain subtypes of CRC that pose diagnostic challenges for daily practice due to sometimes overlapping morphologic and immunohistochemical features. These subtypes include poorly differentiated adenocarcinoma NOS, in the absence of conventional morphology (PDA-NOS), large cell neuroendocrine carcinoma (LCNEC), medullary carcinoma (MC), undifferentiated carcinoma (UC) and lymphoepithelioma-like carcinoma (LELC).

View Article and Find Full Text PDF

INVITED REVIEW: A review of some commonly used meta-analysis methods in dairy science research.

J Dairy Sci

December 2024

Department of Animal Science, Michigan State University, East Lansing, MI, USA, 48824. Electronic address:

Meta-analyses have become increasingly common, providing meaningful summaries of cumulative knowledge in the dairy science literature. Some of the corresponding meta-analytic techniques have been developed by knowledgeable dairy scientists, some of which pre-date tractable likelihood-based random or mixed effects model meta-analytic techniques and associated software developed by statisticians. This review compares various meta-analytic techniques on aggregate data (i.

View Article and Find Full Text PDF

Prednisolone pharmacokinetics in dogs with protein-losing enteropathy.

J Vet Intern Med

December 2024

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.

Background: It is unknown if glucocorticoid malabsorption contributes to the approximate 50% treatment failure rate in dogs with protein-losing enteropathy (PLE).

Objective: To compare pharmacokinetics (PK) of orally administered prednisolone in dogs with PLE vs healthy controls.

Animals: Fourteen dogs with well-characterized PLE and 7 control dogs.

View Article and Find Full Text PDF

Purpose: Looking while listening (LWL) tasks track eye movements while children view images (e.g., a dog and a ball) and hear an auditory prompt (e.

View Article and Find Full Text PDF