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Protocol-Based Resuscitation Bundle to Improve Outcomes in Septic Shock Patients: Evaluation of the Michigan Health and Hospital Association Keystone Sepsis Collaborative.
Crit Care Med
December 2016
1Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI.2Keystone Center for Patient Safety & Quality, Michigan Health & Hospital Association, Okemos, MI.3Division of Pulmonary, Critical Care, and Sleep Medicine, Henry Ford Health System, Detroit, MI.4St. Joseph Mercy Hospital, Ann Arbor, MI.
Objectives: To evaluate the impact of a multi-ICU quality improvement collaborative implementing a protocol-based resuscitation bundle to treat septic shock patients.
Design: A difference-in-differences analysis compared patient outcomes in hospitals participating in the Michigan Health & Hospital Association Keystone Sepsis collaborative (n = 37) with noncollaborative hospitals (n = 50) pre- (2010-2011) and postimplementation (2012-2013). Collaborative hospitals were also stratified as high (n = 19) and low (n = 18) adherence based on their overall bundle adherence.