Molecular interaction profiling and binding dynamics of Cinnamomum zeylanicum phytochemicals with human pancreatic amylase.

Diabetes mellitus, characterized by persistent hyperglycemia, remains a critical global health challenge. Inhibition of human pancreatic alpha-amylase, a key enzyme catalyzing carbohydrate digestion, is a promising approach to manage postprandial glucose levels. Cinnamomum zeylanicum, a medicinal plant known for its therapeutic potential, harbors bioactive compounds that can act as natural alpha-amylase inhibitors, though their mechanisms remain underexplored.

Bio-fabrication of calcium oxide nanoparticles from Coccinia grandis as a potential photocatalyst for dye degradation with antimicrobial activity.

In the current study, Coccinia grandis fruit extract was used to synthesize calcium oxide nanoparticles (CaO NPs) in an economical and environmentally friendly manner. UV-Vis spectroscopy and Fourier transform infrared spectroscopy revealed that the phytoconstituents found in Coccinia grandis fruit extract facilitated the production of CaO NPs by acting as better stabilizing, biodegradable, and reducing agents. The synthesized CG-CaO NPs were also tested for photocatalytic activity in the breakdown of selective dyes such as methyl red, methyl orange, and methylene blue in the presence of sunlight.

Annulation reactions of electrophilic benzannulated heterocycles towards heteroacenes.

The current review describes different annulation strategies reported with electrophilic benzannulated heterocycles for accessing heteroacenes. For the past two decades, the chemistry of electrophilic benzannulated heterocycles was extensively investigated, and several dipolar cycloadditions, metal and organo-catalyzed transformations were introduced for the generation of fused heterocycles. In this review, we have collected all the reports where the annulation of electrophilic benzannulated heterocycles results in a fully aromatic system, heteroacenes with tri-, tetra-, and pentacyclic rings.

Heavy metals in wetlands of southwestern India: from sediments through invertebrates to migratory shorebirds.

Heavy metal pollution in Indian wetlands is rising due to industrial, agricultural and urban development activities. Shorebirds occupy upper trophic levels and are therefore especially vulnerable to heavy metal pollution. We evaluated the concentration of heavy metals (zinc, copper, cobalt, chromium, lead and cadmium) in 22 common species of migrant shorebirds (220 shorebird dropping samples) with diverse foraging behaviors, in their different prey (55 prey samples) and in the sediments (90 sediment samples) in different habitat types (mudflats, mangroves and sand beaches) between 2019 and 2021.

Isolation and Characterization of Anti-Inflammatory Compounds from L.f. Stem Bark.

The anti-inflammatory effect of the ethyl acetate extract of bark (EAFMB) was investigated in acute and chronic (21 days) inflammation induced in Wistar albino rats. EAFMB (200 mg/kg b.w.

Genomic insight into the environmental adaptations and toxigenic features of endophytic CaB1 isolated from L.

Unlabelled: In the study, a previously isolated plant beneficial endophytic CaB1 was selected for the detailed analysis by whole-genome sequencing. The WGS has generated a total of 1.9 GB high-quality data which was assembled into a 5,257,162 bp genome with G + C content of 35.

Hybrid of Metapenaeus dobsoni lectin and platinum nanoparticles exert antimicrobial and immunostimulatory effects to reduce bacterial bioburden in infected Nile tilapia.

A novel antibacterial immunostimulant using Platinum nanoparticles (PtNPs) and lectin from Metapenaeus dobsoni (Md-Lec) was developed. The Md-Lec and PtNPs (Pt-lec) hybrid formed through non-covalent interaction exhibits antimicrobial activity against fish specific pathogens by affecting membrane integrity and producing excess reactive oxygen species. The therapeutic efficacy of Pt-lec was demonstrated through rescuing Aeromonas hydrophila infected Nile Tilapia.

Identification of cancer types from gene expressions using learning techniques.

Tumor is the major cause of death all around the world in recent days. Early detection and prediction of a cancer type are important for a patient's well-being. Functional genomic data has recently been used in the effective and early detection of cancer.

Alterations in hydrological variables and substrate qualities and its impacts on a critical conservation reserve in the southwest coast of India.

The present study investigated the long-term fluctuation in the hydrological and substrate variables at different habitats of Kadalundi-Vallikkunnu Community Reserve (KVCR) over the last decade. We hypothesize that natural impact represented by climate change and long-term impact from anthropogenic activities including industrialization and intensified agricultural practices have a direct effect on the natural hydrological cycle and the quality of coastal shores and thus can be a reason for coastal habitat and wildlife degradation. Results indicate a significant degradation in nutrient and organic matter concentration in the sediment and dramatic increase in nutrient concentration, salinity, temperature, and pH in the water.

Role of vitamin D in targeting cancer and cancer stem cell populations and its therapeutic implications.

Cancer is recognized globally as the second-most dominating and leading cause of morbidities. Fighting the global health epidemic threat posed by cancer requires progress and improvements in imaging techniques, surgical techniques, radiotherapy, and chemotherapy. The existence of a small subpopulation of undifferentiated cells known as cancer stem cells has been supported by accumulating evidence and ongoing research.

evaluation of NO donor heterocyclic vasodilators as SARS-CoV-2 M protein inhibitor.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 disease has been exponentially increasing throughout the world. The mortality rate is increasing gradually as effective treatment is unavailable to date. based screening for novel testable hypotheses on SARS-CoV-2 M protein to discover the potential lead drug candidate is an emerging area along with the discovery of a vaccine.

Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin-angiotensin-aldosterone system (RAAS) dysregulation.

The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19), has had a dramatic negative impact on public health and economies worldwide. Recent studies on COVID-19 complications and mortality rates suggest that there is a higher prevalence in cardiovascular diseases (CVD) patients. Past investigations on the associations between pre-existing CVDs and susceptibility to coronavirus infections including SARS-CoV and the Middle East Respiratory Syndrome coronavirus (MERS-CoV), have demonstrated similar results.

Imaging cancer cells with nanostructures: Prospects of nanotechnology driven non-invasive cancer diagnosis.

The application of nanostructured materials in medicine is a rapidly evolving area of research that includes both the diagnosis and treatment of various diseases. Metals, metal oxides and carbon-based nanomaterials have shown much promise in medical technological advancements due to their tunable physical, chemical and biological properties. The nanoscale properties, especially the size, shape, surface chemistry and stability makes them highly desirable for diagnosing and treating various diseases, including cancers.

Characterisation and comparative analysis of hydrophobin isolated from Pleurotus floridanus (PfH).

Hydrophobins are a class of small cysteine rich surface active proteins produced exclusively by filamentous fungi. It forms a nano layer in the cell-water interface, thereby protecting the emerging fungal hyphae from surrounding water. Even though hydrophobins have similar functions in fungi, they share less sequence similarity.

MFAP9: Characterization of an extracellular thermostable antibacterial peptide from marine fungus with biofilm eradication potential.

An extracellular thermostable antibacterial peptide designated as MFAP9 was purified from marine Aspergillus fumigatus BTMF9 by ammonium sulfate precipitation followed by ion exchange chromatography on a DEAE-sepharose column. The molecular weight of MFAP9 was found to be∼3 kDa in SDS-PAGE gel corresponding a single intensity peak in MALDI-TOF. The distinct peak with a retention time of 32.

Influence of lattice strain on FeO@carbon catalyst for the destruction of organic dye in polluted water using a combined adsorption and Fenton process.

In this study, 8, 25 and 50 wt% FeO@activated carbon (AC) catalysts were prepared by simple coprecipitation method. The efficiency of the catalysts for the advanced Fenton's oxidation process using methylene blue (MB) as a model substrate was tested. Both modified and unmodified activated carbon catalysts exhibited similar activity towards the Fenton's oxidation process.

Rapid Antibody-Based COVID-19 Mass Surveillance: Relevance, Challenges, and Prospects in a Pandemic and Post-Pandemic World.

The aggressive outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as COVID-19 (coronavirus disease-2019) pandemic demands rapid and simplified testing tools for its effective management. Increased mass testing and surveillance are crucial for controlling the disease spread, obtaining better pandemic statistics, and developing realistic epidemiological models. Despite the advantages of nucleic acid- and antigen-based tests such as accuracy, specificity, and non-invasive approaches of sample collection, they can only detect active infections.

Synthesis, phase transformation, and morphology of hausmannite MnO nanoparticles: photocatalytic and antibacterial investigations.

Nano structured Hausmannite (MnO) has efficacious applications in numerous fields, such as catalytic, medical, biosensors, waste water remediation, energy storage devices etc. The potential application in wastewater treatment is due to its distinct structural features combined with fascinating physicochemical properties. Another area of interest is the oxidative properties imparted due to its reduction potential.

Cl NQR frequency and spin lattice relaxation study in 3,4-dichloronitrobenzene as a function of temperature and pressure.

Cl NQR frequency and spin lattice relaxation time in 3,4-dichloronitrobenzene have been measured as a function of temperature and pressure. Two NQR signals were observed in the temperature range 77 to 300 K and pressure up to 5.1 kbar at 300 K.

Isolation, purification and characterization of a pH tolerant and temperature stable proteinaceous protease inhibitor from marine Pseudomonas mendocina.

Objectives: An extracellular protease inhibitor (BTPI-301) of trypsin was purified and characterized from an isolate of Pseudomonas mendocina.

Results: BTPI-301was purified to homogeneity by (NH)SO, precipitation, DEAE Sepharose and CNBr-activated Sepharose chromatography. Homogeneity was proved by native PAGE and SDS-PAGE.

Extract of Adenanthera pavonina L. seed reduces development of diabetic nephropathy in streptozotocin-induced diabetic rats.

Objective: The aim of the present study was to investigate the renal protective effect of Adenanthera pavonina (A. pavonina) seed aqueous extract (APSAE), in streptozotocin (STZ)-induced diabetic rats.

Materials And Methods: The renal protective effect of A.

In vitro evaluation of tetrazoles as a novel class of Antimycobacterium tuberculosis agents.

Purpose: We report here the antimycobacterial activity of some already synthesized tetrazole derivatives containing tetrazole against Mycobacterium tuberculosis strain H37Rv.

Methods: In vitro evaluation of the antitubercular activity was carried out within the Tuberculosis Antimicrobial Acquisition & Coordinating Facility (TAACF) screening program for the discovery of novel drugs for the treatment of tuberculosis. Under the direction of the US National Institute of Allergy and Infectious Diseases (NIAID), Southern Research Institute that coordinates the overall program.

Antidiabetic Activity of Aqueous Leaves Extract of Sesbania sesban (L) Merr. in Streptozotocin Induced Diabetic Rats.

The aqueous leaves extract of Sesbania sesban (L) Merr. (Family: Fabaceae) was evaluated for its antidiabetic potential on normal and streptozotocin (STZ)-induced diabetic rats. In the chronic model, the aqueous extract was administered to normal and STZ- induced diabetic rats at the doses of 250 and 500 mg/kg body weight (b.