180 results match your criteria: "MED-X Institute[Affiliation]"

To enhance tumor comprehensive therapeutic effect of nanomedicines, an efficient strategy that integrates polydopamine and IR780 photothermal therapy, glucose oxidase (GOx) starvation therapy, Banoxantrone (AQ4N) and Tirapazamine (TPZ) dual hypoxia chemotherapy is developed in chronological order. Higher tumor accumulation of porous dual infinite coordination polymer nanocomposites are designed and prepared to implement this strategy, in which fluorescent dye IR780 doped hypoxic prodrugs AQ4N and TPZ coordinated with Cu(II) as the core, this core is encapsulated by GOx-loaded porous polydopamine coordinated with Fe(III) (Fe-MPDA). These nanocomposites exhibit a particle dimension of 118.

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Association between the female hormone intake and cardiovascular disease in the women: a study based on NHANES 1999-2020.

BMC Public Health

December 2024

Center for Regenerative and Reconstructive Medicine, Med-X Institute of Western China Science and Technology Innovation Harbour, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.

Although many studies have reported the relationship between female hormone intake and cardiovascular disease (CVD) development, their association has not been fully elucidated and defined, based on data from the Third National Health and Nutrition Examination Survey intending to assess the health and nutritional status of non-institutionalized children and adults in the United States. This study examined the relationship between female hormone intake and coronary artery disease (CVD) development in 38,745 women, averaging 38.10 ± 12.

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Evidence suggests that complex interactions among the gut microbiome, metabolic abnormalities, and brain have important etiological and therapeutic implications in major depressive disorder (MDD). However, the influence of microbiome-gut-brain cross-talk on cognitive impairment in MDD remains poorly characterized. We performed serum metabolomic profiling on 104 patients with MDD and 77 healthy controls (HCs), and also performed fecal metagenomic sequencing on a subset of these individuals, including 79 MDD patients and 60 HCs.

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Background: Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus and causes vision impairment and blindness. The presence of major risk factors for DR, such as high levels of HbA1c, does not predict all DR pathogenesis in the clinic, which suggests that uncovering the underlying mechanisms and identifying novel markers are needed. Previous evidence has shown that the serum metabolic signature of DR is unique and detectable compared with that of diabetes mellitus (DM).

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Renal function and risk of gestational diabetes mellitus: the potential mediating role of carnitine metabolites.

J Clin Endocrinol Metab

December 2024

Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu Sichuan, 610041, China.

Context: Renal function may play a crucial role in the development of gestational diabetes mellitus (GDM). However, prospective studies on this topic are scarce and the mechanisms remain unclear.

Objective: To assess the associations of early-pregnancy renal function with GDM and the mediating role of carnitine metabolites.

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To achieve effective long-term synergistic treatment of inflammatory bowel disease (IBD) with probiotics, we developed a versatile inulin/trans-ferulic acid/silk sericin nanoparticles-nourished probiotic complex. Inulin/TFA/SS nanoparticles were fabricated by inulin, trans-ferulic acid (TFA), and silk sericin (SS), and then loaded onto the surface of poly-l-lysine (PLL) and poly-glutamic acid (PGA)-coated Bifidobacterium longum (BL) to obtain BL@PLL-PGA-Inulin/TFA/SS NPs (BL@PP-NPs). This design simultaneously endowed the complex with excellent gastrointestinal resistance, antioxidant, and anti-inflammation abilities.

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Article Synopsis
  • Intestinal dysbiosis and l-tryptophan metabolism issues contribute to the worsening of inflammatory bowel disease (IBD), affecting intestinal barrier function.
  • A new probiotic, EcN-TRP@A/G, is developed to improve tryptophan metabolism and restore gut health by encapsulating an enhanced probiotic with better stability and targeted release.
  • In experiments with IBD mice, this engineered probiotic significantly improves gut permeability, reduces inflammation, and promotes beneficial gut bacteria, offering a potentially cost-effective treatment strategy for IBD.
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Associations of saccharin intake with all-cause, cardiovascular and cancer mortality risk in USA adults.

Br J Nutr

November 2024

Zhejiang Provincial Center for Cardiovascular Disease Control and Prevention, Zhejiang Hospital, Hangzhou, People's Republic of China.

Article Synopsis
  • Saccharin, a common sugar substitute, has uncertain long-term health effects, particularly on mortality related to cardiovascular disease (CVD) and cancer in diabetic and pre-diabetic, as well as overweight populations.
  • The study found that higher saccharin intake was linked to increased risks of all-cause mortality (HR: 1.41), CVD mortality (HR: 1.93), and cancer mortality (HR: 2.26) in diabetic and pre-diabetic individuals, with even higher risks in overweight individuals (HR: 7.369 for cancer mortality).
  • Substituting saccharin with total sugar or aspartame significantly lowered mortality rates, suggesting that reducing saccharin intake could improve
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Enhanced tumor-targeting ability of transferrin-functionalized magnetic nanoparticles by in vivo AMF stimulation.

Biomaterials

April 2025

Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, 710069, China. Electronic address:

The protein corona formed on the surface of ligand-functionalized nanoparticles has been associated with the loss of targeting capability of the nanoparticles in vivo. Here, we developed a remote magnetothermal stimulation approach to regulate the in vivo active-targeting capability of transferrin (Tf)-functionalized magnetic nanoparticles (SPIO-Tf). This technique harnesses the heat dissipation by the magnetic nanoparticles in response to alternating magnetic fields to re-expose buried Tf on the nanoparticle surface, thereby restoring its binding function.

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Reply-Letter to the editor: The effect of time-restricted eating and low-carbohydrate diet on psychosocial health and appetite in individuals with metabolic syndrome.

Clin Nutr

December 2024

Department of Endocrinology, The First Affiliated Hospital of Xi'an JiaoTong University, No. 277, West Yanta Road, Xi'an, Shaanxi, 710061, PR China; Med-X Institute, Center for Immunological and Metabolic Diseases, The First Affiliated Hospital of Xi'an JiaoTong University, No. 277, West Yanta Road, Xi'an, Shaanxi, 710061, PR China. Electronic address:

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Background: The metabolomic profiles of individuals with different clinical manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have not been clearly characterized.

Methods: We performed metabolomics analysis of 166 individuals, including 62 healthy controls, 16 individuals with asymptomatic SARS-CoV-2 infection, and 88 patients with moderate (n = 42) and severe (n = 46) symptomatic 2019 coronavirus disease (COVID-19; 17 with short-term and 34 with long-term nucleic-acid test positivity). By examining differential expression, we identified candidate metabolites associated with different SARS-CoV-2 infection presentations.

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[Development and Application of Catheter Electrodes for Rat Airway High-Voltage Pulsed Electric Field Ablation].

Zhongguo Yi Liao Qi Xie Za Zhi

September 2024

National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061.

Article Synopsis
  • High-voltage pulsed electric field (HV-PEF) ablation is a potential new treatment for chronic obstructive pulmonary disease (COPD), but research is still in early stages and the mechanisms are unclear.
  • Rats are chosen as the primary model for these studies due to their suitability for COPD modeling and available research tools.
  • The study focused on designing specialized electrodes for HV-PEF in rats, examining various specifications to ensure safety and effectiveness, leading to simulations that support future research on this treatment's mechanisms.
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The management of inflammatory bowel disease (IBD) continues to pose significant challenges due to the absence of curative therapies and a high rate of recurrence. Therefore, it is imperative to explore novel approaches to enhance the efficacy of IBD therapy. Herein, a bioactive nanoparticulate s is tailored designed to achieve a "Pull-Push" approach for efficient and safe IBD treatment by integrating reactive oxygen species (ROS) scavenging (Pull) with anti-inflammatory agent delivery (Push) in the inflammatory microenvironment.

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The Impact of Selenium Deficiency and T-2 Toxin on Zip6 Expression in Kashin-Beck Disease.

Biol Trace Elem Res

October 2024

School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, No.76 Yanta West Road, Xi'an, Shaanxi, 710061, People's Republic of China.

This study investigated the expression of Zip6, a gene predominantly located in the placenta, breast, and prostate tissues, in patients with Kashin-Beck disease (KBD). Environmental risk factor models for KBD were developed using low selenium (Se) feeding (with a Se content of 0.02 mg Se/kg in the feed) and exposure to T-2 toxin (200 ng/g*BW/D).

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Intracellular Magnetic Hyperthermia Sensitizes Sorafenib to Orthotopic Hepatocellular Carcinoma Via Amplified Ferroptosis.

ACS Nano

October 2024

National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine; Shaanxi Province Center for Regenerative Medicine and Surgery Engineering Research; Shaanxi Provincial Key Laboratory of Magnetic Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Sorafenib (SRF) is recognized as the primary treatment for hepatocellular carcinoma (HCC), yet the emergence of SRF resistance in many HCC patients results in unfavorable outcomes. Enhancing the efficacy of SRF in HCC remains a significant challenge. SRF works in inducing ferroptosis, a form of cell death, in cancer cells through the inhibition of glutathione peroxidase 4 (GPX4).

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USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression.

Cell Death Dis

October 2024

The First Affiliated Hospital of Xi'an Jiaotong University, Center for Precision Cancer Medicine, MED-X Institute, 710000, Xi'an, China.

Clear cell renal cell carcinoma (ccRCC) is characterized by Von Hippel Lindau (VHL) gene loss of function mutation, which leads to the accumulation of hypoxia-inducible factor 2α (HIF2α). HIF2α has been well-established as one of the major oncogenic drivers of ccRCC, however, its therapeutic targeting remains a challenge. Through an analysis of proteomic data from ccRCCs and adjacent non-tumor tissues, we herein revealed that Ubiquitin-Specific Peptidase 7 (USP7) was upregulated in tumor tissues, and its depletion by inhibitors or shRNAs caused significant suppression of tumor progression in vitro and in vivo.

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Programmable Circular Multivalent Nanobody-Targeting Chimeras (mNbTACs) for Multireceptor-Mediated Protein Degradation and Targeted Drug Delivery.

Angew Chem Int Ed Engl

December 2024

Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310022, China.

Multispecific therapeutics hold significant promise in drug delivery, protein degradation, and cell recruitment to address clinical issues of tumor heterogeneity, resistance, and immune evasion. However, their modular engineering remains challenging. We developed a targeted degradation platform, termed multivalent nanobody-targeting chimeras (mNbTACs), by encoding diverse nanobody codons on a circular template using DNA printing technology.

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Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy.

Sci Adv

October 2024

Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

Article Synopsis
  • Aberrant cell fate transitions can lead to cancer, and p63 is identified as a key factor in determining cell type in esophageal development, specifically between squamous and neuroendocrine lineages.
  • Deleting p63 in developing mice and human stem cells leads to increased neuroendocrine differentiation, suggesting that this transcription factor is crucial for maintaining proper cell identity.
  • In esophageal neuroendocrine carcinoma, p63 is silenced by EZH2-mediated trimethylation, but reactivating p63 can promote a return to squamous cell characteristics, highlighting its role in cancer progression.
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Dual Orthogonally Polarized Lasing Assisted by Imaginary Fermi Arcs in Organic Microcavities.

Phys Rev Lett

September 2024

Beijing Key Laboratory for Optical Materials and Photonic Devices, Department of Chemistry, Capital Normal University, Beijing 100048, People's Republic of China.

The polarization control of micro- and nanolasers is an important topic in nanophotonics. Up to now, the simultaneous generation of two distinguishable orthogonally polarized lasing modes from a single organic microlaser remains a critical challenge. Here, we demonstrate simultaneously orthogonally polarized dual lasing from a microcavity filled with an organic single crystal exhibiting selective strong coupling.

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Background: radiation-induced skin injury (RISI) is a common complication of radiotherapy, affecting 85-95% of patients. Current treatments lack sufficient evidence of efficacy. Acellular dermal matrix (ADM) hydrogels have shown promise in treating chronic wounds, burns, and ulcers, but their potential in RISI remains unexplored.

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Article Synopsis
  • Chronic rhinosinusitis with nasal polyps (CRSwNP) can be categorized into eosinophilic and noneosinophilic types based on eosinophil levels, with neutrophils being key players in the inflammation process.
  • A study analyzed neutrophils from CRSwNP polyps, revealing five functional subsets and highlighting distinct behaviors in eosinophilic (eCRSwNP) and noneosinophilic (neCRSwNP) cases, particularly with GBP5+ neutrophils showing strong activity in neCRSwNP.
  • The research demonstrated that neutrophils release oncostatin M (OSM), interacting with epithelial cells and fibroblasts, which may enhance immune responses and contribute to the development of CR
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Serum ECM1 is a promising biomarker for staging and monitoring fibrosis in patients with chronic hepatitis B.

Sci China Life Sci

September 2024

Hepatology Department, Centre of Infectious Diseases and Pathogen Biology, First Hospital of Jilin University, Changchun, 130021, China.

It is critical to assess the extent and progression of liver fibrosis for patients to receive suitable treatments, but its diagnostic methods remain unmet. Extracellular matrix protein 1 (ECM1) has previously been reported to be a key factor in the induction and progression of liver fibrosis. However, little is known about the use of ECM1 as a biomarker to evaluate fibrosis.

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Lung cancer as a molecularly and histologically high heterogonous disease, there is an urgent need to predict lung cancer patients' responses to anti-cancer treatment, and patient-derived organoids (PDOs) have been recognized as a valuable platform for preclinical drug screening. In this study, we successfully established 26 PDO lines from various subtypes of lung cancers including benign tumor, adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, large-cell carcinoma, and small-cell carcinoma. These PDOs were shown to retain the major genomic and histological characteristics of primary tumors and remain stable during long-term culture.

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Engineering Two-dimensional tungsten-doped molybdenum selenide transformed conformational nanoarchitectonics: Trimodal therapeutic nanoagents for enhanced synergistic Photothermal/Chemodynamic/Chemotherapy of breast carcinoma.

J Colloid Interface Sci

January 2025

Department of General Surgery, Department of Talent Highland, Center for Gut Microbiome Research, Med-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China; School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an 710049, PR China; Instrumental Analysis Center of Xi'an Jiaotong University, Xi'an 710049, PR China. Electronic address:

Two-dimensional transition metal dichalcogenides (TMDCs) exhibit promising photothermal therapy (PTT) and chemodynamic therapy (CDT) for anti-tumour treatment. Herein, we proposed an engineering strategy to regulate the lattice structure of tungsten-doped molybdenum selenide (MoWSe) transformed conformational nanoarchitectonics using a microwave-assisted solvothermal method for enhancing peroxidase (POD)-like catalytic performance by adjusting the ratio of molybdenum (Mo) and tungsten (W). Furthermore, the optimised MoWSe nanoflakes surface was modified with chitosan (CHI) for improved biocompatibility and nanocatalytic efficacy, then the obtained CHI-MoWSe subsequently loaded the chemotherapeutic drug mitoxantrone (MTO) for enhanced 4 T1 cells killing ability, shortly denoted as CHI-MoWSe-MTO for PTT-augmented CDT and chemotherapy (CT).

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