2 results match your criteria: "MDU MRC. Addenbrooke's Hospital[Affiliation]"
Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK.
Stem Cell Res
January 2019
Stem Cells Therapies in Neurodegenerative Diseases Lab, Centro de Investigacion Principe Felipe (CIPF), Valencia, Spain; National Stem Cell Bank-Valencia Node, Proteomics, Genotyping and Cell Line Platform, PRB3, ISCIII, Research Centre Principe Felipe, c/Eduardo Primo Yúfera 3, 46012, Valencia, Spain. Electronic address:
Article Synopsis
- * Researchers used CRISPR/Cas9 technology to genetically correct this mutation, resulting in two new hiPSC lines with either heterozygous or homozygous corrections.
- * These corrected hiPSC lines maintain their ability to differentiate into various cell types and serve as a valuable tool for studying the genetic basis of the disease as well as for potential therapeutic applications in cell-replacement therapy.
Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.
Sci Rep
December 2015
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC. Addenbrooke's Hospital, Cambridge, CB2 0QQ.
The non-essential fatty acids, C18:1n9, C16:0, C16:1n7, C18:0 and C18:1n7 account for over 75% of fatty acids in white adipose (WAT) triacylglycerol (TAG). The relative composition of these fatty acids (FA) is influenced by the desaturases, SCD1-4 and the elongase, ELOVL6. In knock-out models, loss of SCD1 or ELOVL6 results in reduced Δ9 desaturated and reduced 18-carbon non-essential FA respectively.
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