871,905 results match your criteria: "MA; Department of Internal Medicine; McLean Hospital[Affiliation]"

Regulating tumor cells to awaken T cell antitumor function and enhance melanoma immunotherapy.

Biomaterials

December 2024

Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.

Tumor cells transmit various immunosuppressive signals and induce a dysfunctional state in T cells, which essentially leads to immune escape and tumor progression. However, developing effective strategies to counteract the domestication of T cells by tumor cells remains a challenge. Here, we prepared pH-responsive lipid nanoparticles (NL/PLDs) co-loaded with PCSK9 shRNA, lonidamine (LND), and low-dose doxorubicin (DOX).

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A novel particle size distribution correction method based on image processing and deep learning for coal quality analysis using NIRS-XRF.

Talanta

December 2024

State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Laser Spectroscopy, Shanxi University, Taiyuan, 030006, China; Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan, 030006, China.

The combined application of near-infrared spectroscopy (NIRS) and X-ray fluorescence spectroscopy (XRF) has achieved remarkable results in coal quality analysis by leveraging NIRS's sensitivity to organic compounds and XRF's reliability for inorganic composition. However, variations in particle size distribution negatively affect the diffuse reflectance of NIRS and the fluorescence signal intensities of XRF, leading to decreased accuracy and repeatability in predictions. To address this issue, this study innovatively proposes a particle size correction method that integrates image processing and deep learning.

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Systematic treatment and management of postpartum hypertension using remote patient monitoring.

Pregnancy Hypertens

December 2024

Section of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago Medicine, IL, United States. Electronic address:

Objective: To describe postpartum visit attendance and postpartum blood pressure control among patients enrolled in a remote patient monitoring program and compare these outcomes by race.

Study Design: A prospective cohort study of postpartum patients with a diagnosis of hypertensive disorders of pregnancy at the University of Chicago between October 2021 and April 2022. All patients received remote patient monitoring as routine care but consented separately for the use of their data.

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Retraction notice to "Clinicopathological significance of SOX4 and epithelial-mesenchymal transition markers in patients with laryngeal squamous cell carcinoma" [Auris Nasus Larynx 48 (2021) 1167-1175].

Auris Nasus Larynx

December 2024

Department of Otolaryngology Head and Neck Surgery, Jinan University, Guangzhou, Guangdong 510632, China; Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, China. Electronic address:

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Background: With many rare tumour types, acquiring the correct diagnosis is a challenging but crucial process in paediatric oncology. Historically, this is done based on histology and morphology of the disease. However, advances in genome wide profiling techniques such as RNA sequencing now allow the development of molecular classification tools.

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Ion flux regulating with Au-modified separator to realize a homogenize Zn metal deposition.

J Colloid Interface Sci

December 2024

State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China. Electronic address:

Aqueous Zn-ion batteries (AZIBs) have attracted widespread attention owing to the feature of low cost, inherent safety and eco-friendliness. However, the poor reversibility of Zn anode severely hinders the practical applicability of AZIBs. Separator modification is an effective way to functionalize the electrode/electrolyte interface and improve the cycling performance.

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Nonequilibrium-corrosive engineering synthesis of Pt anchored on FeO with oxygen vacancy for efficient electrocatalytic hydrogen evolution reaction.

J Colloid Interface Sci

December 2024

Key Laboratory of Eco-chemical Engineering, Ministry of Education, International Science and Technology Cooperation Base of Eco-chemical Engineering and Green Manufacturing, College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, 53 Zhengzhou Road, 266042 Qingdao, PR China. Electronic address:

The development of suitable support to maximize the atomic utilization efficiency of platinum is of great significance for the hydrogen evolution reaction (HER). Herein, we report a simple and fast nonequilibrium-corrosive approach to prepare oxygen defect-enriched FeO decorated with trace Pt onto nickel-iron foam (Pt/FeO-O/NIF). The Pt/FeO-O/NIF electrode is superhydrophilic with intimate contact with the electrolyte.

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Amidst the escalating global energy crisis, the quest for efficient electrocatalysts for water splitting has become increasingly imperative. Herein, we develop a bifunctional electrocatalyst comprising RuNi alloy nanoparticles anchored on fluorine-doped NiMoO nanorods (RuNi-F-NiMoO), engineered for efficient hydrogen production from seawater and urea oxidation reactions. The strategic F doping effectively reduces the difference in work functions and modulates the electronic interactions between the RuNi alloy and the NiMoO substrate, enhancing electron transfer kinetics and significantly improving electrocatalytic activity and stability.

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Peroxynitrite (ONOO) and viscosity are critical indicators of lysosome functionality, intimately linked to numerous diseases' pathophysiological processes. Hence, creating reliable analytical techniques to observe fluctuations in lysosomal ONOO and viscosity is highly important. This study presents the development of a novel naphthalimide-based fluorescent probe, Nap-Cy, specifically designed to target lysosomes and simultaneously detect both ONOO and viscosity.

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Inhibition of proliferation, migration and invasion of RM-1 cells by roemerine: Insights from in vitro and in vivo studies.

Tissue Cell

December 2024

Department of Urology, Women and Children's Hospital, Qingdao University, Qingdao, Shandong Province 266109, China. Electronic address:

Prostate cancer is the second leading cause of cancer-related among men globally, with a rising incidence rate, particularly in developing countries. This highlights the urgent need to identify novel therapeutic agents. Roemerine, a naturally abundant alkaloid, has demonstrated antibacterial and antitumor properties, suggesting its potential utility in prostate cancer treatment.

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A heptasaccharide was isolated from an active fraction of Trillium tschonoskii using HILIC and high-temperature PGC chromatography methods. UHPLC-Q/TOF-MS analysis gave this oligosaccharide a degree of polymerization (DP) of 7 and MS/MS showed that it has a six-carbon aldehyde glucan structure with the possible chain 1 → 4 connected. The structure was determined by series 1D and 2D NMR in two solvents DO and DMSO‑d.

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Background: Real-world outcomes, especially patterns of failure, are limited for patients with muscle-invasive bladder cancer (MIBC) treated with trimodality therapy (TMT). We aim to evaluate patterns of failure after TMT for MIBC in a typical heterogeneous population.

Methods: In the national Veterans Affairs database, patients with urothelial histology, MIBC (T2-4a/N0-3/M0) who underwent definitive intent TMT between 2000-2018.

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Altered coupling relationships across resting-state functional connectivity measures in schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder.

Psychiatry Res Neuroimaging

December 2024

Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address:

Resting-state functional connectivity (rsFC) measures have enjoyed significant success in discovering the neuropathological characteristics of schizophrenia (SZ), bipolar disorder (BD), and attention deficit/hyperactivity disorder (ADHD). However, it is unknown whether and how the spatial and temporal coupling relationships across rsFC measures would be altered in these psychiatric disorders. Here, resting-state fMRI data were obtained from a transdiagnostic sample of healthy controls (HC) and individuals with SZ, BD, and ADHD.

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Glucagon-like Peptide-1 Agonists Reduce Cardiovascular Events in Cancer Patients on Immune Checkpoint Inhibitors.

Eur J Cancer

December 2024

Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Immune checkpoint inhibitors (ICIs) are associated with an increased risk of major adverse cardiovascular events (MACE). Glucagon-like peptide-1 agonists (GLP1a), initially developed for type 2 diabetes mellitus (T2DM), have shown promising results in reducing cardiovascular events. We aimed to investigate the effect of GLP1a on cardiovascular events in patients receiving ICIs.

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Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.

Neurobiol Aging

December 2024

Department of Psychology, Northwestern University, Evanston, IL, USA; Department of Psychology, Florida State University, Tallahassee, FL, USA; University of Illinois Urbana-Champaign, Champaign, IL, USA.

Healthy aging is associated with cognitive decline across multiple domains, including executive function, memory, and attention. These cognitive changes can often influence an individual's ability to function and quality of life. However, the degree to which individuals experience cognitive decline, as well as the trajectory of these changes, exhibits wide variability across people.

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Suspended sediment (SPS) triggers nitrogen retention by altering microbial network stability and electron transport behavior during the aerobic-anoxic transition.

J Environ Manage

December 2024

Shaanxi Key Laboratory of Environmental Engineering, Key Laboratory of Northwest Water Resource, Environment and Ecology, MOE, Xi'an University of Architecture and Technology, Xi'an, 710055, China; School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an, 710055, China. Electronic address:

NO-N transformation, the vital biological process, determines nitrogen removal and retention in aquatic environment. Suspended sediment (SPS) ubiquitous in freshwater ecosystems can accelerate the transitions from aerobic to anoxic states, inevitably impacting NO-N transformation. To elaborate on the microbial mechanism by which SPS content affected NO-N transformation, we explored nitrogen removal and retention, microbial communities, co-occurrence networks, and electron transfer behavior under different SPS content during the aerobic-anoxic transition.

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The influence of enterprise ESG performance on overseas business income - Evidence from China.

J Environ Manage

December 2024

The People's Bank of China Hubei Provincial Branch, Wuhan, 430071, China. Electronic address:

As an emerging information disclosure system, enterprise ESG performance holds substantial importance for the international expansion of Chinese enterprises. Nevertheless, there is a paucity of literature examining the relationship between the ESG performance of Chinese enterprises and their overseas business income. This research utilizes data from Chinese A-share listed companies spanning from 2009 to 2022 to explore the causal link between ESG performance and overseas business income.

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Removal, conversion and utilization technologies of alkali components in bayer red mud.

J Environ Manage

December 2024

China MCC22 Group Corporation Ltd., No.16 Xingfu Road, Fengrun District, Tangshan, Hebei, China.

Bayer red mud is a highly alkaline industrial solid waste generated during alumina production, and its massive discharge and stockpiling poses significant environmental risks. The strong alkalinity of red mud is a primary challenge limiting its effective utilization. This study systematically analyzes the composition and characteristics of alkaline components in red mud, emphasizing the roles of soluble free alkali and chemically bound alkali in regulating its alkalinity.

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Introduction: Antibody-drug conjugates (ADCs) trastuzumab-deruxtecan (T-DXd) and sacituzumab-govitecan (SG) provided significant progression-free survival (PFS) and overall survival (OS) improvements over chemotherapy (CT) in pretreated hormone receptor-positive (HR+) and triple-negative (TN)/HER2-low metastatic breast cancer (MBC). However, no direct comparison between the two exists, nor with the more recent datopotamab-deruxtecan (Dato-DXd).

Methods: We conducted a network meta-analysis (NMA) to compare efficacy and safety of T-DXd and SG in CT-pretreated HR+ and TN/HER2-low MBC and assess their benefit over standard CT, exploring also a comparison with Dato-DXd.

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Ginsenoside Rh2 promotes cell apoptosis in T-cell acute lymphocytic leukaemia by MAPK and PI3K/AKT signalling pathways.

Nat Prod Res

December 2024

State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.

T-cell acute lymphoblastic leukaemia (T-ALL) is a common childhood malignant tumour, which has poor prognosis and high recurrence rate. Ginsenoside Rh2 (GRh2), a bioactive ingredient of has significant anti-tumour effect. In this study, we found that gene expressions of Jurkat cells were significantly changed in the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) signalling pathways after 35 µm GRh2 treatment, involving in JUN, PIEN, AKT3 and MAPK8IP2.

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Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer.

Cell Rep

December 2024

Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Androgen receptor (AR) splice variants, of which ARv7 is the most common, are increased in castration-resistant prostate cancer, but the extent to which they drive AR activity is unclear. We generated a subline of VCaP cells (VCaP16) that is resistant to the AR inhibitor enzalutamide (ENZ). AR activity in VCaP16 is driven by ARv7, independently of full-length AR (ARfl), and its cistrome and transcriptome mirror those of ARfl in VCaP cells.

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Transcriptional profile of the rat cardiovascular system at single-cell resolution.

Cell Rep

December 2024

Precision Cardiology Laboratory, The Broad Institute, Cambridge, MA 02142, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

We sought to characterize cellular composition across the cardiovascular system of the healthy Wistar rat, an important model in preclinical cardiovascular research. We performed single-nucleus RNA sequencing (snRNA-seq) in 78 samples in 10 distinct regions, including the four chambers of the heart, ventricular septum, sinoatrial node, atrioventricular node, aorta, pulmonary artery, and pulmonary veins, which produced 505,835 nuclei. We identified 26 distinct cell types and additional subtypes, with different cellular composition across cardiac regions and tissue-specific transcription for each cell type.

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Knee osteoarthritis contributes substantially to worldwide disability. Post-traumatic osteoarthritis (PTOA) develops secondary to joint injury, such as ligament rupture, and there is increasing evidence suggesting a key role for inflammation in the aetiology of PTOA and associated functional deficits. Colony stimulating factor 1 receptor (CSF1-R) has been implicated in the pathogenesis of musculoskeletal degeneration following anterior cruciate ligament (ACL) injury.

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The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample. These Biotypes cut across DSM diagnoses of schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis. Two recently developed post hoc ancestry adjustment methods of Polygenic Risk Scores (PRSs) generate Ancestry-Adjusted PRSs (AAPRSs), which allow for PRS analysis of multi-ancestry samples.

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