Sequential recruitment of F-BAR proteins controls cytoskeletal crosstalk at the yeast bud neck.

In vivo functions of the septin and actin cytoskeletons are closely intertwined, yet the mechanisms underlying septin-actin crosstalk have remained poorly understood. Here, we show that the yeast-bud-neck-associated Fes/CIP4 homology Bar-amphiphysin-Rvs (F-BAR) protein suppressor of yeast profilin 1 (Syp1)/FCHo uses its intrinsically disordered region (IDR) to directly bind and bundle filamentous actin (F-actin) and to physically link septins and F-actin. Interestingly, the only other F-BAR protein found at the neck during bud development, Hof1, has related activities and also potently inhibits the bud-neck-associated formin Bnr1.

Joint Associations of Sedentary Time and Intensity-Specific Physical Activity With Cancer Mortality: A Device-Based Cohort Study of 72,458 UK Adults.

Background: There are no studies examining the prospective joint association of device-based measures of sedentary time and physical activity (PA) with cancer mortality. We examined the joint associations of sedentary time and intensity-specific PA with cancer mortality in 72,458 adults from UK Biobank.

Methods: Participants wore an Axivity AX3 accelerometer on their dominant wrist for at least 3 days (with at least 1 weekend day).

Clinical advances of mRNA vaccines for cancer immunotherapy.

The development of mRNA vaccines represents a significant advancement in cancer treatment, with more than 120 clinical trials to date demonstrating their potential across various malignancies, including lung, breast, prostate, melanoma, and more challenging cancers such as pancreatic and brain tumors. These vaccines work by encoding tumor-specific antigens and immune-stimulating molecules, effectively activating the immune system to target and eliminate cancer cells. Despite these promising advancements, significant challenges remain, particularly in achieving efficient delivery and precise regulation of the immune response.

The effects of corticotropin-releasing factor (CRF) and urocortins on the serotonin (hydroxytryptamine, 5HT) released from the raphe nuclei (RN).

Corticotropin-releasing factor (CRF) and urocortins (UCN1, UCN2 and UCN3) belong to the same CRF family of neuropeptides. They regulate the neuroendocrine, autonomic and behavioral responses to stress via two CRF receptors (CRF1 and CRF2). Stress, anxiety and depression affects the activity of the hypothalamic-pituitary-adrenal (HPA) axis and the serotoninergic neurotransmission, both being regulated by CRF and CRF-related peptides.

Leveraging almost hydrophobic PVDF membrane and in-situ ozonation in O/UF/BAC system for superior anti-fouling and rejection performance in drinking water treatment.

The almost hydrophobic PVDF membrane (PVDF matrix) commonly exhibited excellent performance in pollutant rejection but with poor anti-fouling performance. This study intended to develop the rejection performance and enhance anti-fouling of the PVDF membrane in an O/UF/BAC system for high quality water production through leveraging the advantages of in-situ ozonation and the nature of the PVDF membrane. Reduced density gradient (RDG) analysis demonstrated that the PVDF membrane exhibited excellent ozone resistance by reducing hydrogen bonds and electrostatic interactions between the membrane surface and ozone.

Lifting of travel restrictions brings additional noise in COVID-19 surveillance through wastewater-based epidemiology in post-pandemic period.

The post-pandemic world still faces ongoing COVID-19 infections, although international travel has returned to pre-pandemic conditions. Wastewater-based epidemiology (WBE) is considered an efficient tool for the population-wide surveillance of COVID-19 infections during the pandemic. However, the performance of WBE in post-pandemic era with travel restrictions lifted remains unknown.

Responses of microbial communities in coastal sediments exposed to triclocarban and triclosan.

Triclocarban (TCC) and triclosan (TCS) are applied in a wide range of pharmaceutical and personal care products to prevent or reduce bacterial growth. Due to their extensive application, they are frequently detected in marine environments. In this study, marine sediment systems exposed to different concentrations of TCC and TCS were established to evaluate their effects on microbial communities.

TinyML and edge intelligence applications in cardiovascular disease: A survey.

Tiny machine learning (TinyML) and edge intelligence have emerged as pivotal paradigms for enabling machine learning on resource-constrained devices situated at the extreme edge of networks. In this paper, we explore the transformative potential of TinyML in facilitating pervasive, low-power cardiovascular monitoring and real-time analytics for patients with cardiac anomalies, leveraging wearable devices as the primary interface. To begin with, we provide an overview of TinyML software and hardware enablers, accompanied by an examination of networking solutions such as Low-power Wide area network (LPWAN) that facilitate the seamless deployment of TinyML frameworks.

Math anxiety mediates the association between gender and STEM-related attitudes: Evidence from a large-scale study.

Math anxiety (MA) is a prevalent academic anxiety that can affect student mental health and academic performance worldwide. Using a very large sample of students in grades 7 to 10 (N = 7172) in Qatar, the present study examined the associations among gender, math anxiety, and attitudes towards Science, Technology, Engineering, and Mathematics (STEM). In addition, the factorial structure of the "Student Attitudes towards STEM Survey" (STEM-S) was examined.

Characterization changes of volatile organic compounds in Aconitum sinomontanum Nakai (Gao Wu Tou) with different proportions of yellow wine steamed by GC-IMS, E-nose.

Gas chromatography-ion mobility spectrometry (GC-IMS) combined with multiple analytical methods and E-nose were used to study the differences in volatile organic compounds (VOCs) in 0 %, 10 %, 15 %, 20 %, 25 % yellow wine steamed A. sinomontanum and its raw products. The results indicated that the VOCs in different proportions of yellow wine steamed A.

Resveratrol alleviates blast lung injury by modulating the epithelial sodium channel (ENaC) via the PI3K/AKT pathway.

Blast lung injury (BLI) is a major cause of death in blast injuries, largely due to pulmonary edema. Effective clearance of alveolar fluid is critical for resolving pulmonary edema, with the epithelial sodium channel (ENaC) playing a key role in this process. Resveratrol (RES), a natural compound with known antioxidant and anti-inflammatory properties, has shown promise in treating respiratory diseases.

The chain mediating role of social support and coping strategy: Type D personality and psychological distress among Chinese COPD patients.

This study examines how coping strategies and social support mediate the relationship between type D personality and psychological distress in COPD patients. A sample of 351 patients completed surveys on demographics, psychological distress (Kessler Psychological Distress Scale), social support (Social Support Self-Rating Scale), coping strategies (Chinese version of Medical Coping Modes Questionnaire), and type D personality (Type D Personality Scale). Using structural equation modeling (SEM) via AMOS 23.

Synthesis and biological evaluation of novel pyrrolo[2,3-b]pyridine derivatives as potent GSK-3β inhibitors for treating Alzheimer's disease.

The development of potent glycogen synthase kinase-3β (GSK-3β) inhibitor has been increasingly recognized as the candidate treatment against the multifactorial pathogenic mechanism of Alzheimer's disease (AD). This study prepared various new pyrrolo[2,3-b]pyridine derivatives, evaluated the anti-AD activities and detected the security based on the structure-guided rational design. Our results indicated that many pyrrolo[2,3-b]pyridine derivatives had strong GSK-3β inhibitory activities, particularly compounds 41, 46 and 54, with the half maximal inhibitory concentrations (IC) of 0.

Transformation of polycyclic aromatic hydrocarbons during frying stinky tofu.

Reductions in polycyclic aromatic hydrocarbon (PAH) concentrations have been observed during frying. However, transformation mechanisms of PAHs remain unclear. We hypothesize that PAHs may be oxidized into oxygenated polycyclic aromatic hydrocarbons (OPAHs) and other derivatives during frying.

Combined use of steam explosion, alkali, and microbial methods improving the yield, structure and properties of soluble dietary fiber from bamboo shoot shells.

Developing an effective method for extracting soluble dietary fiber (SDF) from bamboo shoot shell (BSS) is of great significance for the resource utilization of BSS. Here, we proposed the combinational strategy of steam explosion (SE), alkaline extraction (AE), and microbial extraction (ME) to enhance BSS-SDF yield. The highest yield of 28.

User preference interaction fusion and swap attention graph neural network for recommender system.

Recommender systems are widely used in various applications. Knowledge graphs are increasingly used to improve recommendation performance by extracting valuable information from user-item interactions. However, current methods do not effectively use fine-grained information within the knowledge graph.

DCS-RISR: Dynamic channel splitting for efficient real-world image super-resolution.

Real-world image super-resolution (RISR) has received increased focus for improving the quality of SR images under unknown complex degradation. Existing methods rely on the heavy SR models to enhance low-resolution (LR) images of different degradation levels, which significantly restricts their practical deployments on resource-limited devices. In this paper, we propose a novel Dynamic Channel Splitting scheme for efficient Real-world Image Super-Resolution, termed DCS-RISR.

Mixed grafting of small auto- and cryopreserved allo-skin for residual wound repair in severe burn patients: A retrospective study.

Background: The wound repair process for extensively deep burn patients is a recurring and highly challenging endeavor. A prolonged healing time beyond 3 weeks after injury often leads to compromised healing outcomes. The limited availability of autologous skin grafts remains the primary obstacle in achieving timely wound repair.

[The challenges of new digital technologies on the Moroccan health system : Case of the cardiology departement -B- University Hospital Center Ibn Sina Rabat].

Introduction: We live in the era of information technology (IT) innovations in the health sector, this has led to the appropriation of new organizational models which are profoundly changing the practice of medicine. Our study aims to determine the challenges of new digital technologies in the Moroccan health system, the case of the cardiology department - B - of the Ibn Sina University Hospital Center.

Materials And Methods: This is a single-center observational descriptive-analytical study carried out at the level of the cardiology department - B- for 6 months, from September 1, 2022.

Preexisting opioid daily MME and use duration within a national cohort of lumbar spine surgery patients on quality outcomes.

Objective: Pain management surrounding lumbar spine surgery is a complex topic. Though some authors suggest that preoperative opioid use is a negative prognostic factor, its association with patient-reported outcomes and satisfaction after surgery remains controversial. We aimed to uncover the effect of preoperative opioid use on long-term outcomes using a national sample.

Akkermansia muciniphila inhibits jejunal lipid absorption and regulates jejunal core bacteria.

Insufficiency of Akkermansia muciniphila (Akk) has been implicated in the pathogenesis of metabolic diseases, and administration or restoration of Akk has ameliorated these disorders. Recently, Pasteurized Akk (PA-Akk) has been approved as a functional food. However, the impact of Akk on lipid absorption in the proximal intestine, which is directly exposed to orally administered Akk, remains largely unexplored.

Using network analysis to characterize clinical improvement during cognitive processing therapy.

Objective: Cross-sectional network studies find mixed results regarding changes in network structure as a response to treatment across disorders. This study characterized improvement in mental health following Cognitive Processing Therapy (CPT) for PTSD in veterans from the perspective of network psychometrics and explored how cross-sectional networks inform our understanding of PTSD recovery.

Methods: Veterans with PTSD participated in CPT-based intensive treatment programs (ITPs), offered in two-week (N = 635) or three-week (N = 457) formats.