300 results match your criteria: "M.D. University[Affiliation]"

Sun persuades excess ROS production in the skin, altering pro-inflammatory factors and cellular responses, thereby contributing to the progression of skin disorders and skin cancer. In this study, the non-animal, and methods have been employed to interpret the potential of bioactive mangiferin against skin inflammation and skin cancer. In the approach, auto blind docking tool CB Dock 2 was utilized to assess and compare the efficacy of mangiferin against some conventional drugs like aspirin, diclofenac, betamethasone for inflammation and with 5-fluorouracil, docetaxel, doxorubicin, imiquimod, paclitaxel, sonidegib, vincristine and vismodegib for skin cancer.

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Fungal infections are considered a great threat to human life and are associated with high mortality and morbidity, especially in immunocompromised individuals. Fungal pathogens employ various defense mechanisms to evade the host immune system, which causes severe infections. The available repertoire of drugs for the treatment of fungal infections includes azoles, allylamines, polyenes, echinocandins, and antimetabolites.

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Article Synopsis
  • Cancer is a complex disease with rising cases, and current treatments like chemotherapy and radiation have limited effectiveness and serious side effects.* -
  • This study explored the therapeutic potential of seven phytochemicals against key cancer-associated proteins using computational docking and in-vitro experiments.* -
  • Results showed that certain phytochemicals can inhibit cancer cell growth and trigger cell death, indicating their promise as multi-targeted therapeutic agents.*
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Numerous thiazole compounds have been developed as cutting-edge inhibitors because of a rising fascination with using corrosion inhibitors (CIs) and preventative measures to prevent mild steel (MS) from deteriorating. In this study, the ability of a novel thiazole derivative, 2-hydrazono-3-methyl-2,3-dihydrobenzo[]thiazole hydrochloride (HMDBT), to prevent corrosion of MS (MS) in HCl has been reconnoitered using various approaches, Viz. gravimetric analysis, electrochemical (EC) analysis, and different surface characterizations.

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Motion sickness also known as kinetosis is a condition in which there exists a disagreement between visually perceived movement and the vestibular system's sense of movement. Nausea, vomiting, dizziness, fatigue, and headache are the most common symptoms of motion sickness. This study mainly focuses on the taste masking of Promethazine Hydrochloride (PMZ) by inclusion complexation method, its formulation development in the chewing gum form by using directly compressible gum base HIG® and its quality and performance testing.

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Developing potent medicinal alternates for tuberculosis (TB) is highly desirable due to the advent of drug-resistant lethal TB strains. Novel indole-isoniazid integrates have been synthesized with promising antimycobacterial action against the strain, and the nitro analogs and show the highest efficacy with a minimum inhibitory concentration of 1.25 μg/ml.

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In pursuit of potential chemotherapeutic alternates to combat severe tuberculosis infections, novel heterocyclic templates derived from clinically approved anti-TB drug isoniazid and isatin have been synthesized that demonstrate potent inhibitory action against Mycobacterium tuberculosis, and compound 4i with nitrophenyl motif exhibited the highest anti-TB efficacy with a MIC value of 2.54 μM/ml. Notably, the same nitro analog 4i shows the best antioxidant efficacy among all the synthesized compounds with an IC value of 37.

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Introduction: Cardiovascular disease (CVD) stands as a pervasive catalyst for illness and mortality on a global scale, underscoring the imperative for sophisticated prediction methodologies within the ambit of healthcare data analysis. The vast volume of medical data available necessitates effective data mining techniques to extract valuable insights for decision-making and prediction. While machine learning algorithms are commonly employed for CVD diagnosis and prediction, the high dimensionality of datasets poses a performance challenge.

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Review of nano-based smart coatings for corrosion mitigation: mechanisms, performance, and future prospects.

Environ Sci Pollut Res Int

April 2024

Department of Chemistry, Banasthali Vidhyapith, Rajasthan, Rajasthan, 304022, India.

In response to environmental concerns about toxic corrosion inhibitors, nanomaterials have gained attention for their enhanced corrosion inhibition properties due to their high surface-to-volume ratio. This paper summarizes advancements in utilizing nanomaterials to control corrosion, exploring various preparation methods and effectiveness as inhibitors. Nano-based intelligent coatings have emerged as promising solutions, with this review examining their corrosion inhibition mechanisms, performance attributes, and future prospects.

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A convenient synthesis of a novel 1,3,4-oxadiazole derivative, specifically known as, 2-(5-methylthiophen-2-yl)-5-(pyridin-3-yl)-1,3,4-oxadiazole (MTPO), is reported along with a comprehensive evaluation of its ability to inhibit the corrosion of mild steel (MS) in a 1 N HCl environment using weight loss, EIS, PDP, SEM, EDX, and UV-Vis spectroscopy. The investigated inhibitor expressed excellent inhibition efficiency (99.05% at 500 ppm, 298 K) with a mixed-type inhibitory mechanism as demonstrated by the PDP technique.

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With a lack of targeted therapy and significantly high metastasis, heterogeneity, and relapse rates, Triple-Negative Breast Cancer (TNBC) offers substantial treatment challenges and demands more chemotherapeutic interventions. In the present study, indole-endowed thiadiazole derivatives have been synthesized and screened for antiproliferative potency against the triple-negative breast cancer MDA-MB-231 cell line. Compound 4 h, possessing chlorophenyl moiety, displays the best anticancer potency (IC: 0.

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An Updated Review on Nanoemulsion: Factory for Food and Drug Delivery.

Curr Pharm Biotechnol

September 2024

Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana, 124001, India.

Background: A nanoemulsion is a colloidal system of small droplets dispersed in another liquid. It has attracted considerable attention due to its unique properties and various applications. Throughout this review, we provide an overview of nanoemulsions and how they can be applied to various applications such as drug delivery, food applications, and pesticide formulations.

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Antimicrobial resistance has become a critical health concern, and quorum-sensing exacerbates the resistance by facilitating cell-to-cell communication within the microbial community, leading to severe pathogenic outbreaks. Novel 1-(2-((5-[1,2,4]-triazino[5,6-]indol-3-yl)thio)acetyl)indoline-2,3-diones were synthesized. The title compounds exhibit outstanding anti-quorum-sensing efficacy, and compound demonstrated the maximum proficiency (IC = 0.

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The current production of recombinant insulin via fermenter-based platforms (Escherichia coli and yeast) could not fulfill its fast-growing commercial demands, thus leading to a great interest in its sustainable large-scale production at low cost using a plant-based system. In the present study, Agrobacterium tumefaciens-mediated nuclear stable genetic transformation of an industrial oilseed crop, Camelina sativa, to express pro-insulin (with three furin endoprotease cleavage sites) fused with cholera toxin B subunit (CTB) in their seeds was successfully achieved for the first time. The bar gene was used as a selectable marker for selecting transformants and producing herbicide-resistant camelina plants.

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Schiff bases are one of the important classes of organic compounds containing imine or azomethine functional groups with potential biological applications in medicinal chemistry. Nowadays, these compounds have attracted the scientific community's attention due to their ability to act as ligands in the formation of stable metal complexes with significant biological activity. In this connection, we have designed and synthesized six novel thiophene-based organoltellurium (IV) complexes using a novel N-((5-methylthiophen-2-yl) methylene)-2-nitroaniline (5MTCONA) schiff base.

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Advances in xanthine biosensors and sensors: A review.

Enzyme Microb Technol

March 2024

Department of Biochemistry, M.D. University, Rohtak, 124001 Haryana, India. Electronic address:

Xanthine is derived from hypoxanthine by xanthine oxidase (XOD), a flavoprotein containing molybdenum and non-haem iron, sulfur and from guanine by guanine deaminase enzyme. Xanthine is oxidized into uric acid by XOD. Xanthine is used as an indicator of fish freshness, based on the reactions in which ATP is degraded into xanthine and its quantity increases with time of fish death.

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Background: Yellow fever is a mosquito-borne viral hemorrhagic disease transmitted by several species of virus-infected mosquitoes endemic to tropical regions of Central and South America and Africa. Earlier in the twentieth century, mass vaccination integrated with mosquito control was implemented to eradicate the yellow fever virus. However, regular outbreaks occur in these regions which pose a threat to travelers and residents of Africa and South America.

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Electrochemical and computational insights into the utilization of 2, 2- dithio bisbenzothiazole as a sustainable corrosion inhibitor for mild steel in low pH medium.

Environ Res

February 2024

Nalanda College of Engineering, Bihar Engineering University, Science, Technology and Technical Education Department , Government of Bihar, 803108, India. Electronic address:

Industries today place a high premium on environmentally friendly supplies that may effectively inhibit metal dissolution at a reasonable cost. Hence, in this paper, we assessed the corrosion inhibition effectiveness of the Thiazole derivative namely, 2, 2-Dithio Bisbenzothiazole (DBBT) against mild steel (MS) corrosion in 1 M HCl. Several experimental approaches, including gravimetric analysis, potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS), and surface exploration using scanning electron/atomic force microscopy (SEM/AFM) and contact angle (CA), were utilized to conduct the measurements.

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An overview of contemporary developments and the application of graphene-based materials in anticorrosive coatings.

Environ Sci Pollut Res Int

November 2023

Department of Chemistry, Nalanda College of Engineering, Bihar Engineering University, Science, Technology and Technical Education Department, Government of Bihar, Nalanda, Bihar, 803108, India.

Although graphene and graphene-based materials (GBMs) offer a wide range of possible applications, interest in their use as barrier layers or as reinforcements in coatings for the mitigation of corrosion has grown during the past decade. Because of its unique two-dimensional nanostructure and exceptional physicochemical characteristics, graphene has gotten a lot of attention as an anti-corrosion material. This enthusiasm is largely driven by the requirement to integrate more features, improve anti-corrosion effectiveness, and eventually prolong the service duration of metallic components.

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Frequent consumption of fruits and vegetables in the daily diet may alleviate the risk of developing chronic diseases. L. (carrot), L.

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Polymer-mediated nanoformulations: a promising strategy for cancer immunotherapy.

Naunyn Schmiedebergs Arch Pharmacol

March 2024

Department of Bioscience and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India.

Engineering polymer-based nano-systems have attracted many researchers owing to their unique qualities like shape, size, porosity, mechanical strength, biocompatibility, and biodegradability. Both natural and synthetic polymers can be tuned to get desired surface chemistry and functionalization to improve the efficacy of cancer therapy by promoting targeted delivery to the tumor site. Recent advancements in cancer immunoediting have been able to manage both primary tumor and metastatic lesions via activation of the immune system.

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The utilization of plant-derived supplements for disease prevention and treatment has long been recognized because of their remarkable potential. , commonly known as pineapple, produces a group of enzymes called bromelain, which contains sulfhydryl moieties. Recent studies have shown that bromelain exhibits a wide range of activities, including anti-inflammatory, anti-diabetic, anti-cancer, and anti-rheumatic properties.

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In the past, curcumin was the go-to medication for diabetes, but recent studies have shown that tetrahydrocurcumin is more effective. The problem is that it's not very soluble in water or very bioavailable. So, our research aims to increase the bioavailability and anti-diabetic efficacy of tetrahydrocurcumin in streptozotocin-induced diabetic rats by synthesizing tetrahydrocurcumin-loaded solid lipid nanoparticles.

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An easy synthesis of two 1,3,4-oxadiazole derivatives, namely, 2-phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazole (POX) and 2-(4-methoxyphenyl)-5-(pyridin-3-yl)-1,3,4-oxadiazole (4-PMOX), and their corrosion-inhibition efficacy against mild steel corrosion in 1 N HCl, is evaluated using weight loss from 303 to 323 K, Electrochemical Impedance Spectroscopy (EIS), Potentiodynamic Polarization (PDP), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), UV-Vis spectroscopy, along with theoretical evaluation. Both POX and 4-PMOX exhibit excellent inhibition efficiency, with values reaching 97.83% and 98% at 500 ppm, respectively.

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Biogenic Zinc Oxide Nanoparticles and Their Biomedical Applications: A Review.

J Inorg Organomet Polym Mater

April 2023

Department of Biochemistry, M.D. University, Rohtak, 124001 India.

Nanotechnology has inscribed novel perception into the material science and one of the most extensively used nanomaterials is Zinc oxide nanoparticles (ZnO NPs) with healthcare and biomedical applications. Because of its outstanding biocompatibility, low toxicity, and low cost, ZnO NPs have become one of the most prominent metal oxide NPs in biological applications. This review highlights the different aspects of ZnO NPs, like their green synthesis as a substitute of conventional route due to avoidance of threat of hazardous, costly precursors and subsequent mostly therapeutic applications.

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