Treadmill exercise supplemented by OPN promote axon regeneration through the IGF-1R/Akt/mTOR signaling pathway.

Regeneration of the corticospinal tract (CST) is considered a therapeutic target to achieve improved recovery of motor function after spinal cord injury (SCI), which is an incurable CNS damage that affects millions of people. Exercise training is effective in improving multiple functions in spinal cord-injured patients. However, the effects of exercise training on axon regeneration have not been sufficiently reported.

Australian parents' attitudes, perceptions and supply of alcohol to adolescents: a national cross-sectional survey.

Parental supply of alcohol to adolescents is associated with increased risk of subsequent adolescent alcohol use and harms, so identifying factors associated with parents' decision-making is critical. This study examined how parental supply is associated with attitudes toward adolescent alcohol use, perceived norms of parental supply, perceived behavioural control and perceived acceptable age to drink alcohol. A total of 1197 Australian parents with children aged 12-17 years completed an online cross-sectional survey assessing their parental supply behaviours, attitudes and perceptions in April 2022.

Prognostic Value of Coronary CT Angiography-Derived Quantitative Flow Ratio in Suspected Coronary Artery Disease.

Background The prognostic value of coronary CT angiography (CTA)-derived quantitative flow ratio (CT-QFR) remains unknown. Purpose To determine the prognostic value of CT-QFR in predicting the long-term outcomes of patients with suspected coronary artery disease (CAD) in comparison with invasive coronary angiography (ICA)/SPECT and to determine the influence of prior percutaneous coronary intervention (PCI) on the prognostic value of CT-QFR. Materials and Methods In this secondary analysis of the prospective international CORE320 study, 379 participants who underwent coronary CTA and SPECT within 60 days before ICA between November 2009 and July 2011 were included for follow-up.

Identifying and Quantifying Borate Environments in Borosilicate Glasses: B NMR-Peak Assignments Assisted by Double-Quantum Experiments.

We discuss the prospects for accurate B magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) spectral deconvolutions for reaching beyond the readily extracted borate speciations offered by the integrated resonances of the coexisting B and B species of the respective BO and BO network groups in borosilicate (BS) glasses. We critically review hitherto proposed B and B NMR-peak assignments relating to their neighboring Si, B and B species, as quantified by MAS NMR spectral deconvolution. Guidance to these resonance assignments was offered from double-quantum-single-quantum (2Q-1Q) B MAS NMR experiments that inform about the B-O-B network linkages.

Seeking under threat of adversity: assessing control over reward pursuit in rats.

Rationale: Substance use disorder (SUD) is a chronic relapsing brain disorder that is characterised by loss of control over substance use. A variety of rodent models employing punishment setups have been developed to assess loss of control over substance use, i.e.

Soundboard-trained dogs produce non-accidental, non-random and non-imitative two-button combinations.

Early studies attempting interspecies communication with great apes trained to use sign language and Augmented Interspecies Communication (AIC) devices were limited by methodological and technological constraints, as well as restrictive sample sizes. Evidence for animals' intentional production of symbols was met with considerable criticisms which could not be easily deflected with existing data. More recently, thousands of pet dogs have been trained with AIC devices comprising soundboards of buttons that can be pressed to produce prerecorded human words or phrases.

The Dual PIM/FLT3 Inhibitor MEN1703 Combines Synergistically With Gilteritinib in FLT3-ITD-Mutant Acute Myeloid Leukaemia.

MEN1703 is a first-in-class, oral, Type I dual PIM/FMS-like tyrosine kinase 3 inhibitor (FLT3i) investigated in a Phase I/II DIAMOND-01 trial in patients with acute myeloid leukaemia (AML). Gilteritinib is a highly potent and selective oral FLT3i approved for the treatment of relapsed/refractory AML with FLT3 mutations. Although gilteritinib showed strong single-agent activity in FLT3-mutated AML, the development of gilteritinib resistance limits response durability, indicating the importance of novel combination strategies to improve disease outcome.

Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma.

Background: Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma, a precursor disease of active multiple myeloma for which no treatments have been approved.

Methods: In this phase 3 trial, we randomly assigned patients with high-risk smoldering multiple myeloma to receive either subcutaneous daratumumab monotherapy or active monitoring.

l-Cysteine-Modified Carbon Dots Derived from for Thiram Pesticides Identification on Edible Perilla Leaves.

In this work, environmentally friendly fluorescent carbon dots (C-dots) were developed for the purpose of thiram identification in the leaves of perilla plants. Powdered plant petals from were hydrothermally combined to create C-dots. Analytical techniques, such as scanning electron microscopy, energy dispersive X-ray spectroscopy, high resolution transmission electron microscopy, Raman spectroscopy, ultraviolet spectroscopy, Fourier transmission infrared spectroscopy, and photoluminescence were employed to examine the properties of C-dots.

Lactational exposure of human infants to metal(loid)s in Sub-Saharan Africa and Mediterranean Europe: A systematic review and meta-analysis.

Breast milk, a fundamental component of infant nutrition, may serve as a reservoir for various metal(loid)s, which could pose significant health risks to infants of mothers exposed to toxic metals. Human exposure levels to metal(loid)s vary across regions, influenced by differences in diet, lifestyle, and environmental factors. This systematic review compares metal(loid) concentrations in breast milk from Sub-Saharan Africa (SSA) and Mediterranean Europe (Med.

Comparison of Clinical Outcomes Between Arthroscopic Rotator Cuff Repair and Reverse Total Shoulder Arthroplasty in Patients With Massive Rotator Cuff Tears and High-Grade Fatty Atrophy Without Glenohumeral Osteoarthritis.

Background: Despite the effectiveness of reverse total shoulder arthroplasty (RSA) and arthroscopic rotator cuff repair (ARCR) for treating massive rotator cuff tears (MRCTs), controversies remain in patients without glenohumeral osteoarthritis (GHOA).

Purpose: To compare clinical outcomes of ARCR or RSA in patients with MRCT with high-grade fatty atrophy without GHOA.

Study Design: Cohort study; Level of evidence, 3.

Robust self-supervised denoising of voltage imaging data using CellMincer.

Voltage imaging is a powerful technique for studying neuronal activity, but its effectiveness is often constrained by low signal-to-noise ratios (SNR). Traditional denoising methods, such as matrix factorization, impose rigid assumptions about noise and signal structures, while existing deep learning approaches fail to fully capture the rapid dynamics and complex dependencies inherent in voltage imaging data. Here, we introduce CellMincer, a novel self-supervised deep learning method specifically developed for denoising voltage imaging datasets.

Exploring Sex Differences in Outcomes of Dual Antiplatelet Therapy for Patients With Noncardioembolic Mild-to-Moderate Ischemic Stroke or High-Risk Transient Ischemic Attack: A Propensity-Matched Analysis of the READAPT Study Cohort.

Background: Sex may impact clinical outcomes in patients with stroke treated with dual antiplatelet therapy (DAPT). We aimed to investigate the sex differences in the short-term outcomes of DAPT within a real-world population of patients with noncardioembolic mild-to-moderate ischemic stroke or high-risk transient ischemic attack.

Methods: We performed a propensity score-matched analysis from a prospective multicentric cohort study (READAPT [Real-Life Study on Short-Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke or Transient Ischemic Attack]) by including patients with noncardioembolic mild-to-moderate stroke (National Institutes of Health Stroke Scale score of 0-10) or high-risk transient ischemic attack (age, blood pressure, clinical features, duration of transient ischemic attack, presence of diabetes [ABCD] ≥4) who initiated DAPT within 48 hours of symptom onset.

Beeswax-based nanoconstructs enriched dual responsive hydrogel for diabetic foot ulcers in streptozotocin-induced diabetic rats.

Diabetic foot ulcer (DFU) is a complicated pathophysiological process, and there is now no recognized treatment. Hyperglycemia, neuropathy, impaired angiogenesis, reactive oxygen species, and advanced glycation end products construct the distinctive wound environment of diabetic wounds. This study aimed to develop naringenin-ferulic acid beeswax-based nanoconstructs enriched dual-responsive hydrogel (NAR-FA NLC HG) for topical application for DFU.

Taxonomic status of the genus Lunakia, including a redescription of the male and female genitalia of Lunakia alyssella (Klimesch, 1941) (Lepidoptera, Plutellidae).

The genital morphology of the Lunakia alyssella (Klimesch, 1941) is redescribed. Additional details of both male and female genitalia are provided, supplemented with accompanying drawings. Anatomical evidence confirms that the genus Lunakia is distinct from the genus Eidophasia within the family Plutellidae.

Revision of the Anerastia lotella complex in Europe, with description of a new species from the Southern Ukraine (Lepidoptera: Pyralidae: Phycitinae).

As a result of our study of cryptic diversity in the Anerastia lotella complex, a new species, Anerastia oleshkyella sp. nov. is described from Southern Ukraine based on genitalia characters and molecular data.

Coleophora elea Baldizzone & Huemer, new species of the Coleophora oriolella Zeller, 1849 species-group (Lepidoptera, Coleophoridae).

Coleophora elea Baldizzone & Huemer, sp. nov., is described based on specimens collected from the Peloponnese peninsula (Greece).

Scrobipalpa chardonnayi Huemer and Özden, sp. nov.: a new presumably endemic species from Cyprus (Lepidoptera, Gelechiidae).

Scrobipalpa chardonnayi Huemer & Özden, sp. nov. is described from the limestone mountains of northern Cyprus and considered as a possible island endemism.

Peucela acutativalva Qi & Li, 2020 (Lepidoptera: Pyralidae): An addition to the Indian fauna.

Peucela acutativalva Qi & Li, 2020 is reported from the Kumaon Himalaya, Uttarakhand, India. The specimens examined are slightly different from those described by Qi et al. (2020).

Combining Paracentral Acute Middle Maculopathy and Peripapillary Fluid as Biomarkers in Anterior Ischemic Optic Neuropathy.

Purpose: To determine if paracentral acute middle maculopathy (PAMM) and peripapillary intraretinal and subretinal fluid (IRF/SRF) could help distinguish between arteritic anterior ischemic optic neuropathy (A-AION) and nonarteritic AION (NA-AION) at an early stage.

Design: Nested prospective cross-sectional diagnostic accuracy study.

Methods: This study used single-center optical coherence tomography (OCT) data from 8 patients with A-AION and 24 patients with NA-AION from two prospective cross-sectional studies with consecutive sampling (ClinicalTrials.

Model for an International Case Sharing Program to Enhance Global Palliative Care Education.

Context: In Thailand, the field of palliative medicine is growing but access and training remain limited. We sought to expand education of resident physicians at Chiang Mai University (CMU) in Thailand through development of an international case sharing program.

Objectives: The goals of this project were to increase knowledge of core palliative care topics, to cultivate a culture of reflective clinical practice, and to create a model for collaboration in international palliative care education that can be replicated by other institutions.

Differentiating Glioma Recurrence and Pseudoprogression by APTw CEST MRI.

Objectives: Recurrent glioma is highly treatment resistant due to its metabolic, cellular, and molecular heterogeneity and invasiveness. Tumor monitoring by conventional MRI has shortcomings to assess these key glioma characteristics. Recent studies introduced chemical exchange saturation transfer for metabolic imaging in oncology and assessed its diagnostic value for newly diagnosed glioma.