571 results match your criteria: "M.A.B.; and H.M. Hospitales-Centro Integral Oncologico H.M. Clara Campal[Affiliation]"
Native and Post-Repair Residual Mitral Valve Prolapse Increases Forces Exerted on the Papillary Muscles: A Possible Mechanism for Localized Fibrosis?
Circ Cardiovasc Interv
December 2022
Department of Cardiothoracic Surgery, Stanford University, CA (M.H.P., R.J.W., Y.Z., H.W., P.K.P., Y.J.W.).
Background: Recent studies have linked mitral valve prolapse to localized myocardial fibrosis, ventricular arrhythmia, and even sudden cardiac death independent of mitral regurgitation or hemodynamic dysfunction. The primary mechanistic theory is rooted in increased papillary muscle traction and forces due to prolapse, yet no biomechanical evidence exists showing increased forces. Our objective was to evaluate the biomechanical relationship between prolapse and papillary muscle forces, leveraging advances in ex vivo modeling and technologies.
View Article and Find Full Text PDFTranscriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
Circulation
March 2023
Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN.
Article Synopsis
- Brugada syndrome (BrS) is an inherited heart condition caused by mutations in the sodium channel gene, and a specific family was found to have a rare G145R variant in a different gene, TBX5, associated with BrS.* -
- Researchers created induced pluripotent stem cells (iPSCs) from family members with the G145R variant and studied the resulting heart cells (iPSC-CMs) to analyze their electrical properties and gene expression differences, comparing them with edited versions using CRISPR technology.* -
- The study found that the G145R variant leads to reduced gene activity and abnormal heart cell behavior, specifically affecting sodium currents, while correcting the mutation restored normal function; disruptions in
Detection of chromosomal alteration after infusion of gene-edited allogeneic CAR T cells.
Mol Ther
March 2023
Allogene Therapeutics, South San Francisco, CA 94080, USA. Electronic address:
A chromosome 14 inversion was found in a patient who developed bone marrow aplasia following treatment with allogeneic chimeric antigen receptor (CAR) Tcells containing gene edits made with transcription activator-like effector nucleases (TALEN). TALEN editing sites were not involved at either breakpoint. Recombination signal sequences (RSSs) were found suggesting recombination-activating gene (RAG)-mediated activity.
View Article and Find Full Text PDFProject EPIC (Early Palliative Care In COPD): A Formative and Summative Evaluation of the EPIC Telehealth Intervention.
J Pain Symptom Manage
April 2023
Center for Palliative and Supportive Care, Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine (A.S.I., R.D.W., J.N.D., J.C., M.A.B.), University of Alabama at Birmingham, Birmingham, Alabama; School of Nursing (A.S.I., R.D.W., J.N.D., J.C., M.A.B.), University of Alabama at Birmingham, Birmingham, Alabama.
Context: Early, concurrent palliative care interventions in chronic obstructive pulmonary disease (COPD) are limited. Project EPIC (Early Palliative Care In COPD) is a multiphase mixed methods study working to fill this gap.
Objectives: To conduct a formative and summative evaluation of EPIC, a telephonic nurse coach-led early palliative care intervention for COPD adapted from the ENABLE© intervention in cancer.
Cardiac Nuclear Medicine: Techniques, Applications, and Imaging Findings.
Radiographics
January 2023
From the Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (A.P., A.C.H., P.S.R.); Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India (A.P); Department of Radiology, University of Tubingen, Tubingen, Germany (P.K., K.N.); and Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio (S.S.H., W.J., M.A.B.).
Trial of Deferiprone in Parkinson's Disease.
N Engl J Med
December 2022
From the Departments of Medical Pharmacology (D. Devos, A.-S.R., R.B., J.-C.D.), Neuroradiology (R.V., G.K., R.L., J.-P.P.), and Neurology (L.D., C.M.), University of Lille, Lille Neuroscience and Cognition, Team DVCD, INSERM Unité Mixte de Recherche Scientifique (UMRS) 1172, Centre Hospitalier Universitaire (CHU) de Lille, Expert Center of Parkinson's Disease, Lille Center of Excellence for Neurodegenerative Disorders (LiCEND) Network of Centers of Excellence in Neurodegeneration (CoEN) Center, NS-Park/FCRIN network, the Department of Biostatistics, University of Lille, CHU de Lille (J.L., A.D.), CHU de Lille, Direction de la Recherche et de l'Innovation (P.G.D., T.O., C.P., C.L.) and Vigilance des Essais Cliniques and Service de Pharmacologie (T.O., C.P., C.L.), CHU de Lille, Laboratoire de Biochimie-Hormonologie, Centre de Biologie Pathologie (P.P.), the University of Lille, CHU de Lille, Institut Pasteur de Lille, ULR4483-Impact de l'Environnement Chimique sur la Santé Humaine (G.G., O.S., J.C.), and the University of Lille, INSERM, CHU de Lille, Unité 1172-Degenerative and Vascular Cognitive Disorders (D. Deplanque), Lille, Clinical Investigation Center 1436, Departments of Neurosciences and Clinical Pharmacology, NS-Park/FCRIN network and NeuroToul CoEN Center, University Hospital of Toulouse, INSERM, University of Toulouse 3, Toulouse (O.R., F.O.-M.), Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), INSERM, Centre National de la Recherche Scientifique (CNRS), Paris Brain Institute-Institut du Cerveau et de la Moelle Épinière (ICM), Department of Neurology, Centre d'Investigation Clinique Neurosciences, Hôpital Pitié-Salpêtrière (J.-C.C.), Sorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, and AP-HP, Hôpital Pitié-Salpêtrière, Department of Nuclear Medicine (M.-O.H.), Centre pour l'Acquisition et le Traitement des Images, US52-UAR2031, Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), ICM, Sorbonne Université, CNRS, INSERM, AP-HP (M.-O.H., J.-F.M., M.C.), Paris Brain Institute-ICM, Center for Neuroimaging Research, Sorbonne Université, INSERM Unité 1127, CNRS 7225, Department of Neuroradiology, Hôpital Pitié-Salpêtrière, AP-HP (S.L.), and ICM, CNRS UMR 7725, INSERM, Unité 1127, Sorbonne Université (J.-F.M., M.C.), Paris, the Department of Neurology, NS-Park/FCRIN network, Strasbourg University Hospital, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg (C.T.), Assistance Publique-Hôpitaux de Marseille, Department of Neurology and Movement Disorders, Timone University Hospital and Institut de Neurosciences de la Timone, Unité Mixte de Recherche (UMR) 7289, CNRS-Aix Marseille Université, Marseille (A.E.), University of Lyon, CNRS, UMR 5229, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie, Centre Expert Parkinson NS-Park/FCRIN network, Bron (S.T.), Université Clermont Auvergne, EA7280, Clermont-Ferrand University Hospital, Neurology Department, Clermont-Ferrand (A.-R.M.), CHU de Bordeaux, Service de Neurologie des Maladies Neurodégénératives, Institut des Maladies Neurodégénératives (IMN) Clinique, University of Bordeaux, CNRS, IMN, UMR 5293, Bordeaux (W.G.M.), and Université Paris-Saclay, CEA, CNRS, NeuroSpin, Baobab, Gif-sur-Yvette (J.-F.M., M.C.) - all in France; the Department of Neurology, Medical University Innsbruck, Innsbruck, Austria (W.P., K.S.); Parkinson's Disease and Movement Disorders Unit, Hospital Clínic de Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer-Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)-European Reference Network for Rare Neurological Diseases, Maria de Maeztu Excellence Center-Institut de Neurociències, Universitat de Barcelona (Y.C.), and the Movement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Department of Medicine, Sant Pau Biomedical Research Institute, and CIBERNED (J.K.), Barcelona, and the Movement Disorders Unit, Hospital Germans Trias i Pujol, Badalona (D.V.) - all in Spain; Clinical Ageing Research Unit, Newcastle University, Newcastle upon Tyne (N.P.), Addenbrooke's Hospital (P.W.) and the ALBORADA Drug Discovery Institute, University of Cambridge, Cambridge Biomedical Campus (J.A.D.), Cambridge, and Parkinson's UK, London (D.T.D.) - all in the United Kingdom; the Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic (E.R., P.D.); Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Department of Neurology, Nijmegen (B.P., B.R.B.), and Amsterdam UMC location University of Amsterdam, Department of Neurology, and Amsterdam Neuroscience, Neurodegeneration, Amsterdam (R.M.A.B.) - all in the Netherlands; the Department of Neurology, Christian Albrechts University Kiel, Kiel (D.B., W.M.), the Department of Neurology, University Clinic, Ulm (M.O.), the Department of Geriatric Medicine, University Duisburg-Essen, Essen (R.D.), Rostock University Medical Center, Department of Neurology, and the German Center for Neurodegenerative Diseases, Research Site Rostock, Rostock (U.W.), and University Hospital of the Saarland, Homburg (S.B.) - all in Germany; Centro de Investigação em Arquitetura, Urbanismo e Design, Faculdade de Arquitetura, Universidade de Lisboa (J.F.), and Hospital de Santa Maria (M.V.S.C.), Lisbon, the Department of Neurology, Hospital da Senhora da Oliveira, Guimarães (M.G.), Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga (M.G.), and Hopitais da Universidade de Coimbra, Department of Neurology, Coimbra (C.J.) - all in Portugal; the Department of Medicine, University of Otago, Christchurch Campus, and New Zealand Brain Research Institute - both in Christchurch, New Zealand (W.G.M.); the Department of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden (D.N.); Leslie Dan Faculty of Pharmacy, University of Toronto, ApoPharma, and Chiesi Canada - all in Toronto (C.F., M.S., F.T.); Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia (S.A., A.I.B., J.A.D.); and the Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel (I.C.).
Background: Iron content is increased in the substantia nigra of persons with Parkinson's disease and may contribute to the pathophysiology of the disorder. Early research suggests that the iron chelator deferiprone can reduce nigrostriatal iron content in persons with Parkinson's disease, but its effects on disease progression are unclear.
Methods: We conducted a multicenter, phase 2, randomized, double-blind trial involving participants with newly diagnosed Parkinson's disease who had never received levodopa.
Underreporting and Triggering Factors for Reporting ADRs of Two Ophthalmic Drugs: A Comparison between Spontaneous Reports and Active Pharmacovigilance Databases.
Healthcare (Basel)
October 2022
Pharmacovigilance Department, Laboratorios Sophia, S.A. de C.V., Zapopan 45010, Jalisco, Mexico.
(1) Aims of the study: calculating the underreporting ratio for two different medications, a fixed combination of 0.5% timolol + 0.2% brimonidine + 2.
View Article and Find Full Text PDFSpatiotemporal Control of Vascular Ca1.2 by α1 S1928 Phosphorylation.
Circ Res
December 2022
Department of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).
Background: L-type Ca1.2 channels undergo cooperative gating to regulate cell function, although mechanisms are unclear. This study tests the hypothesis that phosphorylation of the Ca1.
View Article and Find Full Text PDFTen-Year Follow-up of Internal Neurofibroma Growth Behavior in Adult Patients With Neurofibromatosis Type 1 Using Whole-Body MRI.
Neurology
February 2023
From the Stephen E. and Catherine Pappas Center for Neuro-Oncology (K.I.L., V.L.M., R.D.T., J.L.D., C.C.O., H.P.H., S.R.P., J.T.J.), Massachusetts General Hospital; Department of Radiology (W.C., M.A.B., C.Y.C., G.J.H.), Massachusetts General Hospital; Biostatistics Center (A.M.), Massachusetts General Hospital; and Department of Obstetrics and Gynecology (M.E.M.), Massachusetts General Hospital, Boston.
Background And Objectives: Internal neurofibromas, including plexiform neurofibromas (PNF), can cause significant morbidity in patients with neurofibromatosis type 1 (NF1). PNF growth is most pronounced in children and young adults, with more rapid growth thought to occur in a subset of PNF termed distinct nodular lesions (DNL). Growth behavior of internal neurofibromas and DNL in older adults is not well documented; yet knowledge thereof is important for patient risk stratification and clinical trial design.
View Article and Find Full Text PDFIn-Hospital Virtual Peer-to-Peer Consultation to Increase Guideline-Directed Medical Therapy for Heart Failure: A Pilot Randomized Trial.
Circ Heart Fail
February 2023
Division of Cardiology (V.N.R., J.M., S.G.B., M.D.K., S.J.G., M.F., A.D.D., C.B.P., M.A.B., R.J.M.), Duke University Medical Center, Durham, NC.
Background: Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) improves clinical outcomes and quality of life. Optimizing GDMT in the hospital is associated with greater long-term use in HFrEF. This study aimed to describe the efficacy of a multidisciplinary virtual HF intervention on GDMT optimization among patients with HFrEF admitted for any cause.
View Article and Find Full Text PDFMild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.
Circulation
November 2022
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (L.G., L.S., S. Bell, S.K.K., S. Burgess, K.M., A.M.M., T.R.B., E.A., L.C., J.R.S., P.W., L. Pennells, S.H., M.I., J.D., A.S.B., A.M.W., E.D.A.).
Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke.
Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.
Mental Health Implications of Abortion Restrictions for Historically Marginalized Populations.
N Engl J Med
October 2022
From the Department of Psychiatry and Behavioral Sciences (L.O.-N., M.T., C.M.) and the Department of Obstetrics, Gynecology, and Reproductive Sciences (M.A.B.), University of California, San Francisco, San Francisco; the Department of Psychiatry and Behavioral Sciences (R.S.S.) and the Department of Family and Community Medicine (M.G.), University of California, Davis, Sacramento; the Department of Psychiatry and Behavioral Sciences, Morehouse School of Medicine, Atlanta (S.Y.V.); the Department of Psychiatry, Columbia University, New York (E.M.F.); and the Department of Child, Family, and Population Health Nursing, University of Washington School of Nursing, Seattle (M.R.M.).
Pediatric traumatic hemorrhagic shock consensus conference recommendations.
J Trauma Acute Care Surg
January 2023
From the Division of Pediatric Surgery, Department of Surgery (R.T.R., J.R.E.), University of Alabama at Birmingham, Children's of Alabama, Birmingham, Alabama; Division of Pediatric Surgery, Department of Surgery (M.A.B.), University of Michigan, Ann Arbor, Michigan; Department of Surgery (P.J.A.), University of Alabama at Birmingham, Birmingham, Alabama; Division of Anesthesiology and Critical Care Medicine (M.M.B.), Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pediatrics (M.A.B.), Brooke Army Medical Center, Uniformed Services University; Division of Trauma and Burn Surgery (R.S.B.), Children's National Hospital, Washington, DC; Department of Surgery (B.A.G.), University of Pittsburgh School of Medicine, UPMC Children's Hospital, Pittsburgh, Pennsylvania; Division of Pediatric Surgery (M.J.), Doernbecher Children's Hospital, Oregon Health and Science University, Portland, Oregon; Departments of Pathology and Laboratory Medicine (C.D.J.) and Pediatrics (C.D.J.), Emory University School of Medicine, Atlanta, Georgia; Department of Surgery (C.L.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Pediatrics (J.C.L.), Division of Emergency Medicine, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio; Division of Critical Care Medicine (J.A.M.), The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio; Department of Pathology and Laboratory Medicine (K.K.N.), Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio; Department of Emergency Medicine (D.K.N.), Davis School of Medicine, University of California, Sacramento, California; Department of Anesthesiology and Critical Care (P.A.S.), The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Divisions of Pediatric Surgery (A.M.V.) and Critical Care (A.M.V.), Texas Children's Hospital, Baylor College of Medicine, Houston, Texas; Department of Pathology (T.E.W.), Division of Pediatric Hematology and Oncology, Oregon Health and Science University, Portland, Oregon; and Department of Surgery and Critical Care Medicine (P.C.S.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Hemorrhagic shock in pediatric trauma patients remains a challenging yet preventable cause of death. There is little high-quality evidence available to guide specific aspects of hemorrhage control and specific resuscitation practices in this population. We sought to generate clinical recommendations, expert consensus, and good practice statements to aid providers in care for these difficult patients.
View Article and Find Full Text PDFDiagnostic Performance of Whole-Body Ultra-Low-Dose CT for Detection of Mechanical Ventriculoperitoneal Shunt Complications: A Retrospective Analysis.
AJNR Am J Neuroradiol
November 2022
Department of Neurosurgery (R.P., H.C., H.A.H.).
Background And Purpose: Radiographic shunt series are still the imaging technique of choice for radiologic evaluation of VP-shunt complications. Radiographic shunt series are associated with high radiation exposure and have a low diagnostic performance. Our aim was to investigate the diagnostic performance of whole-body ultra-low-dose CT for detecting mechanical ventriculoperitoneal shunt complications.
View Article and Find Full Text PDFPediatric traumatic hemorrhagic shock consensus conference research priorities.
J Trauma Acute Care Surg
January 2023
From the Department of Surgery (R.T.R.), Division of Pediatric Surgery, University of Alabama at Birmingham, Children's of Alabama, Birmingham, Alabama; Division of Anesthesiology and Critical Care Medicine (M.M.B.), Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pediatrics (M.A.B.), Brooke Army Medical Center, Uniformed Services University; Division of Trauma and Burn Surgery (R.S.B.), Children's National Hospital, Washington, DC; Department of Surgery (B.A.G.), University of Pittsburgh School of Medicine, UPMC Children's Hospital, Pittsburgh, Pennsylvania; Division of Pediatric Surgery (M.J.), Doernbecher Children's Hospital, Oregon Health and Science University, Portland, Oregon; Department of Oncology (C.D.J.), Sydney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Cancer and Blood Disorders Institute (C.D.J.), Johns Hopkins All Children's Hospital, St. Petersburg, Florida; Department of Surgery (C.M.L.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Pediatrics (J.C.L.), Division of Emergency Medicine, Division of Critical Care Medicine (J.A.M.), and Department of Pathology and Laboratory Medicine (K.K.N.), Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio; Department of Emergency Medicine (D.K.N.), Davis School of Medicine, University of California, Sacramento, California; Department of Anesthesiology and Critical Care (P.A.S.), The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Divisions of Pediatric Surgery (A.M.V.) and Critical Care (A.M.V.), Texas Children's Hospital, Baylor College of Medicine, Houston, Texas; Division of Pediatric Hematology and Oncology (T.E.W.), and Department of Pathology (T.E.W.), Oregon Health and Science University, Portland, Oregon; and Department of Surgery and Critical Care Medicine (P.C.S.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Background: Traumatic injury is the leading cause of death in children and adolescents. Hemorrhagic shock remains a common and preventable cause of death in the pediatric trauma patients. A paucity of high-quality evidence is available to guide specific aspects of hemorrhage control in this population.
View Article and Find Full Text PDFOrai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension.
Circ Res
October 2022
Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France (B.M., H.L.R., L.L.., Y.R, M.D, A.B., M.-R.G., M.H., D.M., V.C., F.A.).
Background: Pulmonary arterial hypertension (PAH) is characterized by progressive distal pulmonary artery (PA) obstruction, leading to right ventricular hypertrophy and failure. Exacerbated intracellular calcium (Ca) signaling contributes to abnormalities in PA smooth muscle cells (PASMCs), including aberrant proliferation, apoptosis resistance, exacerbated migration, and arterial contractility. Store-operated Ca entry is involved in Ca homeostasis in PASMCs, but its properties in PAH are unclear.
View Article and Find Full Text PDFThe natural history of fibrodysplasia ossificans progressiva: A prospective, global 36-month study.
Genet Med
December 2022
Departments of Orthopaedic Surgery and Medicine, Center for Research in FOP and Related Disorders, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:
Purpose: We report the first prospective, international, natural history study of the ultra-rare genetic disorder fibrodysplasia ossificans progressiva (FOP). FOP is characterized by painful, recurrent flare-ups, and disabling, cumulative heterotopic ossification (HO) in soft tissues.
Methods: Individuals aged ≤65 years with classical FOP (ACVR1 variant) were assessed at baseline and over 36 months.
Calibration of concomitant field offsets using phase contrast MRI for asymmetric gradient coils.
Magn Reson Med
January 2023
GE Research, Niskayuna, New York, USA.
Purpose: Asymmetric gradient coils introduce zeroth- and first-order concomitant field terms, in addition to higher-order terms common to both asymmetric and symmetric gradients. Salient to compensation strategies is the accurate calibration of the concomitant field spatial offset parameters for asymmetric coils. A method that allows for one-time calibration of the offset parameters is described.
View Article and Find Full Text PDFCompounding of Low-Concentration Atropine for Myopia Control.
Eye Contact Lens
December 2022
University of Houston (K.R., E.T., M.A.B.), College of Optometry, Houston, TX; PharmaLogic Development, Inc (G.D.N.), San Rafael, CA; and Department of Ophthalmology & Vision Sciences (G.D.N.), School of Medicine, University of California, Davis, CA.
Objectives: Low-concentration atropine is commonly prescribed to slow myopia progression in children but is not Food and Drug Administration-approved for that indication and is only available in the United States from compounding pharmacies. The purpose of this study was to ascertain its reported compounding and labeling in the United States.
Methods: US compounding pharmacies were identified through a survey of eye doctors, social media, conferences, and web search.
Demographics, Outcomes, and Risk Factors for Patients with Sarcoma and COVID-19: A CCC19-Registry Based Retrospective Cohort Study.
Cancers (Basel)
September 2022
Department of Medicine, Division of Hematology and Oncology, Vanderbilt University, Nashville, TN 37232, USA.
Background: Patients with sarcoma often require individualized treatment strategies and are likely to receive aggressive immunosuppressive therapies, which may place them at higher risk for severe COVID-19. We aimed to describe demographics, risk factors, and outcomes for patients with sarcoma and COVID-19.
Methods: We performed a retrospective cohort study of patients with sarcoma and COVID-19 reported to the COVID-19 and Cancer Consortium (CCC19) registry (NCT04354701) from 17 March 2020 to 30 September 2021.
Improvement in symptom-related disruptions is associated with fewer days of short-acting beta-agonist use in asthma.
NPJ Prim Care Respir Med
September 2022
Department of Pediatrics, University of Cincinnati and Pulmonary Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Significant indirect healthcare costs are related to uncontrolled asthma, including productivity loss. Days with short-acting beta-agonist (SABA) use is associated with symptom-related disruptions at work, home, and school. Digital self-management platforms may support fewer days with SABA medication use and may reduce symptom-related disruptions.
View Article and Find Full Text PDFTranexamic acid in pediatric hemorrhagic trauma.
J Trauma Acute Care Surg
January 2023
From the Brooke Army Medical Center (M.A.B.), Uniformed Services University, Ft. Sam Houston, Texas; and UC Davis Medical Center (D.K.N.), University of California, Sacramento, California.
There is strong evidence in adult literature that tranexamic acid (TXA) given within 3 hours from injury is associated with improved outcomes. The evidence for TXA use in injured children is limited to retrospective studies and one prospective observational trial. Two studies in combat settings and one prospective civilian US study have found association with improved mortality.
View Article and Find Full Text PDFLinoleate-Rich Safflower Oil Diet Increases Linoleate-Derived Bioactive Lipid Mediators in Plasma, and Brown and White Adipose Depots of Healthy Mice.
Metabolites
August 2022
Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43212, USA.
Polyunsaturated fats are energy substrates and precursors to the biosynthesis of lipid mediators of cellular processes. Adipose tissue not only provides energy storage, but influences whole-body energy metabolism through endocrine functions. How diet influences adipose-lipid mediator balance may have broad impacts on energy metabolism.
View Article and Find Full Text PDFEngineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model.
Sci Rep
August 2022
Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA.
Novel approaches for malaria prophylaxis remain important. Synthetic DNA-encoded monoclonal antibodies (DMAbs) are a promising approach to generate rapid, direct in vivo host-generated mAbs with potential benefits in production simplicity and distribution coupled with genetic engineering. Here, we explore this approach in a malaria challenge model.
View Article and Find Full Text PDFNonalcoholic Fatty Liver Disease: Does This Metabolic Condition Have Brain Function Sequelae?
Neurology
August 2022
From the Laboratory of Epidemiology and Population Sciences (M.A.B.), National Institute on Aging, NIA/NIH/IRP, Baltimore, MD; and Johns Hopkins All Children's Hospital (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburg, FL.