5 results match your criteria: "M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (Gliwice Branch)[Affiliation]"
Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma.
Leukemia
September 2019
ProfilExpert, Lyon, France.
Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study.
Neuro Oncol
May 2015
University of Alabama at Birmingham, Birmingham, Alabama (L.B.N.); Baylor University Medical Center, Dallas, Texas (K.L.F.); Henry Ford Hospital, Detroit, Michigan (T.M.); Clinic for Neurosurgery, Clinical Center of Serbia, Medical Faculty University of Belgrade, Belgrade, Serbia (D.G.); Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Radiotherapy and Chemotherapy Clinic, Gliwice, Poland (R.T.); Samsung Medical Center, Seoul, South Korea (D.H.N.); Centrum Onkologii Ziemi Lubelskiej, Lublin, Poland (M.M.); St. Luke's Brain Tumor Center, St. Luke's Hospital, Kansas City, Missouri (M.S.); Barrow Neurological Institute, Phoenix, Arizona (L.A.); Medical Oncology Unit 1, IOV, IRCCS, Padova, Italy (V.Z.); Policlinico di Modena, Modena, Italy (R.D.); Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (J.R.P.); Merck KGaA, Darmstadt, Germany (C.H., M.P.); Department of Clinical Neurosciences, University Hospital Lausanne, Lausanne, Switzerland (M.E.H.); Institute of Pathology, University Hospital Lausanne, Lausanne, Switzerland (B.L.); Dana-Farber Cancer Institute, Boston, Massachusetts (D.A.R.).
Background: Survival outcomes for patients with glioblastoma remain poor, particularly for patients with unmethylated O(6)-methylguanine-DNA methyltransferase (MGMT) gene promoter. This phase II, randomized, open-label, multicenter trial investigated the efficacy and safety of 2 dose regimens of the selective integrin inhibitor cilengitide combined with standard chemoradiotherapy in patients with newly diagnosed glioblastoma and an unmethylated MGMT promoter.
Methods: Overall, 265 patients were randomized (1:1:1) to standard cilengitide (2000 mg 2×/wk; n = 88), intensive cilengitide (2000 mg 5×/wk during wk 1-6, thereafter 2×/wk; n = 88), or a control arm (chemoradiotherapy alone; n = 89).
Direct and bystander effects induced by scattered radiation generated during penetration of radiation inside a water-phantom.
Mutat Res
March 2011
Department of Experimental and Clinical Radiobiology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, ul. Wybrzeze Armii Krajowej 15, Gliwice, Poland.
In this study, the dose distribution of photon (6 MV) and electron (22 MeV) radiation in a water-phantom was compared with the frequency of apoptotic and micronucleated cells of two human cell lines (BEAS-2B normal bronchial epithelial cells and A549 lung cancer epithelial cells). Formation of micronuclei and apoptotic-like bodies was evaluated by the cytokinesis-block micronucleus test. Measurements were performed for five different phantom depths (3-20 cm).
View Article and Find Full Text PDFTwo-dimensional imaging of tumour control probabilities and normal tissue complication probabilities.
Rep Pract Oncol Radiother
December 2013
Department of Radiotherapy and Brachytherapy Planning, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Poland.
Aim: To create a presentation method of TCP and NTCP distributions calculated based on dose distribution for a selected CT slice.
Materials And Methods: Three 24-bit colour maps - of dose distribution, delineated structures and CT information - were converted into m-by-n-by-3 data arrays, containing intensities of red, green, and blue colour components for each pixel. All calculations were performed with Matlab v.
X-irradiation and bystander effects induce similar changes of transcript profiles in most functional pathways in human melanoma cells.
DNA Repair (Amst)
June 2009
Department of Experimental and Clinical Radiobiology, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (Gliwice Branch), Wybrzeze Armii Krajowej 15, 44-101 Gliwice, Poland.
Article Synopsis
- Unirradiated cells near those exposed to ionizing radiation experience bystander effects, leading to DNA damage, chromosomal instability, mutations, and apoptosis.
- Researchers compared the gene expression changes in human melanoma cells grown in conditioned medium from irradiated cells against those exposed directly to irradiation, finding significant overlap in the affected gene transcripts.
- The study highlights that factors from irradiated cells can alter gene expression in bystander cells for extended periods, suggesting long-term impacts of radiation exposure on neighboring cells.