1,628 results match your criteria: "M. Sechenov First Moscow State Medical University Sechenov University[Affiliation]"
Correlation of Edema/Tumor Index With Histopathological Outcomes According to the WHO Classification of Cranial Tumors.
Cureus
November 2024
Neurosurgery, Russian People's Friendship University, Moscow, RUS.
Article Synopsis
- Metastatic brain tumors commonly cause vasogenic edema, which can impact patient prognosis, but there is limited research on its diagnostic significance.
- This study analyzed MRI data from 60 patients to investigate the correlation between the edema/tumor index (ETI) and tumor histopathology based on the 2021 WHO classification.
- Results showed that although malignant tumors had larger edema volumes, the ETI didn't significantly correlate with histopathological grades, and ROC analysis indicated ETI wasn't a reliable predictor for malignancy.
Development of Technology for the Synthesis of Nanocrystalline Cerium Oxide Under Production Conditions with the Best Regenerative Activity and Biocompatibility for Further Creation of Wound-Healing Agents.
Pharmaceutics
October 2024
Southwest State University, 50 let Oktyabrya Str., 94, 305040 Kursk, Russia.
The issue of effective wound healing remains highly relevant. The objective of the study is to develop an optimal method for the synthesis of nanosized cerium oxide powder obtained via the thermal decomposition of cerium carbonate precipitated from aqueous nitrate solution for the technical creation of new drugs in production conditions; the select modification of synthesis under different conditions based on the evaluation of the physicochemical characteristics of the obtained material and its biological activity, and an evaluation of the broad-spectrum effect on cells involved in the regeneration of skin structure as well as antimicrobial properties. Several modes of the industrial synthesis of cerium dioxide nanoparticles (NPs) were carried out.
View Article and Find Full Text PDFInterleukin-6: Cardiovascular Aspects of Long-Term Cytokine Suppression in Patients with Rheumatoid Arthritis.
Int J Mol Sci
November 2024
Department of Systemic Rheumatic Diseases, V.A. Nasonova Research Institute of Rheumatology, Kashirskoe Shosse, 115522 Moscow, Russia.
Article Synopsis
- Inflammation from cytokines, especially IL-6, is linked to increased cardiovascular disease (CVD) risk, particularly in rheumatoid arthritis (RA) patients, but the impact of IL-6 inhibitors like tocilizumab on CVD is unclear.
- A study of 45 RA patients on long-term tocilizumab therapy showed no significant increase in cardiovascular risk or structural changes in carotid arteries, and cholesterol levels remained stable for those not on statins.
- For patients on statins, there were significant improvements in cholesterol metrics, including a 43% increase in beneficial HDL-C and reductions in total cholesterol and atherogenicity, with associations found between cholesterol changes and inflammation markers.
Morphofunctional Features of Glomeruli and Nephrons After Exposure to Electrons at Different Doses: Oxidative Stress, Inflammation, Apoptosis.
Curr Issues Mol Biol
November 2024
Department of Digital Oncomorphology, National Medical Research Centre of Radiology, 2nd Botkinsky Pass., 3, 125284 Moscow, Russia.
Article Synopsis
- Kidney disease is becoming a major global health concern, with projections indicating it will rank as the fifth-leading cause of life lost by 2040.
- The research focuses on understanding the dose-dependent effects of electron irradiation on renal tissue, as the impact of this type of radiation is not well studied compared to others like gamma and X-rays.
- Findings show that higher doses of electron irradiation cause increased oxidative stress, inflammation, and significant damage to kidney tissue, including apoptosis and early fibrosis, highlighting the importance of managing radiation doses to protect kidney function.
The Role of Neuropeptide Y in the Pathogenesis of Alzheimer's Disease: Diagnostic Significance and Neuroprotective Functions.
Neurol Int
November 2024
Mental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, Russia.
. Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. It has been suggested that the factors that cause pathologic changes and lead to the development of AD may also include changes in certain neuropeptides.
View Article and Find Full Text PDFA Two-Country Questionnaire Study of Biomedical Student Opinions Regarding Online Teaching During COVID-19.
Epidemiologia (Basel)
November 2024
N.A. Semashko Public Health and Healthcare Department, F.F. Erismann Institute of Public Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia.
Background: The purpose of this study was to compare the opinions of biomedical students from Russia and Central Serbia about learning methods in the time of the COVID-19 pandemic.
Methods: This is a comparative questionnaire study that used the validated questionnaire tool eMedQ, conducted via the online platform Anketolog.ru from February to May 2022 at Sechenov University and the University of Kragujevac in the same period.
The Effect of Transplantation of Ensheathing Cells of the Olfactory Mucosa into the Hippocampal Area on the Restoration of Cognitive Abilities in Rats with Experimental Alzheimer's Disease.
Bull Exp Biol Med
November 2024
V. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
Article Synopsis
- Alzheimer's disease was experimentally induced in female Wistar rats through injections of β-amyloid into the hippocampus.
- Following this, olfactory mucosa cells were transplanted into the same brain region and showed survival and clustering by week 4.
- The transplanted cells improved cognitive functions significantly between weeks 3-5, suggesting potential for further research on these cells as a personalized treatment for Alzheimer's disease.
[Brain magnetic resonance imaging features in Leber's hereditary optic neuropathy].
Vestn Oftalmol
November 2024
Research Center of Neurology, Moscow, Russia.
Leber's hereditary optic neuropathy (LHON) is the most common inherited mitochondrial disease, characterized by the development of bilateral partial optic nerve atrophy. Modern neuroimaging technologies enable the acquisition of high-quality images, allowing for the evaluation of all structural components of the orbits, including the optic nerve. Consequently, the relevance of performing magnetic resonance imaging (MRI) in patients with LHON has increased.
View Article and Find Full Text PDF[Heavy eye syndrome: clinical manifestations, diagnosis and treatment].
Vestn Oftalmol
November 2024
Krasnov Research Institute of Eye Diseases, Moscow, Russia.
Article Synopsis
- Heavy eye syndrome (HES) is a unique type of strabismus caused by a significant elongation of the eye's axial length, leading to misalignment and reduced eye movement, often seen in patients with high myopia.
- Identification of HES relies on multislice computed tomography (MSCT), which reveals a key sign of the condition: the dislocation of the posterior pole from the muscle cone.
- The preferred surgical option for HES involves techniques that reposition the superior and lateral rectus muscles, as traditional surgeries are less effective and may complicate future treatment.
Unlabelled: In recent years, there has been a growing interest in the contribution of neuroretinal degeneration to the pathogenesis of diabetic retinopathy (DR), preceding the classic vascular changes associated with DR.
Purpose: This study evaluated the impact of the polypeptide drug Retinalamin on the structural and functional condition of the retina in patients with DR using optical coherence tomography (OCT) (Topcon OCT 2000 FA, Japan) and the Diopsys Nova vision testing system for electrophysiological studies of the visual organ.
Material And Methods: The clinical study included 56 patients (112 eyes) with type 1 and type 2 diabetes and DR without macular edema.
[Application of parametric statistics to visual acuity data].
Vestn Oftalmol
November 2024
Habib Thameur University Hospital, Tunis, Tunisia.
Unlabelled: ETDRS charts with logarithmic notation are widely used for measuring visual acuity in clinical studies worldwide. However, the distribution of measurement results often deviates from normal, limiting the applicability of parametric statistical methods, which are more powerful than the non-parametric ones. In cases of significant skewness, raw data can undergo power transformation with varying exponents (λ), as described by J.
View Article and Find Full Text PDFBackground: Post-traumatic stress disorder (PTSD) can occur after a traumatic event. PTSD is characterized by nightmares, flashbacks and avoidance of stressors. It currently affects 2-8% of the population, with military personnel particularly susceptible.
View Article and Find Full Text PDFRecent developments in Achilles tendon risk-analyzing rupture factors for enhanced injury prevention and clinical guidance: Current implications of regenerative medicine.
J Orthop Translat
November 2024
Department of Human Anatomy and Histology, I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Article Synopsis
- Many countries have increased focus on physical education and sports, yet there's been a notable rise in injuries, particularly Achilles tendon ruptures, which make up 47% of such cases.
- The review aims to identify risk factors for Achilles tendon ruptures and propose personalized prevention strategies based on extensive database research.
- It highlights non-modifiable factors like genetics and age as well as modifiable factors such as nutrition and exercise habits, emphasizing the importance of early treatment and the latest advancements in injury management.
Editorial Expression of Concern: Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy.
Eur J Med Res
November 2024
Virology Department, Faculty of Veterinary Medicine, The University of Tehran, Tehran, Iran.
Projected epidemiological trends and burden of liver cancer by 2040 based on GBD, CI5plus, and WHO data.
Sci Rep
November 2024
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, 450000, People's Republic of China.
Incidence of liver cancer as one of the most common cancers worldwide and become the significant contributor for the mortality among cancer patients. The disease burden, risk factors, and trends in incidence and mortality of liver cancer globally was described subsequently estimated the projections of liver cancer incidence or mortality by 2040. Data regarding age-standardized incidence and mortality rates for liver cancer was obtained from multiple databases, including GLOBOCAN 2020, CI5 volumes I-XI, WHO mortality database, and Global Burden of Disease (GBD)-2019.
View Article and Find Full Text PDFThe Association of Genetic Polymorphisms and Atypical Depression in Adults: A Systematic Review.
Clin Neuropsychiatry
October 2024
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, 119435.
Article Synopsis
- - Atypical depression (AD) is a subtype of depression characterized by mood reactivity and features like increased appetite, hypersomnia, and sensitivity to interpersonal rejection, with a focus on the genetic factors influencing its development.
- - Recent research found nine studies linking specific genetic markers, including those related to the serotonin transporter gene and other regulatory genes, to atypical depression, although no comprehensive reviews on this topic exist yet.
- - The findings suggest that atypical depression has a hereditary component, indicating that identifying individual genetic risk markers for AD could be a significant area for future research.
Background: Some studies connect the popularity of food-tracking apps to an increase in restrictive eating and other disordered eating behaviors and find those apps harmful for psychological well-being, but there is a lack of empirical studies, especially of Russian samples.
Objective: To examine the connection between disordered eating symptoms, psychological well-being, and the use of a mobile food-tracking application.
Design: The participants were 26 women aged 18-30 ( = 21.
[THE INCIDENCE OF DIABETES MELLITUS IN THE ADULT POPULATION OF MOSCOW IN 2013-2022].
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
October 2024
Research Institute of Health Care Organization and Medical Management of the Moscow Health Care Department, 115088, Moscow, Russia,
Introduction: Diseases of the endocrine system continue to be an acute social problem for the state. The negative trend in the prevalence of diabetes mellitus, as well as the increase in the number of cases among adolescents and people of working age, should be the main driver for building a sustainable health care system.
Objective: to analyze the incidence of type 1 and type 2 diabetes mellitus in the adult population of Moscow and the Russian Federation in the period 2013-2022 according to official statistics.
The Basic Principles of Pathophysiology of Venous Thrombosis.
Int J Mol Sci
October 2024
Center of Pathology of Pregnancy and Hemostasis «Medlabi», Tbilisi 340112, Georgia.
Article Synopsis
- Recent developments have improved our understanding of the molecular processes that lead to thrombus formation, particularly regarding deep vein thrombosis (DVT), which can be triggered by various factors like trauma, immobility, or genetic issues.
- About half of DVT cases are unprovoked, involving mechanisms such as venous stasis and hypoxia, raising the importance of immunothrombosis, especially during conditions like COVID-19 that exacerbate inflammation and promote microthrombi formation.
- Research involving animal models and clinical studies has revealed the intricate relationship between immune cells, blood components, and various factors influencing coagulation, providing a deeper insight into the causes of hypercoagulability and venous thromboembolism.
[Impact of various rehabilitation programs on anxiety and depression after surgery of early-stage cervical cancer].
Vopr Kurortol Fizioter Lech Fiz Kult
November 2024
S.S. Yudin City Clinical Hospital, Moscow, Russia.
Article Synopsis
- Cervical cancer (CC) is increasingly common and presents significant health care challenges, even with HPV vaccination and screening efforts; there's a need to understand rehabilitation's role in reducing anxiety and depression post-surgery.
- A study involving 103 female CC patients compared two rehabilitation programs: one multicomponent and the other adhering to standard guidelines, assessing anxiety and depression levels pre-surgery and over 36 months post-op using the Hospital Anxiety and Depression Scale (HADS).
- Results showed that the multicomponent rehabilitation significantly decreased anxiety and depression more effectively than the standard program, highlighting its importance in recovery for early-stage CC patients.
A new technique of primary retroperitoneal approach for minimally invasive surgical treatment of cecal colon cancer with d3 lymph node dissection.
Tech Coloproctol
October 2024
Department of Faculty Surgery, No. 2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Article Synopsis
- * A single-port system was utilized for dissection around key anatomical landmarks, including Toldt’s and Gerota’s fascia, which facilitated access to the ileocolic vessels and lymph nodes while minimizing complications associated with past surgical adhesions.
- * The operation lasted 240 minutes with minimal blood loss and low postoperative pain, indicating that this approach is safe and effective, allowing for successful treatment of cecal colon cancer and ensuring a manageable recovery time of 7 days
Dose-Response Effect of Various Concentrations of Cl-Containing Water-Soluble Derivatives of C Fullerenes on a Selective Regulation of Gene Expression in Human Embryonic Lung Fibroblasts (HELF).
Front Biosci (Landmark Ed)
October 2024
Laboratory of molecular biology, Research Centre for Medical Genetics, 115478 Moscow, Russia.
Background: The new synthesized water-soluble derivatives of C fullerenes are of a great interest to researchers since they can potentially be promising materials for drug delivery, bioimaging, biosonding, and tissue engineering. Surface functionalization of fullerene derivatives changes their chemical and physical characteristics, increasing their solubility and suitability for different biological systems applications, however, any changes in functionalized fullerenes can modulate their cytotoxicity and antioxidant properties. The toxic or protective effect of fullerene derivatives on cells is realized through the activation or inhibition of genes and proteins of key signaling pathways in cells responsible for regulation of cellular reactive oxygen species (ROS) level, proliferation, and apoptosis.
View Article and Find Full Text PDFChest x-ray images: transfer learning model in COVID-19 detection.
J Eval Clin Pract
February 2025
Department of Polyclinic Therapy, Institute of Clinical Medicine named after N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
Article Synopsis
- The research focuses on creating a machine learning algorithm to diagnose COVID-19 from chest X-rays using transfer learning and support vector machines, utilizing data from 10 clinics and a total of 10,000 X-ray images.
- Results indicated high accuracy rates for the proposed model with 95% for COVID-19, 89% for pneumonia, and 92% for normal cases, outperforming several other advanced models in terms of sensitivity and overall performance.
- The study highlights the potential of machine learning in medical diagnostics, showcasing the model's effectiveness across various clinical settings and its ability to maintain consistency between predicted and actual results.
Immunogenicity and Protectivity of Sputnik V Vaccine in hACE2-Transgenic Mice against Homologous and Heterologous SARS-CoV-2 Lineages Including Far-Distanced Omicron BA.5.
Vaccines (Basel)
October 2024
Federal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Article Synopsis
- The SARS-CoV-2 virus mutates continuously, leading to new variants like Omicron, which has reduced the effectiveness of vaccines worldwide.
- The study evaluated the Sputnik V vaccine's effectiveness against several SARS-CoV-2 variants using various research methods on transgenic mice.
- Results showed that while Sputnik V generates a strong immune response, its efficacy is significantly lower against the Omicron variant, highlighting the need for ongoing monitoring and potential development of new vaccines.
Role of Sterilization on In Situ Gel-Forming Polymer Stability.
Polymers (Basel)
October 2024
A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.
Article Synopsis
- New drug delivery systems that respond to stimuli have been created for injections, focusing on using smart polymers that change at the injection site.
- Sterility is crucial for all injectable and eye medication forms, and choosing the right sterilization method is key, as it can alter the drug’s properties.
- There is a lack of research on the risks of sterilizing these sensitive systems, but this review offers recommendations based on existing experimental data to help manage these risks.