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Oncogenic alterations in papillary thyroid cancers of young patients.
Thyroid
January 2012
Centre de Recherche en Cancérologie de Lyon, Rhône-Alpes Registry of Thyroid Cancers, Université Lyon UMR INSERM U1052, CNRS 5286, Lyon-R.T.H. Laennec School of Medicine, Lyon, France.
Background: Papillary thyroid carcinoma (PTC) in young people usually has an aggressive initial presentation, though a good general prognosis despite recurrences in 10%-20% of patients. A number of genetic alterations that activate the mitogen-activated protein kinase (MAPK) pathway have been found in PTC. Some of these alterations have been identified as prognostic factors of PTC in adults.
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