39,416 results match your criteria: "Lymphoma Bone"
Semin Radiat Oncol
January 2025
Department of Therapeutic Radiology, Yale Cancer Center, New Haven, CT. Electronic address:
Chimeric antigen receptor (CAR) T-cell receptor therapy has transformed outcomes for patients with relapsed and refractory diffuse large B-cell lymphoma (R/R DLBCL). It is currently approved in the third line for all patients and in the second line for early relapsed or primary refractory disease. Although CAR T cell therapy offers the potential for improved outcomes, its use may also include logistical delays related to referral, medical, social, and financial clearance as well as manufacturing time; more than half of patients experience disease recurrence or progression while awaiting CAR T infusion.
View Article and Find Full Text PDFSemin Radiat Oncol
January 2025
Department of Radiation Oncology, Institut Curie, Paris, France.
Radiotherapy has a long history in the treatment of lymphoma and leukemia, in which late toxicity outcomes have motivated current goals to improve how radiotherapy is delivered. Contemporary advanced radiotherapy techniques, including intensity modulated radiation therapy (IMRT), proton therapy, deep inspiration breath hold (DIBH), aim to reduce the risk of cardiac morbidity and second cancers caused by radiotherapy while maintaining local control. We use treatment of mediastinal and gastric lymphomas to introduce how modern techniques are chosen for optimal dose delivery, followed by an anatomic site-specific discussion of testicular, bone, and central nervous system disease.
View Article and Find Full Text PDFAnn Hematol
December 2024
Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Transient abnormal myelopoiesis (TAM) generally affects newborns with Down syndrome and is associated with constitutional trisomy 21 and a somatic GATA1 mutation. Here we describe a case of TAM which evolved after umbilical cord blood transplantation (UCBT), whose origin was identified as a GATA1 mutation-harboring clone in umbilical cord blood (UCB) by detailed genetic analyses. A 58-year-old male who received UCBT for peripheral T-cell lymphoma presented progressive anemia and thrombocytopenia, and leukocytosis with blast cells in the peripheral blood (PB).
View Article and Find Full Text PDFSci Prog
December 2024
Oral pathology, Department of Oral Diagnostic Sciences, College of Dentistry, University of Baghdad, Baghdad, Iraq.
Objectives: This study compared the clinicopathological, immunohistochemical characteristics and Epstein-Barr virus (EBV) detection of Burkitt's lymphoma (BL) in the abdomen and jaw of Iraqi patients.
Methods: A cohort/retrospective study was carried out between August and September 2024 using 25 tissue blocks (14 gnathic and 11 abdominal BL) from the Oral and Maxillofacial Laboratory, University of Baghdad, College of Dentistry, and the National Centre for Educational Laboratories. The sections were stained with haematoxylin and eosin (H&E), while CD10, CD20, Bcl-2, BCl-6, C-Myc and Ki-67 markers were used for diagnosis.
J Rhinol
July 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Background And Objectives: Natural killer T-cell lymphoma (NKTCL) and diffuse large B-cell lymphoma (DLBCL) are the two most prevalent subtypes of lymphoma in the sinonasal region. Accurately differentiating between sinonasal DLBCL and NKTCL is crucial for determining the appropriate treatment and prognosis. The present study compared the clinical characteristics of these two conditions.
View Article and Find Full Text PDFAnn Hematol
December 2024
The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
The prevalence of anti-CD20 monoclonal antibody (MoAb)-associated delayed-onset neutropenia (DON) varies between 8 and 27%. Despite the wide use of MoAbs as maintenance in follicular lymphoma (FL), data regarding DON occurrence and clinical consequences are limited. This study assessed DON prevalence, severity and risk factors in FL patients during maintenance.
View Article and Find Full Text PDFCureus
November 2024
Internal Medicine and Infectiology, Universitair Ziekenhuis Brussel, Brussels, BEL.
A 53-year-old woman was hospitalized due to a fever of unknown origin for three weeks. Given the presence of fever and fatigue, the laboratory findings, and a bone marrow biopsy confirming hemophagocytic lymphohistiocytosis (HLH), a hematological malignancy was suspected. Peripheral lymphocytic typing, bone marrow biopsy, and imaging could not identify an underlying cause of HLH.
View Article and Find Full Text PDFBMC Cancer
December 2024
Hematology, Oncology and Bone Marrow Transplantation Unit, Pediatric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Evading apoptosis fuels the aggressive nature of acute lymphoblastic leukemia (ALL). This study explored the potential roles of TNF-α, a pro-apoptotic cytokine, and TGF-β, a pro-proliferative factor, in the risk of developing ALL in Egyptian children. We investigated the TNF-α rs1800629 polymorphism and serum TGF-β levels in 100 ALL patients and 100 healthy controls.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
December 2024
Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
J Cell Mol Med
December 2024
Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.
The bone marrow-infiltrated immune microenvironment plays a crucial role in blood system diseases, such as leukaemia. In this study, we aimed to investigate the critical role of the immune microenvironment in the onset and progression of childhood acute lymphoblastic leukaemia (ALL). Through high-throughput detection and screening of the GPCR database in the childhood ALL immune microenvironment, we identified CD312 as a candidate target.
View Article and Find Full Text PDFMedicine (Baltimore)
December 2024
School of Medicine, Pingdingshan University, Pingdingshan, China.
Primary myelofibrosis (PMF) is characterized by bone marrow fibrosis, but the underlying molecular mechanisms remain incompletely understood. Here, we investigated the role of lysyl oxidase-like 2 (LOXL2), an enzyme involved in extracellular matrix remodeling, in PMF pathogenesis. Analysis of bone marrow cells from PMF patients revealed significantly elevated LOXL2 mRNA expression compared to healthy controls, which was further validated using 2 independent Gene Expression Omnibus datasets (GSE26049 and GSE12234).
View Article and Find Full Text PDFCureus
November 2024
Otolaryngology, Royal Surrey County Hospital, Guildford, GBR.
A 66-year-old woman with no prior medical history presented to the emergency department with diplopia and parosmia. The neurological examination identified an isolated left abducens nerve (CN VI) palsy. A head CT scan, followed by a brain MRI, showed a large, locally advanced tumour in the left sphenoid sinus with extensive skull base involvement and perineural extension into the left orbit.
View Article and Find Full Text PDFCancer Manag Res
December 2024
Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
Waldenström macroglobulinemia (WM) is a relatively rare hematological malignancy characterized by serum monoclonal IgM gammopathy and bone marrow infiltration of lymphoma cells (small B lymphocytes, plasmacytoid lymphocytes, or plasma cells). Elevated CA125 is most seen in ovarian cancer or some benign diseases such as pelvic inflammatory disease and endometriosis. No cases of WM combined with elevated CA125 have been reported so far.
View Article and Find Full Text PDFHell J Nucl Med
December 2024
3rd Internal Medicine Department and Liver Outpatient Unit, Evangelismos General Hospital, Athens, Greece.
Hematology Am Soc Hematol Educ Program
December 2024
Department of Lymphoma/Myeloma and Department of Stem Cell Transplantation/Cellular Therapy, MD Anderson Cancer Center, Houston, TX.
Hodgkin lymphoma (HL) is a rare hematologic malignancy with a bimodal distribution of incidence, with most patients diagnosed between the ages of 15 and 30 years and another peak in patients older than 55 years. It is estimated that in 2023, almost 9000 people were diagnosed with HL in the United States. Most patients will be cured using conventional chemotherapy and radiotherapy.
View Article and Find Full Text PDFJCO Oncol Pract
December 2024
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Purpose: Lymphomas are a heterogeneous group of diseases that develop in individuals of all ages and have variable prognoses. Improved survival resulting from therapy advances has led to the emergence of diverse late effects. Although several (US)-based organizations have developed survivorship guidelines, the distinct features of lymphoma subtypes and diverse therapies used raise concerns regarding their applicability to lymphoma survivors.
View Article and Find Full Text PDFCureus
November 2024
Hematology, Centro Hospitalar de Setúbal, Hospital de São Bernardo, Setúbal, PRT.
Burkitt lymphoma has a high proliferation rate and a significant risk of tumor lysis syndrome. Risk stratification and early identification are imperative since it is an oncological emergency. We report the case of a 20-year-old woman, without relevant past medical history, admitted to the Emergency Department with a three-week history of fatigue, chest discomfort, productive cough, night sweats, myalgia, odynophagia, and holocranial headache.
View Article and Find Full Text PDFPneumologie
December 2024
Medizinische Klinik 5 (Pneumologie), Klinikum Fulda gAG, Campus Fulda, Universitätsmedizin Marburg, Fulda, Deutschland.
Zhonghua Nei Ke Za Zhi
December 2024
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing100730, China.
Front Immunol
December 2024
Department of Hematology, Cangzhou People's Hospital, Cangzhou, China.
Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a promising approach for treating relapsed/refractory (r/r) T-cell acute lymphoblastic leukemia (T-ALL). However, it is mostly used as a bridging therapy for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, secondary allo-HSCT is costly and associated with significantly high treatment-related mortality rate than the primary transplants.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
November 2024
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Background: In primary central nervous system lymphoma (PCNSL), the extent to which post-methotrexate consolidation contributes to neurotoxicity is unclear. Concerns for neurotoxicity from standard-dose whole-brain radiotherapy (WBRT) have led to declining use. Cerebral atrophy is an established surrogate for neurotoxicity; however, the relative extent to which modern consolidation (i.
View Article and Find Full Text PDFJBMR Plus
December 2024
Department of Orthopaedic Surgery, University of California Davis Medical Center, Sacramento, CA 95817, United States.
Femur fracture leads to loss of bone at uninjured skeletal sites, which may increase risk of subsequent fracture. Osteocytes, the most abundant bone cells, can directly resorb bone matrix and regulate osteoclast and osteoblast activity, but their role in systemic bone loss after fracture remains poorly understood. In this study we used a transgenic (TG+) mouse model that overexpresses human B-cell lymphoma 2 (BCL-2) in osteoblasts and osteocytes.
View Article and Find Full Text PDFbioRxiv
November 2024
Department of Medicine.
Mutations in the histone methyltransferase EZH2, particularly the Y641 hotspot mutation, have been implicated in hematologic malignancies, yet the effect of timing and cellular context on their oncogenic potential has remained unknown. In this study, we utilized a conditional allele with tissue-specific Cre drivers to investigate the effects of mutations at various stages of development, with a focus on the hematopoietic system. We found that ubiquitous heterozygous expression at birth, or conditional expression in hematopoietic or mesenchymal stem cells, led to decreased survival due to hematopoietic defects and bone marrow failure, with no evidence of malignancy.
View Article and Find Full Text PDFBMJ Case Rep
November 2024
Pathology, Hackensack Meridian Hackensack University Medical Center, Hackensack, New Jersey, USA.
Plasmablastic multiple myeloma (MM) is a rare and highly aggressive variant of MM that presents significant diagnostic and therapeutic challenges. This variant is characterised by a bone marrow infiltration of ≥2% plasmablasts and is distinguished by its atypical pleomorphic morphology, unique immunohistological profile and extensive extramedullary involvement. The anaplastic features of plasmablastic MM can closely mimic those of high-grade lymphomas, leukaemia, non-haematopoietic malignancies and high-grade carcinomas, often leading to initial diagnostic errors.
View Article and Find Full Text PDFTransplant Cell Ther
November 2024
Department of Bone Marrow Transplantation, Beijing Gobroad Boren Hospital, Beijing, China. Electronic address:
T-ALL is caused by abnormal proliferation of T cells. It comprises 25%-50% of ALL cases in children and adults. Outlook for R/R T-ALL/LBL and patients over 60 is even dimmer.
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