411 results match your criteria: "Lymphogranuloma Venereum LGV"
The challenges in lymphogranuloma venereum diagnosis whether NAAT is negative, a case series.
Int J STD AIDS
December 2024
Internal Medicine and infectious Diseases Department, UZ Brussel, Vije Universiteit Brussel (VUB), Brussel, Belgium.
Article Synopsis
- Persistent inguinal lymphadenopathy can be caused by various conditions, including the sexually transmitted infection lymphogranuloma venereum (LGV), which may be overlooked due to diagnostic challenges.
- Two male patients with a high risk for STIs presented with inguinal lymphadenopathy; initial tests were negative, leading to prolonged diagnostic delays before confirming LGV.
- Both patients improved significantly after treatment with doxycycline, highlighting the importance of considering LGV in similar cases of persistent lymphadenopathy.
[Translated article] AEDV Expert Document on the Management of Ulcerative Venereal Infections.
Actas Dermosifiliogr
November 2024
Servicio de Dermatología, CIBERINFEC, Hospital La Paz, Madrid, Spain. Electronic address:
Currently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission.
View Article and Find Full Text PDFDistribution of -genotypes over three decades in Portugal.
Sex Transm Infect
September 2024
National Reference Laboratory (NRL) for Sexually Transmitted Infections (STI), Department of Infectious Diseases, National Institute of Health (Instituto Nacional de Saúde Doutor Ricardo Jorge, INSA, IP), Lisboa, Lisboa, Portugal
Article Synopsis
- * Genotype E was the most commonly detected, while lymphogranuloma venereum (LGV) genotypes, particularly L2, saw an increase starting in 2016, notably in male anorectal samples.
- * Findings emphasize the importance of -genotyping for ongoing molecular surveillance and enhancing the detection of sexually transmitted infections in the country.
Article Synopsis
- The study examined MSM (men who have sex with men) diagnosed with rectal lymphogranuloma venereum (LGV) and treated with doxycycline for either 7 or 21 days from 2015 to 2022.
- A total of 143 MSM were part of the study, with 58 (41%) specifically diagnosed with LGV.
- Results showed a 100% microbiologic cure rate for both symptomatic and asymptomatic LGV cases treated with either duration of doxycycline.
Clinically Defined Lymphogranuloma Venereum among US Veterans with Human Immunodeficiency Virus, 2016-2023.
Microorganisms
June 2024
Public Health National Program Office, Department of Veterans Affairs, Washington, DC 20420, USA.
Article Synopsis
- A study of 1381 HIV-positive Veterans from 2016 to 2023 found that 20.6% met the clinical criteria for lymphogranuloma venereum (LGV), with 63% classified as probable cases.
- Of the identified LGV cases, 81% presented with proctitis, and key risk factors included male birth sex and being a man who has sex with men.
- Only 43.7% of the LGV cases received standard treatment, suggesting that LGV may be underestimated and inadequately treated in this population.
Genetic characterisation of lymphogranuloma venereum in Spain: a multicentre study.
Sex Transm Infect
November 2024
Sexually Transmitted Infections Study Group (GEITS), Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid, Spain
Article Synopsis
- Lymphogranuloma venereum (LGV) is a sexually transmitted infection primarily affecting men who have sex with men (MSM), with significant prevalence in HIV-positive individuals and proctitis as a common symptom.
- A study was conducted to analyze the genetic characteristics of LGV isolates from six hospitals in Spain using multilocus sequence typing (MLST) and other genetic methods.
- Results showed that a majority of isolates were L2 genotypes, with L2-ST53 and L2-ST58 being the most common profiles, indicating complex transmission networks and potential co-circulation of different strains.
Lymphogranuloma venereum of the neck in a young man living with HIV: a rare extragenital presentation.
BMJ Case Rep
July 2024
Infecciologia e Medicina Tropical, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal.
Article Synopsis
- Lymphogranuloma venereum (LGV) is a sexually transmitted infection that primarily affects the anogenital area but can occasionally manifest in extragenital locations, like the neck.
- A case study highlights a young man with HIV who experienced painful swelling in his neck, leading to a challenging diagnosis that required various medical tests.
- The patient's diagnosis of LGV was confirmed via genotyping, and he was effectively treated with doxycycline and surgical drainage, underscoring the need for thorough testing in patients with unexplained neck swelling, especially those with a history of unprotected oral sex.
Anorectal lymphogranuloma venereum among men who have sex with men: a 3-year nationwide survey, France, 2020 to 2022.
Euro Surveill
May 2024
Members of the Anachla study group are listed under Acknowledgements.
Article Synopsis
- In France, a nationwide survey from 2020 to 2022 reinstated universal LGV testing after switching to selective testing in 2016, focusing on samples from men and women with anorectal positivity.
- The results showed stable LGV positivity rates among men who have sex with men (MSM) but a notable increase in asymptomatic cases, rising from 36.1% in 2020 to 52.4% in 2022.
- The findings emphasize the importance of universal LGV testing and ongoing surveillance due to the increase in asymptomatic cases and changes in genotypes observed in the study.
AEDV Expert Document on the Management of Ulcerative Venereal Infections.
Actas Dermosifiliogr
March 2024
Servicio de Dermatología, CIBERINFEC, Hospital La Paz, Madrid, España. Electronic address:
Article Synopsis
- - Ulcerative sexually transmitted infections (STIs) like syphilis, herpes, and monkeypox are on the rise, particularly in Spain, posing challenges for healthcare professionals and increasing HIV transmission risk.
- - Young people, men who have sex with men (MSM), and commercial sex workers are the most vulnerable groups to these infections.
- - Accurate diagnosis is essential as ulcerative lesions can be confused with other medical conditions; dermatologists play a vital role in identifying and managing these STIs.
A Sequencing and Multilocus Sequence Typing of Lymphogranuloma Venereum Cases in Buenos Aires Reveal New Genotypes.
Microorganisms
March 2024
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Microbiología Clínica, Buenos Aires C1113AAD, Argentina.
Article Synopsis
- The Lymphogranuloma venereum (LGV) outbreak in Buenos Aires, first identified in 2017, revealed unique strain characteristics that prompted further study.
- Researchers analyzed 88 LGV strains from symptomatic patients between 2017 and 2019, identifying various types including L2b, L1-like, and L2, with notable genetic diversity.
- By employing Multilocus Sequence Typing (MLST), they discovered new strain mutations and sequence types, highlighting the evolving nature of LGV infections in a relatively small geographical area.
Effective Treatment of Lymphogranuloma Venereum With a 7-Day Course of Doxycycline.
Sex Transm Dis
July 2024
Department of Sexual Health/HIV Medicine, Western Health & Social Care Trust, Derry, Northern Ireland, United Kingdom.
Article Synopsis
- Lymphogranuloma venereum (LGV) is prevalent in the UK, mainly affecting gay, bisexual, or other men who have sex with men (GBMSM), and recent studies indicate that a shorter 7-day doxycycline treatment may be as effective as the standard 21-day course.
- The study involved reviewing cases from a South London sexual health service where 52 GBMSM, including some with HIV and other STIs, were treated with 7 days of doxycycline; most individuals were asymptomatic and follow-up showed successful eradication of LGV.
- The findings suggest that a 7-day doxycycline treatment could be routinely recommended for those with mild symptoms or
Genotypic study of Chlamydia trachomatis for lymphogranuloma venereum diagnosis in rectal specimens from men who have sex with men: a cost-effectiveness analysis.
BMC Infect Dis
March 2024
Microbiology Service, Hospital Clínico Universitario, INCLIVA Research institute, Valencia, Spain.
Article Synopsis
- The study investigates the high rate of underdiagnosis of lymphogranuloma venereum (LGV) among asymptomatic men who have sex with men (MSM) and analyzes different diagnostic strategies for cost-effectiveness.
- It involved molecular testing of Chlamydia trachomatis-positive samples from MSM patients and compared four diagnostic approaches, revealing varying costs and effectiveness ratios for each strategy.
- The findings indicated that genotyping all rectal exudates was the most cost-effective method, especially given that 30% of patients were asymptomatic, suggesting that more inclusive diagnostic criteria could lead to better outcomes despite higher costs.
Aetiological molecular identification of sexually transmitted infections that cause urethral discharge syndrome and genital ulcer disease in Brazilian men: a nationwide study.
Sex Transm Infect
April 2024
Department of Surveillance, Prevention and Control of Sexually Transmitted Infections, HIV/AIDS and Viral Hepatitis, Secretariat of Health Surveillance, Ministry of Health, Brasília, Distrito Federal, Brazil.
Article Synopsis
- Limited knowledge of urethral discharge syndrome (UDS) and genital ulcer disease (GUD) in Brazil prompted a nationwide study aimed at updating treatment guidelines from 2018 to 2020.
- The study involved collecting samples from male participants across Brazil and utilized advanced PCR testing to identify various pathogens linked to UDS and GUD.
- Findings revealed that Neisseria gonorrhoeae was the most common pathogen in UDS, while herpes simplex virus type 2 was most prevalent in GUD, highlighting significant coinfection rates and providing crucial insights into the local aetiology of these conditions.
Analytical and clinical validation of a multiplex PCR assay for detection of and including simultaneous LGV serotyping on an automated high-throughput PCR system.
Microbiol Spectr
March 2024
Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Article Synopsis
Asymptomatic lymphogranuloma venereum is commonly found among men who have sex with men in Austria.
J Dtsch Dermatol Ges
March 2024
Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- Serovar L1-L3 of Chlamydia trachomatis causes lymphogranuloma venereum (LGV), with rising cases among HIV-positive men who have sex with men (MSM), making differentiation between LGV and other CT infections crucial for treatment.
- A study analyzed 2,083 CT infections from 1,479 patients in Austria between 2014 and 2021, revealing that LGV was found in 15% of cases and accounted for 23% of rectal CT infections in MSM.
- Most LGV cases were among MSM, often HIV-positive, and frequently included concurrent syphilis; interestingly, 45% of LGV cases were asymptomatic, indicating the need
Article Synopsis
- Before widespread PrEP availability in British Columbia (from 2004-2017), lymphogranuloma venereum (LGV) cases were mainly in HIV-positive MSM; however, from 2018-2022, cases increased significantly, with 62.4% of the total 545 cases occurring during the PrEP era.* -
- The rate of LGV cases among PrEP users has doubled, reaching 1535.2 cases per 100,000, with a significant portion (65.3%) of infections now found in HIV-negative MSM, primarily those on PrEP (72.6%).* -
- Asymptomatic infections have become more prevalent in the PrEP era (38.
Single case of lymphogranuloma venereum on the tongue.
Sex Transm Infect
February 2024
Dermatology Department, La Paz University Hospital, Madrid, Spain.
Traditionally, lymphogranuloma venereum (LGV) has been associated with disease of the genital area. However, atypical presentations and proctitis are increasingly observed. We report a case of LGV affecting the dorsum of the tongue, which presented as a very painful ulcer.
View Article and Find Full Text PDFOrogenital and anal infection by , , , and other sexually transmitted infections in men who have sex with men in Lisbon.
Int J STD AIDS
April 2024
Laboratório Nacional de Referência das Infeções Sexualmente Transmissíveis, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal.
Background: Men who have sex with men (MSM) are at risk for sexually transmitted infections (STIs), but more data on extragenital carriage are needed.
Aim: We assessed the genital and extragenital prevalence of bacterial and other STIs in MSM in a Lisbon sexual health clinic.
Methods: We screened oral, anal, and urine samples of MSM visiting the GAT-CheckpointLX clinic June 2017-December 2021 for (including lymphogranuloma venereum, LGV), , , , , , and .
Painful proctitis associated with anorectal mpox, syphilis, HSV, LGV, gonorrhoea and in a person living with virologically suppressed HIV and vaccinated against mpox.
Sex Transm Infect
February 2024
Department of Sexual Health Medicine, Sydney Local Health District, Sydney, NSW, Australia.
Article Synopsis
- A gay man, who is HIV positive but well-managed and vaccinated against mpox, experienced severe proctitis.
- Tests showed he had multiple infections: anorectal mpox, herpes simplex virus, lymphogranuloma venereum, and infectious syphilis.
- This case emphasizes the importance of considering various sexually transmitted infections in proctitis patients, even if they are vaccinated against mpox.
Rapid expansion of lymphogranuloma venereum infections with fast diversification and spread of L genovariants.
Microbiol Spectr
January 2024
Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
Numerous international organizations, including the World Health Organization, have been drawing attention to the global increase in sexually transmitted infections. Twenty years ago, lymphogranuloma venereum (LGV) was mainly considered a tropical disease; in recent decades, however, LGV has been increasingly present in high-income countries. This increase has been linked to men who have sex with men who participate in highly interconnected sexual networks, leading to a rapid spread of LGV.
View Article and Find Full Text PDFEpidemiological Characteristics and Factors Associated with Repeat Sexually Transmitted Infections in Barcelona, Spain Over a Decade.
Arch Sex Behav
February 2024
Servei d'Epidemiologia, Agència de Salut Pública de Barcelona, Barcelona, Spain.
Article Synopsis
- * Out of 9,927 people diagnosed with a bacterial STI, 1,690 had multiple episodes, highlighting a significant prevalence of reinfection.
- * Key risk factors for repeated infections included being assigned male at birth, being under 34 years old, identifying as part of the gay, bisexual, or transgender community, and having initial diagnoses of gonorrhea or LGV, as well as coinfection with HIV.
Swelling of inguinal lymph nodes in a patient with HIV: a case report.
Acta Dermatovenerol Alp Pannonica Adriat
September 2023
Dermatology Department, Ljubljana University Medical Center, Ljubljana, Slovenia.
Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by the L1, L2, and L3 serotypes of Chlamydia trachomatis (CT). It primarily affects regional lymph nodes. Although it is not endemic in Europe and North America, recent reports indicate an increasing prevalence among men who have sex with men, with proctocolitis as the most frequently reported symptom.
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