2,106 results match your criteria: "Lymphogranuloma Venereum"
The challenges in lymphogranuloma venereum diagnosis whether NAAT is negative, a case series.
Int J STD AIDS
December 2024
Internal Medicine and infectious Diseases Department, UZ Brussel, Vije Universiteit Brussel (VUB), Brussel, Belgium.
Article Synopsis
- Persistent inguinal lymphadenopathy can be caused by various conditions, including the sexually transmitted infection lymphogranuloma venereum (LGV), which may be overlooked due to diagnostic challenges.
- Two male patients with a high risk for STIs presented with inguinal lymphadenopathy; initial tests were negative, leading to prolonged diagnostic delays before confirming LGV.
- Both patients improved significantly after treatment with doxycycline, highlighting the importance of considering LGV in similar cases of persistent lymphadenopathy.
[Translated article] AEDV Expert Document on the Management of Ulcerative Venereal Infections.
Actas Dermosifiliogr
November 2024
Servicio de Dermatología, CIBERINFEC, Hospital La Paz, Madrid, Spain. Electronic address:
Currently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission.
View Article and Find Full Text PDFDistribution of -genotypes over three decades in Portugal.
Sex Transm Infect
September 2024
National Reference Laboratory (NRL) for Sexually Transmitted Infections (STI), Department of Infectious Diseases, National Institute of Health (Instituto Nacional de Saúde Doutor Ricardo Jorge, INSA, IP), Lisboa, Lisboa, Portugal
Article Synopsis
- * Genotype E was the most commonly detected, while lymphogranuloma venereum (LGV) genotypes, particularly L2, saw an increase starting in 2016, notably in male anorectal samples.
- * Findings emphasize the importance of -genotyping for ongoing molecular surveillance and enhancing the detection of sexually transmitted infections in the country.
Shifting Grounds-Facilitating Self-Care in Testing for Sexually Transmitted Infections Through the Use of Self-Test Technology: Qualitative Study.
J Particip Med
August 2024
Clinical Institute, Health Sciences, University of Southern Denmark, Odense, Denmark.
Article Synopsis
- * To address this, a sexual health clinic has developed a self-testing technology (STT) that allows individuals to test for chlamydia and gonorrhea without needing to meet with a healthcare provider in person.
- * A study evaluated the effectiveness and user experience of this STT, finding it more appealing and convenient than traditional testing, as it provided an easy and flexible solution for patients.
Article Synopsis
- The study examined MSM (men who have sex with men) diagnosed with rectal lymphogranuloma venereum (LGV) and treated with doxycycline for either 7 or 21 days from 2015 to 2022.
- A total of 143 MSM were part of the study, with 58 (41%) specifically diagnosed with LGV.
- Results showed a 100% microbiologic cure rate for both symptomatic and asymptomatic LGV cases treated with either duration of doxycycline.
Clinically Defined Lymphogranuloma Venereum among US Veterans with Human Immunodeficiency Virus, 2016-2023.
Microorganisms
June 2024
Public Health National Program Office, Department of Veterans Affairs, Washington, DC 20420, USA.
Article Synopsis
- A study of 1381 HIV-positive Veterans from 2016 to 2023 found that 20.6% met the clinical criteria for lymphogranuloma venereum (LGV), with 63% classified as probable cases.
- Of the identified LGV cases, 81% presented with proctitis, and key risk factors included male birth sex and being a man who has sex with men.
- Only 43.7% of the LGV cases received standard treatment, suggesting that LGV may be underestimated and inadequately treated in this population.
Genetic characterisation of lymphogranuloma venereum in Spain: a multicentre study.
Sex Transm Infect
November 2024
Sexually Transmitted Infections Study Group (GEITS), Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid, Spain
Article Synopsis
- Lymphogranuloma venereum (LGV) is a sexually transmitted infection primarily affecting men who have sex with men (MSM), with significant prevalence in HIV-positive individuals and proctitis as a common symptom.
- A study was conducted to analyze the genetic characteristics of LGV isolates from six hospitals in Spain using multilocus sequence typing (MLST) and other genetic methods.
- Results showed that a majority of isolates were L2 genotypes, with L2-ST53 and L2-ST58 being the most common profiles, indicating complex transmission networks and potential co-circulation of different strains.
Lymphogranuloma venereum of the neck in a young man living with HIV: a rare extragenital presentation.
BMJ Case Rep
July 2024
Infecciologia e Medicina Tropical, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal.
Article Synopsis
- Lymphogranuloma venereum (LGV) is a sexually transmitted infection that primarily affects the anogenital area but can occasionally manifest in extragenital locations, like the neck.
- A case study highlights a young man with HIV who experienced painful swelling in his neck, leading to a challenging diagnosis that required various medical tests.
- The patient's diagnosis of LGV was confirmed via genotyping, and he was effectively treated with doxycycline and surgical drainage, underscoring the need for thorough testing in patients with unexplained neck swelling, especially those with a history of unprotected oral sex.
Incidence of Sexually Transmitted Infections in Youth with HIV During Pre-COVID and COVID Era.
AIDS Patient Care STDS
June 2024
Department of Pediatrics, Division of Pediatric Infectious Diseases, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Article Synopsis
- * A study compared STI incidence rates before (2009-2019) and during (2020-2021) the COVID era among 766 AYAs in Atlanta, revealing significant increases in both first and recurrent STIs.
- * The findings emphasize the need to maintain STI prevention programs to mitigate the potential health and economic impacts of rising infection rates in this vulnerable population.
Article Synopsis
- * In Portugal, the incidence of Chlamydia has been rising, highlighting the need for improved awareness and strategies for identifying and treating cases.
- * Recommendations have been adapted from international guidelines to fit Portugal's healthcare system, aiming to create standardized protocols for both symptomatic and asymptomatic individuals.
Do not forget mpox!
Travel Med Infect Dis
July 2024
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro, "University of Palermo, Palermo, Italy; Infectious and Tropical Disease Unit, AOU Policlinico "P. Giaccone", Palermo, Italy; Checkpoint Palermo Fast-Track City, Casa dei Diritti, Palermo, Italy. Electronic address:
Anorectal lymphogranuloma venereum among men who have sex with men: a 3-year nationwide survey, France, 2020 to 2022.
Euro Surveill
May 2024
Members of the Anachla study group are listed under Acknowledgements.
Article Synopsis
- In France, a nationwide survey from 2020 to 2022 reinstated universal LGV testing after switching to selective testing in 2016, focusing on samples from men and women with anorectal positivity.
- The results showed stable LGV positivity rates among men who have sex with men (MSM) but a notable increase in asymptomatic cases, rising from 36.1% in 2020 to 52.4% in 2022.
- The findings emphasize the importance of universal LGV testing and ongoing surveillance due to the increase in asymptomatic cases and changes in genotypes observed in the study.
AEDV Expert Document on the Management of Ulcerative Venereal Infections.
Actas Dermosifiliogr
March 2024
Servicio de Dermatología, CIBERINFEC, Hospital La Paz, Madrid, España. Electronic address:
Article Synopsis
- - Ulcerative sexually transmitted infections (STIs) like syphilis, herpes, and monkeypox are on the rise, particularly in Spain, posing challenges for healthcare professionals and increasing HIV transmission risk.
- - Young people, men who have sex with men (MSM), and commercial sex workers are the most vulnerable groups to these infections.
- - Accurate diagnosis is essential as ulcerative lesions can be confused with other medical conditions; dermatologists play a vital role in identifying and managing these STIs.
A Sequencing and Multilocus Sequence Typing of Lymphogranuloma Venereum Cases in Buenos Aires Reveal New Genotypes.
Microorganisms
March 2024
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Microbiología Clínica, Buenos Aires C1113AAD, Argentina.
Article Synopsis
- The Lymphogranuloma venereum (LGV) outbreak in Buenos Aires, first identified in 2017, revealed unique strain characteristics that prompted further study.
- Researchers analyzed 88 LGV strains from symptomatic patients between 2017 and 2019, identifying various types including L2b, L1-like, and L2, with notable genetic diversity.
- By employing Multilocus Sequence Typing (MLST), they discovered new strain mutations and sequence types, highlighting the evolving nature of LGV infections in a relatively small geographical area.
Article Synopsis
- * Conducted in 2022, the research involved 97 MSM participants who provided demographic information and underwent testing for various STIs, revealing that 24.7% had an extragenital STI and 9.4% had high syphilis antibody titers.
- * Key risk factors identified for having extragenital STIs included drug use during sex and engaging in condomless receptive anal intercourse with casual partners, highlighting the urgency for regular screening in this population. *
Effective Treatment of Lymphogranuloma Venereum With a 7-Day Course of Doxycycline.
Sex Transm Dis
July 2024
Department of Sexual Health/HIV Medicine, Western Health & Social Care Trust, Derry, Northern Ireland, United Kingdom.
Article Synopsis
- Lymphogranuloma venereum (LGV) is prevalent in the UK, mainly affecting gay, bisexual, or other men who have sex with men (GBMSM), and recent studies indicate that a shorter 7-day doxycycline treatment may be as effective as the standard 21-day course.
- The study involved reviewing cases from a South London sexual health service where 52 GBMSM, including some with HIV and other STIs, were treated with 7 days of doxycycline; most individuals were asymptomatic and follow-up showed successful eradication of LGV.
- The findings suggest that a 7-day doxycycline treatment could be routinely recommended for those with mild symptoms or
Genotypic study of Chlamydia trachomatis for lymphogranuloma venereum diagnosis in rectal specimens from men who have sex with men: a cost-effectiveness analysis.
BMC Infect Dis
March 2024
Microbiology Service, Hospital Clínico Universitario, INCLIVA Research institute, Valencia, Spain.
Article Synopsis
- The study investigates the high rate of underdiagnosis of lymphogranuloma venereum (LGV) among asymptomatic men who have sex with men (MSM) and analyzes different diagnostic strategies for cost-effectiveness.
- It involved molecular testing of Chlamydia trachomatis-positive samples from MSM patients and compared four diagnostic approaches, revealing varying costs and effectiveness ratios for each strategy.
- The findings indicated that genotyping all rectal exudates was the most cost-effective method, especially given that 30% of patients were asymptomatic, suggesting that more inclusive diagnostic criteria could lead to better outcomes despite higher costs.
A systematic review and meta-analysis of sexually transmitted infections and blood-borne viruses in travellers.
J Travel Med
June 2024
UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Australia.
Article Synopsis
- - This review investigates the prevalence of sexually transmitted infections (STIs) and blood-borne viruses (BBVs) among international travellers, highlighting the role of this population in spreading infectious diseases.
- - A comprehensive search of various databases resulted in 32 studies analyzing the morbidity and prevalence of STIs across different types of travellers, such as tourists, students, and men who have sex with men (MSM).
- - Key findings reveal that VFRs, backpackers, and MSM exhibited the highest rates of STIs, both in symptomatic (like syphilis and chlamydia) and asymptomatic cases (such as HIV and hepatitis B).
Aetiological molecular identification of sexually transmitted infections that cause urethral discharge syndrome and genital ulcer disease in Brazilian men: a nationwide study.
Sex Transm Infect
April 2024
Department of Surveillance, Prevention and Control of Sexually Transmitted Infections, HIV/AIDS and Viral Hepatitis, Secretariat of Health Surveillance, Ministry of Health, Brasília, Distrito Federal, Brazil.
Article Synopsis
- Limited knowledge of urethral discharge syndrome (UDS) and genital ulcer disease (GUD) in Brazil prompted a nationwide study aimed at updating treatment guidelines from 2018 to 2020.
- The study involved collecting samples from male participants across Brazil and utilized advanced PCR testing to identify various pathogens linked to UDS and GUD.
- Findings revealed that Neisseria gonorrhoeae was the most common pathogen in UDS, while herpes simplex virus type 2 was most prevalent in GUD, highlighting significant coinfection rates and providing crucial insights into the local aetiology of these conditions.
Analytical and clinical validation of a multiplex PCR assay for detection of and including simultaneous LGV serotyping on an automated high-throughput PCR system.
Microbiol Spectr
March 2024
Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Article Synopsis
Proctitis: An Approach to the Symptomatic Patient.
Med Clin North Am
March 2024
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine.
Article Synopsis
- - Proctitis is inflammation of the rectum that can be linked to common STIs like gonorrhea, chlamydia, and syphilis.
- - For patients with ulcers in the rectum, conditions like syphilis, Mpox, lymphogranuloma venereum, and herpes simplex virus should also be considered.
- - A thorough history, clinical exam (including anoscopy), and rectal STI testing can help identify the cause of proctitis for better treatment.
Asymptomatic lymphogranuloma venereum is commonly found among men who have sex with men in Austria.
J Dtsch Dermatol Ges
March 2024
Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- Serovar L1-L3 of Chlamydia trachomatis causes lymphogranuloma venereum (LGV), with rising cases among HIV-positive men who have sex with men (MSM), making differentiation between LGV and other CT infections crucial for treatment.
- A study analyzed 2,083 CT infections from 1,479 patients in Austria between 2014 and 2021, revealing that LGV was found in 15% of cases and accounted for 23% of rectal CT infections in MSM.
- Most LGV cases were among MSM, often HIV-positive, and frequently included concurrent syphilis; interestingly, 45% of LGV cases were asymptomatic, indicating the need
Article Synopsis
- Before widespread PrEP availability in British Columbia (from 2004-2017), lymphogranuloma venereum (LGV) cases were mainly in HIV-positive MSM; however, from 2018-2022, cases increased significantly, with 62.4% of the total 545 cases occurring during the PrEP era.* -
- The rate of LGV cases among PrEP users has doubled, reaching 1535.2 cases per 100,000, with a significant portion (65.3%) of infections now found in HIV-negative MSM, primarily those on PrEP (72.6%).* -
- Asymptomatic infections have become more prevalent in the PrEP era (38.