164 results match your criteria: "Lymphangitic Carcinomatosis Imaging"

Article Synopsis
  • Lymphangitic carcinomatosis (LC) is a serious condition often seen in advanced metastatic cancers, especially affecting the lungs, and presents symptoms like coughing and difficulty breathing.
  • A 70-year-old man with generally good health experienced a persistent dry cough and other symptoms, leading to a diagnosis of Stage 4 prostate cancer with rare lung involvement.
  • Imaging and biopsy confirmed the diagnosis, raising concerns for LC, which prompted urgent chemotherapy, highlighting the rarity of this condition in prostate cancer and its poor prognosis.
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This case report presents a rare instance of pulmonary lymphangitic carcinomatosis (PLC) in a prostate cancer patient, showcasing uptake of 99mTc-prostate-specific membrane antigen and 99mTc-fibroblast activation protein inhibitor-46 on imaging scans. A 70-year-old man with elevated serum prostate-specific antigen (PSA) levels exhibited respiratory symptoms and was diagnosed with widespread skeletal and pulmonary metastases. Following taxane-based chemotherapy and androgen deprivation therapy, imaging revealed decreased uptake and improvement in clinical symptoms, indicating treatment response.

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Unusual pattern: Diffuse pulmonary FDG uptake on PET/CT.

Radiol Case Rep

December 2024

Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.

Article Synopsis
  • - A 75-year-old female with lung metastasis from head and neck squamous cell carcinoma exhibited a mass in the right lung area, alongside unusual 18-FDG uptake, without visible lung abnormalities on a CT scan.
  • - Initial thoughts leaned towards lymphangitic spread of the cancer, indicating spread through lymphatic vessels.
  • - However, follow-up imaging revealed a mass invading the right inferior pulmonary vein and significant decreased blood flow in specific lung lobes, leading to a diagnosis of right pulmonary venous occlusion instead.
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Article Synopsis
  • * The patient's imaging tests revealed extensive periportal calcifications and hyperintense masses in the bile duct and lymph nodes, suggesting tumor presence and possible metastasis.
  • * An endoscopic biopsy confirmed the diagnosis of mucinous carcinoma, which was associated with lymphatic vessel involvement and multiple lymph node metastases, with calcification thought to relate to the tumor's mucin production.
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We report the case of an 88-year-old man recently diagnosed with prostate cancer. The patient underwent a 68 Ga-prostate-specific membrane antigen-11 PET/CT for staging assessment. This examination revealed intense and expected uptake in the primary prostate cancer, widespread metastatic involvement including typical adenopathy and bone metastasis, and a less common pulmonary lymphangitic carcinomatosis.

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A rare case of disseminated rhinosporidiosis mimicking tuberculosis.

IDCases

June 2024

Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.

Rhinosporidiosis is one of the granulomatous diseases endemic in Asia, Africa, and Europe, with Southern India and Sri Lanka having the greatest prevalence rates. It is typically understood to affect the upper respiratory system. Involvement of the lungs beyond the trachea is infrequent as compared to the upper respiratory tract.

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Post-RFA Pulmonary Vein Stenosis Mimicking Lymphangitic Carcinomatosis in a Patient With History of Liposarcoma.

Clin Nucl Med

August 2024

Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Article Synopsis
  • - A 58-year-old man with removed liposarcoma showed irregular thickening in the lung's interlobular septa on a CT scan, raising concerns for lymphangitic metastasis.
  • - FDG PET/CT scans confirmed the presence of abnormal areas, and there was a new narrowing of the pulmonary veins after radiofrequency ablation for atrial fibrillation.
  • - This case underlines how tricky it can be to diagnose lung issues in cancer patients, emphasizing the importance of thorough history reviews and advanced imaging to differentiate between post-treatment effects and cancer spread.
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In pulmonary lymphangitic carcinomatosis, it can be difficult to identify the primary site of the cancer on computed tomography (CT) imaging. Here, we report a rare case of pulmonary lymphangitic carcinomatosis, which was difficult to diagnose as gallbladder cancer. An 81-year-old woman, previously followed up for gallbladder adenomyomatosis, presented with persistent cough.

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Article Synopsis
  • The study aims to differentiate pulmonary sarcoidosis (PS) from pulmonary lymphangitic carcinomatosis (PLC) in tumor patients using 18F-FDG PET/CT imaging, given their similar appearances on scans.
  • Researchers reviewed imaging data from 114 patients with confirmed PS and PLC, using three independent readers for a blinded comparative analysis and a logistic regression model to establish diagnostic criteria.
  • The resulting model identified five key factors that can distinguish between PS and PLC, achieving high accuracy with a sensitivity of 87.5% and specificity of 98.28%, indicating its potential as a valuable clinical diagnostic tool.
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Article Synopsis
  • Pulmonary lymphangitic carcinomatosis involves the spread of cancerous cells to the lungs' lymphatic system, causing inflammation and swelling, and is often seen in people with a history of cancer.
  • The symptoms usually affect the respiratory system, but some patients may present atypically, and initial chest x-rays may not show clear signs of the disease.
  • Diagnosis may require advanced imaging techniques and tissue analysis, and once identified, the prognosis is generally poor, with treatment focusing on the underlying cancer, as demonstrated in a rare case of a man without prior cancer history.
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Prognosis of pulmonary lymphangitic carcinomatosis in patients with non-small cell lung cancer.

Transl Lung Cancer Res

November 2021

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Article Synopsis
  • - This study investigates how pulmonary lymphangitic carcinomatosis (a specific lung cancer spread) impacts the survival of patients with non-small cell lung cancer compared to those with intrapulmonary metastases.
  • - Researchers analyzed data from 103 patients with pulmonary lymphangitic carcinomatosis, finding a 5-year overall survival rate of 33%, which was higher than the 21% rate for patients with intrapulmonary metastases.
  • - The study concluded that patients with lymphangitic carcinomatosis classified as cLy1 or cLy2 (less advanced) had better survival rates than those with more severe classifications (cLy3/cLy4) or intrapulmonary metastases,
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Clinical and Imaging Features of Non-Small Cell Lung Cancer with G12C KRAS Mutation.

Cancers (Basel)

July 2021

Department of Radiology, Division of Thoracic Imaging and Intervention, Massachusetts General Hospital, Boston, MA 02114, USA.

KRAS G12C mutations are important oncogenic mutations that confer sensitivity to direct G12C inhibitors. We retrospectively identified patients with KRAS+ NSCLC from 2015 to 2019 and assessed the imaging features of the primary tumor and the distribution of metastases of G12C NSCLC compared to those of non-G12C KRAS NSCLC and NSCLC driven by oncogenic fusion events (RET, ALK, ROS1) and EGFR mutations at the time of initial diagnosis. Two hundred fifteen patients with KRAS+ NSCLC (G12C: 83; non-G12C: 132) were included.

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A 55-year-old man with cough, bone pain, and cervical lymphadenopathy underwent both 18F-FDG and 18F-PSMA-1007 PET/CT scans with clinical suspicion of malignant disease. Compared with 18F-FDG PET/CT, 18F-PSMA PET/CT showed intense tracer uptake in the prostate gland, lungs, osteogenic lesions, and multiple lymph nodes. Interestingly, we also found the high tracer concentration of pulmonary lymphangitic carcinomatosis, a very rare form of prostate cancer metastasis to the lung, on 18F-PSMA-1007 PET/CT images.

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Micronodular lung disease on high-resolution CT: patterns and differential diagnosis.

Clin Radiol

June 2021

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

With the advent of high-resolution computed tomography (HRCT), micronodular lung disease is a routinely encountered pathology in thoracic imaging. This article will review how to differentiate the three main micronodular patterns and review the differential diagnosis for each. Differential diagnosis of micronodular lung disease may be extensive, but by identifying the pattern and using additional clues, such as distribution, additional imaging findings, and clinical history, a radiologist can make an accurate diagnosis.

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