Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology.

High-throughput genomic analyses are being implemented in clinical practice. MODIFY is a retrospective study of the first introduction of genomic profiling and molecular tumor boards in the country of Luxembourg. The primary objective was to assess whether patients derived a clinical benefit by measuring the percentage of patients who presented a progression-free survival (PFS) on matched therapy (PFS2) 1.

On learning what to learn: Heterogeneous observations of dynamics and establishing possibly causal relations among them.

Before we attempt to (approximately) learn a function between two sets of observables of a physical process, we must first decide what the and of the desired function are going to be. Here we demonstrate two distinct, data-driven ways of first deciding "the right quantities" to relate through such a function, and then proceeding to learn it. This is accomplished by first processing simultaneous heterogeneous data streams (ensembles of time series) from observations of a physical system: records of multiple of the system.

Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects.

Background: Quantification of Amyloid beta (Aβ) oligomers in plasma enables early diagnosis of Alzheimer's Disease (AD) and improves our understanding of underlying pathologies. However, quantification necessitates an extremely sensitive and selective technology because of very low Aβ oligomer concentrations and possible interference from matrix components.

Methods: In this report, we developed and validated a surface-based fluorescence distribution analysis (sFIDA) assay for quantification of Aβ oligomers in plasma.

The global multiple myeloma incidence and mortality burden in 2022 and predictions for 2045.

Background: Multiple myeloma (MM) is an important haematological malignancy in older adults, with a relatively poor prognosis. We aimed to present the current global patterns of incidence and mortality from MM, and predict new cases and deaths by 2045.

Methods: Estimated numbers of MM cases and deaths and age-standardized (World) incidence and mortality rates per 100,000 people were obtained from the GLOBOCAN 2022 database covering 185 countries.

Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways.

This work focuses on the need for modeling and predicting adverse outcomes in immunotoxicology to improve nonclinical assessments of the safety of immunomodulatory therapies. The integrated approach includes, first, the adverse outcome pathway concept established in the toxicology field, and, second, the systems medicine disease map approach for describing molecular mechanisms involved in a particular pathology. The proposed systems immunotoxicology workflow is illustrated with chimeric antigen receptor (CAR) T cell treatment as a use case.

Context-Tailored Food-Based Nutrition Education and Counseling for Pregnant Women to Improve Birth Outcomes: A Cluster-Randomized Controlled Trial in Rural Malawi.

Background: Inadequate maternal dietary intakes remain a public health challenge in low-income countries like Malawi and can cause adverse birth outcomes.

Objectives: To improve maternal dietary intakes and thus reduce the prevalence of adverse birth outcomes in rural Malawi.

Methods: We performed a 2-armed (1:1) cluster-randomized controlled trial in Southern Malawi, enrolling pregnant women at gestational age 12-18 wk.

Internal consistency of the Mental Health Professional Culture Inventory: A pilot study in Romanian population.

The objective of this study (registered under number 2020 006) was to assess the internal consistency of the revised Mental Health Professional Culture Inventory (MHPCI) scale, which comprises 15 items, among mental health service workers in Romania. To examine the psychometric properties of the MHPCI questionnaire within the Romanian population, we employed two main methods: The partial credit model (PCM) and Exploratory factor analysis (EFA). A total of 94 individuals were interviewed, and among them, 71 provided complete responses to the questionnaire.

Digital Electrocardiographic Complex for Risk Stratification of Paroxysmal Atrial Fibrillation.

Unlabelled: was to develop and clinically test a hardware and software system capable of identifying the predictors of the hidden forms of atrial fibrillation (AF) using 12-lead ECG data in sinus rhythm.

Materials And Methods: There was developed the hardware and software system "Intecard 8.1" to assess a set of markers for atrial electrical instability by 3-5-minute ECG recordings in sinus rhythm.

Sense of coherence in students while studying abroad.

Background: In the 1970s, medical sociologist Aaron Antonovsky developed the concept of salutogenesis, which is the study of health and development focusing on sense of coherence (SOC). Although salutogenesis has been well researched in higher education contexts, the concept has not been studied in depth in intercultural and cross-cultural settings, such as the one provided by semester at sea (SAS), which is a United States (US) study-abroad programme.

Aim: The aim was to investigate and compare levels of SOC in students in the SAS study-abroad programme.

Active motor-cognitive recovery supports reactive agility performance in trained athletes.

Active breaks are suggested to support recovery and performance in sports. Previous research in ball and team sports focused on motor performance such as repetitive sprinting or change of direction. This does not account for the interaction between motor and cognitive task demands in sports.

Environmental benefits of re-using excavated soil flows: The case of Luxembourg.

The management of soil excavated during construction can lead to substantial environmental impact, especially in Luxembourg, where high per capita soil waste and limited landfill capacity intensify the challenge. This study employs an ad hoc spatially resolved model to assess the environmental impacts of current excavated soil management practices in Luxembourg from a life cycle perspective. It compares these impacts with alternative scenarios, where excavated soil is reproposed as substrate for nature-based solution (NbS) projects rather than backfilled.

Quantum Magnetic Skyrmion Operator.

We propose a variational wave function to represent quantum skyrmions as bosonic operators. The operator faithfully reproduces two fundamental features of quantum skyrmions: their classical magnetic order and a "quantum cloud" of local spin-flip excitations. Using exact numerical simulations of the ground states of a 2D chiral magnetic model, we find two regions in the single-skyrmion state diagram distinguished by their leading quantum corrections.

A New (Trifluoromethane)Sulfonylimide Single-Ion Conductor with PEG Spacer for All-Solid-State Lithium-Based Batteries.

The choice of ionic-liquid-like monomers (ILM) for single-ion conducting polyelectrolytes (SICPs) is crucial for the performance of all-solid-state lithium batteries. In the current study, we propose a novel approach for development of SICPs via design and synthesis of a new ILM with long poly(ethylene oxide) spacer between methacrylic group and (trifluoromethane)sulfonylimide anion. Its homopolymer shows an ionic conductivity that is ∼5 orders of magnitude higher (9.

Red flags for potential serious pathologies in people with neck pain: a systematic review of clinical practice guidelines.

Introduction: We conducted a systematic review of clinical practice guidelines to identify red flags for serious pathologies in neck pain mentioned in clinical practice guidelines, to evaluate agreement in red flag recommendations across guidelines, and to investigate the level of evidence including what study type the recommendations are based on.

Methods: We searched for guidelines focusing on specific and nonspecific neck pain in MEDLINE, EMBASE, and PEDro up to June 9, 2023. Additionally, we searched for guidelines through citation tracking strategies, by consulting experts in the field, and by checking guideline organization databases.

Facilitating comprehensive child health monitoring within REDCap - an open-source code for real-time Z-score assessments.

Background: Monitoring of somatic development through the assessment of anthropometric variables such as weight, height, and BMI is vital for evaluating the physical development and nutritional status of children. This approach aids in the early identification of somatic developmental disorders, enabling timely medical interventions. It traditionally relies on Z-scores, which compare anthropometric variables with reference standards.

Modulation of physical exercise intensity in motor-cognitive training of adults using the SKILLCOURT technology.

Motor-cognitive training and exergaming often only reach low-to-medium intensities that limits their training efficiency. This study evaluated the physiological profile of different exercises on a novel motor-cognitive training technology designed to cover a broad range of exercise intensities. Twenty-six healthy trained adults (17 males, 23.

Cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the NESCAV study.

Previous studies have found associations between exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiovascular risk factors. However, the internal dose of PAH exposure was often examined by quantifying monohydroxylated metabolites of PAHs (OH-PAHs) in urine, which can only reflect recent exposure. On the other hand, hair covers wider temporal windows than urine and has been demonstrated to be a suitable matrix for PAH exposure assessment.

Protocol for immunofluorescence staining and large-scale analysis to quantify microglial cell morphology at single-cell resolution in mice.

Here, we present a protocol for quantifying microglial cell morphology at the single-cell level in mice. We provide comprehensive details, starting from optimal mouse brain dissection to computational analyses of up to 350 microglial cells per brain slice. Analyzing the morphology of microglial cells is essential for understanding their functional and activation states in different conditions, including during disease development and progression, as well as for assessing the effect of therapeutic interventions.