Upgrading skin barrier Protection: Addition of active ingredients to a Gelatin/Tannic Acid-Based hydrogel patch for treating skin lesions related to Personal protective Equipment.

Prolonged use of Personal Protective Equipment, like surgical masks, can cause skin issues such as acne ("maskne") and rosacea flare-ups due to pressure and moisture. While dressings can protect the skin, they often reduce mask effectiveness and lack pharmaceuticals to treat common skin lesions. This study introduces an innovative dual-function gelatin/tannic acid-based hydrogel patch incorporating metronidazole (1% w/w) or salicylic acid (2% w/w) to offer both skin protection and treatment.

Analysis of the use of digital technologies in the preliminary diagnosis of dermatological diseases: a systematic review.

Dermatological diseases are a significant global health concern, and advanced technologies have demonstrated considerable potential to improve the diagnosis and treatment of these conditions. The overall objective of this systematic review is to analyze and evaluate the use of preliminary digital diagnostic technologies in the field of dermatological diseases. The PRISMA methodology was used to collect approximately 50 products to support the article.

Macrophages in inflammatory skin diseases and skin tumors.

Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being the largest immune organ in the human body, presents an intriguing landscape for macrophage research, particularly regarding their roles in inflammatory skin diseases and skin tumors. In this review, we compile the latest research on macrophages in conditions such as atopic dermatitis, psoriasis, systemic sclerosis, systemic lupus erythematosus, rosacea, bullous pemphigoid, melanoma and cutaneous T-cell lymphoma.

Impaired Angiogenesis and Th1/Th17 Polarization: A Possible Explanation for the Decreased Incidence of Rosacea in the Aged.

Background: Rosacea is a common inflammatory skin disorder characterized by frequent facial flushing, erythema, telangiectasia, and papules, with a higher incidence observed in individuals aged 30-50 years and a tendency to decrease in the elderly. This age-related decline in incidence drew our attention to further explore the relationship between rosacea pathogenesis and aging.

Methods: We analyzed the incidence of rosacea across 8340 individuals without systemic diseases.

Effects of Botulinum Toxin Type A Treatment on Clinical and Biophysical Parameters in Patients With Erythematotelangiectatic Rosacea: A Prospective, Randomized, Controlled, Double-Blind Study.

Background: Erythematotelangiectatic rosacea (ETR) lacks a gold-standard treatment. Recent studies show that intradermal Botulinum Toxin-A (BoNT-A) is effective for erythema, though objective data are limited.

Objective: This study aims to evaluate the efficacy and tolerability of intradermal BoNT-A in patients with ETR.

Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation.

Activation of dermal mast cells through the Mas-related G protein-coupled receptor B2 receptor (MrgprB2 in mice and MrgprX2 in humans) is a key component of numerous inflammatory skin diseases, including dermatitis and rosacea. Sensory neurons actively suppress mast cell activation through the regulated release of glutamate, resulting in reduced expression of as well as genes associated with proteins found in mast cell granules. To determine whether exogenous glutamate receptor agonism could suppress mast cell function, we determined that mast cells have relatively selective expression of the glutamate receptor ionotropic, kainate 2 (GluK2).

The causal relationship between negative emotions and inflammatory dermatoses: a bidirectional Mendelian randomization study.

Purpose: Observational studies have suggested a potential link between emotions and inflammatory dermatoses. However, research on the causal relationship between different types of emotions and inflammatory dermatoses is lacking. This study is aimed to investigate the causal relationship between negative emotions and inflammatory dermatoses through Mendelian randomization (MR) analysis.

The Prevalence and Clinical Significance of Skin Manifestations in Parkinson's Disease Patients.

Background: Parkinson's disease (PD) is primarily characterized by motor symptoms, but non-motor symptoms, including skin manifestations, are increasingly recognized. These remain underexplored despite their potential impact on quality of life.

Objectives: This study aimed to evaluate the prevalence and clinical features of skin findings in PD patients, with a focus on identifying potential pathogenetic links between dermatological conditions and PD.

Serum Biomarkers IL-6 and HIF-1α in Rosacea: Assessing Their Significance in Disease Pathogenesis and Telangiectasia Formation.

Introduction: Rosacea, a chronic inflammatory disease primarily affecting the central area of the face, is a complex condition whose mechanisms are still not fully understood. However, research has indicated a positive correlation between two molecules: hypoxia-inducible factor-1α (HIF-1α) and interleukin-6 (IL-6). The levels of HIF-1α in rosacea patients have yet to be assessed.

New Ecological Observations and Occurrence for Asteroidea and Echinoidea in Hong Kong.

This paper reports several new occurrences for Asteroidea and Echinoidea in Hong Kong. New records for asteroids include Anseropoda rosacea, Aquilonastra cepheus, Pentaceraster alveolatus, Pentaceraster sibogae, and Culcita novaeguineae. For echinoids, new records include Coelopleurus maculatus, Eucidaris metularia, Prionocidaris baculosa, Echinostrephus molaris, Pseudoboletia indiana, Salmacis bicolor, Stomopneustes variolaris, Toxopneustes pileolus, Clypeaster reticulatus, Metalia spatagus, and Nacospatangus altus.

Description of a new species of the genus Atanycolus Foerster (Hymenoptera: Braconidae) parasitizing Lamprodila nobilissima bellula (Lewis) (Coleoptera: Buprestidae) in China.

Atanycolus yangi sp. nov. (Hymenoptera, Braconidae), a new species parasitizing the flatheaded wood borer, Lamprodila nobilissima bellula (Lewis) (Coleoptera: Buprestidae), is described.

Race and Appointment Availability Influence Continuity of Care for Chronic Inflammatory Skin Disease: A Cross-Sectional Study of United States Practice Data.

Background: In the management of chronic inflammatory skin disease (CISD), continuity of care may influence the achievement of long-term disease control. Barriers to care have been identified in this population, which may leave some patients more vulnerable to loss of follow-up.

Objective: We aim to identify predictors of continuity of care for CISD patients across demographic groups and healthcare practice types in the United States (US).

Optimizing the Dermatologic Formulary at a Free Clinic.

Objectives: Free clinics provide care to underserved populations nationwide. The Birmingham Free Clinic offers dermatology care and operates an onsite dispensary. Little is known about specialty care services and medication optimization in the free clinic setting.

Topographical variations in the skin barrier and their role in disease pathogenesis.

The skin barrier can be divided into at least four functional units: chemical, microbial, physical and immunological barriers. The chemical and microbial barriers have previously been shown to exhibit different characteristics in topographically distinct skin regions. There is increasing evidence that the physical and immunological barriers also show marked variability in different areas of the skin.

A comparative study between fractional microneedling radiofrequency with systemic isotretinoin and fractional microneedling alone in the treatment of rosacea.

Introduction: Rosacea is a chronic inflammatory disease presenting with facial flushing, non-transient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. The pathogenesis of rosacea is not fully understood, but immune dysfunction, Demodex infection, neurovascular dysregulation, and exposure to ultraviolet radiation represent contributing factors.

Utilization of Injectable and Device-Based Treatments in Medical Dermatology: A Survey on Demographics, Conditions, and Resident Involvement.

Background: Injectable and device-based treatments are used for medical dermatologic conditions, but understanding dermatologists' practices remains limited.

Objective: This study examines injectable and device-based treatments for medical dermatologic conditions to identify patterns and potential improvements.

Materials And Methods: A survey was distributed to Association of Academic Cosmetic Dermatology members, covering practice settings, conditions treated, pricing, and resident involvement.

Toll-like receptor-4 expression and oxidative stress in ocular rosacea.

Purpose: To investigate systemic and ocular toll-like receptor (TLR)-4 expression and its association with oxidative stress markers in ocular rosacea (OR).

Methods: This prospective study included 40 patients with rosacea with ocular involvement and 20 healthy volunteers. Tear break-up time (TBUT), Schirmer test, meibomoscore, and ocular surface disease index (OSDI) scores were estimated for all participants.

A Retrospective Pragmatic Two-Center Clinical Study to Evaluate the Clinical Outcome of Triple-Frequency Ultrasound in the Treatment of Mild-to-Severe Acne Vulgaris.

Objectives: Earlier, quickly alternating dual-frequency ultrasound waves (LDM technology) were successfully applied for the treatment of different inflammatory skin conditions such as rosacea and acne. In this retrospective pragmatic two-center clinical study, we applied the triple-frequency LDM (TF-LDM) technology with frequencies of 1/3/10 and 3/10/19 MHz for the treatment of mild-to-severe acne skin to assess the effectivity and sustainability of the treatment outcomes.

Methods: Twenty-two patients with mild-to-severe acne were included in this study: 11 patients were treated with TF-LDM (1/3/10 MHz), and other 11 patients-with TF-LDM (3/10/19 MHz).

[Neuroimmune mechanism of rosacea].

The neuroimmune mechanism of rosacea has not been fully elucidated, and it is believed that the innate immune system, immune cells, immune regulation, neuroimmune system, signaling pathway abnormalities and microbial dysbiosis are involved in the progress of the neuroimmune mechanism of rosacea. This article reviews the neuroimmune mechanism of rosacea.