4,243 results match your criteria: "Lupus Erythematosus Discoid"
Treatment of recalcitrant discoid lupus erythematosus with roflumilast 0.3% cream following suboptimal response to anifrolumab and improvement of hypopigmentation.
JAAD Case Rep
December 2024
Department of Dermatology, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia.
Association Between Neuropsychiatric Event and Systemic Lupus Erythematosus Clinical Manifestation: A Meta-Analysis.
J Coll Physicians Surg Pak
December 2024
Department of Rheumatology and Nephrology, Huabei Petroleum Administration Bureau General Hospital, Renqiu, China.
To uncover the clinical characteristics and investigate the underlying causes of psychiatric manifestations in patients with systemic lupus erythematosus (SLE), including its subset, neuropsychiatric systemic lupus erythematosus (NPSLE). Through comprehensive database searches in PubMed, Embase, Medline, and Cochrane, from their inception to August 2023, the study focused on adult SLE and NPSLE cases. From the selected studies, data were synthesised via a random-effects meta-analysis, encompassing a total of 2,997 subjects across six studies.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on pemphigus, a rare but serious skin blistering disease linked to multiple genetic factors and an increased risk of other autoimmune disorders.
- Researchers analyzed data from 126 million patients, finding 18,000 cases of pemphigus, to explore the relationship between pemphigus and 74 different autoimmune diseases.
- Results indicated strong associations between pemphigus and several conditions, including pemphigoid diseases, discoid lupus erythematosus, lichen planus, and undifferentiated connective tissue disease, highlighting the importance of understanding these links across different ethnic groups.
Secukinumab-Aggravated Disseminated Discoid Lupus Erythematosus Misdiagnosed as Psoriasis.
Cureus
October 2024
Dermatology, Shanghai Skin Disease Hospital , Tongji University, Shanghai, CHN.
Article Synopsis
Epidemiology of isolated Cutaneous Lupus Erythematosus in the multiethnic population of Reunion Island (France): a retrospective multicentric study.
J Rheumatol
December 2024
L. Raffray (Md, Phd), Internal Medicine and Dermatology Unit, Reunion University Hospital, Saint-Denis, Reunion Island, France; UMR PIMIT "Processus Infectieux en Milieu Insulaire Tropical" CNRS 9192, INSERM1187, IRD 249, Reunion Island University, Saint-Denis, Reunion Island, France.
Article Synopsis
- * A total of 268 CLE cases were recorded, with a standardized prevalence of 43/100,000 and an estimated incidence of 5.7/100,000 person-years, showing higher rates compared to lighter-skinned populations.
- * Findings indicate that darker-skinned patients are more likely to experience severe forms of CLE and that certain clinical features may indicate a higher risk of progression to systemic lupus erythematosus (SLE), underscoring the need for tailored patient follow-up.
Ruxolitinib cream for discoid lupus erythematosus: An open-label pilot study of 10 subjects.
J Am Acad Dermatol
November 2024
Dermatology, University of Rochester Medical Center, Rochester, New York. Electronic address:
Utility of the 2019 EULAR/ACR SLE classification criteria for predicting mortality and hospitalisation: development and cross-validation of ominosity score.
RMD Open
November 2024
Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA.
Objective: The 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria score (≥20 points) has been associated with poor outcomes. We aimed to evaluate its utility as a predictor for mortality and hospitalisation and to derive and validate an ominosity score based on the SLE classification criteria set.
Methods: Incident patients with SLE in a population-based cohort were included.
Spatial Transcriptomics in Inflammatory Skin Diseases Using GeoMx Digital Spatial Profiling: A Practical Guide for Applications in Dermatology.
JID Innov
January 2025
Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.
The spatial organization of the skin is critical for its function. In particular, the skin immune microenvironment is arranged spatially and temporally, such that imbalances in the immune milieu are indicative of disease. Spatial transcriptomic platforms are helping to provide additional insights into aberrant inflammation in tissues that are not captured by tissue processing required for single-cell RNA sequencing.
View Article and Find Full Text PDFSuccessful treatment of discoid lupus erythematosus with tapinarof 1% cream monotherapy.
JAAD Case Rep
December 2024
Department of Dermatology, George Washington School of Medicine, Washington, District of Columbia.
Acneiform lesions in a 57-year-old woman.
Int J Dermatol
November 2024
Department of Dermatology, Rush University Medical Center, Chicago, Illinois, USA.
A 57-year-old woman on leflunomide with a history of chronic obstructive pulmonary disease and rheumatoid arthritis presented with multiple flesh-colored to hyperpigmented dome-shaped papules, scattered comedones, and underlying scarring on bilateral cheeks and chin. These dermatologic manifestations, laboratory evaluation, and punch biopsy led to a final diagnosis of acneiform or comedonal discoid lupus erythematosus (ACDLE). For patients with acneiform or comedonal lesions, ACDLE should be considered if the lesions do not improve with conventional treatment for acne vulgaris.
View Article and Find Full Text PDFHistopathologic Comparisons of Discoid Lupus Erythematosus and Folliculotropic Mycosis Fungoides in a Series of 43 Cases.
J Cutan Pathol
November 2024
Oakland University William Beaumont School of Medicine, Rochester Hills, Michigan, USA.
Background: Folliculotropic mycosis fungoides (FMF) is a rare cutaneous malignancy that can be mistaken for inflammatory diseases, such as discoid lupus erythematosus (DLE), due to the variability of histopathological findings.
Methods: This study aims to provide dermatopathologists with evidence-based histopathologic criteria to distinguish DLE from FMF by reporting overlapping and distinguishing microscopic features. Forty-three biopsies from patients with a confirmed diagnosis of DLE or FMF were graded for the presence or absence of 18 histopathologic features.
Imatinib associated discoid lupus erythematosus in a patient with chronic myeloid leukemia.
JAAD Case Rep
November 2024
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Oral lichen planus-like lesions in skin of color: a review.
Int J Dermatol
November 2024
Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- Lichenoid lesions in dermatology are characterized by a violaceous color due to basal cell damage and inflammation beneath the epithelium.
- These lesions are primarily associated with lichen planus but can appear in various other disorders, which complicates diagnosis.
- Accurate diagnosis is crucial for treatment, and dermatologists use clinical features, patient history, and additional tests like histopathology to differentiate these conditions from mimickers.
[Translated article] Use of Anifrolumab in Systemic Lupus Erythematosus, Cutaneous Lupus Erythematosus, and Other Autoimmune Dermatoses.
Actas Dermosifiliogr
October 2024
Servicio de Dermatología, Hospital de Figueres, Fundació Salut Empordà, Girona, Spain; Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain. Electronic address:
Article Synopsis
- Anifrolumab is a drug that blocks a specific receptor (IFNAR1) and is approved for treating moderate-to-severe systemic lupus erythematosus (SLE).
- * In clinical trials, it has shown effectiveness for skin-related lupus issues, even though it's not specifically approved for cutaneous lupus erythematosus (CLE).
- * Ongoing studies aim to assess its effectiveness for different types of lupus and related conditions, while its common side effects include respiratory infections and herpes zoster.
Trichoscopy of Discoid Lupus Erythematosus in Caucasian Scalp: A Review.
Skin Appendage Disord
October 2024
Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Article Synopsis
- Scalp discoid lupus erythematosus is a rare condition among Caucasians, with varying clinical signs, and its dermoscopic features are not well documented, especially in this demographic.
- A review was conducted to analyze existing literature by examining dermoscopic patterns like follicular openings and vessel patterns in affected individuals.
- Key findings revealed that chronic lesions displayed specific characteristics such as a lack of follicular openings, white or red patches, and thick arborizing vessels, along with the presence of yellow-brown and red dots.
Treatment of discoid lupus with lenalidomide and anifrolumab: Case report and review of the literature.
Lupus
November 2024
Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Article Synopsis
- Discoid lupus erythematosus (DLE) is a serious autoimmune disease, and there aren't many treatments that work well for it.
- A 46-year-old woman with tough DLE didn't improve with regular treatments but got better after trying a combination of lenalidomide and anifrolumab, along with another medication called hydroxychloroquine.
- The patient has not had any major infections and could reduce her steroid use, but more research is needed to see if the new treatment combination is safe and effective for others with DLE.
Clinical Features and Survival Analysis of Lupus Nephritis among Patients with Systemic Lupus Erythematosus: A Three-Decade-Long Retrospective Cohort Study.
Biomedicines
September 2024
Division of Clinical Immunology, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Article Synopsis
- Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE), and a study analyzed 384 SLE patients to compare characteristics, treatments, and outcomes between those with and without LN over a 30-year period.
- The findings indicated that while certain conditions were more common in non-LN patients, anemia and anti-RNP positivity were more prevalent in LN patients, with sepsis being a significant cause of death among LN sufferers.
- Important changes post-2005 include higher use of mycophenolate mofetil, decreased corticosteroid dosage, reduced SLICC Damage Index scores, and an emphasis on achieving remission to improve long-term outcomes for all SLE patients.
Discoid Lupus Erythematosus.
N Engl J Med
September 2024
Hôpitaux Universitaires de Genève, Geneva, Switzerland
Myositis: A Rare First Presentation of Systemic Lupus Erythematosus.
Cureus
September 2024
Nephrology, Al-Karama General Hospital, Baghdad, IRQ.
Article Synopsis
- * This case report details an 18-year-old female patient whose SLE first presented with generalized muscle weakness, joint pain, and distinctive rashes indicative of lupus and vasculitis.
- * After extensive testing, she was diagnosed and treated with a combination of medications, leading to significant improvement in her symptoms and muscle strength over time.
Identifying heterogeneous subgroups of systemic autoimmune diseases by applying a joint dimension reduction and clustering approach to immunomarkers.
BioData Min
September 2024
Department of Computer Science, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Article Synopsis
- This study explores the complexity and heterogeneity of systemic autoimmune diseases (SADs) by analyzing a large dataset of patients diagnosed with conditions like systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjögren's syndrome (SS) in Taiwan from 2001 to 2016.
- Researchers used a joint cluster analysis method to categorize 11,923 patients into six distinct groups based on their immunomarkers, revealing that no cluster was solely made up of one type of SAD and that these groups exhibited significant differences in clinical features.
- The findings highlight that this method can identify more relevant subgroups within SADs, suggesting it may enhance the accuracy of diagnoses
Diagnostic dilemma in pigmented basal cell carcinoma: A case report.
J Educ Health Promot
July 2024
Department of Hospital Administration, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- * The study conducted in 2023 at a cancer center in North India focused on pigmented BCC, a rare variant that shows increased pigmentation and can be mistaken for other skin conditions.
- * To prevent BCC, it's recommended to avoid direct sunlight and use sunscreen when exposure is unavoidable.
A Rare Case of Concurrent Lupus Mastitis and Sarcoidosis in a 62-Year-Old Female.
Eur J Breast Health
July 2024
Department of Radiology University of Miami Miller School of Medicine, Sylvester Cancer Center, and Jackson Memorial Hospital, Miami, FL, USA.
Article Synopsis
- * A 62-year-old woman with discoid lupus and Graves' disease had an abnormal mammogram that led to a biopsy revealing lupus mastitis, along with features of sarcoidosis.
- * This case highlights the rarity of lupus mastitis and sarcoidosis in the breast, illustrating how these autoimmune diseases can coexist and present atypically.
Performance of the Systemic Lupus Erythematosus Risk Probability Index (SLERPI) in a cohort of Colombian population.
Clin Rheumatol
November 2024
Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 # 63-C- 69, 110010, Bogota, D.C, Colombia.
Article Synopsis
- The study aimed to assess how well the Systemic Lupus Erythematosus Risk Probability Index (SLERPI) performs in diagnosing systemic lupus erythematosus (SLE) among Colombian patients, comparing it with established diagnostic criteria.
- Researchers collected data from 435 SLE patients and 430 control subjects with other autoimmune diseases, finding that SLE patients had significantly higher SLERPI scores, with key influential factors including immunological disorders and specific skin symptoms.
- SLERPI showed high sensitivity in identifying SLE, particularly for hematological and renal forms, but had lower specificity compared to traditional criteria, indicating it might be more effective in ruling out SLE rather than confirming it.
Cutaneous Squamous Cell Carcinoma Arising Within Discoid Lupus Erythematosus-Utilizing Acitretin and Hydroxychloroquine to Preoperatively Decrease Lupus Burden.
Dermatol Surg
January 2025
Department of Dermatology, Augusta University, Augusta, Georgia.