705 results match your criteria: "Lupus Erythematosus Bullous"
Macrophages in inflammatory skin diseases and skin tumors.
Front Immunol
December 2024
Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being the largest immune organ in the human body, presents an intriguing landscape for macrophage research, particularly regarding their roles in inflammatory skin diseases and skin tumors. In this review, we compile the latest research on macrophages in conditions such as atopic dermatitis, psoriasis, systemic sclerosis, systemic lupus erythematosus, rosacea, bullous pemphigoid, melanoma and cutaneous T-cell lymphoma.
View Article and Find Full Text PDFA review on toxic epidermal necrolysis-like superficial wound lesions: Issue and challenge on 10 clinical entities.
Int Wound J
December 2024
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Toxic epidermal necrolysis (TEN) is a severe skin reaction caused by extensive epidermal and mucosal necrosis. This clinical phenomenon is known as an acute syndrome of apoptotic pan-epidermolysis (ASAP). The ASAP phenomenon is observed in conditions that mimic TEN, highlighting the challenge in distinguishing these conditions.
View Article and Find Full Text PDFDe novo Presentation of Systemic Lupus as Bullous Erythematosus: A Case Report.
Curr Rheumatol Rev
December 2024
Specialist Dermatologist, Department of Dermatology, Qassimi Hospital Sharjah.
Background: Systemic Lupus Erythematosus (SLE) (C1) is a disease with multi-organ involvement that can have a variety of cutaneous manifestations in 76% of cases during the disease. Less than 1% of these patients are diagnosed with confirmed bullous systemic lupus erythematosus (C1). Given the wide differential diagnosis of a bullous lesion, it is imperative to reach a conclusive diagnosis as it can have a direct impact on the course of management of the disease.
View Article and Find Full Text PDFEvidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study.
Clin Cosmet Investig Dermatol
November 2024
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 31000, People's Republic of China.
Aim: Increasing observational studies are revealing a positive correlation between body mass index (BMI) and the risk of Immune-mediated and Inflammatory Skin Diseases (IMID), however the causal relationship is not yet definite.
Objective: The aim of the study was to conduct a two-sample Mendelian randomization (TSMR) to explore the potential causality between BMI, and IMID and biomarkers.
Methods: The summary statistics for BMI (n = 322,154), at genome-wide significant level, were derived from the Genetic Investigation of Anthropometric Traits consortium (GIANT).
This Month in JAAD Case Reports: January 2025.
J Am Acad Dermatol
January 2025
Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia. Electronic address:
Long-Term Risk of Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19.
JAMA Dermatol
December 2024
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Article Synopsis
- A study was conducted to explore the long-term risks of autoimmune and autoinflammatory diseases following COVID-19, addressing a gap in existing research.
- The study utilized a large national database, including over 6.9 million participants, with those who had confirmed COVID-19 compared against a control group from 2018.
- Results indicated an increased risk of various disorders, such as alopecia, vitiligo, Crohn's disease, and rheumatoid arthritis, in COVID-19 patients, suggesting a significant association between the virus and these health issues.
Bullous Cutaneous Lupus Erythematosus and Class V Lupus Nephritis: Rare Concurrence.
Eur J Rheumatol
October 2024
Department of Nephrology, Dr Ram Manohar Lohia Institute of Medical Sciences, Uttar Pradesh, India.
AGA Clinical Practice Update on Esophageal Dysfunction Due to Disordered Immunity and Infection: Expert Review.
Clin Gastroenterol Hepatol
December 2024
Division of Gastroenterology, University of Utah, Salt Lake City, Utah. Electronic address:
Article Synopsis
- The American Gastroenterological Association (AGA) commissioned this expert review to provide guidance on diagnosing infectious and immune-mediated esophageal disorders, which are often under-recognized and lead to dysfunction and health costs.
- The review offers Best Practice Advice (BPA) statements based on published literature and expert opinions, but lacks formal evidence ratings due to the absence of systematic reviews.
- Increased awareness among gastroenterologists regarding these disorders can enhance patient care by improving diagnosis and limiting unnecessary medical procedures, particularly in patients presenting with dysphagia, heartburn, and odynophagia.
Current Knowledge on Nail Involvement in Autoimmune Bullous Disorders.
Skin Appendage Disord
October 2024
Dermatology Departement, Saint Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, Brussels, Belgium.
Article Synopsis
- Nail involvement in autoimmune bullous disorders presents diverse symptoms, often differing from skin manifestations, such as paronychia, onychomadesis, and onycholysis without blisters.
- Various autoimmune conditions like pemphigus vulgaris and bullous pemphigoid can cause nail changes, and the presence of Langerhans cells in the nails is noteworthy due to its unique immunological aspects.
- Diagnosing these nail issues typically requires histopathological and immunofluorescence tests, and researchers stress the need for more studies to improve treatment strategies for affected individuals.
The role of intravenous immunoglobulin in autoimmune diseases with dermatological implications.
Ital J Dermatol Venerol
October 2024
School of Medicine, Clinic of Dermatology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
Article Synopsis
- Intravenous immunoglobulin (IVIG) therapy shows promise for treating various dermatological autoimmune diseases due to its ability to modulate the immune system and low risk of severe side effects.
- The exact mechanism of how IVIG works in autoimmune diseases is still debated, but it involves neutralizing harmful autoantibodies and preventing tissue damage.
- While IVIG is primarily used off-label for conditions like dermatomyositis and systemic sclerosis, a key study (ProDERM 2022) demonstrated its effectiveness specifically for dermatomyositis, and it is commonly used as first-line treatment for scleromyxedema.
Two-sample Mendelian randomization analysis of causal relationship between eczema and autoimmune diseases.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
June 2024
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013.
Article Synopsis
- This study investigates whether there is a causal relationship between eczema and various autoimmune diseases, using a technique called Mendelian randomization to analyze genetic data.
- Findings reveal that genetic susceptibility to eczema is linked to an increased risk of Crohn's disease and ulcerative colitis, but not to other autoimmune diseases like systemic lupus erythematosus or multiple sclerosis.
- The research concludes that while eczema is associated with certain autoimmune conditions, it doesn't have a causal influence on many others, and there's no evidence of autoimmune diseases causing eczema.
Histopathologic Overlap Between Bullous Lupus Erythematosus and Linear IgA Bullous Dermatosis: A Comparative Study.
Am J Dermatopathol
November 2024
Department of Pathology, St. John's Medical College, Bangalore, India .
Article Synopsis
- * This study analyzed the histopathologic characteristics of 11 cases of each disease, noting that both conditions commonly present with itchy blisters and certain similar microscopic findings, but with differences in eosinophil presence and specific epidermal changes.
- * Ultimately, the researchers concluded that histopathology is not effective for distinguishing between BLE and LAD; accurate diagnosis relies on immunofluorescence and serological tests, even when clinical signs appear typical for one condition.
The causal effects of inflammatory and autoimmune skin diseases on thyroid diseases: evidence from Mendelian randomization study.
Front Endocrinol (Lausanne)
September 2024
Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Article Synopsis
- The study used two-sample Mendelian randomization (MR) to investigate the links between inflammatory or autoimmune skin diseases and thyroid diseases.
- Genetic data was analyzed from a large sample of participants with various skin conditions and thyroid disorders to assess risks.
- Key findings indicated that atopic dermatitis (AD), systemic lupus erythematosus (SLE), and seborrheic dermatitis (SD) significantly increase the risk of hypothyroidism, while bullous pemphigoid (BP) lowers that risk; no causal effects were found for hyperthyroidism.
Generalised Blisters and Respiratory distress: A Case of Bullous Systemic Lupus Erythematosus.
Clin Cosmet Investig Dermatol
September 2024
Department of Dermatology, the First Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Article Synopsis
- Tjalma's syndrome is a benign condition found in patients with systemic lupus erythematosus, characterized by ascites, pleural effusion, and elevated CA-125 levels.
- Case reports are limited, making this case particularly significant; the patient presented with skin issues, massive pleural effusion, and elevated CA-125 but was ultimately diagnosed with bullous systemic lupus erythematosus after ruling out cancer.
- The hope is that sharing this case will enhance understanding of Tjalma's syndrome, helping to reduce unnecessary anxiety and medical procedures for similar patients.
Targeting Bruton's tyrosine kinase (BTK) as a signaling pathway in immune-mediated diseases: from molecular mechanisms to leading treatments.
Adv Rheumatol
August 2024
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- BTK, or Bruton's tyrosine kinase, is crucial for transmitting signals in cells, especially B and T immune cells, affecting their growth and survival.
- Various BTK inhibitors are being researched for treating immune disorders and blood cancers, with ongoing clinical trials exploring their effectiveness.
- The article reviews how these inhibitors work, discusses recent findings in autoimmune and inflammatory diseases, and addresses potential side effects and patient risks associated with their use.
Detection of autoantibodies to heat shock protein 70 in the saliva and urine of normal individuals.
Front Immunol
August 2024
Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Article Synopsis
- Cells under stress produce heat shock proteins (Hsps), with Hsp70 being found in all human cell types and fluids like blood, urine, and saliva.
- * The existence of anti-Hsp70 autoantibodies in healthy individuals' serum is known, and their levels increase with conditions like coeliac disease and dermatitis herpetiformis.
- * This study is the first to identify these autoantibodies in saliva and urine, raising questions about their role and potential as noninvasive biomarkers for autoimmune disease diagnosis and prediction, warranting further research.*
Causal associations between both psoriasis and psoriatic arthritis and multiple autoimmune diseases: a bidirectional two-sample Mendelian randomization study.
Front Immunol
August 2024
Department of Dermatology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China.
Article Synopsis
- Numerous observational studies indicate a potential link between psoriasis (PsO), psoriatic arthritis (PsA), and various autoimmune diseases (AIDs), but causation has not been established.
- A Mendelian Randomization study analyzed associations between PsO/PsA and AIDs like Crohn's disease, vitiligo, and systemic lupus erythematosus, utilizing several statistical models to ensure the findings were robust.
- The study found that Crohn's disease and vitiligo could be risk factors for developing PsO, while Crohn's disease, Hashimoto's thyroiditis, rheumatoid arthritis, ankylosing spondylitis, and other conditions may increase the risk for PsA.
A Case Report on Senear-Usher Syndrome.
Cureus
November 2023
Dermatology, Venereology, and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- * A 21-year-old woman presented with multiple thick plaques on seborrheic areas like her face, chest, and elbows, leading to a diagnosis based on her clinical signs and positive lab tests for specific antibodies.
- * The patient was treated with immunosuppressive therapy, and the details of her treatment course are documented in a case report.
Development of bullous systemic lupus erythematosus in patient treated with NB-UVB: A case report and comprehensive review of the literature.
Clin Case Rep
June 2024
Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS) Tehran Iran.
Article Synopsis
- Phototherapy, particularly UVB treatment, is effective for various skin diseases, including psoriasis, but can lead to vesiculobullous lesions that may indicate Bullous Systemic Lupus Erythematosus (BSLE).
- BSLE is a rare form of lupus that presents as blisters and can be diagnosed through specific immunofluorescence findings.
- The study discusses a case of a 70-year-old man with vesicular lesions after UVB therapy, confirming BSLE and noting improvement with dapsone treatment, emphasizing the need to consider BSLE in similar cases.
Anti-Herpes zoster vaccination in patients with dermatologic diseases: a position statement from the Italian SIDeMaST group of sexually transmitted, infectious and tropical diseases.
Ital J Dermatol Venerol
August 2024
Terni Dermatology Clinic, Terni, Italy -
Article Synopsis
- - Herpes zoster (HZ) occurs when the varicella-zoster virus (VZV), which causes chickenpox, reactivates due to weakened immune systems, particularly in the elderly or those with immune deficiencies.
- - About 1 in 3 people will experience HZ in their lifetime, and 30% of these individuals may develop post-herpetic neuralgia, a painful complication following the skin rash.
- - The text discusses the risk of HZ and post-herpetic neuralgia in patients with various dermatological conditions and outlines vaccination options and recommendations for preventing HZ in these high-risk groups.
Article Synopsis
- Hydroxychloroquine (HCQ) is commonly used to treat autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus but can lead to serious side effects, such as skin hyperpigmentation and eye damage.
- A case study highlighted a 65-year-old woman who developed blurred vision and hyperpigmentation after three years on HCQ for rheumatoid arthritis, leading to a diagnosis of drug-induced skin pigmentation and macular lesions.
- Following the discontinuation of HCQ and switching to iguratimod treatment, her skin pigmentation improved, although her vision issues persisted, stressing the importance of monitoring and regular eye exams for patients on HCQ.
Lupus erythematosus-specific bullous lesions.
Dermatol Online J
December 2023
Department of Dermatology, University of Florida, Gainesville, Florida, USA.
Article Synopsis
- The study discusses a case of a 49-year-old woman with systemic lupus erythematosus (SLE) presenting recurrent tense bullae on her forearms, which are unique skin lesions associated with the disease.
- It emphasizes the challenges in differentiating lupus-specific bullous lesions from other similar skin conditions related to SLE, such as bullous systemic lupus erythematosus and Rowell syndrome.
- The researchers provide insights into clinical, histopathologic, and serological findings that aid in accurately diagnosing these lesions and highlight key diagnostic clues.
Superficial and Bullous Neutrophilic Dermatoses: Sneddon-Wilkinson, IgA Pemphigus, and Bullous Lupus.
Dermatol Clin
April 2024
Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:
Article Synopsis
- Sneddon-Wilkinson disease (SWD), IgA pemphigus, and bullous systemic lupus erythematosus (BSLE) are skin conditions characterized by neutrophilic inflammation, which is a type of immune response.
- SWD and IgA pemphigus both feature flaccid pustules and involve the epidermis, but they may represent variations of the same disease, with IgA pemphigus confirmed by specific immunofluorescence results.
- In contrast, BSLE is marked by tense bullae and a different immune response, exhibiting linear IgG deposits at the junction between the dermis and epidermis.