A new method has been created to synthesize -3-alkenyl-2-amido-3-hydroxy esters from racemic α-amino-β-keto esters using an ATH/DKR protocol.
This technique provides moderate to excellent yields and demonstrates high selectivity across various chemical characteristics for many different substrates.
The methodology was successfully utilized in the asymmetric synthesis of the complex compound (+)-alexine, showcasing its versatility.