102,725 results match your criteria: "Lumbar Spine"

Lumbosacral transitional vertebrae in small-breed dogs: Prevalence, classification, and characteristics.

Vet Radiol Ultrasound

January 2025

Section of Veterinary Medical Imaging, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea.

The lumbosacral transitional vertebra (LTV) is an abnormally formed vertebra that can be associated with cauda equina syndrome, lumbosacral (LS) degeneration, and pelvic rotation. However, there is little information on LTV in small-breed dogs, and no studies have investigated the association between LTV and LS diseases or degenerative changes in the coxofemoral joints. The purpose of this multicenter, retrospective, and cross-sectional study was to determine the prevalence of LTV in small-breed dogs (<10 kg), classify the type of LTV, and identify its association with degenerative changes in the LS and coxofemoral joints using CT images.

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Purpose: To evaluate incidental lumbar durotomy incidence and risk-factors, and the association of durotomy with perioperative metrics and patient-reported outcomes.

Methods: A total 3140 cases of 1-3 level elective decompressive surgery from 2008 to 2023 at a single centre were included. Multivariable analysis was performed on literature derived variables to identify independent risk-factors for durotomy.

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Spinal instrumentation length affects adjacent segment range of motion and intradiscal pressure.

Sci Rep

December 2024

Institute of Orthopaedic Research and Biomechanics, Trauma Research Centre Ulm, Ulm University Medical Centre, Helmholtzstraße 14, 89081, Ulm, Germany.

Scoliosis instrumentation length depends on the type and degree of deformity and the individual preference of the surgeon. This in vitro study aimed to explore effects of increasing instrumentation length on adjacent segment mobility and intervertebral disc loading. Six fresh frozen human spine specimens (C7-sacrum) with entire rib cage from young adult donors (26-45 years) were loaded with pure moments of 5 Nm.

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We have proposed to the Food and Drug Administration (FDA) that treatment-related increases in total hip bone mineral density (TH BMD) at two years could be a surrogate endpoint for fracture risk reduction in clinical trials. The qualification of a surrogate includes a strong association of the surrogate with the clinical outcome. We compiled a large database of individual patient data (IPD) through the FNIH-ASBMR-SABRE project, and this analysis aimed to assess the relationship between baseline BMD and fracture risk in the placebo groups.

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Introduction: The effectiveness of the direct anterior approach (DAA) compared to other surgical approaches for total hip arthroplasty (THA) in patients with lumbar spine stiffness remains unclear. This systematic review and meta-analysis aimed to compare clinical outcomes, including dislocation rates and other complications, between DAA and other surgical approaches for THA in patients with lumbar spine stiffness.

Materials And Methods: We conducted a systematic review and meta-analysis to compare the DAA with other surgical approaches (anterolateral, direct lateral, posterolateral and direct superior) in patients with lumbar spine stiffness undergoing THA.

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Estimating the minimum clinically important difference (MCID) of the five-repetition sit-to-stand test in patients with lumbar disc herniation.

Eur Spine J

December 2024

Machine Intelligence in Clinical Neuroscience and Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.

Article Synopsis
  • This study investigates the effectiveness of surgical interventions for lumbar disc herniation (LDH) by analyzing the minimum clinically important difference (MCID) in the five-repetition sit-to-stand (5R-STS) test one year after surgery.
  • The researchers recruited 134 patients and gathered various measurements related to their health before and after surgery, ultimately determining the MCID as an average of 3.6 seconds for meaningful improvement in their performance.
  • The conclusion highlights that a 3.6-second improvement in the 5R-STS test signifies a clinically relevant enhancement in patients recovering from LDH.
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Objectives: This study aims to assess the impact of a Tai Chi exercise program (TCEP) on pain, spinal flexibility, muscle strength, stability and balance, functional status, and quality of life (QoL) among home-dwelling patients with osteoarthritis (OA) or inflammatory arthritis (iA).

Patients And Methods: Between October 2018 and April 2019, a total of 28 participants (4 males, 24 females; median age: 62 years; range, 34 to 79 years) who completed the training program participating in at least 18 sessions were included. The TCEP consisted of 50 sessions for 60 min twice a week.

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Objective: To investigate the effects of zoledronic acid (ZA) on periodontal indices, serum inflammatory markers, and bone metabolism in postmenopausal osteoporosis (PMO) patients with periodontitis (PD).

Methods: A total of 113 PMO+PD cases were recruited between May 2021 and February 2024. Fifty-two cases in the control group received standard therapy, while 61 cases in the observation group were treated with ZA.

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The objective of this study was to systematically evaluate the safety and efficacy of local anesthesia, general anesthesia, and epidural anesthesia in percutaneous endoscopic lumbar discectomy (PELD). We searched PubMed, EMBASE, and OVID databases for all relevant studies. All statistical analysis was performed using STATA 17.

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Background: Post-dural puncture headache (PDPH) is still mostly regarded a minor complication after lumbar puncture. In the International Classification of Headache Disorders (ICHD)-3 headaches lasting longer than 14 days or persisting after epidural blood patch (EBP) are not even considered. We illustrate that there may be many patients with persisting headaches and a large disease burden.

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Background: Disulfiram is widely used to treat alcohol use disorder. Alcohol per se adversely affects bone health. In the experimental study, disulfiram leads to apoptosis of osteoblast and significant osteopenia in adult rats.

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Introduction:  Yoga practices emphasize spinal energy's role in physical, mental, and spiritual well-being, suggesting specific techniques that can enhance energy flow along the spine. Modern research aims to validate these claims and understand the mechanisms behind these effects, potentially integrating them into contemporary healthcare models. This study explores the relationship between yoga breathing techniques, spinal energy dynamics, and health based on yoga philosophy and bioenergetics.

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Vertebral fractures (VFs) occasionally appear as the first manifestation of acute lymphocytic leukemia (ALL) in children. However, in adults, it is uncommon for VFs to lead to a diagnosis of ALL, and surgical intervention is even rarer. We encountered a case of a 42-year-old man with ALL who presented with acute severe back pain, lower limb numbness, dysuria, and hamstring weakness.

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Transforaminal lumbar interbody fusion (TLIF) is a widely utilized surgical procedure for the treatment of degenerative lumbar spinal conditions, including lumbar disc herniations, spinal stenosis, and spondylolisthesis. One such rare and underreported complication is vision loss following spinal surgery. Postoperative vision loss (POVL) is an extremely uncommon complication, occurring in approximately 0.

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Background: Chronic hyperglycemia can damage the microcirculation, which impairs the function of various organs and tissues and predisposes individuals to chronic complications. Sarcopenia (SP) is the age-related decline in muscle mass and function that contributes to the sequelae of type 2 diabetes. In particular, diabetic patients are at higher risk of SP because of insulin resistance, chronic inflammation, and decreased physical activity.

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Article Synopsis
  • Poncet disease (PD) is a rare condition linked to acute tuberculosis that impacts joints, specifically noted in a 76-year-old patient with symptoms in the hands and spine.
  • Radiographic imaging identified destructive bone lesions in the trapezium and spine, leading to a biopsy that confirmed TB-related damage.
  • The case emphasizes the need to consider PD in elderly patients showing multiple TB foci, particularly affecting the hands, and the patient was referred to a specialized TB facility for treatment.
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Study Design: Retrospective case serie.

Objectives: Assess the correlation between pedicle screw (PS) position of the first instrumented vertebra (FIV) with proximal adjacent segment degeneration (ASD) development or progression.

Methods: Patients ≥55 years who have undergone lumbar fusion with a minimum 2-year follow-up were included.

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The "July Effect" scrutinized: A coarsened-exact match analysis of lumbar fusion outcomes during resident transition.

Clin Neurol Neurosurg

December 2024

Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; McKenna EpiLog Fellowship in Population Health, at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Objective: The aim of this study was to assess for a "July Effect" by comparing exact matched patients undergoing single-level spinal fusions in July or in the latter half of the academic year.

Methods: Data from 2338 patients who underwent single-level, posterior-only lumbar fusion at a single, multicenter university hospital system were retrospectively reviewed. The primary outcomes were 90-day unplanned hospital readmissions, Emergency Department (ED) evaluations, reoperations, non-home discharge, and all-cause mortality.

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Introduction: Although sagittal alignment is known to influence pelvic position, few studies accurately identify the relationship between sagittal alignment and acetabular orientation. We hypothesized that postoperative PT should be correlated with acetabular change in native hips after surgical correction of adult spinal deformity. The objective of this study was therefore to describe the correlation between the change in pelvic tilt and the change in acetabular orientation two years after surgical correction of adult spinal deformity.

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Purpose: This study evaluated the efficacy, safety, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of SB16 versus reference denosumab (DEN) up to 18 months in postmenopausal osteoporosis (PMO) patients, and assessed outcomes after switching from DEN to SB16 compared to those who continued with DEN or SB16.

Methods: 457 PMO patients were initially randomized, with 407 re-randomized at Month 12 to either continue DEN (DEN+DEN), switch to SB16 (DEN+SB16), or continue SB16 (SB16 + SB16) through Month 18. Efficacy was assessed by the percent change from baseline in bone mineral density (BMD) at the lumbar spine, total hip, and femoral neck.

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Objective: The minimally invasive (MI) lateral approach to the TL junction for treating various spinal pathologies is quite challenging for spine surgeons due to this region's unfamiliar and complex anatomical structures. In addition, controversy still exists regarding approach selection, the need for rib resection, and diaphragm manipulation.

Methods: We present the senior author (NA) technique of an intercostal subdiaphragmatic retroperitoneal approach without rib resection for the LLIF procedure at L1/2 in patients who underwent multilevel LLIF from L1/2 to L5/S1.

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Introduction: The global incidence of spinal pathology is increasing due to the progressive aging of the population and increased life expectancy. Vertebral fixation with transpedicular screws is the most commonly used technique in unstable or potentially unstable pathologies. There are different implantation methods, the most recently developed being implantation guided by robotic navigation.

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Feasibility of a novel back support device to improve spine stability and muscular activity during trunk flexion: A prospective cross-sectional study with healthy controls and low back pain subjects - preliminary.

Clin Biomech (Bristol)

December 2024

Musculoskeletal Biomechanics Research Lab, Department of Mechanical Engineering, McGill University, 845 Sherbrooke St. W, Montréal, H3A 0G4, Québec, Canada; Orthopaedic Research Laboratory, Research Institute MUHC, Montreal General Hospital, McGill University, Montréal H3G 1A4, Québec, Canada. Electronic address:

Background: Low back pain is a prevalent global condition often challenging to address due to the absence of a definitive diagnosis in over 80 % of cases. Manual lifting, common in many work environments, contributes to low back pain due to lumbar spine stresses, and existing assistive technologies like abdominal belts and exoskeletons have limitations in managing low back pain effectively. This paper presents a novel back support device designed to generate abdominal compression during flexion activities, potentially enhancing lumbar stability through increased intra-abdominal pressure.

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Verifying the effectiveness of romosozumab re-administration on bone mineral density.

J Bone Miner Res

December 2024

Department of Orthopedic Surgery, Division of Osteoporosis, Locomotive Syndrome, Joint Disease Center, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan.

Upon completing romosozumab therapy for osteoporosis, sequential treatment with other agents is required. However, for patients at high fracture risk despite such therapy, re-administration of romosozumab might be a potent option for subsequent medication to prevent additional fractures. Currently, there is still insufficient real-world clinical data verifying the efficacy of romosozumab re-administration, therefore, this study aimed to evaluate its efficacy.

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Context: Individually, bone resorption or formation markers do not reflect bone balance.

Objective: 1) Combine reference bone resorption (collagen type I C-telopeptide, CTX) and formation (procollagen type I propeptide, PINP) markers to estimate balance by creating a bone balance index (BBI); 2) Examine associations of BBI, CTX, or PINP with bone mineral density (BMD) change.

Design: Mixed effects linear regression quantified associations of BBI, CTX, or PINP with BMD change rate.

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