1 results match your criteria: "Ludwig-Maximilians-University-Grobetahadern[Affiliation]"
Tissue levels of reduced folates in patients with colorectal carcinoma after infusion of folinic acid at various dose levels.
Clin Cancer Res
December 2008
Department of Internal Medicine III, Ludwig-Maximilians-University-Grobetahadern, Marchioninistr. 15, Munich, Germany.
Article Synopsis
- Patients with colorectal cancer (CRC) benefit from increased response rates and overall survival when 5-fluorouracil (5-FU) is combined with folinic acid (FA), though the ideal FA dosage remains uncertain.
- A study analyzed tissue samples from 86 CRC patients to assess reduced folate levels after FA was given at doses of 20, 200, and 500 mg/m² before surgery.
- Results showed that higher FA doses led to significant increases in reduced folate levels in both normal and tumor tissues, suggesting that administering high doses of FA is optimal for enhancing the effects of 5-FU in mCRC patients.