1 results match your criteria: "Ludwig-Maximilians-University (LMU) in Munich[Affiliation]"
Targeting miR-497-5p rescues human keratinocyte dysfunction upon skin exposure to sulfur mustard.
Cell Death Dis
August 2024
Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) in Munich, Munich, Germany.
Article Synopsis
- Sulfur mustard (SM) is a toxic chemical agent that causes severe skin lesions and impairs wound healing, with no current effective treatments available.
- Research identified a pathomechanism involving the miRNA miR-497-5p and survivin, which leads to keratinocyte dysfunction after SM exposure.
- Inhibiting miR-497-5p improved keratinocyte proliferation and differentiation, and using lipid-nanoparticles to deliver the inhibitor promoted skin recovery in human biopsies, suggesting potential therapeutic strategies for SM exposure.