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22 results match your criteria: "Ludwig-Maximilian-University Munich (LMU)[Affiliation]"
Contact Dermatitis
February 2025
Department of Environmental Toxicology, Trier University, Trier, Germany.
Positive patch test responses to benzoyl peroxide (BPO) have been reported from patients without and with known exposure. Up to 6.5% were found in the United States and 7.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Molecular Physiology of Exercise and Nutrition, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.
Mol Psychiatry
November 2024
Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Sci Transl Med
July 2024
Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilian-University Munich (LMU), 81377 Munich, Germany.
Patients with sepsis experience metabolic and immunologic dysfunction that may be amplified by standard carbohydrate-based nutrition. A ketogenic diet (KD) may offer an immunologically advantageous alternative, although clinical evidence is limited. We conducted a single-center, open-label, randomized controlled trial to assess whether a KD could induce stable ketosis in critically ill patients with sepsis.
View Article and Find Full Text PDFFront Oncol
April 2024
Breast Center, Department of Gynecology and Obstetrics, and Comprehensive Cancer Center Ludwig-Maximilian University Munich (LMU) University Hospital, Munich, Germany.
Introduction: The negative impact of unmanaged psychological distress on quality of life and outcome in breast cancer survivors has been demonstrated. Fortunately, studies indicate that distress can effectively be addressed and even prevented using evidence-based interventions. In Germany prescription-based mobile health apps, known as DiGAs (digital health applications), that are fully reimbursed by health insurances, were introduced in 2020.
View Article and Find Full Text PDFJ Alzheimers Dis
April 2024
German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany.
Background: Studies demonstrate associations between low social activity in older adults and cognitive decline. Little has been investigated regarding which factors are associated with low social activity in older adults at increased risk of dementia.
Objective: We investigate which sociodemographic, psychological, health-related, and environmental factors are associated with low social activity in older adults at increased risk of dementia.
J Eur Acad Dermatol Venereol
June 2024
Department of Dermatology, Universitair Ziekenhuis Brussel (UZB), Vrije Universiteit Brussel (VUB), SKIN Research Group, Brussels, Belgium.
Clin Nutr
July 2023
Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilian-University Munich (LMU), Munich, Germany; Department of Anaesthesiology, Research Unit Molecular Medicine, University Hospital, LMU Munich, Munich, Germany. Electronic address:
Background: Western dietary habits (WD) have been shown to promote chronic inflammation, which favors the development of many of today's non-communicable diseases. Recently, ketogenic diets (KD) have emerged as an immune-regulating countermeasure for WD-induced metaflammation. To date, beneficial effects of KD have been solely attributed to the production and metabolism of ketone bodies.
View Article and Find Full Text PDFJ Clin Med
April 2023
Department of Orthopedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, Ludwig Maximilian University Munich (LMU), Marchioninistr. 15, 81377 Munich, Germany.
Background: Low energy falls (LEF) in older adults constitute a relevant cause for emergency department (ED) visits, hospital admission and in-hospital mortality. Patient-reported outcome measures containing information about patients' medical, mental and social health problems might support disposition and therapy decisions. We investigated the value of a tablet-based (self-)assessment in predicting hospital admission and in-hospital mortality.
View Article and Find Full Text PDFAllergy
January 2023
Departments of Dermatology and Medicine, University of Utah Health, Salt Lake City, UT, USA.
Eosinophilia and eosinophil activation are recurrent features in various reactive states and certain hematologic malignancies. In patients with hypereosinophilia (HE), HE-induced organ damage is often encountered and may lead to the diagnosis of a hypereosinophilic syndrome (HES). A number of known mechanisms and etiologies contribute to the development of HE and HES.
View Article and Find Full Text PDFNat Commun
August 2022
Division of Peptide Biochemistry, TUM School of Life Sciences, Technical University of Munich (TUM), 85354, Freising, Germany.
Amyloid self-assembly is linked to numerous devastating cell-degenerative diseases. However, designing inhibitors of this pathogenic process remains a major challenge. Cross-interactions between amyloid-β peptide (Aβ) and islet amyloid polypeptide (IAPP), key polypeptides of Alzheimer's disease (AD) and type 2 diabetes (T2D), have been suggested to link AD with T2D pathogenesis.
View Article and Find Full Text PDFFront Med (Lausanne)
June 2022
Research Unit Molecular Medicine, Department of Anaesthesiology, LMU University Hospital, Ludwig-Maximilian-University Munich (LMU), Munich, Germany.
Severe COVID-19 is characterized by profound CD8 T-cell dysfunction, which cannot be specifically treated to date. We here investigate whether metabolic CD8 T-cell reprogramming by ketone bodies could be a promising strategy to overcome the immunoparalysis in COVID-19 patients. This approach was triggered by our recent pioneering study, which has provided evidence that CD8 T-cell capacity in healthy subjects could be significantly empowered by a Ketogenic Diet.
View Article and Find Full Text PDFFront Oncol
October 2021
Department of Radiation Oncology, University Hospital of Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Introduction: Several kinase inhibitors (KI) bear the potential to act as radiosensitizers. Little is known of the radiosensitizing effects of a wide range of other KI like palbociclib, which is approved in ER+/HER2- metastatic breast cancer.
Method: In our study, we used healthy donor fibroblasts and breast cancer and skin cancer cells to investigate the influence of a concomitant KI + radiation therapy.
Prev Vet Med
August 2021
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Dairy cows suffer poor metabolic adaptation syndrome (PMAS) during early post-calving periods caused by negative energy balance. Measurement of blood beta-hydroxy butyric acid (BHBA) and blood non-esterified fatty acids (NEFA) allow early and accurate detection of negative energy balance. Machine learning prediction of blood BHBA and blood NEFA using milk testing samples represents an opportunity to identify at-risk animals, using less labor than direct blood testing methods.
View Article and Find Full Text PDFGMS J Med Educ
November 2021
LMU Munich, Institute for Medical Education, University Hospital, Munich, Germany.
Due to the pandemic-related restrictions in classroom teaching at the medical faculties of the LMU Munich and the University of Basel, teaching methods with standardized patients (SPs), were shifted to a digital, web-based format at short notice as of April 2020. We report on our experiences with the WebEncounter program, which was used for the first time in German-speaking countries. The program enables one-to-one encounters between SPs and students.
View Article and Find Full Text PDFBMC Med Res Methodol
December 2020
Institute and Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital Munich, Munich, Germany.
Background: Long-term effectiveness of asthma control medication has been shown in clinical trials but results from observational studies with children and adolescents are lacking. Marginal structural models estimated using targeted maximum likelihood methods are a novel statistiscal approach for such studies as it allows to account for time-varying confounders and time-varying treatment. Therefore, we aimed to calculate the long-term risk of reporting asthma symptoms in relation to control medication use in a real-life setting from childhood to adulthood applying targeted maximum likelihood estimation.
View Article and Find Full Text PDFNat Commun
December 2019
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 10, 80804, Munich, Germany.
Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly-ubiquitination of BECN1, thus promoting its proteasomal degradation. SKP2 activity is regulated by phosphorylation in a hetero-complex involving FKBP51, PHLPP, AKT1, and BECN1.
View Article and Find Full Text PDFBreast Care (Basel)
October 2019
Department of Plastic and Hand Surgery, Technical University Munich, Munich, Germany.
Introduction: In the surgical world of breast cancer reconstruction, fat grafting is commonly viewed as an oncogenic risk. Scientific studies add confusion, given the stark lack of clinical evidence suggesting pro-oncogenic links. Typically, classic migration assays (e.
View Article and Find Full Text PDFExpert Opin Drug Saf
March 2018
a Breast Center, Department of Obstetrics and Gynecology , University Hospital, Ludwig-Maximilian-University Munich (LMU), Munich , Germany.
Despite improvements in the diagnosis and management of early stage breast cancer, about one third of the patients still progress to metastatic disease. Most of the patients with metastatic breast cancer have a hormone receptor positive and human epidermal growth factor receptor 2 negative subtype with a median survival of more than 3 years. For these patients, endocrine therapy with its favorable toxicity profile is the current standard of care.
View Article and Find Full Text PDFInt J Parasitol
February 2016
Technion-Israel Institute of Technology, Faculty of Biology, Haifa 32000, Israel.
Parasitic protozoa of the genus Leishmania are obligatory intracellular parasites that cycle between the phagolysosome of mammalian macrophages, where they proliferate as intracellular amastigotes, and the midgut of female sand flies, where they proliferate as extracellular promastigotes. Shifting between the two environments induces signaling pathway-mediated developmental processes that enable adaptation to both host and vector. Developmentally regulated expression and phosphorylation of protein kinase A subunits in Leishmania and in Trypanosoma brucei point to an involvement of protein kinase A in parasite development.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
April 2014
Ludwig Maximilian University Munich (LMU), Department of Chemistry, Butenandtstrasse 5-13, Haus D, 81377 Munich (Germany) http://www.cup.uni-muenchen.de/ac/kornath/index.php.
The homogeneous mixture of anhydrous hydrogen fluoride aHF and antimony pentafluoride AsF5 is known as a superacidic system. The high acidity is derived from the formation of [H2F](+) [AsF6](-). No experimental evidence exists for the existence of the free acid molecule HAsF6.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
April 2011
Ludwig Maximilian University Munich (LMU), Department of Chemistry, Butenandtstrasse 5-13, Haus D, 81377 Munich, Germany.