Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias.

Background: Many cardiomyopathy-associated pathogenic variants are heterozygous truncations, and pathogenic variants are associated with arrhythmias. Arrhythmia triggers in filaminopathy are incompletely understood.

Methods And Results: We describe an individual with biallelic pathogenic variants, p.

Otolaryngology Care Disparities in American Indian Populations.

Our objectives were to quantify geographical disparities in otolaryngology care access with respect to American Indian (AI) populations and to identify gaps in care. Although increased incidence and mortality rates of ear, nose, and throat (ENT) conditions in AI populations are well documented, few studies address factors contributing to these differential outcomes. We conducted a cross-sectional study of US states with AI areas that either met the population threshold for the American Community Survey annual estimate or annual supplemental estimate.

Displacement of the Inferior Alveolar Bundle Secondary to Post Coronectomy Root Migration: A Case Report.

Intentional coronectomy has become a commonplace procedure as an alternative to full third molar removal in order to decrease the occurrence of inferior alveolar nerve (IAN) injury. It is well known that one of the sequelae of this procedure is superior root migration. This is usually not a significant problem as the migrated roots may erupt to a position where they are more readily removed.

Healthcare Utilization and Costs for Patients With Parkinson's Disease After Deep Brain Stimulation.

Objective: To compare the complications, healthcare utilization and costs following DBS or medical management for patients with Parkinson's disease (PD).

Methods: We examined healthcare utilization and costs for up to 5 years between veterans with DBS and those with medical management for PD. Veterans who received DBS between 2007 and 2013 were matched with veterans who received medical management using propensity score approaches.

Fine-needle aspiration cytology of epithelioid leiomyoblastoma.

Purpose. Epithelioid leiomyoblastomas comprise the majority of gastric sarcomas and are uncommon in other parts of the gastrointestinal tract. Diagnosis of this lesion by fine-needle aspiration cytology has been occasionally described in the literature.

Unstable angina treatment: 2006 update.

Properly treated, unstable angina and non-Q wave myocardial infarction have low hospital mortality, but if untreated, mortality is high. Symptoms and labs usually suffice for diagnosis. Abnormal physical findings are rarely helpful and often absent.

Pharmacological approaches to the treatment of aphasia.

The catecholaminergic agonists, d-amphetamine and bromocriptine, have shown some promise in the treatment of aphasia. Although studies indicate that patients with aphasia experience language improvement after taking these agents, the experimental controls necessary to prove their efficacy are lacking. Rigorously controlled investigations using a significant number of aphasic patients and a double-blind-placebo controlled design, as well as studies using these drugs as acute care performance enhancers are needed.