2,037 results match your criteria: "Low Back Pain and Sciatica"

Discogenic low back pain (DLBP) is difficult to diagnose. We performed full endoscopic spinal surgery (FESS) with thermal annuloplasty for DLBP and achieved good results. Here, we report a case in which thermal annuloplasty resulted in good outcomes for refractory DLBP accompanied by a residual high-intensity zone (HIZ) after full endoscopic discectomy (FED).

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Purpose: The aim of this study was to evaluate the performance and safety of a new hernia blocking system (HBS), implanted after a limited discectomy, to prevent recurrence of lumbar disc herniation.

Methods: Prospective, multicenter (6 sites), cohort clinical investigation. Thirty patients with a postero-lateral disc herniation between L4-S1 and large annular defects (> 6 mm wide), who underwent a limited discectomy and were treated with a new HBS (DISC care, NEOS Surgery S.

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Objective: The Qing'e Pill (QEP) is widely used to alleviate low back pain and sciatica caused by Intervertebral Disc Degeneration (IDD). However, its active components, key targets, and molecular mechanisms are not fully understood. The aim of this study is to elucidate the molecular mechanisms through which the QEP improves IDD using database mining techniques.

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[Lumbar disc herniation].

Orthopadie (Heidelb)

November 2024

Wirbelsäulenzentrum, Schön Klinik München Harlaching, Harlachinger Straße 51, 81547, München, Deutschland.

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Background: Pediculolysis is bone hypertrophy and pseudoarthrosis caused by pedicle fracture and has often been combined with contralateral spondylolysis in previous reports. Multilevel pediculolysis with spondylolysis is extremely rare, and we report a case who underwent surgery. Cases of multisegment pediculolysis were reviewed to inspire the diagnosis and treatment of similar pathological phenomena.

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Electroacupuncture alleviates neuropathic pain in a rat model of CCD via suppressing P2X3 expression in dorsal root ganglia.

Chin Med

November 2024

Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Background: Sciatica and low back pain are prevalent clinical types of neuropathic pain that significantly impair patients' quality of life. Conventional therapies often lack effectiveness, making these conditions challenging to treat. Electroacupuncture (EA) is an effective physiotherapy for pain relief.

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  • The study evaluated the cost-effectiveness of using a caudal epidural block combined with a transforaminal nerve root block for treating lumbar spine degenerative diseases.
  • 47 patients with lumbar sciatica were assessed for pain levels before and one week after the procedure using a visual analogue scale (VAS).
  • Results showed significant pain reduction for both low back and leg pain, with a low procedural cost, indicating this treatment is cost-effective for managing these conditions.
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Urge incontinence, often linked to prolapsed intervertebral disc (PIVD) due to nerve compression, involves sudden, involuntary urine leakage. Management includes behavioral therapy, bladder training, and pelvic floor muscle training (PFMT) to strengthen pelvic muscles and regulate voiding, effectively reducing symptoms and improving quality of life. A 40-year-old female patient presented with chief complaints of lower back pain radiating down the right lower limb below the knee, accompanied by a right-sided listing.

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  • Chiropractors focus on diagnosing and treating musculoskeletal disorders, often using spinal manipulative therapy (SMT), with increased acceptance in the US since Medicare funded it in 1972.
  • A review of chiropractic research from 1972-2024 revealed over 6,000 articles, showing an upward trend in publication and a shift from historical topics to more clinical studies like randomized controlled trials.
  • Recent clinical practice guidelines (CPGs) have made 59 recommendations for SMT, mainly endorsing its use for low back pain (90% efficacy) and neck pain (100% efficacy), along with recent support for treating tension-type headaches.
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Introduction: Lumbar disc herniation (LDH) and disc degeneration (DD) are associated with low back pain (LBP) and sciatica, which are common health problems. Emerging evidence suggests a link between vascular health, specifically abdominal aortic calcification (AAC) and systemic lipid profiles, and these spinal conditions.

Research Question: This study investigates the associations between AAC, systemic lipid profiles, lumbar Modic Changes (MC), DD/LDH, and the occurrence of LBP or sciatica.

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Causal impacts of smoking on pain conditions and the mediating pathways: a mendelian randomization study.

Sci Rep

October 2024

Department of intensive care unit, Xi'an NO.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710018, Shaanxi, P.R. China.

Article Synopsis
  • Smoking significantly increases the risk of various pain conditions, as shown through mendelian randomization analyses that used genetic factors linked to smoking initiation.
  • A multivariable analysis identified major depression, insomnia, and sedentary behavior as key mediators, affecting the strength of the association between smoking and pain.
  • The study's results indicate that while smoking contributes to pain, the impact is largely influenced by these mediators, with findings remaining consistent across multiple sensitivity checks.
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  • A study was conducted to improve the diagnosis of piriformis syndrome (PS) by initially excluding it, rather than ruling out other causes of sciatica, potentially saving time and unnecessary tests.
  • The research involved 110 patients with sciatica, focusing on those who showed tenderness in the piriformis muscle and had pain relief after an injection; out of 66 evaluated, 27 (40.9%) were diagnosed with PS.
  • The findings suggest that PS is often underestimated as a cause of sciatica, and while a positive Freiberg test can indicate PS, it requires confirmation through tenderness assessment and injection response.
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A ganglioglioma versus a schwannoma: Which is in the sacral spine?

Int J Surg Case Rep

November 2024

Head of Neurosurgery Department, Faculty of Medical Sciences, Lebanese University, Lebanon.

Article Synopsis
  • - The text discusses sacral spinal gangliogliomas, rare tumors that can cause symptoms like lower back pain and bladder issues, and are treated primarily through surgical resection due to their location near critical nerves.
  • - A case study of a 66-year-old woman highlights the surgical challenges faced, where a misdiagnosis led to unexpected findings during surgery but ultimately resulted in successful near-total tumor removal and symptom relief.
  • - The conclusion emphasizes the need for accurate diagnosis and careful surgical planning to minimize neurological risks, and it calls for ongoing research to enhance treatment strategies for these tumors.
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  • Abnormal lipid metabolism has been connected to issues like intervertebral disc degeneration (IVDD), sciatica, and low back pain (LBP), prompting this study to explore whether lipid-lowering drugs can help prevent these conditions.
  • The research used genetic data and Mendelian randomization to investigate the impacts of specific drug targets (PCSK9, HMGCR, NPC1L1) on the development of IVDD, sciatica, and LBP, along with using data from the National Health and Nutrition Examination Survey (NHANES) to study LBP's connection to statin use.
  • Results showed that not using statins was linked to a higher risk of LBP, while reductions in total cholesterol
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  • Lumbar disc herniation (LDH) involves the displacement of disc material, causing symptoms like radiculopathy and significant healthcare utilization.
  • Current treatments include epidural steroid injections (ESIs) and lumbar discectomy, but ESIs have limited long-term benefits and potential risks, while discectomy can lead to complications and recurrent issues.
  • Emerging treatments in development aim to provide better, less invasive options for LDH, including sustained-release ESIs and new methods to reduce disc material without surgery.
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  • Lumbar disc herniation significantly affects quality of life, involving the displacement of the intervertebral disc's nucleus pulposus beyond its normal space.* ! * A systematic review assessed various treatment options, finding that while conservative treatments often provide immediate symptom relief, surgery may be necessary for patients with severe symptoms or those unresponsive to initial treatments.* ! * Limitations of the review include a small number of included studies and a focus only on English-language research from 2019 to 2024, which could affect the broader applicability of the results.* !
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Purpose: National Clinical Guidelines recommend an integrated combination of conservative management strategies for sciatica. However, the efficacy of such combinations have not been established. The purpose of this systemic review with meta-analysis was to determine the efficacy of combined conservative (non-pharmacological) compared to single interventions for people with sciatica with a confirmed neuropathic mechanism.

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Aim Of The Study: To compare clinical findings with MRI findings and evaluate the role of physical examination in the diagnosis, localization of the level, site, size, and type of lumbosacral disc herniation.

Materials And Methods: A prospective study of 104 patients with low back pain and/or sciatica was conducted et al.-Kindy Teaching Hospital between January to December 2022.

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Objective: The present study sought to investigate predictors of hospitalisation in adults diagnosed with non-specific low back pain (LBP) and/or sciatica from an ED.

Methods: A 5-year, multicentre retrospective observational study was conducted across six public hospitals (metropolitan and regional) using data from electronic medical records. Patient presentations were identified using LBP diagnostic codes and key data extracted (patient demographics, clinical activity, discharge destination).

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  • Caudal epidural steroid injections (ESIs) are commonly used for treating low back pain and radiculopathy, but physician practices in administering them vary widely.
  • A survey of physicians indicated a strong preference for using particulate steroids and spinal needles, with many not using catheters for accessing higher pathology.
  • Notably, 100% of respondents reported no incidents of permanent neurological injuries associated with these procedures, suggesting that caudal ESIs are generally safe.
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  • Recent developments in treating lumbar disc herniation focus on minimally invasive methods like percutaneous laser disc decompression (PLDD) to reduce the need for major surgeries.
  • A study compared the effects of PLDD alone versus PLDD combined with a new oral food supplement on patients with neuropathic pain, with one group receiving both treatments.
  • Results showed that those taking the supplement experienced significantly better pain relief at the three-month follow-up, improving sensory fiber function in lumbar nerve roots.
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  • Cavernous hemangiomas (cavernomas) are benign vascular malformations often found in the central nervous system, primarily in the brain, but can also occur in the spine, notably in the cauda equina, which is rare.
  • A case study details a 69-year-old woman with low back pain and sciatica, where MRI revealed an intradural mass at the L1-L2 level, later confirmed as a cavernous hemangioma after surgical resection.
  • The report includes a literature review on cauda equina cavernomas, covering their clinical symptoms, imaging features, histology, and surgical approaches.
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Objectives: The objective was to determine whether specific physical activity (PA) or psychological stress factors are associated with different definitions of flare-ups (pain-defined flares [PDFs]: periods of increased pain lasting at least 2 h, when pain intensity is distinctly worse than it has been recently; and non-pain-defined flares [NPDFs]: obviously uncomfortable feelings, such as fatigue, loss of function, or emotional/psychosocial fluctuations, without major fluctuations in pain intensity based on 11-point scales) among people with lumbar radicular pain.

Methods: This was a case-crossover study. Participants with acute or subacute lumbar radicular pain completed serial face-to-face or online assessments for 6 weeks at 3-day intervals to determine whether they experienced sciatica flare-ups (PDF/NPDF) after specific types of PA or psychological stresses.

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Introduction: The aim of this research is to study the clinical outcome and symptomatic improvement for patients with lumbar radiculopathy treated with selective nerve root block (SNRB) under fluoroscopic guidance. This non-surgical management can be used at various sites including cervical and lumbar regions and also can prevent early surgeries for patients with radiculopathy.

Materials And Methods: Thirty patients with low back pain with or without sciatica were treated by fluoroscopic-guided nerve root block (F- NRB) as therapeutic management in government Cuddalore Medical College during the period of August 2020-2022.

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Objective: The purpose of this study is to use two-sample Mendelian randomization (MR) to investigate the causal relationship between skin microbiota, especially Propionibacterium acnes, and intervertebral disc degeneration (IVDD), low back pain (LBP) and sciatica.

Methods: We conducted a two-sample MR using the aggregated data from the whole genome-wide association studies (GWAS). 150 skin microbiota were derived from the GWAS catalog and IVDD, LBP and sciatica were obtained from the IEU Open GWAS project.

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