59 results match your criteria: "Lovely Professional University. Phagwara[Affiliation]"

Cancer is a major global concern. Despite considerable advancements in cancer therapy and control, there are still large gaps and requirements for development. In recent years, various naturally occurring anticancer drugs have been derived from natural resources, such as alkaloids, glycosides, terpenes, terpenoids, flavones, and polyphenols.

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The synthesis of polymer/oligomer-stabilized metal nanostructures (MNS) opens up a wide range of possibilities, from fundamental materials science to practical applications in domains such as medicine, catalysis, sensing, and energy. Because of the versatility of this synthetic approach, it is a dynamic and ever-changing field of study. These polymers/oligomers have precise control over the nucleation and growth kinetics, allowing the production of mono-disperse MNS with well-defined properties.

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The combination of 4,4,4-trifluoro-1-phenyl-1,3-butanedione (TFPB) and pyrazine (pyz) with Tb ions forms two distinct types of complexes, represented by the formulas [Tb(TFPB)(L)], where L is either HO or pyz, and [(Tb(TFPB))pyz]. A detailed examination of the impact of the surrounding environment on the photophysical properties of these synthesized complexes was conducted. Photoluminescence (PL) analysis indicated that the magnetic dipole transition (D → F) is dominant in Tb(iii)-based systems.

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In the vast landscape of materials science, bismuth emerges as a compelling element with unique properties and diverse applications. Its intriguing characteristics and advancements in nanotechnology have propelled bismuth-based nanoparticles to the forefront of scientific exploration, promising breakthroughs in various disciplines. This comprehensive review explores diverse methods for synthesizing bismuth-based nanoparticles and nanocomposites, ranging from conventional approaches such as hydrothermal and sol-gel to innovative techniques such as microwave-assisted, microemulsion, and green synthesis.

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Animal flesh is a major food source with economic and industrial value for consumer demand. These meats produced biowaste during and after preparation and use. Chicken intestines make up most of the waste thrown away after processing or frying.

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Cancer is a disease that involves uncontrolled cell division triggered by genetic damage to the genes that control cell growth and division. Cancer starts as a localized illness, but subsequently spreads to other areas in the human body (metastasis), making it incurable. Cancer is the second most prevalent cause of mortality worldwide.

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Microalgae presents an inducing potential as a primary raw material in crafting plant-based seafood alternatives, revolutionizing the landscape of sustainable food production. These microscopic organisms display a rich nutritional profile, presenting an array of nutrients such as essential amino acids, polyunsaturated fatty acids, vitamins, and minerals comparable to those found in seafood. Their versatile nature allows for the replication of seafood flavors and textures, addressing the sensory aspects crucial to consumer acceptance of substitutes.

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Article Synopsis
  • Lung cancer (LC) is the leading cause of cancer mortality, with significant implications from the interplay between human genetics and microbial cells in the body.
  • The gut-lung axis and interactions between gut and lung microbiomes are believed to influence the progression of lung cancer and other lung diseases.
  • Advances in 16s rDNA sequencing have revealed the role of the lung microbiome in tumor development and treatment responses, suggesting that microbiome-based therapies could be a promising approach for improving LC treatment outcomes.
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Inflammatory diseases exert a significant influence on the periodontium, serving as a primary contributor to the development of periodontitis. The advancement of periodontitis, characterized by manifestations, such as gingival recession, increased periodontal pocket depth and resorption across the alveolar bone, cementum and periodontal ligaments, poses a significant risk of dental detachment. Untreated or delayed treatment further worsens these deleterious outcomes.

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Ready to Eat Food: A Reason for Enhancement in Multidrug Resistance in Humans.

Adv Pharm Bull

October 2024

Department of Sponsored Research, Division of Research & Development, Lovely Professional University Phagwara (Punjab), India.

The increasing trend of consuming ready-to-eat (RTE) food has become a global phenomenon, and this has raised concerns about the potential negative impacts on human health. Recent studies have shown a correlation between the consumption of RTE foods and the expansion of multidrug resistance (MDR) in humans. MDR is a significant challenge in the effective theory of infectious diseases, as it limits the effectiveness of antibiotics and other drugs used in therapy.

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Heterocyclic scaffolds, particularly, pyridine-containing azaheterocycles, constitute a major part of the drugs approved in the past decade. In the present review, we explored the pyridine ring part of US FDA-approved small molecules (2014-2023). The analysis of the approved drugs bearing a pyridine ring revealed that a total of 54 drugs were approved.

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  • Rheumatoid Arthritis (RA) is a chronic autoimmune disease mainly affecting individuals aged 30-50, characterized by symptoms like morning stiffness, joint pain, and fatigue.
  • Various risk factors for RA include hormonal, genetic, and environmental influences, as well as lifestyle choices like smoking and diet.
  • The review emphasizes the therapeutic potential of 17 native plant species with anti-arthritic properties, while also highlighting the need for more thorough research to confirm their efficacy and safety for RA treatment.
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  • Nonalcoholic fatty liver disease (NAFLD) is increasingly concerning due to fat buildup in the liver, often related to obesity and inflammation; this study focuses on using silymarin-supplemented cookies as a potential treatment.
  • A clinical trial with 64 NAFLD patients assessed the effects of these cookies on liver enzyme activity, inflammatory markers, and lipid profiles over three months, comparing treatment groups with a placebo.
  • Results showed significant improvements in liver enzymes and inflammatory markers in the treatment groups, particularly the third group, highlighting silymarin's potential benefits for managing NAFLD.
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  • Patient-derived xenografts (PDX) involve transplanting patient tumors into mice, providing better disease models compared to traditional methods due to their stability and resemblance to the original tumors.
  • While PDX models have great potential for advancing cancer research and personalizing treatment, challenges like high costs, variability in results, and the need for further understanding of their predictive power remain.
  • The review discusses the methodologies for creating PDX models, their benefits in cancer studies, and highlights the incorporation of AI and machine learning to enhance drug testing efficiency and deepen insights into cancer biology.
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The tropical and subtropical regions of the world support the growth of the Indian plant . It usually goes by the name drumstick tree or horseradish tree and thrives in warm climates. The leaves of the tree are now frequently used as nutrients and nutraceuticals due to their availability of various minerals.

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Article Synopsis
  • The review emphasizes the critical role of a healthy immune system in preventing infectious diseases, especially highlighted during the pandemic.
  • It discusses how various nutrients, vitamins, and dietary patterns can enhance immune function, based on a thorough analysis of scientific literature.
  • The paper also focuses on personalized nutrition for vulnerable groups and offers practical strategies to boost immunity both during and after the pandemic.
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Cell wall polysaccharides (dietary fiber) in cereal grains contribute to health benefits. The novelty of the current study was an effort to explore the in vivo therapeutic potential of different cereal bran cell walls against hypercholesterolemia. For this purpose, the cell walls were isolated from different cereal brans (wheat, maize, oats, and barley), and the intake of these cereal bran cell walls was evaluated for their anti-lipidemic activity in normal and hypercholesterolemic rats.

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This research was aimed to investigate the utilization of mung bean starch as an innovative edible coating material to enhance the shelf-life of cut papaya fruits. The study focused on the extraction process of mung bean starch and its subsequent characterization through various analyses. Particle size (142.

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A new, easy-to-prepare, and highly selective fluorescent chemosensor, , 5-aminoisophthalate-based kojic acid-appended bis-1,2,3-triazole, was synthesized from an alkyne of 5-aminoisophthalic acid and azido-kojic acid using Cu(i)-catalyzed click chemistry and then successfully characterized. The alkyne structure of 5-aminoisophthalic acid, 1, was supported by the single-crystal X-ray crystallographic data. The fluorescent probe 3 was found to be highly selective for Cu ions supported by the Job's plot with a stoichiometric ligand : metal ratio of 2 : 1, exhibiting almost a two-fold enhancement in the emission intensity upon the addition of Cu ions (0-25 μM) with a detection limit of 8.

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The growing preference for natural remedies has resulted in increased use of medicinal plants. One of the most significant and varied plants is garden cress (), which has large concentrations of proteins, fatty acids, minerals, and vitamins. It also contains a wide range of bioactive components, including kaempferol glucuronide, gallic acid, protocatechuic acid, coumaric acid, caffeic acid, terpenes, glucosinolates, and many more.

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Lecithin is constituted of a glycerophospholipid mixture and is abundantly used as an emulsifying agent in various food applications including chocolate production. However, overconsumption of lecithin may create an adverse effect on human health. Thus, this study aims to replace the lecithin with plant-based gums.

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Low-oxalate diets are useful for treating hyperoxaluria in nephrolithiasis patients. This study was unique in examining how a low-oxalate diet in addition to a standard diet affected hyperoxaluria and renal function tests in nephrolithiasis patients. The effects of a low-oxalate diet were analyzed by different biochemical tests, that is, anthropometric measurements, blood oxalate test, renal function test, electrolyte profile test, and 24 h urine analysis.

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In this study, two novel chalcone-derived 1,2,3-triazole-appended positional isomers (probe 6 and probe 9) were synthesized the 'CuAAC' (Cu(i) - catalysed alkyne azide cycloaddition) methodology for the purpose of metal ion detection. The synthesized probes underwent characterization utilizing standard spectroscopic methodologies including FTIR, NMR (H and C), and mass spectrometry. Subsequently, the sensing capabilities of these probes were explored using UV-Vis and fluorescence spectroscopy, wherein their selective recognition potential was established for Pb(ii) and Cu(ii), both of which can pose serious health hazards when prevalent in the environment above permissible limits.

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Polysaccharides from non-conventional sources, such as fruits, have gained significant attention recently. (Bael), a non-conventional fruit, is an excellent source of biologically active components with potential indigenous therapeutic and food applications. Apart from polyphenolic components, this is an excellent source of mucilaginous polysaccharides.

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In the quest to scrutinize and modify biological systems, the global research community has continued to explore bio-orthogonal click reactions, a set of reactions exclusively targeting non-native molecules within biological systems. These methodologies have brought about a paradigm shift, demonstrating the feasibility of artificial chemical reactions occurring on cellular surfaces, in the cell cytosol, or within the body - an accomplishment challenging to achieve with the majority of conventional chemical reactions. This review delves into the principles of bio-orthogonal click chemistry, contrasting metal-catalyzed and metal-free reactions of bio-orthogonal nature.

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