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Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial.
JAMA
February 2014
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana3Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana4Tulane Hypertension and Renal Center of Excellence, Ne.
Importance: Although the benefit of reducing blood pressure for primary and secondary prevention of stroke has been established, the effect of antihypertensive treatment in patients with acute ischemic stroke is uncertain.
Objective: To evaluate whether immediate blood pressure reduction in patients with acute ischemic stroke would reduce death and major disability at 14 days or hospital discharge.
Design, Setting, And Participants: The China Antihypertensive Trial in Acute Ischemic Stroke, a single-blind, blinded end-points randomized clinical trial, conducted among 4071 patients with nonthrombolysed ischemic stroke within 48 hours of onset and elevated systolic blood pressure.