Tissue-specific biological aging predicts progression in prostate cancer and acute myeloid leukemia.

Introduction: Chronological aging is a well-recognized diagnostic and prognostic factor in multiple cancer types, yet the role of biological aging in manifesting cancer progression has not been fully explored yet.

Methods: Given the central role of chronological aging in prostate cancer and AML incidence, here we investigate a tissue-specific role of biological aging in prostate cancer and AML progression. We have employed Cox proportional hazards modeling to associate biological aging genes with cancer progression for patients from specific chronological aging groups and for patients with differences in initial cancer aggressiveness.

Fault Detection in 3D Printing: A Study on Sensor Positioning and Vibrational Patterns.

This work examines the use of accelerometers to identify vibrational patterns that can effectively predict the state of a 3D printer, which could be useful for predictive maintenance. Prototypes using both a simple rectangular shape and a more complex Octopus shape were fabricated and evaluated. Fast Fourier Transform, Spectrogram, and machine learning models, such as Principal Component Analysis and Support Vector Machine, were employed for data analysis.

Strong Constraints on Jet Quenching in Centrality-Dependent p+Pb Collisions at 5.02 TeV from ATLAS.

Jet quenching is the process of color-charged partons losing energy via interactions with quark-gluon plasma droplets created in heavy-ion collisions. The collective expansion of such droplets is well described by viscous hydrodynamics. Similar evidence of collectivity is consistently observed in smaller collision systems, including pp and p+Pb collisions.

Test of CP Invariance in Higgs Boson Vector-Boson-Fusion Production Using the H→γγ Channel with the ATLAS Detector.

A test of CP invariance in Higgs boson production via vector-boson fusion has been performed in the H→γγ channel using 139  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV collected by the ATLAS detector at the LHC. The optimal observable method is used to probe the CP structure of interactions between the Higgs boson and electroweak gauge bosons, as described by an effective field theory. No sign of CP violation is observed in the data.

Search for Heavy Neutral Leptons in Decays of W Bosons Using a Dilepton Displaced Vertex in sqrt[s]=13 TeV pp Collisions with the ATLAS Detector.

A search for a long-lived, heavy neutral lepton (N) in 139  fb^{-1} of sqrt[s]=13  TeV pp collision data collected by the ATLAS detector at the Large Hadron Collider is reported. The N is produced via W→Nμ or W→Ne and decays into two charged leptons and a neutrino, forming a displaced vertex. The N mass is used to discriminate between signal and background.

RNA capture pin technology: investigating long-term stability and mRNA purification specificity of oligonucleotide immobilization on gold and streptavidin surfaces.

Advancing biomedical studies necessitates the development of cutting-edge technologies for the rapid extraction of nucleic acid. We characterized an RNA capture pin (RCP) tool that is non-destructive to the sample and enables rapid purification and enrichment of mRNA for subsequent genetic analysis. At the core of this technology is a pin (200 µm × 3 cm) functionalized with dT15 capture sequences that hybridize to mRNA within 2 min of insertion in the specimen.

A novel method intersecting three-dimensional motion capture and medial elbow strength dynamometry to assess elbow injury risk in baseball pitchers.

In baseball pitching, resultant elbow varus torque reaches the peak value of 50-120 N m, exceeding the joint failure limit that risks damage to the ulnar collateral ligament (UCL). In-vivo methodology is lacking to assess whether pitchers have sufficient muscular strength to shield UCL and how strongly the elbow musculature must contract to minimize valgus loading on UCL. This study introduces a method to assess relative percentages of muscular varus strength required to unload the UCL.

A collaborative approach to improving representation in viral genomic surveillance.

The lack of routine viral genomic surveillance delayed the initial detection of SARS-CoV-2, allowing the virus to spread unfettered at the outset of the U.S. epidemic.

Electrochemical Redox Cycling Behavior of Gold Nanoring Electrodes Microfabricated on a Silicon Micropillar.

We report the microfabrication and characterization of concentric gold nanoring electrodes (Au NREs), which were fabricated by patterning two gold nanoelectrodes on the same silicon (Si) micropillar tip. Au NREs of 165 ± 10 nm in width were micropatterned on a 6.5 ± 0.

Climate predicts wildland fire extent across China.

Wildland fire extent varies seasonally and interannually in response to climatic and landscape-level drivers, yet predicting wildfires remains a challenge. Existing linear models that characterize climate and wildland fire relationships fail to account for non-stationary and non-linear associations, thus limiting prediction accuracy. To account for non-stationary and non-linear effects, we use time-series climate and wildfire extent data from across China with unit root methods, thus providing an approach for improved wildfire prediction.

Exploratory Investigation Into the Impact of Bilateral and Unilateral Jump Characteristics on Ground Reaction Force Applications in Baseball Pitching.

Lis, R, Szymanski, DJ, Qiao, M, and Crotin, RL. An exploratory investigation into the impact of bilateral and unilateral jump characteristics on ground reaction force applications in baseball pitching. J Strength Cond Res 37(9): 1852-1859, 2023-Jump tests are effective, valid, and reliable in examining lower-body power that can influence ground reaction forces (GRFs) in baseball pitching.

Clay Nanotubes Loaded with Diazepam or Xylazine Permeate the Brain through Intranasal Administration in Mice.

The blood-brain barrier (BBB) is an obstacle to the permeation of most therapeutic drugs into the brain, limiting treatments for neurological disorders. Drugs loaded within nanocarriers that pass through the BBB can overcome this limitation. Halloysite consists of naturally occurring biocompatible clay nanotubes of 50 nm diameter and 15 nm lumen, allowing the loading and sustained release of loaded drugs.

Microbial Fuel Cell Construction Features and Application for Sustainable Wastewater Treatment.

A microbial fuel cell (MFC) is a system that can generate electricity by harnessing microorganisms' metabolic activity. MFCs can be used in wastewater treatment plants since they can convert the organic matter in wastewater into electricity while also removing pollutants. The microorganisms in the anode electrode oxidize the organic matter, breaking down pollutants and generating electrons that flow through an electrical circuit to the cathode compartment.

Characterization and Energy Densification of Mayhaw Jelly Production Wastes Using Hydrothermal Carbonization.

Research Background: Mayhaw jelly, made from mayhaw berries from the southern United States, is a popular food product that on processing produces a berry pomace waste. Little information is available in the literature about this waste or how to valorize it. This study investigated this food production waste and its possibilities for conversion to a biofuel.

Let sleeping logs lie: Beta diversity increases in deadwood beetle communities over time.

Research Highlight: Seibold, S., Weisser, W., Ambarli, D.

Selection of gait parameters during constrained walking.

It is commonly thought that at prescribed speeds humans choose gait parameters that minimize the cost of transportation. However, it is unclear whether and how the relationship between step length and step frequency is affected by the additional physiological factors caused by constraints. We performed a series of experiments to understand the selection of gait parameters under different constraints from a probabilistic perspective.

Folate Targeting Peptide Conjugates for Inflammatory Response Suppression.

Background And Objective: Protein kinases known as mitogen-activated protein kinases (MAPKs) are responsible for regulating a wide variety of physiological cell responses by generating and release of inflammatory mediators. Suppressing these inflammatory mediators can be utilized to control the propagation of inflammation. During the course of this research, we created folate-targeted MK2 inhibitor conjugates and analyzed the antiinflammatory effects of these compounds.

An Exploratory Investigation Evaluating the Impact of Fatigue-Induced Stride Length Compensations on Ankle Biomechanics among Skilled Baseball Pitchers.

Altered propulsive and bracing ground reaction forces from lower-body fatigue significantly impact stride length to increase weakness in dynamic elbow stabilizers and risk of medial elbow injury in baseball pitchers. This work investigated altered stride length on three-dimensional ankle joint dynamics to illustrate fatigue-induced changes in ankle motion that can also be impacted by coaching errors. Nineteen pitchers (15 collegiate and 4 high school) were randomized in a crossover design study that encouraged fatigue by throwing two simulated 80-pitch games at ±25% of their desired stride length.

Proximal to distal sequencing impacts on maximum shoulder joint angles and the risk of impingement in baseball pitching involving a scapular independent thoracohumeral model.

Background: Hyperangulation of the scapulohumeral joint due to poor coordination of the scapula during throwing motion is claimed to be a major cause of internal impingement in baseball pitchers. However, evidence of injurious scapular kinematics is lacking, particularly regarding how hyperangularion actually occurs in full-effort pitching. The purpose of this study was to describe sequential scapular motions involved in attaining maximum joint angles during pitching and the implications for internal impingement in elite baseball pitchers.

Supervisor-subordinate fit need for autonomy and subordinate job crafting: a moderated mediation model.

Employees often change various aspects of their jobs to their liking (i.e., job crafting), yet little is known about how different aspects of supervisor-subordinate fit influence this behavior.

Simultaneous removal of pharmaceuticals and heavy metals from aqueous phase via adsorptive strategy: A critical review.

The coexistence of pharmaceuticals and heavy metals is regarded as a serious threat to aquatic environments. Adsorbents have been widely applied to the simultaneous removal of pharmaceuticals and metals from aqueous phase. Through a comprehensive review, behaviors that promote, inhibit, or have no effect on simultaneous adsorption of pharmaceuticals and heavy metals were found to depend on the system of contaminants and adsorbents and their environmental conditions, such as: characteristics of adsorbent and pollutant, temperature, pH, inorganic ions, and natural organic matter.

Characterization and Optimization of Injectable In Situ Crosslinked Chitosan-Genipin Hydrogels.

In recent years, there has been an increased interest in injectable, in situ crosslinking hydrogels due to their minimally invasive application and ability to conform to their environment. Current in situ crosslinking chitosan hydrogels are either mechanically robust with poor biocompatibility and limited biodegradation due to toxic crosslinking agents or the hydrogels are mechanically weak and undergo biodegradation too rapidly due to insufficient crosslinking. Herein, the authors developed and characterized a thermally-driven, injectable chitosan-genipin hydrogel capable of in situ crosslinking at 37 °C that is mechanically robust, biodegradable, and maintain high biocompatibility.

Surface plasmon enhanced fluorescence: self-consistent classical treatment in the quasi-static limit.

The problem of enhanced molecular emission in close proximity to dielectric and metallic interfaces is of great importance for many physical and biological applications. Here we present an exact treatment of the problem from the view point of classical electromagnetism. Self-consistent analytical theory of the surface enhanced fluorescence (SEF) is developed for configurations consisting of an emitter in proximity to core-shell metal-dielectric nanoparticles.

Stable in-vivo electrochemical sensing of tonic serotonin levels using PEDOT/CNT-coated glassy carbon flexible microelectrode arrays.

Chronic sampling of tonic serotonin (5-hydroxytryptamine, 5-HT) concentrations in the brain is critical for tracking neurological disease development and the time course of pharmacological treatments. Despite their value, in vivo chronic multi-site measurements of tonic 5-HT have not been reported. To fill this technological gap, we batch-fabricated implantable glassy carbon (GC) microelectrode arrays (MEAs) onto a flexible SU-8 substrate to provide an electrochemically stable and biocompatible device/tissue interface.

Determining the Conformational Stability of a Protein from Urea and Thermal Unfolding Curves.

This article contains protocols for determining the conformational stability of a globular protein from either urea or thermal unfolding curves. Circular dichroism is the optical spectroscopic technique most commonly used to monitor protein unfolding. These protocols describe how to analyze data from an unfolding curve to obtain the thermodynamic parameters necessary to calculate conformational stability, and how to determine differences in stability between protein variants.