Thiourea-based rotaxanes: anion transport across synthetic lipid bilayers and antibacterial activity against .

We report the synthesis of two rotaxanes (1 and 2) whose rings have appended thiourea units for the selective recognition of Cl anions. Rotaxane 1 transports Cl across synthetic lipid bilayers more efficiently than 2, exhibiting EC values of 0.243 mol% 0.

The Adr1 Interacts with the C-Terminus of Human Vitronectin in a Salt-Sensitive Manner.

Spotted fever group (SFG) species are inoculated into the mammalian bloodstream by hematophagous arthropods. Once in the bloodstream and during dissemination, the survival of these pathogens is dependent upon the ability of these bacteria to evade serum-borne host defenses until a proper cellular host is reached. expresses an outer membrane protein, Adr1, which binds the complement inhibitory protein vitronectin to promote resistance to the anti-bacterial effects of the terminal complement complex.