Immune Protection against Lethal Fungal-Bacterial Intra-Abdominal Infections.

Polymicrobial intra-abdominal infections (IAIs) are clinically prevalent and cause significant morbidity and mortality, especially those involving fungi. Our laboratory developed a mouse model of IAI and demonstrated that intraperitoneal inoculation with or other virulent non- (NAC) species plus resulted in 70 to 80% mortality in 48 to 72 h due to robust local and systemic inflammation (sepsis). Surprisingly, inoculation with or with resulted in minimal mortality, and rechallenge of these mice with lethal / (i.