The quandary of diagnosing mathematical difficulties in a generally low performing population.

Unlabelled: Brazilian students' mathematical achievement was repeatedly observed to fall below average levels of mathematical attainment in international studies such as PISA.

Objective: In this article, we argue that this general low level of mathematical attainment may interfere with the diagnosis of developmental dyscalculia when a psychometric criterion is used establishing an arbitrary cut-off (e.g.

Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast-derived extracellular vesicles to promote human bone marrow stem cell osteogenic differentiation.

Extracellular vesicles (EVs) are emerging in tissue engineering as promising acellular tools, circumventing many of the limitations associated with cell-based therapies. Epigenetic regulation through histone deacetylase (HDAC) inhibition has been shown to increase differentiation capacity. Therefore, this study aimed to investigate the potential of augmenting osteoblast epigenetic functionality using the HDAC inhibitor Trichostatin A (TSA) to enhance the therapeutic efficacy of osteoblast-derived EVs for bone regeneration.

Visualisation of Chemical Shielding Tensors (VIST) to Elucidate Aromaticity and Antiaromaticity.

Aromaticity is a central concept in chemistry, pervading areas from biochemistry to materials science. Recently, chemists also started to exploit intricate phenomena such as the interplay of local and global (anti)aromaticity or aromaticity in non-planar systems and three dimensions. These phenomena pose new challenges in terms of our fundamental understanding and the practical visualisation of aromaticity.

Reconstructed monthly river flows for Irish catchments 1766-2016.

A 250-year (1766-2016) archive of reconstructed river flows is presented for 51 catchments across Ireland. By leveraging meteorological data rescue efforts with gridded precipitation and temperature reconstructions, we develop monthly river flow reconstructions using the GR2M hydrological model and an Artificial Neural Network. Uncertainties in reconstructed flows associated with hydrological model structure and parameters are quantified.

K-edge X-ray absorption spectroscopy of the ligand environment of single-site Au/C catalysts during acetylene hydrochlorination.

The replacement of HgCl/C with Au/C as a catalyst for acetylene hydrochlorination represents a significant reduction in the environmental impact of this industrial process. Under reaction conditions atomically dispersed cationic Au species are the catalytic active site, representing a large-scale application of heterogeneous single-site catalysts. While the metal nuclearity and oxidation state under operating conditions has been investigated in catalysts prepared from and thiosulphate, limited studies have focused on the ligand environment surrounding the metal centre.

Expansion of human mesenchymal stem/stromal cells on temporary liquid microcarriers.

Background: Traditional large-scale culture systems for human mesenchymal stem/stromal cells (hMSCs) use solid microcarriers as attachment substrates. Although the use of such substrates is advantageous because of the high surface-to-volume ratio, cell harvest from the same substrates is a challenge as it requires enzymatic treatment, often combined with agitation. Here, we investigated a two-phase system for expansion and non-enzymatic recovery of hMSCs.

Applications of ambient ionization mass spectrometry in 2020: An annual review.

Recent developments in mass spectrometry (MS) analyses have seen a concerted effort to reduce the complexity of analytical workflows through the simplification (or removal) of sample preparation and the shortening of run-to-run analysis times. Ambient ionization mass spectrometry (AIMS) is an exemplar MS-based technology that has swiftly developed into a popular and powerful tool in analytical science. This increase in interest and demonstrable applications is down to its capacity to enable the rapid analysis of a diverse range of samples, typically in their native state or following a minimalistic sample preparation approach.

The forgotten drought of 1765-1768: Reconstructing and re-evaluating historical droughts in the British and Irish Isles.

Historical precipitation records are fundamental for the management of water resources, yet rainfall observations typically span 100-150 years at most, with considerable uncertainties surrounding earlier records. Here, we analyse some of the longest available precipitation records globally, for England and Wales, Scotland and Ireland. To assess the credibility of these records and extend them further back in time, we statistically reconstruct (using independent predictors) monthly precipitation series representing these regions for the period 1748-2000.

Centennial clonal stability of asexual in Greenland lakes despite climate variability.

Climate and environmental condition drive biodiversity at many levels of biological organization, from populations to ecosystems. Combined with paleoecological reconstructions, palaeogenetic information on resident populations provides novel insights into evolutionary trajectories and genetic diversity driven by environmental variability. While temporal observations of changing genetic structure are often made of sexual populations, little is known about how environmental change affects the long-term fate of asexual lineages.

Alkali modified P25 with enhanced CO adsorption for CO photoreduction.

To improve the CO adsorption on the photocatalyst, which is an essential step for CO photoreduction, solid solutions were fabricated using a facile calcination treatment at 900 °C. Using various alkalis, namely NaOH, NaCO, KOH, KCO, the resulted samples presented a much higher CO adsorption capacity, which was measured with the pulse injection of CO on the temperature programmed desorption workstation, compared to the pristine Evonik P25. As a result, all of the fabricated solid solutions produced higer yield of CO under UV light irradiation due to the increased basicity of the solid solutions even though they possessed only the rutile polymorph of TiO.

Scale-down studies for the scale-up of a recombinant fed-batch fermentation: loss of homogeneity leads to lower levels of cadaverine production.

Background: The loss of efficiency and performance of bioprocesses on scale-up is well known, but not fully understood. This work addresses this problem, by studying the effect of some fermentation gradients (pH, glucose and oxygen) that occur at the larger scale in a bench-scale two-compartment reactor [plug flow reactor (PFR) + stirred tank reactor (STR)] using the cadaverine-producing recombinant DM1945 Δact3 Ptuf-ldcC_OPT. The new scale-down strategy developed here studied the effect of increasing the magnitude of fermentation gradients by considering not only the average cell residence time in the PFR ( ), but also the mean frequency at which the bacterial cells entered the PFR ( ) section of the two-compartment reactor.

Multi-century trends to wetter winters and drier summers in the England and Wales precipitation series explained by observational and sampling bias in early records.

Globally, few precipitation records extend to the 18th century. The England Wales Precipitation (EWP) series is a notable exception with continuous monthly records from 1766. EWP has found widespread use across diverse fields of research including trend detection, evaluation of climate model simulations, as a proxy for mid-latitude atmospheric circulation, a predictor in long-term European gridded precipitation data sets, the assessment of drought and extremes, tree-ring reconstructions and as a benchmark for other regional series.

Motivations, understandings, and experiences of open-access mega-journal authors: Results of a large-scale survey.

Open-access mega-journals (OAMJs) are characterized by their large scale, wide scope, open-access (OA) business model, and "soundness-only" peer review. The last of these controversially discounts the novelty, significance, and relevance of submitted articles and assesses only their "soundness." This article reports the results of an international survey of authors ( 11,883), comparing the responses of OAMJ authors with those of other OA and subscription journals, and drawing comparisons between different OAMJs.

Dielectric barrier discharge plasma microbubble reactor for pretreatment of lignocellulosic biomass.

A novel lignocellulosic biomass pretreatment reactor has been designed and tested to investigate pretreatment efficacy of miscanthus grass. The reactor was designed to optimize the transfer of highly oxidative species produced by dielectric barrier discharge plasma to the liquid phase immediately after generation, by arranging close proximity of the plasma to the gas-liquid interface of microbubbles. The reactor produced a range of reactive oxygen species and reactive nitrogen species, and the rate of production depended on the power source duty cycle and the temperature of the plasma.

Using a Scenario-Neutral Framework to Avoid Potential Maladaptation to Future Flood Risk.

This study develops a coherent framework to detect those catchment types associated with a high risk of maladaptation to future flood risk. Using the "scenario-neutral" approach to impact assessment the sensitivity of Irish catchments to fluvial flooding is examined in the context of national climate change allowances. A predefined sensitivity domain is used to quantify flood responses to +2 °C mean annual temperature with incremental changes in the seasonality and mean of the annual precipitation cycle.

A new integrated collision risk assessment methodology for autonomous vehicles.

Real-time risk assessment of autonomous driving at tactical and operational levels is extremely challenging since both contextual and circumferential factors should concurrently be considered. Recent methods have started to simultaneously treat the context of the traffic environment along with vehicle dynamics. In particular, interaction-aware motion models that take inter-vehicle dependencies into account by utilizing the Bayesian interference are employed to mutually control multiple factors.

Microwave synthesised Pd-TiO for photocatalytic ammonia production.

Palladium doped anatase TiO nanoparticles were synthesised by a rapid (3 min) one-pot microwave synthesis technique at low temperature and pressure. After being fully characterised by SEM, XRD, Raman, XPS and EDX, photocatalytic nitrate reduction and ammonia production were studied over various dopant levels between 0-3.97 wt% Pd and compared to similar previous literature.

Body size trajectories and cardio-metabolic resilience to obesity.

Individuals with obesity do not represent a single homogenous group in terms of cardio-metabolic health prospects. The concept of metabolically healthy obesity is a crude way of capturing this heterogeneity and has resulted in a plethora of research linking to future outcomes to show that it is not a benign condition. By contrast, very few studies have looked back in time and modelled the life course processes and exposures that explain the heterogeneity in cardio-metabolic health and morbidity and mortality risk among people with the same body mass index (BMI) (or waist circumference or percentage body fat).

Impacts of speed variations on freeway crashes by severity and vehicle type.

Speed variations are identified as potentially important predictors of freeway crash rates; however, their impacts on crashes are not entirely known. Existing findings tend to be inconsistent possibly because of the different definitions for speed variations, different crash type consideration or different modelling and data aggregation approaches. This study explores the relationships of speed variations with crashes on a freeway section in the UK.

Enhanced catalytic performance of reduced graphene oxide-TiO hybrids for efficient water treatment using microwave irradiation.

Towards achieving efficient waste water treatment, the degradation of a common water pollutant, Orange G azo dye, was studied using a new hybrid catalyst and microwave irradiation. The fabrication of a hybrid catalyst based on reduced graphene oxide-titania (rGO-TiO), was first achieved in a single mode microwave cavity by reducing the precursor consisting of graphene oxide (GO) and titania. Catalytic performance was then assessed in both microwave assisted and conventional heat treatment conditions.

Mapping Quantitative Trait Loci Underlying Circadian Light Sensitivity in Drosophila.

Despite the significant advance in our understanding of the molecular basis of light entrainment of the circadian clock in Drosophila, the underlying genetic architecture is still largely unknown. The aim of this study was to identify loci associated with variation in circadian photosensitivity, which are important for the evolution of this trait. We have used complementary approaches that combined quantitative trait loci (QTL) mapping, complementation testing, and transcriptome profiling to dissect this variation.

The Effects of Alcohol Intoxication on Accuracy and the Confidence-Accuracy Relationship in Photographic Simultaneous Line-ups.

Acute alcohol intoxication during encoding can impair subsequent identification accuracy, but results across studies have been inconsistent, with studies often finding no effect. Little is also known about how alcohol intoxication affects the identification confidence-accuracy relationship. We randomly assigned women ( = 153) to consume alcohol (dosed to achieve a 0.

Carbon Nanotubes in TiO Nanofiber Photoelectrodes for High-Performance Perovskite Solar Cells.

1D semiconducting oxides are unique structures that have been widely used for photovoltaic (PV) devices due to their capability to provide a direct pathway for charge transport. In addition, carbon nanotubes (CNTs) have played multifunctional roles in a range of PV cells because of their fascinating properties. Herein, the influence of CNTs on the PV performance of 1D titanium dioxide nanofiber (TiO NF) photoelectrode perovskite solar cells (PSCs) is systematically explored.

Maximal Oxygen Uptake Is Achieved in Hypoxia but Not Normoxia during an Exhaustive Severe Intensity Run.

Highly aerobically trained individuals are unable to achieve maximal oxygen uptake ([Formula: see text]) during exhaustive running lasting ~2 min, instead [Formula: see text] plateaus below [Formula: see text] after ~1 min. Hypoxia offers the opportunity to study the ([Formula: see text]) response to an exhaustive run relative to a hypoxia induced reduction in [Formula: see text]. The aim of this study was to explore whether there is a difference in the percentage of [Formula: see text] achieved (during a 2 min exhaustive run) in normoxia and hypoxia.

Characterization of Solid Fuel Chars recovered from Microwave Hydrothermal Carbonization of Human Biowaste.

Microwave hydrothermal carbonization (M-HTC) is reported in this study as a viable sanitation technology that can reliably overcome the heterogeneous nature of human faecal biowaste (HBW) and realize its intrinsic energy value. Solid chars produced from the M-HTC process at 180°C and 200°C were characterized to further the understanding of the conversion pathways and their physicochemical, structural and energetic properties. The study revealed solid chars recovered were predominantly via a solid-solid conversion pathway.