Source-dependent absorption Ångström exponent in the Los Angeles Basin: Multi-time resolution factor analyses of ambient PM and aerosol optical absorption.

Advanced receptor models can leverage the information derived from optical and chemical variables as input by a variety of instruments at different time resolutions to extract the source specific absorption Ångström exponent (AAE) from aerosol absorption. The multilinear engine (ME-2), a Positive Matrix Factorization (PMF) solver, serves as a proficient tool for performing such analyses, thereby overcoming the constraints imposed by the assumptions in current optical source apportionment methods such as the Aethalometer approach since the use of a-priori AAE values introduces additional uncertainty into the results of optical methods. Comprehensive PM chemical speciation datasets, and aerosol absorption coefficients (b, λ) at seven wavelengths measured by an Aethalometer (AE33), were used in multi-time source apportionment (MT-PMF).

Inequities in Unmet Oral Care Needs after a Swedish Subsidization Reform: An Intersectional Analysis.

Introduction: The main strategy to achieve equal provision of oral care in Sweden has been to offer partial subsidies for the adult population. However, their effects on unmet oral care needs (UOCNs) have not been extensively assessed.

Objective: This study used an intersectionality framework to examine 1) the overall frequency of UOCNs, 2) single-indicator inequities, and 3) intersectional inequities in total UOCNs and financial-related UOCNs (FUOCNs) in Sweden before and after implementation of a partial subsidization reform in 2008.

Antiviral Use Among Children Hospitalized With Laboratory-Confirmed Influenza Illness: A Prospective, Multicenter Surveillance Study.

Background: Guidelines state that all hospitalized children with suspected or confirmed influenza receive prompt treatment with influenza-specific antivirals. We sought to determine the frequency of, and factors associated with, antiviral receipt among hospitalized children.

Methods: We conducted active surveillance of children presenting with fever or respiratory symptoms from 1 December 2016 to 31 March 2020 at 7 pediatric medical centers in the New Vaccine Surveillance Network.

Development and Initial Outcomes of the Interdisciplinary 'Early Identification and Intervention for Infants Network' (Ei3) in Los Angeles.

: The Early Identification and Intervention for Infants (Ei3) Network is an interdisciplinary team dedicated to improving early detection and intervention of cerebral palsy (CP) in California. This paper describes the key (1) awareness-building and (2) capacity-building strategies utilized by the Ei3 Network in the first two years. : Awareness-building methods included interactive conference discussions, resource deliverable creation, and the creation of a framework for dissemination.

Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients.

Anthracyclines, such as doxorubicin, are important anti-cancer therapies but are associated with arterial injury. Histopathological insights have been limited to small animal models, and the role of inflammation in the arterial toxic effects of anthracycline is unclear in humans. Our aims were (1) to evaluate aortic media fibrosis and injury in non-human primates treated with anthracyclines; (2) to assess the effect of anthracycline on aortic inflammation in patients treated for lymphoma.

Innovative Orthodontic-Restorative Treatment With Customized CAD/CAM Smartwires.

Background: The demand for discreet and low-compliance appliances has driven innovation in orthodontics, particularly with technological advances in artificial intelligence, robotics, and CAD/CAM technology. The evolution of Programmed Non-Sliding Mechanics for precise, automated tooth movement is the latest innovation.

Aim: In this article, we aimed to demonstrate the application of a novel orthodontic lingual appliance, The Gen 2 InBrace system (InBrace, Irvine, CA), in the orthodontic-restorative treatment of an adult patient with anterior tooth-size discrepancies, anterior openbite, and incisor proclination.

Respiratory Syncytial Virus Disease Burden and Nirsevimab Effectiveness in Young Children From 2023-2024.

Importance: During the 2023-2024 respiratory syncytial virus (RSV) season in the United States, 2 new RSV prevention products were recommended to protect infants in their first RSV season: nirsevimab and Pfizer's maternal RSV vaccine. Postlicensure studies are needed to assess prevention product impact and effectiveness.

Objective: To compare the epidemiology and disease burden of medically attended RSV-associated acute respiratory illness (ARI) among children younger than 5 years during the 2023-2024 RSV season with 3 prepandemic RSV seasons (2017-2020), estimate nirsevimab effectiveness against medically attended RSV-associated ARI, and compare nirsevimab binding site mutations among circulating RSV in infants with and without nirsevimab receipt.

Comparative analysis of deep learning algorithms for dental caries detection and prediction from radiographic images: a comprehensive umbrella review.

Background: In recent years, artificial intelligence (AI) and deep learning (DL) have made a considerable impact in dentistry, specifically in advancing image processing algorithms for detecting caries from radiographical images. Despite this progress, there is still a lack of data on the effectiveness of these algorithms in accurately identifying caries. This study provides an overview aimed at evaluating and comparing reviews that focus on the detection of using DL algorithms from 2D radiographs.

Religious and Spiritual Experiences, Discrimination, and Stress Among Midlife Women in the USA: The Study of Women's Health Across the Nation.

The harmful effects of perceived discrimination for physical and mental health are well documented. Evidence identifies how dimensions of religious/spiritual (R/S) involvement may reduce these harmful effects. This study examined how R/S experiences are associated with the effects of discrimination on perceived stress.

Syndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population.

Human craniofacial shape is highly variable yet highly heritable with numerous genetic variants interacting through multiple layers of development. Here, we hypothesize that Mendelian phenotypes represent the extremes of a phenotypic spectrum and, using achondroplasia as an example, we introduce a syndrome-informed phenotyping approach to identify genomic loci associated with achondroplasia-like facial variation in the general population. We compare three-dimensional facial scans from 43 individuals with achondroplasia and 8246 controls to calculate achondroplasia-like facial scores.

Mapping genes for human face shape: Exploration of univariate phenotyping strategies.

Human facial shape, while strongly heritable, involves both genetic and structural complexity, necessitating precise phenotyping for accurate assessment. Common phenotyping strategies include simplifying 3D facial features into univariate traits such as anthropometric measurements (e.g.

Commentary: Ovarian Cancer: Path to Effective Treatments.

Despite advancements in cancer therapeutics such as checkpoint inhibitors and some targeted therapies, we have not achieved success in effectively treating ovarian cancer, since these therapeutics only benefit a subset of patients, and also provide short-term protection. The use of chemotherapy and radiation therapy can cause depletion and/or lack of immune cells' function. Chimeric antigen receptor T (CAR-T) cell therapy is found to be effective against several blood-based cancers, but limited success was seen against solid tumors.

Ethanolamine-induced assembly of microcompartments is required for virulence.

Many bacteria metabolize ethanolamine as a nutrient source through cytoplasmic organelles named bacterial microcompartments (BMCs). Here we investigated the molecular assembly, regulation, and function of BMCs in - a Gram-negative oral pathobiont that is associated with adverse pregnancy outcomes. The genome harbors a conserved ethanolamine utilization () locus with 21 genes that encode several putative BMC shell proteins and a two-component signal transduction system (TCS), in addition to the enzymes for ethanolamine transport and catabolism.

Models of DEIB: Part I - Approaches to Inclusion from Other Health Professions for Consideration by Dentistry.

This article represents a prologue of the discussion of the article "Models of DEIB: Part II-Exploring Models of Inclusion from other Health Professions for Dentistry". It explores existing practices and philosophies from other disciplines that could be applied toward creating environments of inclusion and belonging in dentistry. The primary focus here is to provide an opportunity for the dental profession to leverage knowledge and experiences from other health professions to enhance and expand inclusion efforts and provide enhance engagement at all levels.

Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse.

Orthodontic relapse is one of the most prevalent concerns of orthodontic therapy. Relapse results in patients' teeth reverting towards their pretreatment positions, which increases the susceptibility to functional problems, dental disease, and substantially increases the financial burden for retreatment. This phenomenon is thought to be induced by rapid remodeling of the periodontal ligament (PDL) in the early stages and poor bone quality in the later stages.

Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins.

As obligate intracellular pathogens, viruses activate host metabolic enzymes to supply intermediates that support progeny production. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of salvage nicotinamide adenine dinucleotide (NAD) synthesis, is an interferon-inducible protein that inhibits the replication of several RNA and DNA viruses through unknown mechanisms. Here, we show that NAMPT restricts herpes simplex virus type 1 (HSV-1) replication by impeding the virion incorporation of viral proteins owing to its phosphoribosyl-hydrolase (phosphoribosylase) activity, which is independent of the role of NAMPT in NAD synthesis.

Conversion of a failing fixed implant prosthesis into an implant-retained overdenture: A clinical report.

Implants supporting a fixed prosthesis may fail leaving unfavorable implant distribution for a fixed prosthesis. This clinical report illustrates a treatment option for converting a failing fixed prosthesis into a mandibular complete overdenture by using a portion of the existing fixed implant prosthesis. The use of a resilient liner to retain a converted mandibular overdenture framework provided satisfactory results in the first year of clinical use.

AI's pivotal impact on redefining stakeholder roles and their interactions in medical education and health care.

Artificial Intelligence (AI) has the potential to revolutionize medical training, diagnostics, treatment planning, and healthcare delivery while also bringing challenges such as data privacy, the risk of technological overreliance, and the preservation of critical thinking. This manuscript explores the impact of AI and Machine Learning (ML) on healthcare interactions, focusing on faculty, students, clinicians, and patients. AI and ML's early inclusion in the medical curriculum will support student-centered learning; however, all stakeholders will require specialized training to bridge the gap between medical practice and technological innovation.