13 results match your criteria: "Los Angeles (K.L.K.); and the Centers for Medicare and Medicaid Services[Affiliation]"
Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke.
Neurology
February 2024
From the Department of Neurology (C.M.A., B.B.W.), University of Virginia, Charlottesville; Department of Neurology (R.B., J.W.C.), University of Maryland, Baltimore; Program in Physical Therapy (K.L.), Washington University; Department of Neurology (K.L.), Washington University, St. Louis, MO; Department of Neurology (A.H.), Center for Brain and Mind Health, Yale University, New Haven, CT; Department of Neurology (S.C.C.), University of California Los Angeles; California Rehabilitation Institute (S.C.C.), Los Angeles; Department of Clinical Sciences Lund, Neurology (A.G.L.), Lund University; Department of Neurology (A.G.L.), Skane University Hospital, Sweden; Department of Public Health Sciences (K.L.K., B.B.W.); Center for Health Equity and Precision Public Health (K.L.K.), University of Virginia, Charlottesville; and Department of Biostatistics (F.-C.H.), School of Medicine, Wake Forest University, Winston-Salem, NC.
Article Synopsis
- - Stroke genetic research has advanced, but recovery applications lag due to the limitations of the modified Rankin Scale (mRS), which doesn’t accurately reflect biological processes following a stroke.
- - The study involved 1,270 participants, assessing changes in cognition and motor skills over two years, which showed significant improvements in cognitive and motor deficits from 20% and 70% to 7.2% and 30%, respectively.
- - Genome-Wide Association Studies (GWAS) uncovered new gene associations linked to cognitive, motor, and global impairments, suggesting that focusing on specific stroke recovery traits can enhance our understanding of genetic influences on recovery.
Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma.
N Engl J Med
March 2023
From the University of Texas M.D. Anderson Cancer Center, Houston (S.P.P., M.I.R., V.G.P.), and the University of Texas Health Science Center at San Antonio, San Antonio (M.S.); Southwest Oncology Group Statistics and Data Management Center (M.O., J.M.) and the Fred Hutchinson Cancer Center (M.O., E.D., J.M.) - both in Seattle; the Cancer Research Consortium of West Michigan National Cancer Institute Community Oncology Research Program (NCORP)-Cancer and Hematology Centers of Western Michigan (Y.C.), the Cancer Research Consortium of West Michigan NCORP-Spectrum Health (G.P.W.), and the Cancer Research Consortium of West Michigan NCORP (K.J.Y.), Grand Rapids, and the University of Michigan Rogel Cancer Center, Ann Arbor (C.D.L., L.A.F.); the University of Utah Huntsman Cancer Institute, Salt Lake City (J.R.H., S.H.-L.); Kaiser Permanente Northern California, Vallejo (T.-G.T.), University of Southern California Norris Comprehensive Cancer Center (G.K.I., N.K.) and University of California Los Angeles Jonsson Comprehensive Cancer Center (B.C., J.G.C., A.R.), Los Angeles, City of Hope Comprehensive Cancer Center-Saint John's Cancer Institute, Santa Monica (K.A.M.), and City of Hope Comprehensive Cancer Center-University of California, Irvine, Irvine (W.A.C.) - all in California; Kaiser Permanente Colorado, Lafayette (J.L.E.); Northwestern University, Chicago (S.C., J.A.S.), and the Cancer Care Specialists of Illinois-Heartland NCORP, O'Fallon (J.D.F.) - both in Illinois; Ohio State University Wexner Medical Center, Columbus (K.L.K., R.C.W.), and University Hospitals Seidman Cancer Center-Case Western Reserve University Case Comprehensive Cancer Center, Cleveland (A.M., A.M.R.); Northwell Health Cancer Institute, Lake Success, NY (C.E.D., G.B.D.); the University of Alabama at Birmingham, Birmingham (A.H., M.K.); Virginia Commonwealth University-Massey Cancer Center-VCU Massey Cancer Center Minority Underserved NCORP, Richmond (A.S.P., G.Q.P.); Marshfield Medical Center Wisconsin NCORP, Weston (A.A.O.), and Marshfield Medical Center Wisconsin NCORP, Minocqua (D.G.Y.); the University of Kansas Cancer Center, Overland Park (B.C.P.), and the University of Kansas Hospital-Westwood Cancer Center, Westwood (G.C.D.); MedStar Georgetown University Hospital, Washington, DC (G.T.G., M.B.A.); Banner University Medical Center-University of Arizona Cancer Center, Tucson (M.S., J.A.W.); the University of Oklahoma, Oklahoma City (A.I.), and the University of Oklahoma-Cancer Centers of Southwest Oklahoma, Lawton (J.E.N.); Saint Louis University School of Medicine, St. Louis (E.H.); Merck, Rahway, NJ (K.F.G.); Emory University, Atlanta (M.C.L.); Dana-Farber Cancer Institute-Harvard Cancer Center, Boston (E.I.B.); the University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh (J.M.K.); the National Cancer Institute Cancer Therapy Evaluation Program, Bethesda, MD (L.K., E.S.); and Moffitt Cancer Center, Tampa, FL (V.K.S.).
Background: Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would increase event-free survival among patients with resectable stage III or IV melanoma is unknown.
Methods: In a phase 2 trial, we randomly assigned patients with clinically detectable, measurable stage IIIB to IVC melanoma that was amenable to surgical resection to three doses of neoadjuvant pembrolizumab, surgery, and 15 doses of adjuvant pembrolizumab (neoadjuvant-adjuvant group) or to surgery followed by pembrolizumab (200 mg intravenously every 3 weeks for a total of 18 doses) for approximately 1 year or until disease recurred or unacceptable toxic effects developed (adjuvant-only group). The primary end point was event-free survival in the intention-to-treat population.
Local monitoring of SARS-CoV-2 variants in two large California counties in 2021.
Sci Rep
October 2022
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA.
Coronavirus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to persist due to mutations resulting in newer, more infectious variants of concern. We aimed to leverage an ongoing private SARS-CoV-2 testing laboratory's infrastructure to monitor SARS-CoV-2 variants in two large California counties. Study enrollment was offered to adults aged 18 years or older in Los Angeles County and Riverside County who recently tested positive for SARS-CoV-2 with a polymerase chain reaction (PCR) assay.
View Article and Find Full Text PDFStroke genetics informs drug discovery and risk prediction across ancestries.
Nature
November 2022
Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France.
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.
View Article and Find Full Text PDFImaging Inflammation with Positron Emission Tomography.
Biomedicines
February 2021
Department of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Hufelandstraße 55, D-45147 Essen, Germany.
The impact of inflammation on the outcome of many medical conditions such as cardiovascular diseases, neurological disorders, infections, cancer, and autoimmune diseases has been widely acknowledged. However, in contrast to neurological, oncologic, and cardiovascular disorders, imaging plays a minor role in research and management of inflammation. Imaging can provide insights into individual and temporospatial biology and grade of inflammation which can be of diagnostic, therapeutic, and prognostic value.
View Article and Find Full Text PDFRationale, design and baseline characteristics of the Microbiome and Insulin Longitudinal Evaluation Study (MILES).
Diabetes Obes Metab
November 2020
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Aim: To investigate the role of the gut microbiome in regulating key insulin homeostasis traits (insulin sensitivity, insulin secretion and insulin clearance) whose dysfunction leads to type 2 diabetes (T2D).
Materials And Methods: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) focuses on African American and non-Hispanic white participants aged 40-80 years without diabetes. Three study visits are planned (at baseline, 15 and 30 months).
A variant erythroferrone disrupts iron homeostasis in -mutated myelodysplastic syndrome.
Sci Transl Med
July 2019
Université de Paris, Paris 75006, France.
Myelodysplastic syndromes (MDS) with ring sideroblasts are hematopoietic stem cell disorders with erythroid dysplasia and mutations in the splicing factor gene. Patients with MDS with mutations often accumulate excessive tissue iron, even in the absence of transfusions, but the mechanisms that are responsible for their parenchymal iron overload are unknown. Body iron content, tissue distribution, and the supply of iron for erythropoiesis are controlled by the hormone hepcidin, which is regulated by erythroblasts through secretion of the erythroid hormone erythroferrone (ERFE).
View Article and Find Full Text PDFPotential Effect of the Protecting Access to Medicare Act on Use of Advanced Diagnostic Imaging in the Emergency Department: An Analysis of the National Hospital Ambulatory Care Survey.
Radiology
April 2019
From the Department of Emergency Medicine (J.F., H.K.K., R.C.W.), Center for Healthcare Value (J.F.), Philip R. Lee Institute for Health Policy Studies (H.K.K.), and Department of Radiology and Biomedical Imaging (J.M.), University of California, San Francisco, 505 Parnassus Ave, L126, San Francisco, CA 94143-0209; Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif (K.L.K.); and RAND Corporation, Santa Monica, Calif (K.L.K.).
Background Clinical decision support is increasingly used to enhance clinicians' exposure to established evidence and patient information during an episode of patient care. Pending legislation specifies clinical decision support before performing advanced imaging at emergency department (ED) visits. Purpose To estimate the volume of advanced imaging tests (CT and MRI) that would require use of clinical decision support to achieve Protecting Access to Medicare Act (PAMA) compliance in the ED.
View Article and Find Full Text PDFImplementation of Medical Homes in Federally Qualified Health Centers.
N Engl J Med
July 2017
From RAND, Arlington, VA (J.W.T., A. Kress, E.K.C., C.B., A. Kofner, A.M.), Pittsburgh (C.M.S.), Boston (M.W.F., R.M.), and Santa Monica, CA (P.J.M., B.A.W., M.K., A.R., L.H., K.L.K.); Tufts Medical Center (T.A.L.) and Brigham and Women's Hospital and Harvard Medical School (M.W.F.), Boston; David Geffen School of Medicine at UCLA, Los Angeles (K.L.K.); and the Centers for Medicare and Medicaid Services, Baltimore (K.G.).
Article Synopsis
- From 2011 to 2014, a program helped 503 federally qualified health centers achieve advanced medical-home recognition, aimed at improving patient care and access.
- About 70% of these centers reached the highest recognition level, while only 11% of comparison sites did.
- Although some service utilization decreased overall, demonstration sites experienced a relative increase in certain services and tests, despite also seeing higher emergency visits and Medicare expenditures.
Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention.
N Engl J Med
November 2016
From the Department of Pathology, Johns Hopkins University School of Medicine (M.G.F.), and the Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health (T.E.T.), Baltimore, and the Division of AIDS, National Institute of Allergy and Infectious Diseases (D.G., K.L.K., R. Browning, L.P.), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (G.K.S.), National Institutes of Health, Bethesda - all in Maryland; the Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston (M.Q., T.F., D.E.S.); the Retrovirology Core Laboratory, University of North Carolina School of Medicine, Chapel Hill (S.A.F., A.J.L.), and FHI 360, Durham (A.S.C.) - both in North Carolina; the UCLA Center for Clinical AIDS Research and Education, Los Angeles (J.S.C.); St. Jude Children's Research Hospital, Memphis, TN (P.M.F.); the Department of Obstetrics and Gynecology, College of Health Sciences, University of Zimbabwe, Harare (T.C.); Anova Health Institute (J.M.), Perinatal HIV Research Unit, University of the Witwatersrand, Faculty of Health Sciences (A.V.), and Empilweni Services and Research Unit (R.S.), Johannesburg, School of Public Health and Family Medicine, University of Cape Town (J.M.), and the Department of Obstetrics and Gynaecology, Stellenbosch University (G.B.T.), Cape Town, and the Centre for the AIDS Programme of Research in South Africa-Umlazi Clinical Research Site (D.M.) and Durban Paediatric HIV (R. Bobat), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban - all in South Africa; the University of North Carolina Project, Kamuzu Central Hospital-Tidziwe Center, Lilongwe, Malawi (F.E.M.); Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda (M.O.); the Department of Obstetrics and Gynecology, B.J. Medical College, Pune, India (R. Bhosale); the Centre for Infectious Disease Research in Zambia, Lusaka, Zambia (B.H.C.); Kilimanjaro Christian Medical Center-Duke University Collaboration, Moshi, Tanzania (P.M.); Frontier Science and Technology Research Foundation, Amherst, NY (M.B.); and the Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC (L.M.M.).
Background: Randomized-trial data on the risks and benefits of antiretroviral therapy (ART) as compared with zidovudine and single-dose nevirapine to prevent transmission of the human immunodeficiency virus (HIV) in HIV-infected pregnant women with high CD4 counts are lacking.
Methods: We randomly assigned HIV-infected women at 14 or more weeks of gestation with CD4 counts of at least 350 cells per cubic millimeter to zidovudine and single-dose nevirapine plus a 1-to-2-week postpartum "tail" of tenofovir and emtricitabine (zidovudine alone); zidovudine, lamivudine, and lopinavir-ritonavir (zidovudine-based ART); or tenofovir, emtricitabine, and lopinavir-ritonavir (tenofovir-based ART). The primary outcomes were HIV transmission at 1 week of age in the infant and maternal and infant safety.
Lymph Node Micrometastases in Early-Stage Cervical Cancer are Not Predictive of Survival.
Int J Gynecol Pathol
July 2015
Department of Obstetrics and Gynecology (M.P.S.), Division of Gynecologic Oncology Departments of Obstetrics and Gynecology (K.L.K.) Research Programs (R.S.H.), Walter Reed National Military Medical Center Uniformed Services University of the Health Sciences (C.M.Z.), Bethesda, Maryland SCL Physicians (P.J.B.S.), Denver, Colorado Department of Obstetrics and Gynecology (J.C.F., L.I.M.), Division of Gynecologic Oncology Departments of Pathology (J.C.F., C.A.A.) Preventive Medicine (S.G., W.Y.), University of Southern California Keck School of Medicine Kaiser Permanente Medical Center (S.E.L.), Los Angeles, California Sibley Memorial Hospital (M.R.C.), Washington, District of Columbia.
Although patients with early-stage cervical cancer have in general a favorable prognosis, 10% to 40% patients still recur depending on pathologic risk factors. The objective of this study was to evaluate if the presence of lymph node micrometastasis (LNmM) had an impact on patient's survival. We performed a multi-institutional retrospective review on patients with early-stage cervical cancer, with histologically negative lymph nodes, treated with radical hysterectomy and pelvic lymphadenectomy for the study period 1994 to 2004.
View Article and Find Full Text PDFHIV status and the risk of ischemic stroke among men.
Neurology
May 2015
From the VA Connecticut Health Care System (J.J.S., A.C.J., M.S., K.M.), West Haven Veterans Administration Medical Center, West Haven; Yale University School of Medicine (J.J.S., K.S.-A., A.C.J.), New Haven, CT; University of Pittsburgh School of Medicine (C.-C.H.C., K.L.K., A.A.B.); University of Pittsburgh Graduate School of Public Health (C.-C.H.C., L.H.K.), Pittsburgh, PA; Boston Medical Center (E.H.), MA; Emory University School of Medicine and Atlanta Veterans Administration Medical Center (D.R.), Atlanta, GA; David Geffen School of Medicine at UCLA and the VA Greater Los Angeles Health Care System (M.B.G., D.L.), Los Angeles, CA; VA Pittsburgh Health Care System (A.A.B.), Pittsburgh, PA; Michael E. DeBakey Veterans Administration Medical Center and Baylor College of Medicine (M.C.R.-B.), Houston, TX; Washington DC Veterans Administration Medical Center and George Washington University School of Medicine (C.G.), Washington, DC; James J. Peters VA (S.T.B.), Bronx; Mount Sinai School of Medicine (S.T.B.), New York, NY; Boston University School of Medicine (J.S.), MA; Center for the Assessment of Pharmaceutical Practices (L.K.), Department of Health Policy and Management, Boston University School of Public Health; Center for Healthcare Organization and Implementation Research (L.K.), a Center for Innovation, Veterans Administration Medical Center, Bedford, MA; National Institute on Alcohol Abuse and Alcoholism (K.B.), Bethesda, MD; and Vanderbilt University School of Medicine and the Nashville Veterans Affairs Medical Center (M.S.F.), Nashville, TN.
Objective: Given conflicting data regarding the association of HIV infection and ischemic stroke risk, we sought to determine whether HIV infection conferred an increased ischemic stroke risk among male veterans.
Methods: The Veterans Aging Cohort Study-Virtual Cohort consists of HIV-infected and uninfected veterans in care matched (1:2) for age, sex, race/ethnicity, and clinical site. We analyzed data on 76,835 male participants in the Veterans Aging Cohort Study-Virtual Cohort who were free of baseline cardiovascular disease.
Blunt abdominal aortic injury: a Western Trauma Association multicenter study.
J Trauma Acute Care Surg
December 2014
From the Division of Vascular Surgery (S.S., B.W.S.), Department of Surgery, University of Washington, Seattle, Washington; R. Adams Cowley Shock Trauma Center (M.L.B.), University of Maryland, Baltimore, Maryland; Department of Surgery (W.L.B., G.J.J.), Denver Health Medical Center and the University of Colorado School of Medicine, Denver, Colorado; Department of Cardiothoracic and Vascular Surgery (A.A.), University of Texas Medical School at Houston; and Department of Surgery (R.A.K.), University of Texas Health Science Center at Houston, Houston, Texas; Division of Trauma and Surgical Critical Care (K.I., D.S.), Department of Surgery, Keck School of Medicine, Los Angeles County + University of Southern California Medical Center, Los Angeles; and Community Regional Medical Center (K.L.K.), Department of Surgery, University of California, San Francisco-Fresno Campus, Fresno, California; Division of Trauma and Critical Care (B.Z., C.N.), Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee; Division of General Surgery (E.A.E., S.M.F.), Department of Surgery, Medical University of South Carolina, Charleston, South Carolina; Division of Trauma and Critical Care (J.S.P.), Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Surgery (D.J.C.), University of South Florida Colleges of Medicine, Tampa, Florida; Department of Surgery (S.R.T.), New York University Langone Medical Center, New York, New York; Division of Trauma and Surgical Critical Care (M.J.S., L.M.C.-W.), Department of Surgery, Cooper University Hospital, Camden, New Jersey.
Background: Blunt abdominal aortic injury (BAAI) is a rare injury. The objective of the current study was to examine the presentation and management of BAAI at a multi-institutional level.
Methods: The Western Trauma Association Multi-Center Trials conducted a study of BAAI from 1996 to 2011.