776 results match your criteria: "London North West University Healthcare.[Affiliation]"

Introduction Mind The Bleep (MTB) is a junior doctor-led online education organisation that produces free open-access medical education (FOAMed) resources. This paper describes MTB vascular surgery online education programme. The target audience was early postgraduate doctors completing a rotation in vascular surgery.

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Article Synopsis
  • Gelling-fibre dressings, like Suprasorb Liquacel Pro, are effective for managing wound exudate by forming a gel upon contact with fluids, which helps maintain a moist environment conducive to healing.
  • These dressings trap cell debris and bacteria within their fibers, aiding in cleanliness during dressing changes.
  • Suprasorb Liquacel Ag enhances this effectiveness with nanosilver, providing antimicrobial properties that help reduce bacterial presence and improve wound care.
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Introduction: Interventional radiology (IR) is a rapidly developing speciality where innovation-especially in teaching practices-is vital. With workforce and capacity shortages, synthesis of classical educational theories and novel strategies utilising virtual reality (VR) and artificial intelligence (AI) provide opportunities to make teaching as efficient and effective as possible. The aim of this review is to examine the literature on different approaches in IR teaching and learning in undergraduates and postgraduates.

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  • Cystoscopy has improved bladder cancer diagnosis, but there's variability among experts in assessing tumor stage and grade, prompting the integration of AI to enhance image analysis.
  • A systematic review and meta-analysis will be conducted using articles from specified databases published between May 2015 and April 2024, focusing on studies utilizing AI for cystoscopic image analysis of bladder cancer.
  • No ethical clearance is needed for this review, and the findings will be shared through peer-reviewed publications and conferences.
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What are the experiences of pregnancy for women living with Inflammatory Bowel Disease?

Midwifery

January 2025

The Elizabeth Bryan Multiple Births Centre, Birmingham City University, School of Health Sciences, Birmingham B15 3TN, UK.

Background: Inflammatory Bowel Disease (IBD) is a long-term condition affecting the digestive tract and is an umbrella term for two main conditions: ulcerative colitis (UC) and Crohn's Disease (CD), which can cause diarrhoea, anaemia, weight loss, rectal bleeding and abdominal pain. Approximately 500,000 people live with IBD in the UK, with half being diagnosed before the age of 35 years (Ferguson, Mahsud-Dornan, and Patterson 2008). IBD increases the risk of pregnancy complications, with symptoms being unpredictable during pregnancy.

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Ceftriaxone-resistant Neisseria gonorrhoeae detected in England, 2015-24: an observational analysis.

J Antimicrob Chemother

December 2024

Blood Safety, Hepatitis, STI & HIV Division, United Kingdom Health Security Agency, London, UK.

Objectives: Since June 2022, there has been a rise in the number of ceftriaxone-resistant Neisseria gonorrhoeae cases detected in England (n = 15), of which a third were XDR. We describe the demographic and clinical details of the recent cases and investigate the phenotypic and molecular characteristics of the isolates. For a comprehensive overview, we also reviewed 16 ceftriaxone-resistant cases previously identified in England since December 2015 and performed a global genomic comparison of all publicly available ceftriaxone-resistant N.

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  • The study aimed to evaluate the effectiveness of biodegradable temporising matrix (BTM) in reconstructing complex wounds through a systematic review and meta-analysis following PRISMA guidelines.
  • It analyzed data from 26 studies involving 1153 complex wounds, finding high integration rates (92.7%) and low infection rates (12.6%) with positive scar outcomes.
  • The authors concluded that BTM serves as a strong dermal template for wound reconstruction, suggesting further randomized controlled trials to strengthen the findings.
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Steroids in severe community-acquired pneumonia.

Breathe (Sheff)

October 2024

Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Article Synopsis
  • There are conflicting findings on the effectiveness of steroids for treating severe community-acquired pneumonia (CAP), with past studies having small sample sizes.
  • Recent large trials, ESCAPe and CAPE COD, evaluated different steroid treatments and timing, with ESCAPe not showing any significant difference in mortality, while CAPE COD found hydrocortisone improved short-term survival and reduced complications.
  • Differences in study design, including patient characteristics and steroid regimens, highlight the need for further research to establish the best dosing and long-term effects of steroid use in severe CAP.
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Background: Anaesthetists of all grades who work on a labour ward are likely to be involved in the insertion or management of an intrathecal catheter after inadvertent dural puncture at some point in their careers. Although the use of intrathecal catheters after inadvertent dural puncture in labour has increased in popularity over recent decades, robust evidence on best practice has been lacking.

Methods: The Obstetric Anaesthetists' Association set up an expert working party to review the literature.

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Incidental findings in research brain MRI: Definition, prevalence and ethical implications.

J Med Imaging Radiat Oncol

September 2024

Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.

Radiological incidental findings (IFs) are previously undetected abnormalities which are unrelated to the original indication for imaging and are unexpectedly discovered. In brain magnetic resonance imaging (MRI), the prevalence of IFs is increasing. By reviewing the literature on IFs in brain MRI performed for research purposes and discussing ethical considerations of IFs, this paper provides an overview of brain IF research results and factors contributing to inconsistencies and considers how the consent process can be improved from an ethical perspective.

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Objectives: The development of technical skills in peripheral and aortic endovascular intervention is an essential part of interventional radiology (IR) training. Access to endovascular training remains contentious, with IR and vascular surgery (VS) trainees competing for opportunities. The Collaborative Peripheral and Aortic Endovascular Training Survey (CPAETS) aimed to evaluate IR trainees' experiences, expectations, and barriers to endovascular training.

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Background: A consensus definition for active sacroiliitis by MRI, mentioned in the Assessment of SpondyloArthritis International Society (ASAS) classification criteria for axial spondyloarthritis (axSpA), was published in 2009 and included a qualitative and quantitative MRI cut-off component. In 2021, updates to the quantitative component were preliminarily proposed. This post hoc analysis of part A of the phase 3 open-label C-OPTIMISE study (NCT02505542) explores the differences by applying the 2009 and preliminary 2021 inflammatory cut-offs on clinical outcomes of axSpA patients treated with certolizumab pegol.

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Background: Carpal tunnel syndrome (CTS) is a very common clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the carpal tunnel in the wrist. Direct and indirect costs of CTS are substantial, with estimated costs of two billion US dollars for CTS surgery in the USA alone. Local corticosteroid injection has been used as a non-surgical treatment for CTS for many years, but its effectiveness is still debated.

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Background: Actinomyces spp. are most commonly found in human commensal flora; however, they have also been shown to cause suppurative infections. We present a case of a rare Actinomyces funkei bacteraemia from an infected deep vein thrombosis in a patient who went on to develop pulmonary cavities secondary to septic emboli.

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Pelvic exenteration (PE) is a radical surgical approach designed for the curative treatment of advanced pelvic malignancies, requiring en-bloc resection of multiple pelvic organs. While the procedure is radical, it has shown promise in enhancing long-term survival and is now comparable in surgical mortality to elective resections for primary pelvic cancers. Imaging plays a crucial role in preoperative planning, with MRI, CT, and PET/CT being pivotal in assessing the extent of cancer and formulating a surgical roadmap.

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Background: The American Society for Gastrointestinal Endoscopy recommends prophylactic antibiotics before endoscopic retrograde cholangiopancreatography (ERCP) in primary sclerosing cholangitis (PSC). We assessed the impact of this approach on the incidence of post-ERCP outcomes using nationwide data.

Methods: Using 2015-2021 Nationwide Inpatient Sample data and relevant ICD-10 codes, we analyzed adult hospitalizations for PSC who underwent ERCP, with and without antibiotic prophylaxis.

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Silicosis due to artificial stone (AS) has emerged over the last decade as an increasing global issue. We report the first eight UK cases. All were men; median age was 34 years (range 27-56) and median stone dust exposure was 12.

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