Peripheral arterial rather than venous blood is a better source of circulating tumor cells in early lung cancer.

Background: Circulating tumor cells (CTCs) play a crucial role in the early diagnosis and prognosis of lung cancer. Identification of a more suitable sample source could be a breakthrough towards enhancing CTC detectability in early-stage lung cancer. We investigated the differences in detectable CTCs between peripheral arterial and venous blood in early- and mid-stage lung cancer patients undergoing surgery and analyzed the association between clinicopathological factors and detectable CTCs in peripheral arterial and venous blood.

A UWB/INS Trajectory Tracking System Application in a Cycling Safety Study.

This paper focuses on the safety issue for cyclists and pedestrians at unsignalized intersections. The cycling speed needs to be calmed when approaching the intersection. This study proposes and deploys an integrated portable ultra-wideband/inertial navigation system (UWB/INS) to extract cycling trajectories for a cycling safety study.

Polymeric Micelles for the Enhanced Deposition of Hydrophobic Drugs into Ocular Tissues, without Plasma Exposure.

Commercial topical ocular formulations for hydrophobic actives rely on the use of suspensions or oil in water emulsions and neither of these formulation modalities adequately promote drug penetration into ocular tissues. Using the ocular relevant hydrophobic drug, cyclosporine A (CsA), a non-irritant ocular penetration enhancer is showcased, which may be used for the formulation of hydrophobic actives. The activity of this penetration enhancer is demonstrated in a healthy rabbit model.

Acting Upon Uncertain Beliefs.

This paper discusses the conditions under which an agent is rationally permitted to leave some uncertain propositions relevant to her decision out of her deliberation. By relying on the view that belief involves a defeasible disposition to treat a proposition as true in one's reasoning, we examine the conditions under which such a disposition can be overridden and under which an agent should take into account her uncertainty as to a proposition she believes in the course of a particular deliberation. We argue that, in some contexts, an agent can be faced with the choice of either accepting or not accepting a proposition she believes in the course of her deliberation.