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Urinary Hypoxanthine as a Measure of Increased ATP Utilization in Late Preterm Infants.

Infant Child Adolesc Nutr

August 2014

Departments of Basic Sciences (MSH, LS, YA, DSB, DA) and Pediatrics (AH), Loma Linda University School of Medicine; Department of Earth and Biological Sciences, Loma Linda University School of Public Health (IE), Loma Linda, California.

Objective: To examine the effect of neonatal morbidity on ATP breakdown in late preterm infants.

Study Design: Urinary hypoxanthine concentration, a marker of ATP breakdown, was measured from 82 late preterm infants on days of life (DOL) 3 to 6 using high-performance liquid chromatography. Infants were grouped according to the following diagnoses: poor nippling alone (n = 8), poor nippling plus hyperbilirubinemia (n = 21), poor nippling plus early respiratory disease (n = 26), and respiratory disease alone (n = 27).

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