3 results match your criteria: "Location VU University Medical Centre Amsterdam[Affiliation]"

Article Synopsis
  • Normal bone remodeling requires a balance between osteoblasts (bone formation) and osteoclasts (bone resorption), which is disrupted in chronic inflammatory diseases like rheumatoid arthritis.
  • Chronic inflammation leads to low bone density and higher fracture risk due to factors like cytokines, reduced mobility, glucocorticoid use, and low vitamin D levels.
  • Future research is needed to better understand fracture risks in chronic arthritides and the effectiveness of various treatments to improve bone health.
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Long-term glucocorticoid (GC) therapy is frequently indicated to treat autoimmune and chronic inflammatory diseases in daily clinical practice. Two of the most devastating untoward effects are bone loss and fractures. Doses as low as 2.

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