Photodynamic Therapy in Cancer: Principles, State of the Art, and Future Directions.

Since its discovery more than 100 years ago, photodynamic therapy (PDT) has become a potent strategy for the treatment of many types of cancer [...

Influence of early-life stress on hippocampal synaptic and network properties.

According to the World Health Organization, the number of people suffering from depressive disorders worldwide is approaching 350 million. The consequences of depressive disorders include considerable worsening of the quality of life, which frequently leads to social isolation. One of the key factors which may cause depression in adulthood is early life stress, in particular, insufficient maternal care during infancy.

Developing Chlorin/Arylaminoquinazoline Conjugates with Nanomolar Activity for Targeted Photodynamic Therapy: Design, Synthesis, SAR, and Biological Evaluation.

In this report, we developed novel chlorin/arylaminoquinazoline conjugates for targeted photodynamic therapy of cancer. The synthesized photosensitizers consisted of chlorin- metallocomplexes (Zn, In, or Pd) conjugated with arylaminoquinazoline ligands with high affinity for epidermal growth factor receptors (EGFR). Additionally, the selectivity and antitumor properties of the conjugates were investigated in the EGFR-expressing A431 human tumor cell line .

The Dose Rate of Corpuscular Ionizing Radiation Strongly Influences the Severity of DNA Damage, Cell Cycle Progression and Cellular Senescence in Human Epidermoid Carcinoma Cells.

Modern radiotherapy utilizes a broad range of sources of ionizing radiation, both low-dose-rate (LDR) and high-dose-rate (HDR). However, the mechanisms underlying specific dose-rate effects remain unclear, especially for corpuscular radiation. To address this issue, we have irradiated human epidermoid carcinoma A431 cells under LDR and HDR regimes.

An expert consensus statement on biomarkers of ageing for use in intervention studies.

Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method.

Preliminary Treatment by Exogenous 24-Epibrassinolide Influences Burning-Induced Electrical Signals and Following Photosynthetic Responses in Pea ( L.).

Long-distance electrical signals (ESs) are an important mechanism of induction of systemic adaptive changes in plants under local action of stressors. ES-induced changes in photosynthesis and transpiration play a key role in these responses increasing plant tolerance to action of adverse factors. As a result, investigating ways of regulating electrical signaling and ES-induced physiological responses is a perspective problem of plant electrophysiology.

Characteristics of Callus and Cell Suspension Cultures of Highbush Blueberry ( L.) Cultivated in the Presence of Different Concentrations of 2,4-D and BAP in a Nutrient Medium.

In this work, cultures of callus and suspension cells originating from leaves of sterile highbush blueberry ( L.) plants were obtained and characterized. For their active growth and production of phenolic compounds, a combination of 2,4-D at a concentration of 0.

Nanoparticles for Creating a Strategy to Stimulate Liver Regeneration.

Unlabelled: Presently, there is a need in the developing new approaches to stimulate liver regeneration, which would make its recovery more effective after resection. Application of nanoparticles, loaded with small bioactive molecules, with their targeted delivery into the liver is a promising approach. is to study the interaction of nanoparticles with various types of hepatic cells on the models of liver slices and primary hepatic cell cultures using the methods of multiphoton microscopy with fluorescence lifetime imaging.

A Method for Assessing Working Memory in Rats Using Controlled Virtual Environment.

Unlabelled: is to develop an experimental method to effectively assess the working memory in rats. The method uses a state-of-the-art controlled virtual environment with a virtual maze. The setup includes a treadmill for rodents, a fixation system, a dome for displaying virtual environment, and a control unit.

Memristor-based model of neuronal excitability and synaptic potentiation.

In this manuscript, we investigate the memristor-based implementation of neuronal ion channels in a mathematical model and an experimental circuit for a neuronal oscillator. We used a FitzHugh-Nagumo equation system describing neuronal excitability. Non-linearities introduced by the voltage-gated ion channels were modeled using memristive devices.

Antibacterial effect of new photocatalytically active "complex oxides/PMMA" composites under visible-light irradiation.

New photocatalytic materials based on complex oxides and a widely used and cheap polymer (PMMA) have been prepared. Among complex oxides previously investigated, the following have been used-RbTeWO, CsTeMoO, CsVTeO, NaVMoO, KVMoO. For comparison, the binary oxides TiO and WO were used.

Development of Analytical Model to Describe Reflectance Spectra in Leaves with Palisade and Spongy Mesophyll.

Remote sensing plays an important role in plant cultivation and ecological monitoring. This sensing is often based on measuring spectra of leaf reflectance, which are dependent on morphological, biochemical, and physiological characteristics of plants. However, interpretation of the reflectance spectra requires the development of new tools to analyze relations between plant characteristics and leaf reflectance.

Circular RNAs as multifaceted molecular regulators of vital activity and potential biomarkers of aging.

Aging presents a significant challenge to health and social care systems due to the increasing proportion of the elderly population. The identification of reliable biomarkers to assess the progression of aging remains an unresolved question. Circular RNAs (circRNAs) are single-stranded covalently closed RNAs.

Mini-review on laser-induced nanoparticle heating and melting.

The development of various nanomaterials production technologies has led to the possibility of producing nanoparticles (NPs) and nanostructures, which can find a wide range of applications, from the fabrication of microelectronic devices to the improvement of material properties and the treatment of cancer. The unique characteristics of nanoparticles are primarily due to their small size, which makes size control important in their preparation. Modification of nanoparticles by laser irradiation and obtaining desired nanoparticle properties is a promising approach because of its ease of implementation.

Diagnosis of Skin Burn-Induced Colon Circulatory Disorders Using Optical Coherence Tomography Angiography and Laser Doppler Flowmetry (Experimental Study).

Unlabelled: The condition of gastrointestinal tract determines in many respects the regenerative capacity and the risk of complications in patients with extensive skin burns. However, the mechanism of developing vascular dysfunction in the colon in the burned individuals has so far been poorly studied. is to study intramural circulatory disorders of the colon using optical coherence tomography angiography (OCTA) and laser Doppler flowmetry (LDF) in different time periods after modeling a thermal burn.

Antibacterial Properties of Copper Oxide Nanoparticles (Review).

The use of metal and metal oxide nanoparticles is frequently regarded as a potential solution to the issue of bacterial antibiotic resistance. Among the proposed range of nanoparticles with antibacterial properties, copper oxide nanoparticles are of particular interest. Although the antibacterial properties of copper have been known for a considerable period of time, studies on the effects of copper oxide nanomaterials with respect to biological systems have attracted considerable attention in recent years.

Generation and Characterization of Three Novel Mouse Mutant Strains Susceptible to Audiogenic Seizures.

The mechanisms of epileptogenesis after brain injury, ischemic stroke, or brain tumors have been extensively studied. As a result, many effective antiseizure drugs have been developed. However, there are still many patients who are resistant to therapy.

A Review on Recently Developed Antibacterial Composites of Inorganic Nanoparticles and Non-Hydrogel Polymers for Biomedical Applications.

Development of new antibacterial materials for solving biomedical problems is an extremely important and very urgent task. This review aims to summarize recent articles (from the last five and mostly the last three years) on the nanoparticle/polymer composites for biomedical applications. Articles on polymeric nanoparticles (NPs) and hydrogel-based systems were not reviewed, since we focused our attention mostly on the composites of polymeric matrix with at least one inorganic filler in the form of NPs.

Enhancing glioma treatment with 3D scaffolds laden with upconversion nanoparticles and temozolomide in orthotopic mouse model.

Targeted drug delivery for primary brain tumors, particularly gliomas, is currently a promising approach to reduce patient relapse rates. The use of substitutable scaffolds, which enable the sustained release of clinically relevant doses of anticancer medications, offers the potential to decrease the toxic burden on the patient's organism while also enhancing their quality of life and overall survival. Upconversion nanoparticles (UCNPs) are being actively explored as promising agents for detection and monitoring of tumor growth, and as therapeutic agents that can provide isolated therapeutic effects and enhance standard chemotherapy.