Histological assessment of extensive or unresectable central giant cell granulomas treated with denosumab - A case series.

Objective: The management of large central giant cell granuloma (CGCG) can pose a significant surgical challenge. In such circumstances, the use of denosumab has been proposed with the literature reporting varying degrees of success. Histopathological assessment of CGCG post-denosumab treatment remains unknown.

Right upper quadrant pain after previous blunt abdominal trauma: undiagnosed traumatic diaphragmatic hernia with strangulated right colon.

A woman in her 40s self-presented to an emergency department in a major trauma centre with severe right-sided abdominal pain, a tender right upper quadrant mass and chest pain. Diagnostic imaging showed a previously undiagnosed diaphragmatic hernia containing strangulated right colon. The patient had been the victim of a high-energy road traffic accident 18 months earlier, but at that time had not presented to hospital or undergone any outpatient investigation.

Comparative Assessment of the Burden of Injury in Sub-Saharan Africa: An Analysis of Estimates From Global Burden of Disease 2021 Study.

Objectives Surgical care for traumatic injuries remains a major concern to public health in sub-Saharan Africa. The 2030 Agenda for Sustainable Development recognizes rising inequalities in global health. The objectives of this study were to compare the Global Burden of Disease (GBD) 2021 estimates on injury mortality and disability across sub-Saharan sub-regions by cause-of-injury category.

Clinical remission among severe asthmatics on monoclonal antibody therapy: real-world outcomes at 2 years.

https://bit.ly/4cA6TkG.

Stigma, depression, and quality of life among people with pulmonary tuberculosis diagnosed through active and passive case finding in Nepal: a prospective cohort study.

Background: The psychosocial consequences of tuberculosis (TB) are key barriers to ending TB globally. We evaluated and compared stigma, depression, and quality of life (QoL) among people with TB diagnosed through active (ACF) and passive (PCF) case-finding in Nepal.

Methods: We prospectively recruited adults with TB diagnosed through ACF and PCF in four districts of Nepal between August 2018 and April 2019.

Long-term Follow Up of a Complex Case of Foldable Capsular Vitreous Bag Implantation.

Purpose: The Foldable Capsular Vitreous Bag (FCVB) implant is useful in maintaining ocular structure in cases of chronic hypotony secondary to trauma or repeated surgery. There are few published reports of long-term outcomes and no indication of the chronic cellular changes of the adjacent tissues associated with FCVB implantation. We describe one of few FCVB cases in the UK and present histological findings associated with it following secondary enucleation.

Opportunities for nurses aspiring to or undertaking clinical academic development globally: protocol for a scoping review.

Introduction: Nurse researchers often lack awareness of how to start a clinical academic research career and often lack clear entry routes. This scoping review aims to identify the range and nature of clinical academic opportunities available for nurses. This will also identify the knowledge gaps and provide the basis for future research.

Relaxin agonists under preclinical and early clinical investigation for the treatment of heart failure.

Introduction: Acute failure is a critical condition, encompassed by the sudden or progressive onset of symptoms or signs of congestion. The treatment strategies available are mainly supportive and do not improve mortality or long-term outcomes. Therefore, there is a need for alternative novel treatment strategies.

Ablative techniques in colorectal liver metastases: A systematic review, descriptive summary of practice, and recommendations for optimal data reporting.

Background: Radiofrequency Ablation (RFA) and Microwave Ablation (MWA) are alternative treatments for colorectal liver metastasis (CRLM) patients that are unsuitable for resection. However, consensus is lacking regarding selection criteria, tumour characteristics, ablation technique delivery, and device settings. This study aims to summarise current evidence to inform future prospective studies.

The history of uveitis: from antiquity to the present day.

This comprehensive review traces the historical understanding and treatment of uveitis from ancient civilisations to modern medicine, a history which reflects the evolution of medical understanding and practice in general. Early descriptions of ocular inflammation appear in Egyptian medical papyri from 1700 BCE, with subsequent contributions from Greek and Roman physicians, including Hippocrates and Galen, who provided foundational observations of ocular inflammatory conditions. Medieval scholars in the Middle East, particularly Avicenna, preserved and advanced classical knowledge while recognising the systemic nature of ocular inflammation.

Psychological interventions for weight reduction and sustained weight reduction in adults with overweight and obesity: a scoping review.

Introduction: Overweight and obesity are growing public health problems worldwide. Both diet and physical activity have been the primary interventions for weight reduction over the past decade. With increasing rates of overweight and obesity, it is evident that a primary focus on diet and exercise has not resulted in sustained obesity reduction within the global population.

The landscape and level of alcohol policy enforcement in Tanzania.

Harmful use of alcohol causes more deaths in Sub-Saharan Africa than in any other region. In Tanzania, where alcohol use disorders rates are twice the overall African average, harmful alcohol consumption is a public health concern. Given the lack of a contemporary overview of the alcohol policy landscape, we conducted a mixed-methods review of key alcohol-related policies, implementers, and initiatives in Tanzania.

Correction: Butt et al. Conjunctival Melanoma: A Clinical Review and Update. 2024, 3121.

The authors would like to include the following acknowledgment in the publication [...

Rapid and non-invasive analysis of paracetamol overdose using paper arrow-mass spectrometry: a prospective observational study.

Background: Paracetamol is the most consumed medicine globally. Its accessibility contributes to common overdose. Paracetamol overdose is responsible for > 50% of acute liver failure cases, making it the second most common reason for a liver transplant.