4 results match your criteria: "Liver Research Institute and Seoul National University College of Medicine[Affiliation]"
GPR15 in colon cancer development and anti-tumor immune responses.
Front Oncol
November 2023
Division of Gastroenterology and Hepatology, Department of Medicine, School of Medicine, Stanford University, Stanford, CA, United States.
Introduction: The chemoattractant receptor, G protein-coupled receptor 15 (GPR15), promotes colon homing of T cells in health and colitis. GPR15 function in colon cancer is largely unexplored, motivating our current studies.
Methods: In human study, immune cells were isolated from tumor tissues and healthy surgical tumor margins (STM), and their proportions as well as expression of GPR15 was analyzed by flow cytometry.
Regulation of psoriasis, colitis, and the intestinal microbiota by clusterin.
Sci Rep
September 2023
Laboratory of Intestinal Mucosa and Skin Immunology, Liver Research Institute and Seoul National University College of Medicine, Seoul, Korea.
Article Synopsis
- - Psoriasis is a chronic inflammatory condition linked to the activation of the IL-23/IL-17 pathway and may be influenced by the gut-skin connection and intestinal microbiota.
- - Researchers studied the impact of clusterin, a glycoprotein, on psoriatic skin inflammation and related systemic issues in a mouse model, revealing that its absence reduced inflammation and altered gut microbiota composition.
- - High clusterin levels were found in the skin of psoriasis patients, suggesting that inhibiting clusterin could potentially reduce symptoms like skin inflammation and colitis while affecting gut microbiota ratios.
Protein stabilization of ITF2 by NF-κB prevents colitis-associated cancer development.
Nat Commun
April 2023
Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Chronic colonic inflammation is a feature of cancer and is strongly associated with tumorigenesis, but its underlying molecular mechanisms remain poorly understood. Inflammatory conditions increased ITF2 and p65 expression both ex vivo and in vivo, and ITF2 and p65 showed positive correlations. p65 overexpression stabilized ITF2 protein levels by interfering with the binding of Parkin to ITF2.
View Article and Find Full Text PDFKorean clinical practice guidelines on biologics for moderate to severe Crohn's disease.
Intest Res
January 2023
Department of Internal Medicine, Liver Research Institute and Seoul National University College of Medicine, Seoul, Korea.
Crohn's disease (CD) is a relapsing and progressive condition characterized by diarrhea, abdominal pain, weight loss, and hematochezia that results in serious complications such as perforations, fistulas, and abscesses. Various medications, interventions, and surgical treatments have been used to treat CD. The Korean guidelines for CD management were distributed in 2012 and revised in 2017 by the Inflammatory Bowel Disease (IBD) Research Group of the Korean Association for the Study of Intestinal Diseases.
View Article and Find Full Text PDF