Prevalence and associations of neurodevelopmental and mental health disorders with academic and well-being challenges among nursing and midwifery students: A cross-sectional study.

Introduction: This study highlights the significant stress faced by nursing and midwifery students stemming from the rigorous requirements of their curriculum, which includes both demanding theoretical and practical elements. This study aims to identify the causes and manifestations of learning environment stress among midwifery and nursing students.

Methods: A cross-sectional study in Lithuania, Poland and Latvia was employed to evaluate students' learning challenges and neurodiversity using 40 different questions assessed on a Likert scale.

Development of a cell-type cylindrical carrot seeder.

Accurate planting of the required number of carrot seeds is one of the important parameters in developing a carrot seeding device. This study developed a metering mechanism that promotes the deposition of <3 carrot seeds on each planting hill at negligible seed damage. The metering disc and hopper were especifically designed to ensure consistency and uniformity in seed loading into the seed cell and their subsequent efficient discharge onto the planting hills.

BAY 81-8973 Demonstrates Long-Term Safety and Efficacy in Children With Severe Haemophilia A: Results From the LEOPOLD Kids Extension Study.

Objectives: To report the long-term safety and efficacy of BAY 81-8973 in the LEOPOLD Kids extension phase.

Methods: Patients received BAY 81-8973 (25-50 IU/kg) at least twice weekly. The primary endpoint was safety, assessed in all patients who entered the extension phase (n = 82).

Comprehensive tetracycline, ciprofloxacin and sulfamethoxazole toxicity evaluation to earthworm Dendrobaena veneta through life-cycle, behavioral and biochemical parameters.

Veterinary antibiotics are widely spread in the environment, however, the knowledge about their impact on soil key species is still limited. This study evaluated the short-term and long-term effects of tetracycline (TC), ciprofloxacin (CIP) and sulfamethoxazole (SMX) (1-500 mg kg) on earthworm Dendrobaena veneta by measuring multiple parameters (survival, growth, reproduction, behavior and biochemical responses). Neither antibiotic induced acute toxicity and low mortality was observed after chronic exposure.

Characterization of human Urotensin II peptide adsorbed on silver electrode by surface-enhanced Raman scattering spectroscopy.

The cyclic human neuropeptide Urotensin II (hU-II) is an important regulatory peptide found in the central nervous system, cardiovascular system, kidney, etc., however, its conformational structure and dynamics in aqueous solutions have not been studied in detail experimentally. In the present study, the structure of hU-II and the mechanism of its adsorption on the electrochemically roughened Ag electrode are investigated using electrochemical surface-enhanced Raman scattering spectroscopy (EC-SERS) in the voltage range from -1.

Cuticular Hydrocarbons as Putative Sex Pheromones and Mating Peculiarity of Cuckoo Wasps Chrysis Angustula, Chrysis fulgida and Chrysis Iris (Hymenoptera: Chrysididae).

Cuckoo wasps, also known as jewel or gold wasps (Hymenoptera: Chrysididae), are kleptoparasites and parasitoids that impose their offspring on the breeding efforts of other wasp species. Chrysidids oviposit in the nests of predatory wasps, and the hatched larva kills the host's larva and consumes the resources collected by the host. When a cuckoo wasp is detected by the host wasp, the host may abandon the nest or take other measures to prevent the development of the kleptoparasite.

TissueGene-C induces anti-inflammatory activity and M2 macrophage polarization via activation of prostaglandin E signaling.

Background And Aim: Osteoarthritis (OA) is the most common form of degenerative joint disease that commonly affects the knees, hips and hands. OA is a mechano-inflammatory disease characterized by low-grade inflammation, which results in breakdown of the cartilage extracellular matrix within joints, leading to pain, stiffness and inflammation. TissueGene-C (TG-C) is a cell and gene therapy investigational drug for treating knee OA that comprises human allogeneic chondrocytes and an irradiated modified cell line stably expressing transforming growth factor beta 1 (TGF-β1).

Amino acid sequence encodes protein abundance shaped by protein stability at reduced synthesis cost.

Understanding what drives protein abundance is essential to biology, medicine, and biotechnology. Driven by evolutionary selection, an amino acid sequence is tailored to meet the required abundance of a proteome, underscoring the intricate relationship between sequence and functional demand. Yet, the specific role of amino acid sequences in determining proteome abundance remains elusive.

Cataract surgical training: Analysis of the results of the European Board of Ophthalmology survey in the Swiss cohort.

Introduction: This study, part of a series, analyses the Swiss cohort from an EBO survey on cataract surgery training in Europe, focusing on Switzerland's unique program. The survey identifies two models: training all residents in surgery, and a "high-volume surgeon" model where only some learn CS post-residency.

Methods: This study analyses the survey results of Swiss participants in the EBO examinations (2018-2022) and compared them with the most important cohorts (Germany, France and Spain).

Structure and mechanism of the Zorya anti-phage defense system.

Zorya is a recently identified and widely distributed bacterial immune system that protects bacteria from viral (phage) infections. Three Zorya subtypes have been discovered, each containing predicted membrane-embedded ZorAB complexes paired with soluble subunits that differ among Zorya subtypes, notably ZorC and ZorD in type I Zorya systems. Here, we investigate the molecular basis of Zorya defense using cryo-electron microscopy, mutagenesis, fluorescence microscopy, proteomics, and functional studies.

Understanding spatio-temporal complexity of vegetation using drones, what could we improve?

Unraveling the intricate spatial and temporal complexities of vegetation represents a crucial key to understanding ecosystem functioning. Drones, as cutting-edge technology, hold immense potential in bridging the gap between on-ground measurements and satellite remote sensing data. Nonetheless, a multitude of challenges still looms, with one of the foremost being the nuanced identification of scales that strike a balance between capturing maximum complexity while minimizing measurement errors.

Chemistry of Street Art: Neural Network for the Spectral Analysis of Berlin Wall Colors.

This research starts with the analysis of some fragments of the Berlin Wall street art for the characterization of the painting materials. The spectroscopic results provide a general description of the paint executive technique but more importantly open the way to a new advantage of Raman application to the analytic analysis of acrylic colors. The study highlights the correlation between peak intensity and compound percentage and explores the powerful application of deep learning for the quantification of a pigment mixture in the acrylic commercial products from Raman spectra acquired with hand-held equipment (BRAVO by Bruker).

'God is always on my side': internal and external predictors of workplace bullying targets' help-seeking behavior in a religious context.

Workplace bullying is a pervasive issue that affects millions of individuals worldwide, leading to severe psychological and social consequences. This study examines the factors influencing the decisions of religious individuals who have experienced workplace bullying, with an explicit focus on their choice to seek help from their religious community. The study involved respondents from various religious groups, most of whom were Roman Catholic.

Ecology and Current Distribution of Three Habitat-Specialized Land Snail Species of the Genus (Gastropoda: Eupulmonata) in Europe.

Our understanding of species distribution and ecology is critical to properly assess their conservation status. , , and have the centre of their current distribution in northern Europe, where their occurrence is relatively frequent. However, to the south their occurrence is fragmented and restricted to sites of late glacial/early Holocene origin.

The subarctic ancient Lake El'gygytgyn harbours the world's northernmost 'limnostygon community' and reshuffles crangonyctoid systematics (Crustacea, Amphipoda).

The northward distribution limit of groundwater fauna is generally dictated by the extent of glacial ice sheets during the Pleistocene. However, some taxa can be found far above this limit, sometimes on isolated oceanic islands, implying long-term survival in subglacial subterranean refugia. Here we report a peculiar assemblage comprising two new depigmented and blind (stygomorphic) amphipods from the subarctic ancient lake El'gygytgyn (northern Far East): Palearcticarellus hyperboreus sp.

Mobile app review analysis for crowdsourcing of software requirements: a mapping study of automated and semi-automated tools.

Mobile app reviews are valuable for gaining user feedback on features, usability, and areas for improvement. Analyzing these reviews manually is difficult due to volume and structure, leading to the need for automated techniques. This mapping study categorizes existing approaches for automated and semi-automated tools by analyzing 180 primary studies.

Prospective comparative clinical trials of novel non-invasive intracranial pressure pulse wave monitoring technologies: preliminary clinical data.

Intracranial pressure (ICP) monitoring is crucial in the management of traumatic brain injury (TBI) and other neurological conditions. Elevated ICP or too low intracranial compliance (ICC) can compromise brain perfusion. Simultaneous monitoring of ICP and ICC is needed to optimize patient-specific brain perfusion in pathological conditions.

Prolonged antithrombotic treatment after de-escalation of dual antiplatelet therapy in patients after acute coronary syndrome - which strategy should be applied? The ELECTRA-SIRIO 2 investigators standpoint.

De-escalation of dual antiplatelet (DAPT) intensity may be considered in patients with high risk of bleeding after acute coronary syndrome. Some high risk patients after de-escalation may require antithrombotic therapy prolonged over 12 months. With the current guideline recommended strategies, there are some doubts and uncertainties with respect to the transition period.

Slow off responses in the rat superior colliculus neurons may contribute to the predator detection.

A slowly moving dark spot imitating the shadow of a hovering bird of prey has been shown to induce freezing in rodents. Such visually triggered behaviours are usually initiated in the superior colliculus (SC); therefore, it is likely that such slowly moving dark spots can produce responses in SC neurons. In SC, two types of visual responses are typically distinguished: ON responses are produced by an increase in image brightness, and OFF responses are produced by a decrease in image brightness.

International consensus statement on microbiome testing in clinical practice.

There is growing interest in the potential exploitation of the gut microbiome as a diagnostic tool in medicine, but evidence supporting its clinical usefulness is scarce. An increasing number of commercial providers offer direct-to-consumer microbiome diagnostic tests without any consensus on their regulation or any proven value in clinical practice, which could result in considerable waste of individual and health-care resources and potential drawbacks in the clinical management of patients. We convened an international multidisciplinary expert panel to standardise best practices of microbiome testing for clinical implementation, including recommendations on general principles and minimum requirements for their provision, indications, pre-testing protocols, method of analyses, reporting of results, and potential clinical value.

How high can trumpet moths occur: documentation of mountainous leaf-mining Tischeriidae, featuring a species from record-high elevations.

This publication describes four new high-altitude species of Tischeriidae, all within the genus Astrotischeria Puplesis & Diškus: A. peruanica Diškus & Stonis, sp. nov.

Description of two new species of the genus Dollmania (Lepidoptera, Lasiocampidae).

Two new species of the genus Dollmania Tams, 1930 are described: Dollmania lola sp. n. from Ivory Coast and Dollmania reggie sp.

Impact of intensive versus nonintensive antithrombotic treatment on device-related thrombus after left atrial appendage closure.

Introduction And Objectives: The optimal antithrombotic therapy (AT) after left atrial appendage closure (LAAC) is debated. We assessed the impact of intensive vs nonintensive AT on the incidence of device-related thrombus (DRT) based on whether the device implantation was classified as optimal or suboptimal.

Methods: This study included patients who underwent successful LAAC in 9 centers.