Unseen Enemy: Mechanisms of Multidrug Antimicrobial Resistance in Gram-Negative ESKAPE Pathogens.

Multidrug antimicrobial resistance (AMR) represents a formidable challenge in the therapy of infectious diseases, triggered by the particularly concerning gram-negative , , , , , and spp. (ESKAPE) pathogens. Designated as a "priority" in 2017, these bacteria continue to pose a significant threat in 2024, particularly during the worldwide SARS-CoV-2 pandemic, where coinfections with ESKAPE members contributed to worsened patient outcomes.

Sense of Happiness and Wellness Among Adolescents and Their School Environment.

Background: Happiness and health are crucial elements of adolescents' lives that significantly impact mental well-being and societal engagement. This article hypothesizes that a suitable school environment may be one of the components that can impact students' subjective feelings of happiness and health. This research aimed to determine the association between a negative school environment, such as experiencing bullying and feeling insecure at school, and students' happiness and health.

Syphilis Infection During Pregnancy: The Possible Effect on the Course of Pregnancy and Fetal Outcomes-A Case Report and Literature Review.

A wide range of syphilis-related pregnancy complications are encountered in clinical practice. Active surveillance of the epidemiological situation in different countries and a series of retrospective data analyses allow for a comprehensive assessment of the feasible consequences of syphilis infection during pregnancy. The negative effects of infection on reproductive health are also described.

Early Effects of Bronchoscopic Cryotherapy in Metastatic Non-Small Cell Lung Cancer Patients Receiving Immunotherapy: A Single-Center Prospective Study.

Cryotherapy is used for local tissue destruction through rapid freeze-thaw cycles. It induces cancer cell necrosis followed by inflammation in the treated tumor microenvironment, and it stimulates systemic adaptive immunity. Combining cryotherapy with immunotherapy may provide a sustained immune response by preventing T cell exhaustion.

Profiles of Killer Systems and Volatile Organic Compounds of Rowanberry and Rosehip-Inhabiting Yeasts Substantiate Implications for Biocontrol.

Yeasts produce numerous antimicrobial agents such as killer toxins, volatile organic compounds (VOCs), and other secondary metabolites, establishing themselves in developing natural and sustainable biocontrol strategies for agriculture and food preservation. This study addressed the biocontrol potential of yeasts, isolated from spontaneous fermentations of rosehips ( L.) and rowanberries ( L.

Proliferative and viability effects of two cyanophages on freshwater bloom-forming species Microcystis aeruginosa and Raphidiopsis raciborskii vary between strains.

Viruses that infect cyanobacteria are an integral part of aquatic food webs, influencing nutrient cycling and ecosystem health. However, the significance of virus host range, replication efficiency, and host compatibility on cyanobacterial dynamics, growth, and toxicity remains poorly understood. In this study, we examined the effects of cyanophage additions on the dynamics and activity of optimal, sub-optimal, and non-permissive cyanobacterial hosts in cultures of Microcystis aeruginosa and Raphidiopsis raciborskii.

SATISFACTION WITH THE QUALITY AND AVAILABILITY OF MEDICAL SERVICES IN RURAL AREAS OF KAZAKHSTAN.

Background: Measuring the level of patient satisfaction is a useful tool for providing quality medical care that aligns with consumer preferences. We aimed to study the satisfaction with the quality and availability of medical services among the rural population of the Republic of Kazakhstan.

Methods And Materials: This study is a cross-sectional analysis.

Modelling harmful algal blooms in a mono- and a polydominant eutrophic lake under temperature and nutrient changes.

Cyanobacterial blooms, driven by nutrient loading and temperature, pose significant ecological and economic challenges. This study employs a combined data-driven and trait-based modelling approach to predict changes in cyanobacterial communities in a mono- and a polydominant shallow temperate lakes under varying temperature and nutrient scenarios. Results of the AQUATOX simulation model for two aquatic systems suggest that a 2 °C temperature increase, consistent with Intergovernmental Panel on Climate Change's predictions, may influence cyanobacteria species composition and dominance, with trends indicating a possible shift favouring Nostocales over Oscillatoriales and Chroococcales.

Prevalence of FGFR2b Protein Overexpression in Advanced Gastric Cancers During Prescreening for the Phase III FORTITUDE-101 Trial.

Purpose: Fibroblast growth factor receptor 2 isoform IIIb (FGFR2b) protein overexpression is an emerging biomarker in gastric cancer and gastroesophageal junction cancer (GC). We assessed FGFR2b protein overexpression prevalence in nearly 3,800 tumor samples as part of the prescreening process for a global phase III study in patients with newly diagnosed advanced or metastatic GC.

Methods: As of June 28, 2024, 3,782 tumor samples from prescreened patients from 37 countries for the phase III FORTITUDE-101 trial (ClinicalTrials.

Actual Roles of Occupational Therapists in Palliative and Hospice Care: A Scoping Review.

Background: This study reviewed the role of occupational therapist's in palliative and hospice care over the past 20 years.

Methods: A scoping review following Arksey and O'Malley's five stages was undertaken using PubMed, OTseeker, Scopus, Elsevier, Cochrane Library-Medline, CINAHL, PsychInfo, Web of Science and Google Scholar.

Results: A total of 41 articles were reviewed.

Effect of In Vitro Ruminal pH on Zearalenone Degradation and Interaction with Other Mycotoxins in a Static Gastrointestinal Model.

The degradation of zearalenone (ZEN) in the rumen of dairy cows is influenced by rumen pH, which is a key factor affecting this process. The aim of this study was to investigate the variation of ZEN in interaction with other mycotoxins at different ruminal pH environments (physiological (pH 6.5) and acidic (pH 5.

Evaluating the Efficacy and Safety of Hepatitis E Vaccination in Reproductive-Age Women: A Systematic Review and Meta-Analysis.

Background: Hepatitis E virus (HEV) infection presents a significant health risk in endemic regions, especially for pregnant women, who face higher risks of severe complications, including maternal and fetal mortality. The recombinant HEV vaccine, HEV239, has demonstrated high efficacy in the general population, yet data on its safety and efficacy in women of a childbearing age remain limited. This systematic review and meta-analysis aim to evaluate the safety and effectiveness of HEV239 in this specific population, with a focus on pregnancy-related outcomes.

A Comprehensive Review of Niobium Nanoparticles: Synthesis, Characterization, Applications in Health Sciences, and Future Challenges.

Niobium nanoparticles (NbNPs) have gained attention as promising materials in biomedical applications due to their exceptional biocompatibility, corrosion resistance, and versatility. These nanoparticles offer potential in drug delivery, imaging, and tissue engineering, where their nanoscale properties allow precise interactions with biological systems. Among niobium-based nanomaterials, niobium pentoxide (NbO) is the most extensively studied due to its chemical stability, bioactivity, and optical properties.

Multidrug-Resistant : Risk Factors for Mortality in a Tertiary Care Teaching Hospital.

Background And Objectives: Due to resistance and the lack of treatment options, hospital-acquired () infections are associated with high mortality. This study aimed to analyze the characteristics of patients with infections caused by multidrug-resistant (MDR) and patients' clinical outcomes as well as determine the risk factors for mortality in a tertiary care teaching hospital.

Materials And Methods: A retrospective cohort study including 196 adult patients with strains isolated from different clinical specimens in the Hospital of the Lithuanian University of Health Sciences in 2016, 2017, 2020, and 2021 was conducted.

Biodegradable Polymers and Textiles.

The increasing interest in developing biodegradable polymers through chemical treatments, microorganisms, and enzymes highlights a commitment to environmentally friendly disposal methods [...

Mental preparation of karateka for sports competition in kata.

Mental preparation for sports competition in karate is significant, as it is deeply embedded in the philosophical and ethical values that underpin this combat method. In practice, the mental preparation of karateka varies depending on the type of competition, for example preparation for kata (forms) and kumite (fights). Thus, this perspective offers a concise account of the authors' viewpoint on the leading mental skills required of kata competitors.

Usability and Usefulness of a Symptom Management Coaching System for Patients With Cancer Treated With Immune Checkpoint Inhibitors: Comparative Mixed Methods Study.

Background: The prognosis for patients with several types of cancer has substantially improved following the introduction of immune checkpoint inhibitors, a novel type of immunotherapy. However, patients may experience symptoms both from the cancer itself and from the medication. A prototype of the eHealth tool Cancer Patients Better Life Experience (CAPABLE) was developed to facilitate symptom management, aimed at patients with melanoma and renal cell carcinoma treated with immunotherapy.

Survey of legislative frameworks and national recommendations governing paediatric maintenance haemodialysis in Europe.

Background: The application of international recommendations for paediatric maintenance haemodialysis (HD) could be strengthened by national laws or written recommendations. Our aim was therefore to describe the national rules governing paediatric maintenance HD in European countries.

Methods: A national representative, approved by the president of each paediatric nephrology society, was contacted in all 42 European countries to complete two online questionnaires.

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users.

Background And Objectives: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify rhinitis as "intermittent" or "persistent" and "mild" or "moderate-severe". To assess ARIA classes in a real-world study in terms of phenotypic differences and their association with asthma.

Methods: We performed a cross-sectional real-world study based on users of the MASK-air® app who reported data for at least 3 different months.

Dynamic Outlier Slicing Allows Broader Exploration of Adaptive Divergence: A Comparison of Individual Genome and Pool-Seq Data Linked to Humic Adaptation in Perch.

How genetic variation contributes to adaptation at different environments is a central focus in evolutionary biology. However, most free-living species still lack a comprehensive understanding of the primary molecular mechanisms of adaptation. Here, we characterised the targets of selection associated with drastically different aquatic environments-humic and clear water-in the common freshwater fish, Eurasian perch (Perca fluviatilis).

Case report: Looking for relationship between type 1 diabetes and chronic recurrent osteomyelitis: short literature review and case presentation.

Background: Childhood autoimmune disorders involve the immune system attacking its own tissues, leading to varied symptoms, while autoinflammatory disorders result from innate immune system dysregulation, both requiring extensive diagnosis and multidisciplinary management due to their complexity.

Case Presentation: We present a unique clinical case of a teenager with a combination of autoimmune and autoinflammatory disorders. The initial manifestation of hip pain, coupled with progressive symptoms over several years and findings in multiple magnetic resonance imaging (MRI) scans, culminated in the diagnosis of chronic recurrent multifocal osteomyelitis (CRMO).

The influence of health literacy on how preschool educators and parents perceive the continuous development of health competencies within the framework of sustainability: Lithuanian case.

Preschool education is one of the most important priorities of modern educational policies and the basis of lifelong learning. Health-literate educators and parents are better equipped to instill sustainable health practices in young children. Therefore, it is important to examine health literacy and determine how preschool educators and parents perceive the continuous development of health competencies within the framework of sustainability.

Tyre rubber exposure causes oxidative stress and intracellular damage in the Baltic clam (Macoma balthica).

Car tyres are considered to release a substantial amount of particles to the environment. Due to the high emission volumes and the chemical risks associated with tyre rubber, there is an urgent need to quantify their ecotoxicological effects. The effects of exposure to particles derived from end-of-life tyres were investigated on the Baltic clam (Macoma balthica), which is one of the key invertebrate species living in the soft-bottom sediments of the northern Baltic Sea.

Evaluation of unitary conductance of gap junction channels based on stationary fluctuation analysis.

Gap junction (GJ) channels, formed of connexin (Cx) protein, enable direct intercellular communication in most vertebrate tissues. One of the key biophysical characteristics of these channels is their unitary conductance, which can be affected by mutations in Cx genes and various biochemical factors, such as posttranslational modifications. Due to the unique intercellular configuration of GJ channels, recording single-channel currents is challenging, and precise data on unitary conductances of some Cx isoforms remain limited.