647 results match your criteria: "Lishui People's Hospital[Affiliation]"
Myelofibrosis predicts deep molecular response 4.5 in chronic myeloid leukaemia patients initially treated with imatinib: An extensive, multicenter and retrospective study to develop a prognostic model.
Clin Transl Med
November 2024
Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Leukopenia-a rare complication secondary to invasive liver abscess syndrome in a patient with diabetes mellitus: A case report.
World J Gastrointest Surg
October 2024
Department of Gastroenterology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing 211200, Jiangsu Province, China.
Background: Thrombocytopenia is a common complication of invasive liver abscess syndrome (ILAS) by () infection, which indicates severe infection and a poor prognosis. However, the presence of leukopenia is rare. There are rare reports on leukopenia and its clinical significance for ILAS, and there is currently no recognized treatment plan.
View Article and Find Full Text PDFReceptor-Interacting Protein Kinase 3 as a Serological Biomarker in Relation to Disease Severity and Delirium After Acute Pancreatitis: A Prospective Cohort Study.
Int J Gen Med
November 2024
Department of Anorectal Surgery, Lishui Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui, Zhejiang Province, People's Republic of China.
Article Synopsis
- Delirium is a common complication experienced by patients with acute pancreatitis, and the study focuses on the role of receptor-interacting protein kinase 3 (RIP3) as a potential predictor of this condition.
- The study involved 297 patients, measuring serum RIP3 levels and assessing illness severity using various scoring systems, revealing that higher RIP3 levels correlated with greater severity and a higher likelihood of developing delirium.
- The findings led to the development of a predictive model that incorporates RIP3 levels and other clinical scores, demonstrating strong effectiveness in predicting in-hospital delirium, verified in a separate validation group.
Advances in sarcopenia and urologic disorders.
Front Nutr
November 2024
Department of Urology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University School of Medicine, Nanjing, China.
Article Synopsis
- Sarcopenia is the decline in muscle strength, mass, and function, increasing the risk of injury and chronic health issues, which can severely affect a person's quality of life and longevity.
- New research shows a strong connection between sarcopenia and urinary tract disorders, indicating that each condition can exacerbate the other, creating a harmful cycle.
- This review aims to define sarcopenia, outline diagnostic methods, and explore its relationship with both benign and malignant urinary diseases, highlighting its significance for effective management and prognosis.
Does Fever Caused by the COVID-19 Virus Before Labor Increase the Rate of MSAF and Affect Maternal and Fetal Outcomes?
Can J Infect Dis Med Microbiol
November 2024
Department of Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210036, China.
Article Synopsis
- The study aims to explore the link between fever and the occurrence of meconium-stained amniotic fluid (MSAF) in pregnant women during the COVID-19 pandemic, comparing data from women with fever to those without.
- Out of 400 pregnant women analyzed, 17.25% exhibited MSAF, with increased prevalence (21.85%) in fever-pregnant women, indicating a statistically significant association between fever and MSAF risk.
- Furthermore, COVID-19 infection notably raised the odds of developing MSAF by 2.567 times, while abnormal fetal heart monitoring and gestational age emerged as independent risk factors, highlighting the need for careful monitoring of these conditions in at-risk pregnant women.
Risk factors and prognostic impact of new decompensated events in hospitalized patients with decompensated cirrhosis.
BMC Gastroenterol
November 2024
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310003, China.
Background: Decompensated cirrhosis (DC) is prone to recurrent episodes of decompensation following the initial event. This study aimed to identify the risk factors for subsequent decompensation and assess their impact on the outcomes of patients hospitalized for DC.
Methods: Patients with DC were divided into two groups based on the occurrence of new decompensated events during hospitalization.
Multiple visible retinal emboli in branch retinal artery occlusion secondary to internal carotid artery occlusion.
Arq Bras Oftalmol
November 2024
Department of Ophthalmology, Xuzhou Third People's Hospital, Xuzhou Hospital Affiliated to Jiangsu University, Xuzhou, Jiangsu Province, China.
Sappanone A attenuates rheumatoid arthritis via inhibiting PI3K/AKT/NF-κB and JAK2/STAT3 signaling pathways in vivo and in vitro.
Int Immunopharmacol
December 2024
College of Pharmacy, Harbin Medical University-Daqing, Daqing 163319, China. Electronic address:
Objective: Sappanone A (SA), a bioactive compound in Caesalpinia sappan L., has anti-inflammation, antioxidant, and bone protection activities. But its effect on rheumatoid arthritis (RA) and the underlying mechanism are incompletely understood.
View Article and Find Full Text PDFThe causal association between COVID-19 and ischemic stroke: a mendelian randomization study.
Virol J
November 2024
Department of Infectious Diseases, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical College of Nanjing University, NO 188 Lingshan North Road, Qixia District, Nanjing, 210046, China.
Background: Current observational data indicates that ischemic stroke (IS) affects a significant proportion of people with COVID-19. The current study sought to evaluate the causal relationship between COVID-19 and IS.
Methods: A two-sample Mendelian randomization (2 S-MR) approach was used to probe the relationship between genetic determinants of three COVID-19 parameters (SARS-CoV-2 infection, COVID-19 hospitalization, and severe COVID-19) and the incidence of IS based on genome-wide association studies (GWAS) data.
Awareness and Uptake of HIV Preexposure Prophylaxis and Postexposure Prophylaxis Among College Students With Sexual Experiences: Institutional-Based Cross-Sectional Study.
JMIR Public Health Surveill
November 2024
Medical Office, Lishui People's Hospital, 15 Dazhong Road, Liandu District, Lishui, 323000, China, 86 13588819303.
Background: Evidence has shown that HIV prevalence among young people, especially college students, has increased disproportionately. Preexposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) are two of the most effective ways to prevent HIV, which are vital for college students with sexual experiences who have sexual risks.
Objective: To provide evidence for effective intervention to reduce the risk of HIV infection among young students, this study aimed to analyze the awareness and uptake of HIV PrEP and PEP among college students with sexual experiences.
Maturity and density of tertiary lymphoid structures associate with tumor metastasis and chemotherapy response.
Front Med (Lausanne)
October 2024
Department of Gastrointestinal Surgery, Lishui People's Hospital, Lishui, China.
Background: Tertiary Lymphoid Structures (TLSs) are abnormal clusters of immune cells that form in tissues not normally associated with the immune system, usually in cases of long-lasting inflammation, like cancer. TLSs have been suggested as a potential prognostic indicator in various cancer types.
Methods: We retrospectively enrolled 223 gastric cancer (GC) patients who had surgical resections in this study.
Gut microbiota modulating therapy for diabetes mellitus should be individualized.
World J Diabetes
October 2024
Department of Ultrasound Medicine, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing 211200, Jiangsu Province, China.
In this editorial, we commented on two articles published online in August and September 2024 in the , which focused on modifying the gut microbiota (GM) to prevent or delay the progression of diabetes mellitus (DM) and DM-related complications. Numerous studies, many of which are animal studies, have indicated the potential role of GM in the pathogenesis of DM. However, the detailed causality and mechanisms between GM and DM have not been fully clarified.
View Article and Find Full Text PDFAn unexpected retained metallic intraocular foreign body.
Doc Ophthalmol
December 2024
Department of Ophthalmology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, Jiangsu Province, China.
Purpose: This case report aims to describe a rare case of asymptomatic retained metallic intraocular foreign body (IOFB) in the retina with reduced full-field electroretinography (ff-ERG) in a Chinese woman.
Methods: This is a clinical investigation of a patient who unexpectedly presented with a metallic IOFB at the superior-temporal region of the left eye ring during a brain computed tomography.
Results: Her best-corrected visual acuity was 20/20 in both eyes.
Therapeutic potential of EVs loaded with CB2 receptor agonist in spinal cord injury via the Nrf2/HO-1 pathway.
Redox Rep
December 2024
Lishui People's Hospital, Central Laboratory of The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, People's Republic of China.
Article Synopsis
- Spinal cord injury (SCI) presents limited treatment options, prompting research into Exo-loaded cannabinoid receptor type 2 (CB2) agonist AM1241, which has shown benefits in other inflammatory diseases but not specifically in SCI.
- In an experiment with C57BL/6 mice, treatments with Exo, AM1241, and a combination of both were administered, with effects assessed on motor function, histological changes, inflammation, and oxidative stress levels.
- The combined treatment of Exo and AM1241 markedly improved motor function recovery by reducing pro-inflammatory cytokines, inhibiting cell apoptosis, enhancing antioxidant defenses, and activating protective signaling pathways in the spinal cord.
Tortuous conjunctival vessels and central retinal vein occlusion in spontaneous dural arteriovenous fistula.
Eye (Lond)
October 2024
Department of Neurology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, Jiangsu, China.
Microwave versus Radiofrequency Ablation in Treating Predominantly Solid Benign Thyroid Nodules: A Randomized Controlled Trial.
Radiology
October 2024
From the Department of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, No. 100 W Fourth Ring Rd, Beijing 100039, China (S.C., J.D., Y. Cang, J.Y., P.L.); Chinese PLA Medical School, Beijing, China (S.C., Y. Cang); Department of Ultrasound, First Affiliated Hospital of Dalian Medical University, Dalian, China (Y. Che); Department of Ultrasound, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (G.D.); Department of Ultrasound, Lishui People's Hospital, Lishui, China (C.Z.); Department of Interventional Ultrasound, Zhejiang Cancer Hospital, Hangzhou, China (D.X.); and Department of Statistics, Guilin Gooclin Technology, Guilin, China (Q.L.).
Background Current guidelines recommend radiofrequency ablation (RFA) as the first-line treatment for benign thyroid nodules. Purpose To compare the efficacy and safety of microwave ablation (MWA) and RFA for the treatment of predominantly solid benign thyroid nodules. Materials and Methods This prospective, randomized, open-label, multicenter study was conducted from August 2019 to February 2023.
View Article and Find Full Text PDFDeep medullary vein abnormalities impact white matter hyperintensity volume through increases in interstitial free water.
BMC Neurol
October 2024
Department of Neurology, Lishui People's Hospital, Lishui, 323000, China.
Article Synopsis
- The study investigated how interstitial free water (FW) acts as a bridge connecting deep medullary vein (DMV) scores to white matter hyperintensity (WMH) volume in patients with cerebral small vessel disease.
- Researchers analyzed clinical and imaging data from 125 patients, scoring six DMV regions to create an overall DMV score, and measured WMH volume using imaging techniques.
- Results showed that higher DMV scores and FW values were linked to increased WMH volumes, with FW mediating the relationship between DMV scores and WMH volume even when accounting for age, gender, and vascular risk factors.
A [F]FDG PET based nomogram to predict cancer-associated cachexia and survival outcome: A multi-center study.
Nutrition
January 2025
Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China; Department of Radiology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China. Electronic address:
Objectives: Cancer patients with cachexia face poor prognosis and shortened survival. Early diagnosis and accurate prognosis prediction remain challenging. This multi-center study aims to develop and externally validate a nomogram integrating [F]fluoro-2-deoxy-D-glucose ([F]FDG) PET findings and routine clinical biochemistry tests for predicting cancer-associated cachexia, while also assessing its potential prognostic value.
View Article and Find Full Text PDFGene expression profile analysis of severe influenza-based modulation of idiopathic pulmonary fibrosis.
Eur J Med Res
October 2024
Department of Infectious Diseases, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical College of Nanjing University, NO 188 Lingshan North Road, Qixia District, Nanjing, 210046, China.
Article Synopsis
- The study explores the interaction between severe influenza and idiopathic pulmonary fibrosis (IPF), highlighting that these conditions may influence each other without previously known mechanisms.
- Researchers analyzed genetic data for severe influenza and IPF from the Gene Expression Omnibus database, identifying 174 common differentially expressed genes (C-DEGs) linked to inflammatory response and cell differentiation.
- They pinpointed 15 hub genes, including MELK and HJURP, which could play a role in the comorbidity of severe influenza and IPF, suggesting these genes may be potential targets for future therapies.
Neutropenia possibly caused by cefoperazone/sulbactam.
Eur J Hosp Pharm
October 2024
Nanjing Lishui People's Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, Jiangsu Province, China
Neutropenia is a rare complication of drug therapy and is usually underdiagnosed. Cefoperazone/sulbactam is a combination of broad-spectrum antibacterial agents. Data on cefoperazone/sulbactam-induced neutropenia are limited.
View Article and Find Full Text PDFA regulatory variant rs9379874 in T1D risk region 6p22.2 affects BTN3A1 expression regulating T cell function.
Acta Diabetol
October 2024
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Article Synopsis
- The study focuses on the 6p22.2 genetic region, which is linked to type 1 diabetes (T1D) risk in the Chinese Han population, aiming to explore its associations with T1D subgroups and clinical features.
- A total of 2,608 T1D patients and 4,814 healthy controls from different regions of China were analyzed, identifying the rs4320356 variant as a key player, although it did not relate to islet function or autoimmunity.
- The research revealed that the variant rs9379874 may be the most relevant causal variant for T1D, as it enhances the expression of the BTN3A1 gene and is potentially involved in mechanisms related to T-cell activation
Preoperative C-reactive protein to albumin ratio may be a good prognostic marker in patients undergoing hepatectomy for hepatocellular carcinoma: a meta-analysis.
Front Nutr
October 2024
Department of General Surgery, Lishui People's Hospital, Lishui, China.
Background: Systemic inflammatory response represented by C-reactive protein to albumin ratio (CAR) was shown to be associated with long-term outcome in patients with hepatocellular carcinoma (HCC). We conducted a meta-analysis to investigate the prognostic value of preoperative CAR in patients undergoing hepatectomy for HCC.
Methods: We searched four databases (PubMed, Embase, Scopus and Cochrane Library) from inception to May 10th, 2024.
Anterior cervical controllable Antedisplacement and Fusion (ACAF) versus Anterior Cervical Corpectomy and Fusion (ACCF) for ossification of the cervical posterior longitudinal ligament (OPLL) in Chinese population: a systematic review and meta-analysis.
Neurosurg Rev
October 2024
Department of Spine Surgery, Lishui People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, China.
Article Synopsis
- This systematic review compared the effectiveness and safety of two surgical methods—anterior cervical controllable antedisplacement and fusion (ACAF) and anterior cervical corpectomy and fusion (ACCF)—for treating ossification of the cervical posterior longitudinal ligament (OPLL) in patients.
- It included 5 studies with 366 participants and found that ACAF had significantly fewer complications, such as cerebrospinal fluid leakage, and better postoperative outcomes, including improvements in neck disability, angle alignment, and spinal measurements.
- However, ACAF required a longer operation time than ACCF, with no notable differences in blood loss or length of hospital stays between the two surgical options.
Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation.
J Inflamm Res
October 2024
Key Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, 323000, People's Republic of China.
Article Synopsis
- Pyroptosis is a type of inflammatory cell death caused by inflammasomes, releasing pro-inflammatory substances like IL-18 and IL-1β, which has generated interest for its potential therapeutic and immunological roles.
- Research shows that pyroptosis and dysregulated inflammasomes are linked to various health issues, including cancers, nerve injuries, inflammatory diseases, and metabolic disorders, notably in gynecological conditions such as endometriosis and endometrial cancer (EC).
- The study highlights that proteins like gasdermin D (GSDMD) related to pyroptosis could serve as important biomarkers for EC, and it discusses potential future strategies for using pyroptosis in developing anti-cancer therapies.
Different peripheral nerve blocks for patients undergoing total knee arthroplasty: a network meta-analysis of randomized controlled trials.
Arch Orthop Trauma Surg
September 2024
Department of Anesthesiology, Lishui People's Hospital, Lishui Hospital of Wenzhou Medical University, No. 1188 Liyang Street, Lishui, Zhejiang, 323000, People's Republic of China.
Introduction: To comprehensively compare the effect of different peripheral nerve blocks for patients undergoing total knee arthroplasty (TKA).
Materials And Methods: PubMed, Embase, Cochrane Library, and Web of Science were comprehensively searched. The outcomes included postoperative pain, postoperative function, adverse events, oral morphine equivalent (OME), and perioperative indicators.