Niraparib plays synergistic antitumor effects with NRT in a mouse ovarian cancer model with HRP.

Objective: PARPi offers less clinical benefit for HRP patients compared to HRD patients. PARPi has an immunomodulatory function. NRT therapy targets tumor neoantigens without off-target immune toxicity.

Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA‑1271‑mediated Capn4/Wnt/β‑catenin signaling pathway in epithelial ovarian cancer.

Circular RNA ABCB10 (circ‑ABCB10) modulates cellular functions and microRNA (miR)‑1271 in epithelial ovarian cancer (EOC). The present study aimed to investigate the interaction between circ‑ABCB10 and miR‑1271 in regulating EOC cellular function and the calpain small subunit 1 (Capn4)/Wnt/β‑catenin signaling pathway. circ‑ABCB10 and miR‑1271 expression levels were detected in EOC cells (OVCAR3, UWB1.

Magnolol suppressed cell migration and invasion and induced cell apoptosis via inhibition of the NF-κB signaling pathway by upregulating microRNA-129 in multiple myeloma.

Multiple myeloma (MM) is incurable cancer in the blood system. Magnolol is an effective component against various cancers. This study tried to investigate the effect and mechanism of magnolol on MM via regulating miR-129.

Resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms, predictive factors, and future perspectives.

PD-1/PD-L1 blockade therapy is a promising cancer treatment strategy, which has revolutionized the treatment landscape of malignancies. Over the last decade, PD-1/PD-L1 blockade therapy has been trialed in a broad range of malignancies and achieved clinical success. Despite the potentially cure-like survival benefit, only a minority of patients are estimated to experience a positive response to PD-1/PD-L1 blockade therapy, and the primary or acquired resistance might eventually lead to cancer progression in patients with clinical responses.

Integrated analysis revealing genome-wide chromosomal copy number variation in supraglottic laryngeal squamous cell carcinoma.

Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribute to the genetic diversity of tumor pathogenesis.

[Study on the incentive strategy of "double guidance" way and "1+2" mode in the cultivation of master's degree postgraduates-A case study of Zhejiang Chinese Medical University].

With the degree of enrollment of postgraduates in medical specialty expanding year by year, medical colleges have been exposed the deficiencies in the education of professional degree, which is paying more attention to clinic but less to scientific research. Postgraduate students have weak scientific awareness and less enthusiasm. This study forward on reforming the teaching model and incentive strategy based on the questionnaire survey.

Characterisation of a class 1 integron associated with the formation of quadruple bla cassettes from an IncP-1β group plasmid in Pseudomonas aeruginosa.

Integrons are genetic platforms responsible for the dissemination of antimicrobial resistance genes among Gram-negative bacteria, primarily due to their association with transposable elements and conjugative plasmids. In this study, a cassette array containing four identical bla genes embedded in a class 1 integron located on an IncP-1β group plasmid from a clinical Pseudomonas aeruginosa strain was identified. Comparative genome analysis and conjugation assay showed that the plasmid pICP-4GES lacked the trbN, trbO and trbP genes but was conjugable.

Comparative Genomics Analysis of Plasmid pPV989-94 from a Clinical Isolate of PV989.

, a gram-negative bacterium from the genus and family , is present in various natural environments and considered to be plant endophytes. We isolated the PV989 strain from the clinic and sequenced its whole genome. Besides a chromosome DNA molecule, it also harboured three large plasmids.

Structure-Function Analysis of the Transmembrane Protein AmpG from Pseudomonas aeruginosa.

AmpG is a transmembrane protein with permease activity that transports meuropeptide from the periplasm to the cytoplasm, which is essential for the induction of the ampC encoding β-lactamase. To obtain new insights into the relationship between AmpG structure and function, comparative genomics analysis, secondary and tertiary structure modeling, site-directed mutational analyses and genetic complementation experiments were performed in this study. AmpGs from different genera of bacteria (Escherichia coli, Vibrio cholerae and Acinetobacter baumannii) could complement AmpG function in Pseudomonas aeruginosa.

Identification and molecular characterization of Escherichia coli bla genes in a Chinese teaching hospital.

Escherichia coli (E. coli) commonly reside in human intestine and most E. coli strains are harmless, but some serotypes cause serious food poisoning.

Comparative genomics analysis of pKF3-94 in Klebsiella pneumoniae reveals plasmid compatibility and horizontal gene transfer.

In order to get insights into plasmid evolution and the dissemination of multidrug resistance, we performed extensive comparative genomics analyses of the Klebsiella pneumoniae plasmid pKF3-94 and some of its related plasmids. pKF3-94 is one of three plasmids isolated from the K. pneumoniae strain KF3.

Molecular variation and horizontal gene transfer of the homocysteine methyltransferase gene mmuM and its distribution in clinical pathogens.

The homocysteine methyltransferase encoded by mmuM is widely distributed among microbial organisms. It is the key enzyme that catalyzes the last step in methionine biosynthesis and plays an important role in the metabolism process. It also enables the microbial organisms to tolerate high concentrations of selenium in the environment.

[Structure and function of class 1 integron in clinical isolates of Klebsiella pneumoniae].

To investigate molecular mechanism of multi-resistance of Klebsiella pneumoniae and its spreading, 179 strains isolated from different clinical samples in the period of 2002-2007 with serious resistance to 14 anti-bacterial agents were examined. Among them, 118 (65.9%) were resistant to at least two anti-bacterial agents; 36.

[Regulation effects of arbuscular mycorrhizal fungi on the interactions between barnyard grass and upland rice under enhanced nitrogen supply].

A pot experiment was conducted to study the regulation effects of arbuscular mycorrhizal fungi (AMF) on the interactions between Echinochloa crus-galli var. mitis L. and Oryza sativa L.

A tetrahedrally coordinated Ag(I) and Ni(II) complex with a two-dimensional framework containing one-dimensional helical chains.

The title complex, poly[bis(mu(6)-pyridine-2,6-dicarboxylato N-oxide)nickel(II)disilver(I)], [Ag(2)Ni(C(7)H(3)NO(5))(2)](n) or [Ag(2)Ni(pydco)(2)](n) (H(2)pydco = pyridine-2,6-dicarboxylic acid N-oxide), has a two-dimensional sheet structure. The two carboxylate groups adopt two coordination modes. The Ni(II) ion displays a distorted octahedral geometry, bonded to two carboxylate O atoms of two different pydco ligands and four O donors from another two ligands, i.

[Cardioprotective effect of ischemic postconditioning and preconditioning against prolonged ischemia and reperfusion induced injury in isolated rat heart].

Objective: To explore the cardioprotection effect of co-treatment with ischemic postconditioning and preconditioning in ischemia/reperfusion (I/R) injury and the related mechanism.

Methods: Male Sprague-Dawley rats were used for Langendorff isolated heart perfusion. The hearts were subjected to global ischemia for 60 min followed by 120 min of reperfusion.

1,2-Bis(2-chloro-benzyl-idene)hydrazine.

The title Schiff base compound, C(14)H(10)Cl(2)N(2), crystallizes with one half-mol-ecule in the asymmetric unit. The mid-point of the N-N bond [1.418 (3) Å] lies on an inversion centre.

[Role of mitochondrial calcium uniporter in myocardial hypoxia/reoxygenation induced injury].

Aim: To investigate the role and mechanism of mitochondrial calcium uniporter (MCU) in myocardial hypoxia/reoxygenation injury.

Methods: Isolated rat hearts were perfused with Langendorff apparatus. The hypoxia/reoxygenation injury was achieved by ligation of left anterior coronary artery for 30 min followed by release of ligation for 120 min.