Phase 1b/2 study of penpulimab (AK105), an antiprogrammed cell death-1 immunoglobulin G1 antibody, in advanced or metastatic solid tumors (AK105-204).

Background: Penpulimab, a new-generation antiprogrammed cell death-1 immunoglobulin G1 monoclonal antibody, was engineered to optimize receptor occupancy and eliminate fragment crystallizable γ-mediated effector function. In this multicenter, phase 1b/2, multicohort study, the objective was to investigate the efficacy, safety, and immunogenicity of penpulimab in advanced solid tumors.

Methods: Patients who had unresectable, advanced solid tumors were enrolled from six centers and received 200 mg penpulimab on day 1 every 2 weeks for up to 24 months.

Effect of Premedication With Pronase Before Upper Gastrointestinal Endoscopy: A Multicenter Prospective Randomized Controlled Study.

Objectives: This study aimed to confirm whether premedication with pronase before endoscopy improves mucosal visualization and increases precancerous lesion and cancer lesion detection rates.

Materials And Methods: From June 2018 to April 2019, out-patients scheduled for endoscopy from 13 hospitals were screened to be randomly allocated in a 2:1 ratio to premedication with pronase (group A) and water (group B). The primary endpoint was mucosal visibility scores, and the secondary endpoint was precancerous and cancer lesion detection rates.

Penpulimab, an anti-PD1 IgG1 antibody in the treatment of advanced or metastatic upper gastrointestinal cancers.

Background: The safety and anti-tumor activity of penpulimab in patients with advanced upper gastrointestinal (UGI) cancers were evaluated in this study.

Methods: Patients with advanced UGI cancers naive to immune checkpoint inhibitors were enrolled in two trials of penpulimab. In the Phase Ia/Ib trial in Australia, patients received penpulimab intravenous infusion of 1, 3 and 10 mg/kg every 2 weeks in dose-escalation phase and 200 mg every 2 weeks in dose-expansion phase.

Prognostic significance of metastasis associated in colon cancer 1 (MACC1) expression in patients with gallbladder cancer.

Background: The clinical significance of metastasis associated in colon cancer 1 (MACC1), in human gallbladder cancer, is not yet established. This study was performed to assess the expression of MACC1 in benign and malignant gallbladder lesions, and to assess its clinicopathological significance.

Materials And Methods: Tissue samples from resected gallbladder cancer (n=70) and cholelithiasis (n=70) were evaluated for MACC1 expression by immunohistochemical staining.

[The effects of different mechanical ventilation flow model on the peak airway pressure during cardiopulmonary resuscitation].

Objective: To observe the method of mechanical ventilation in the chest compressions during cardiopulmonary resuscitation (CPR), and to explore the influence of the flow pattern selection of square-wave and decelerating-wave on airway pressure of patients.

Methods: A prospective self-pairing study was conducted. Forty patients undergoing CPR admitted to Department of Emergency of Lishui City Central Hospital from January 2011 to February 2013 were enrolled.

Ultra-long cardiopulmonary resuscitation with thrombolytic therapy for a sudden cardiac arrest patient with pulmonary embolism.

The recovery of cardiac arrest patients with pulmonary embolism who are given an ultra-long duration of cardiopulmonary resuscitation(CPR) with manual chest compressions is very rare. We reported a 52-year-old woman who came to the hospital because of paroxysmal dyspnea. She experienced in hospital cardiac arrest and underwent prolonged CPR with manual chest compressions for 160 minutes.

Difference in blood pressure between supine and sitting positions in diabetic and non-diabetic subjects.

Background: This study was designed to investigate whether there was any difference in blood pressure (BP) readings between sitting and supine positions in diabetic and non-diabetic subjects.

Material/methods: BP in sitting and supine position was measured in 356 patients with type 2 diabetes (study group) and in 356 age- and sex-matched non-diabetic subjects (control group).

Results: The systolic and diastolic BP in the supine position was significantly higher than in the sitting position in both groups (P<0.

Impact of postures on blood pressure in healthy subjects.

Background: Controversies exist on the nature of influence of body position on the level of blood pressure. This study was designed to investigate the impact of postures on blood pressures in healthy subjects.

Methods: Blood pressure was measured in 6,485 healthy subjects in both supine and sitting positions, using a standard mercury sphygmomanometer.

Relationship between pericardial fluid B-type natriuretic peptide and ventricular structure and function.

Background: We undertook this study to investigate the levels of pericardial B-type natriuretic peptide (BNP) and its relationship with ventricular structure and function.

Methods: Pericardial and plasma BNP concentrations were measured in 18 patients with congenital ventricular septal defect.

Results: The mean level of BNP in the pericardial fluid (324.

Changes in plasma B-type natriuretic peptide after allograft renal transplantation.

Objective: To investigate the dynamic changes in plasma B-type natriuretic peptide (BNP) after allograft renal transplantation.

Methods: Plasma BNP was measured in 17 patients before and after unilateral allograft renal transplantation (study group) and in 17 age- and sex-matched healthy individuals (control group).

Results: Average BNP level in the study group was significantly higher than in the control group before renal transplantation (P < 0.

Anxiety symptoms in patients with hypertension: a community-based study.

Objectives: To investigate incidence and severity of anxiety symptoms in patients with hypertension.

Methods: A cross-sectional survey in 891 (432 females) hypertensive patients was conducted in a regional community. All patients were interviewed and detailed physical examination was performed.

Value of B-type natriuretic peptide in diagnosing left ventricular dysfunction in dialysis-dependent patients.

Background: B-type natriuretic peptide (BNP) is elevated in patients with end-stage renal failure. The reported accuracy of BNP in diagnosing left ventricular dysfunction in these patients has been inconsistent.

Aim: To investigate the diagnostic values of BNP for left ventricular dysfunction in patients undergoing haemodialysis for chronic renal failure.

Systolic and diastolic heart failure are associated with different plasma levels of B-type natriuretic peptide.

Previous studies have found that plasma B-type natriuretic peptide (BNP) is elevated during left ventricular systolic or diastolic dysfunction. It is unclear whether the ventricular systolic and diastolic function is associated with different levels of plasma BNP. Plasma BNP was measured in 149 heart failure patients by a rapid point-of-care assay.

Plasma BNP levels are determined by the severity of left ventricular systolic dysfunction but not the types of underlying heart disease.

Objectives: The primary aim of the study was to investigate whether there is a difference in plasma B-type natriuretic peptide (BNP) levels among the left ventricular systolic dysfunction caused by different types of heart disease.

Methods And Results: Plasma BNP was measured in patients with left ventricular systolic dysfunction as a result of mitral valve regurgitation (n=26), hypertension (n=36), coronary heart disease (n=37) and dilated cardiomyopathy (n=32). The left ventricular end-diastolic diameter and ejection fraction were assessed with echocardiography.

B-type natriuretic peptide in patients with clinical hyperthyroidism.

Aims: To investigate the level and clinical significance of plasma B-type natriuretic peptide (BNP) in patients with hyperthyroidism.

Methods: Plasma BNP was measured in 32 healthy subjects and 67 patients with clinical hyperthyroidism. Left ventricular anatomy and function was assessed with echocardiography.

Bedside tests of B-type natriuretic peptide in the diagnosis of left ventricular diastolic dysfunction in hypertensive patients.

Aims: To investigate the value of B-type natriuretic peptide (BNP) in diagnosing left ventricular diastolic dysfunction in patients with hypertension.

Methods: The left ventricular diastolic function and plasma BNP levels were assessed prospectively in 135 hypertensive patients.

Results: The plasma BNP in patients with (n=61) and without (n=74) diastolic dysfunction was 122+/-105 and 18+/-16 pg/ml, respectively (p<0.

Predicting factors of depression in patients with primary hypertension: a community-based study.

OBJECTIVE To investigate the factors that may predict the occurrence of depression in patients with primary hypertension. METHODS We conducted a cross-sectional survey on 891 hypertensive patients and 651 normal subjects (control group) from a single community. Zung self-rating depression scale (SDS) was applied to evaluate the symptoms of depression, which was diagnosed when the SDS score was >41.

Influence of commissural calcification on the immediate outcomes of percutaneous balloon mitral valvuloplasty.

Objectives: To evaluate the impact of mild to moderate commissural calcification on the immediate outcomes of percutaneous balloon mitral valvuloplasty (PBMV).

Methods And Results: We analysed the results of 223 consecutive patients (mean age 37.6 +/- 8.

Electrocardiographic diagnosis of left atrial enlargement in patients with mitral stenosis: the value of the P-wave area.

Objective: To investigate the value of the P-wave area in diagnosing left atrial enlargement in patients with mitral stenosis.

Methods: We measured the P-wave area from lead II of a standard 12-lead ECG in 136 consecutive patients with mitral stenosis. We also measured the left atrial diameter with two-dimensional echocardiography.