8 results match your criteria: "Lisbon Academic Medical Centre and Cardiovascular Centre of the University of Lisbon[Affiliation]"
Diagnostic and prognostic contribution of DPD scintigraphy in transthyretin V30M cardiac amyloidosis.
Amyloid
March 2024
Department of Cardiology, Santa Maria University Hospital, Lisbon Academic Medical Centre and Cardiovascular Centre of the University of Lisbon, Faculty of Medicine, Lisbon, Portugal.
Article Synopsis
- Early diagnosis of cardiac transthyretin amyloidosis, particularly in individuals with the V30M mutation, is essential, as DPD scintigraphy may not be entirely accurate for this subgroup.
- A study involving 288 V30M mutation carriers revealed that 14.2% had ATTR cardiomyopathy, with a significantly higher mortality rate observed in those with cardiomyopathy or DPD uptake during a 33.6-month follow-up period.
- The combination of septal thickness and DPD uptake provides better risk stratification, indicating that patients without both conditions have the best prognosis, while those with either or both face much higher mortality rates.
Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry.
ESC Heart Fail
June 2021
Department of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes.
Methods And Results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities.
A Primary Prevention Clinical Risk Score Model for Patients With Brugada Syndrome (BRUGADA-RISK).
JACC Clin Electrophysiol
February 2021
The Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom. Electronic address:
Objectives: The goal of this study was to develop a risk score model for patients with Brugada syndrome (BrS).
Background: Risk stratification in BrS is a significant challenge due to the low event rates and conflicting evidence.
Methods: A multicenter international cohort of patients with BrS and no previous cardiac arrest was used to evaluate the role of 16 proposed clinical or electrocardiogram (ECG) markers in predicting ventricular arrhythmias (VAs)/sudden cardiac death (SCD) during follow-up.
Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome: Insights From the International Takotsubo Registry.
Arterioscler Thromb Vasc Biol
January 2020
From the Department of Cardiology, University Heart Center, University Hospital Zurich, Switzerland (K.J.D., V.L.C., K.A.S., B.E.S., D.D.V., F.R., J.R.G., C. Templin).
Objective: Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism.
View Article and Find Full Text PDFBackground Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results TTS patients from the International Takotsubo Registry were included in this study.
View Article and Find Full Text PDFThe myocardium consists of numerous cell types embedded in organized layers of ECM (extracellular matrix) and requires an intricate network of blood and lymphatic vessels and nerves to provide nutrients and electrical coupling to the cells. Although much of the focus has been on cardiomyocytes, these cells make up <40% of cells within a healthy adult heart. Therefore, repairing or regenerating cardiac tissue by merely reconstituting cardiomyocytes is a simplistic and ineffective approach.
View Article and Find Full Text PDFCongenital Submitral Diverticulum.
Rev Esp Cardiol (Engl Ed)
May 2019
Cardiology Department, Santa Maria University Hospital (CHLN), Lisbon Academic Medical Centre and Cardiovascular Centre of the University of Lisbon, Faculty of Medicine, Lisbon, Portugal.
Cardiotoxicity in Hematological Diseases: Are the Tyrosine Kinase Inhibitors Imatinib and Nilotinib Safe?
Cardiovasc Toxicol
October 2018
Cardiology Department, Faculty of Medicine, Santa Maria University Hospital (CHLN), Lisbon Academic Medical Centre and Cardiovascular Centre of the University of Lisbon, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.
Chemotherapy-induced cardiotoxicity is a growing concern. The cardiotoxic impact of new drugs such as tyrosine kinase inhibitors is unknown, especially the ones used for chronic myeloid leukemia. We aim to evaluate nilotinib- and imatinib-induced cardiotoxicity.
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