[Mechanism of astragaloside Ⅳ alleviating PC12 cell injury by activating PI3K/AKT signaling pathway: based on network pharmacology and in vitro experiments].

In this study, the molecular mechanism of astragaloside Ⅳ(AS-Ⅳ) in the treatment of Parkinson's disease(PD) was explored based on network pharmacology, and the potential value of AS-Ⅳ in alleviating neuronal injury in PD by activating the PI3 K/AKT signaling pathway was verified through molecular docking and in vitro experiments. Such databases as SwissTargetPrediction, BTMAN-TAM, and GeneCards were used to predict the targets of AS-Ⅳ for the treatment of PD. The Search Tool for the Retrieval of Interacting Genes/Proteins(STRING) was employed to analyze protein-protein interaction(PPI) and construct a PPI network, and the Database for Annotation, Visualization and Integrated Discovery(DAVID) was used for Gene Ontology(GO) term enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis.

Minimally-invasive stone removal in urinary calculi patients during pregnancy: clinical therapeutic effects and low complications.

Purpose: To study the clinical effect of minimally-invasive surgery to treat urinary calculi and the prevention of surgery-associated complications during pregnancy.

Methods: A retrospective analysis of the clinical data of 96 pregnant urinary calculi patients admitted to our hospital from April 2017 to April 2018 was conducted. The patients were randomly divided into a study group and a control group, with 48 patients in each group.

Study on parental satisfaction and clinical treatment outcomes of 128 diarrheic children receiving comprehensive nursing.

Objective: To explore the clinical treatment outcomes and parental satisfaction of children with diarrhea receiving comprehensive nursing intervention.

Methods: A total of 128 diarrheic children treated in our hospital from June 2016 to June 2017 were recruited and divided into a control group (n=64) receiving conventional nursing and an observation group (n=64) receiving comprehensive nursing intervention, as per a random number table. The clinical outcomes, electrolyte disorders, recovery of gastrointestinal function, quality of life and parental satisfaction were compared between the two groups after nursing.

The effect of individualized exercise prescriptions combined with dietary management on blood glucose in the second-and-third trimester of gestational diabetes mellitus.

Objective: To explore the effect of individualized exercise prescriptions plus dietary management on blood glucose in the second-and-third trimester of gestational diabetes mellitus (GDM).

Methods: We collected and reviewed the clinical data of 106 patients in their second-and-third trimester who had GDM in our hospital from September 2017 to September 2018. They were equally divided into a test group and a control group with a random number table method.

The application value of informatization-based extended nursing care on discharged children with leukemia.

Objectives: This study explored and analyzed the application value of informatization-based extended care on children discharged with leukemia.

Methods: 109 children receiving chemotherapy for acute leukemia in our hospital from January 2018 to January 2020 were selected as research subjects. The children were divided into the control group (n=53) and the observation group (n=56) on the basis of admission time point.

The diagnostic value of 3.0T MRI in cesarean scar pregnancy.

Objective: The purpose was to evaluate the diagnostic value of 3.0T MRI in cesarean scar pregnancy (CSP).

Methods: 56 patients with suspected CSP treated in our hospital from August 2018 to July 2020 were recruited as the study cohort and diagnosed using ultrasound and 3.

Aerosol inhalation of ambroxol hydrochloride combined with terbutaline can promote recovery of children with severe pneumonia.

Objective: This research aimed to investigate the clinical efficacy of aerosol inhalation of ambroxol hydrochloride combined with terbutaline on children with severe pneumonia, and to evaluate its influence on their immune function and inflammatory level.

Methods: Totally 113 severe pneumonia children were included. Thereinto, 55 children in the control group (CG) were treated with terbutaline aerosol inhalation, while 58 in the research group (RG) were given ambroxol hydrochloride on the basis of the CG.

Correlation between serum urea nitrogen, cystatin C, homocysteine, and chronic heart failure.

Objective: To explore the correlation between uric acid (UA), cystatin C (Cys-C), homocysteine (Hcy), and chronic heart failure (CHF).

Methods: 45 patients with CHF were selected as the research group; 45 healthy people were selected as the control group. The levels of serum UA, Cys-C and Hcy were detected.

Effects of rehabilitation nursing care on deep vein thrombosis of the lower limbs following spinal fractures.

Objective: To explore the preventive effect of rehabilitation nursing care for deep vein thrombosis (DVT) of the lower limbs following spinal fractures, and to analyze its influence on the hemorheology of patients.

Methods: A total of 99 patients with spinal fractures were allocated into a study group (n=50) and control group (n=49), and they were treated with internal fixation plus vertebroplasty. Afterwards, patients in the control group were given routine care and postoperative rehabilitation, and those in the study group received rehabilitation nursing care on the day after surgery, including posture guidance, massage of both lower limbs, and functional training.

Smad7 suppresses melanoma lung metastasis by impairing Tregs migration to the tumor microenvironment.

Transforming growth factor β (TGF-β) signaling plays critical roles in both physiological and pathological conditions. In the tumor microenvironment, TGF-β are well demonstrated as a tumor inducer, which also promote tumor growth and metastasis. SMAD family is an important TGF-β signalling transducer, which consists of receptor-regulated SMADs (R-SMADs), common-mediator SMADs (co-SMADs), and inhibitory SMADs (I-SMADs).

Auricular acupuncture for migraine: A protocol for systematic review and meta-analysis.

Introduction: Migraines are caused by neurological and vascular dysfunction, with a side or both sides of the head pain recurrent attack, often accompanied by nausea, vomiting, light, and sound allergy as the characteristics, is the clinical common disease, frequently occurring disease. The incidence of migraine is 8.4% to 28% worldwide (highest in Germany), and the lifetime incidence is about 14.

An easy synthesis of nitrogen and phosphorus co-doped carbon dots as a probe for chloramphenicol.

Heteroatom doping in carbon dots (CDs) was found to be an efficient way to regulate the structure of electronic energy levels and enhance the fluorescence characteristics of CDs. Nevertheless, most reported fabrication processes of heteroatom-doped CDs are rigorous and complex. Herein, a facile and novel strategy was developed to rapidly prepare nitrogen and phosphorus co-doped CDs (N,P-CDs) using acetic acid as the carbon source, and arginine, 1,2-ethylenediamine (EDA) and diphosphorus pentoxide as the dopants, respectively.

LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies.

Although abnormal expression of the long non-coding RNA (lncRNA) MEG3 has been reported in multiple cancer types, the role of MEG3 in the pathobiology of hepatocellular carcinoma (HCC) remains unknown. This study evaluated the expression of lncRNA MEG3 and a microRNA (miRNA-10a-5p) implicated in HCC metastasis in cancer and carcinoma adjacent tissues of HCC samples (n=30 each) via in situ hybridization and quantitative RT-PCR. The effects of overexpressing either MEG3 alone, or MEG3 in combination with miRNA-10a-5p, on the proliferation, apoptosis, cell cycle progression, migration, and invasion of HepG2 cells were evaluated using functional assays.

Decreased expression of long non-coding RNA SNHG7 cause recurrent spontaneous abortion through suppression proliferation and invasion of trophoblast cells via miR-34a.

Little is known about the role of long non-coding RNA SNHG7-1 in the development of recurrent spontaneous abortion (RSA). The aim of the present study was to investigate the levels of SNHG7-1 in villi of RSA, and explore its underlying mechanism. The qRT-PCR assay SNHG7-1 showed that the expression level was downregulated in RSA and HTR-8/SVneo cells.

Prognostic significance of stromal SMYD3 expression in colorectal cancer of TNM stage I-III.

Background: SET and MYND domain-containing protein 3 (SMYD3) is a histone methyltransferases and it promotes progression of many kinds of cancers including lung cancer, ovarian cancer and gastric cancer. In colorectal cancer (CRC), SMYD3 is proved to stimulate the proliferation of cancer cells, but the clinical significance of SMYD3 in CRC has not been elucidated.

Methods: In our study, we detected the expression of SMYD3 in CRC samples in TNM stage I-III with immunohistochemistry.